Homo sapiens (human): 1128 Help Entry 1128              CDS       T01001                                  Gene name CHRM1, HM1, M1, M1R Definition (RefSeq) cholinergic receptor muscarinic 1   KO K04129   muscarinic acetylcholine receptor M1 Organism hsa  Homo sapiens (human) Pathway hsa04020   Calcium signaling pathway hsa04024   cAMP signaling pathway hsa04080   Neuroactive ligand-receptor interaction hsa04151   PI3K-Akt signaling pathway hsa04725   Cholinergic synapse hsa04810   Regulation of actin cytoskeleton hsa05010   Alzheimer disease hsa05022   Pathways of neurodegeneration - multiple diseases Network nt06410  Calcium signaling nt06460  Alzheimer disease   Element N01000   mAChR-Ca2+ -apoptotic pathway N01001   Mutation-caused aberrant Abeta to mAchR-Ca2+ -apoptotic pathway Drug target Aceclidine:  D02750 Acetylcholine (DG01133):  D00999<JP/US> Aclatonium (DG01291):  D01955<JP> Aclidinium bromide:  D08837<JP/US> Alvameline maleate:  D02876 Anisotropine methylbromide:  D00232 Atropine (DG00052):  D00113 D02069<JP/US> Atropine oxide (DG01243):  D03011 D07477 Batefenterol (DG01627):  D10545 D10546 Benapryzine hydrochloride:  D03076 Benzatropine (DG00859):  D00778<US> D07511 Benzetimide (DG01301):  D03087 D07513 Benzilone:  D03088 Bethanechol (DG00991):  D01000<JP/US> Bevonium:  D01532 Biperiden (DG00852):  D00779 D02246<JP> D02247<JP> Blarcamesine (DG03048):  D11383 D11549 Bornaprine:  D07302 Butropium bromide:  D01491<JP> Butylscopolamine:  D01451<JP> Carbachol:  D00524<US> Carpronium (DG01289):  D01175<JP> D09752<JP> Chlorpromazine (DG00867):  D00270 D00789<JP/US> D03274 D04034<JP> D09819 Choline alfoscerate:  D07349 Cimetropium bromide:  D07099 Clidinium bromide:  D00716 Cyclopentolate (DG01141):  D01002<JP/US> D07759 Darotropium bromide:  D09402 Dexetimide (DG00856):  D03711 D07804 Dicycloverine (DG00032):  D00717<US> D07820 Diethazine (DG01921):  D02603 D07823 Difemerine:  D07079 Dihexyverine (DG00033):  D03824 D07821 Diphenidol (DG02880):  D01318<JP> D03858 D03859 Diphenylpiperidinomethyldioxolan iodide:  D01600 Diponium bromide:  D01463 Elantrine:  D03970 Elucaine:  D03979 Esoxybutynin chloride:  D04057 Etomidoline:  D01359 Etybenzatropine:  D04087 Eucatropine hydrochloride:  D04116 Fenpiverinium:  D07070 Fentonium:  D07951 Flutropium bromide:  D02417 Glycopyrronium (DG02467):  D10939<US> Heteronium bromide:  D04434 Homatropine (DG01142):  D01004 Homatropine methylbromide:  D02070 Hyoscyamine (DG00053):  D00147 D00719 D01648 D04479 Imidafenacin:  D06273<JP> Ipratropium bromide:  D02212<JP/US> Mazaticol (DG00857):  D03264<JP> D08157 Mebeverine (DG00030):  D04868 D08160 Mepenzolate (DG00040):  D00720<JP> Methacholine:  D04970<JP/US> Methantheline (DG00036):  D00721 Methscopolamine bromide:  D00715<US> Methylatropine (DG01242):  D01077 D03814 Methylbenactyzium bromide:  D01315 Methylscopolamine:  D01976<JP> Metixene (DG00853):  D01871 D08209 Metoquizine:  D05012 Milameline hydrochloride:  D05035 Otilonium bromide:  D07083 Oxapium iodide:  D01815 Oxitropium bromide:  D01946 Oxybutynin (DG00478):  D00465<US> D00722<JP/US> Oxyphencyclimine (DG00029):  D01006 D08325 Oxyphenonium:  D06877 Parapenzolate bromide:  D05360 Pentapiperium methylsulfate:  D05418 Penthienate:  D07081 Phencarbamide:  D05452 Phenglutarimide:  D07301 Pipenzolate:  D07084 Piperidolate (DG00034):  D01165<JP> D08382 Pipethanate (DG01255):  D01521 D08384 Pipethanate ethobromide:  D01987 Pirenzepine (DG00026):  D01297 D05276<JP> D08389 Piroheptine (DG01272):  D01231<JP> D08395 Poldine:  D05535 Pridinol (DG00774):  D02064<JP> D08418 D08419 Prifinium bromide:  D01377 Procyclidine (DG00854):  D00782 D08425 Profenamine (DG00855):  D01118 D03276 D08426 Propantheline (DG00035):  D00481<JP/US> Propenzolate hydrochloride:  D05628 Propiverine (DG00479):  D01007<JP> D08441 Rapacuronium bromide:  D05703 Revefenacin:  D10978<US> Rocuronium bromide:  D00765<JP/US> Sabcomeline hydrochloride:  D05779 Scopolamine (DG00065):  D00138<US> D02071<JP> Talsaclidine fumarate:  D06000 Tazomeline citrate:  D06015 Telenzepine hydrochloride hydrate:  D11098 Tematropium methylsulfate:  D06061 Tiemonium (DG01254):  D08595 Tiemonium iodide:  D01201 Timepidium bromide (DG00041):  D02535<JP> Tofenacin hydrochloride:  D06175 Toquizine:  D06192 Triampyzine sulfate:  D06217 Tridihexethyl (DG00037):  D00723 Trihexyphenidyl (DG00851):  D00787<JP/US> D08638 Tropatepine (DG00858):  D07303 D08653 Tropicamide:  D00397<JP/US> Umeclidinium (DG01253):  D10180 Umeclidinium bromide:  D10181<JP/US> Valethamate:  D01538 Xanomeline (DG01300):  D06330 D06331 Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04020 Calcium signaling pathway     1128 (CHRM1)    04024 cAMP signaling pathway     1128 (CHRM1)    04151 PI3K-Akt signaling pathway     1128 (CHRM1)   09133 Signaling molecules and interaction    04080 Neuroactive ligand-receptor interaction     1128 (CHRM1)  09140 Cellular Processes   09142 Cell motility    04810 Regulation of actin cytoskeleton     1128 (CHRM1)  09150 Organismal Systems   09156 Nervous system    04725 Cholinergic synapse     1128 (CHRM1)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     1128 (CHRM1)    05022 Pathways of neurodegeneration - multiple diseases     1128 (CHRM1)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04030 G protein-coupled receptors [BR:hsa04030]     1128 (CHRM1) G protein-coupled receptors [BR:hsa04030]  Rhodopsin family   Biogenic amine    Acetylcholine (muscarinic)     1128 (CHRM1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  7tm_1 7TM_GPCR_Srsx 7tm_4 7TM_GPCR_Srbc 7TM_GPCR_Srx Motif Other DBs NCBI-GeneID:  1128 NCBI-ProteinID:  NP_000729 OMIM:  118510 HGNC:  1950 Ensembl:  ENSG00000168539 Vega:  OTTHUMG00000167765 Pharos:  P11229(Tclin) UniProt:  P11229 Q53XZ3 LinkDB All DBs Structure PDB:  6OIJ Thumbnails Position 11q12.3 AA seq 460 aa AA seqDB search MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVN NYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLIS FDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYI QFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSS SERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEV VIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKE KKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYAL CNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC NT seq 1383 nt NT seq  +upstreamnt  +downstreamnt atgaacacttcagccccacctgctgtcagccccaacatcaccgtcctggcaccaggaaag ggtccctggcaagtggccttcattgggatcaccacgggcctcctgtcgctagccacagtg acaggcaacctgctggtactcatctctttcaaggtcaacacggagctcaagacagtcaat aactacttcctgctgagcctggcctgtgctgacctcatcatcggtaccttctccatgaac ctctataccacgtacctgctcatgggccactgggctctgggcacgctggcttgtgacctc tggctggccctggactatgtggccagcaatgcctccgtcatgaatctgctgctcatcagc tttgaccgctacttctccgtgactcggcccctgagctaccgtgccaagcgcacaccccgc cgggcagctctgatgatcggcctggcctggctggtttcctttgtgctctgggccccagcc atcctcttctggcagtacctggtaggggagcggacagtgctagctgggcagtgctacatc cagttcctctcccagcccatcatcacctttggcacagccatggctgccttctacctccct gtcacagtcatgtgcacgctctactggcgcatctaccgggagacagagaaccgagcacgg gagctggcagcccttcagggctccgagacgccaggcaaagggggtggcagcagcagcagc tcagagaggtctcagccaggggctgagggctcaccagagactcctccaggccgctgctgt cgctgctgccgggcccccaggctgctgcaggcctacagctggaaggaagaagaggaagag gacgaaggctccatggagtccctcacatcctcagagggagaggagcctggctccgaagtg gtgatcaagatgccaatggtggaccccgaggcacaggcccccaccaagcagcccccacgg agctccccaaatacagtcaagaggccgactaagaaagggcgtgatcgagctggcaagggc cagaagccccgtggaaaggagcagctggccaagcggaagaccttctcgctggtcaaggag aagaaggcggctcggaccctgagtgccatcctcctggccttcatcctcacctggacaccg tacaacatcatggtgctggtgtccaccttctgcaaggactgtgttcccgagaccctgtgg gagctgggctactggctgtgctacgtcaacagcaccatcaaccccatgtgctacgcactc tgcaacaaagccttccgggacacctttcgcctgctgctgctttgccgctgggacaagaga cgctggcgcaagatccccaagcgccctggctccgtgcaccgcactccctcccgccaatgc tga

Homo sapiens (human): 1131 Help Entry 1131              CDS       T01001                                  Gene name CHRM3, EGBRS, HM3, PBS Definition (RefSeq) cholinergic receptor muscarinic 3   KO K04131   muscarinic acetylcholine receptor M3 Organism hsa  Homo sapiens (human) Pathway hsa04020   Calcium signaling pathway hsa04080   Neuroactive ligand-receptor interaction hsa04725   Cholinergic synapse hsa04742   Taste transduction hsa04810   Regulation of actin cytoskeleton hsa04911   Insulin secretion hsa04970   Salivary secretion hsa04971   Gastric acid secretion hsa04972   Pancreatic secretion hsa05010   Alzheimer disease hsa05022   Pathways of neurodegeneration - multiple diseases Network nt06410  Calcium signaling nt06460  Alzheimer disease   Element N01000   mAChR-Ca2+ -apoptotic pathway N01001   Mutation-caused aberrant Abeta to mAchR-Ca2+ -apoptotic pathway Disease H02129   Prune belly syndrome Drug target Acetylcholine (DG01133):  D00999<JP/US> Aclatonium (DG01291):  D01955<JP> Aclidinium bromide:  D08837<JP/US> Alvameline maleate:  D02876 Anisotropine methylbromide:  D00232 Atropine (DG00052):  D00113 D02069<JP/US> Atropine oxide (DG01243):  D03011 D07477 Batefenterol (DG01627):  D10545 D10546 Benapryzine hydrochloride:  D03076 Benzatropine (DG00859):  D00778<US> D07511 Benzetimide (DG01301):  D03087 D07513 Benzilone:  D03088 Bethanechol (DG00991):  D01000<JP/US> Bevonium:  D01532 Biperiden (DG00852):  D00779 D02246<JP> D02247<JP> Blarcamesine (DG03048):  D11383 D11549 Bornaprine:  D07302 Butropium bromide:  D01491<JP> Butylscopolamine:  D01451<JP> Carbachol:  D00524<US> Carpronium (DG01289):  D01175<JP> D09752<JP> Cevimeline (DG00993):  D00661<JP/US> D07667 Chlorpromazine (DG00867):  D00270 D00789<JP/US> D03274 D04034<JP> D09819 Choline alfoscerate:  D07349 Cimetropium bromide:  D07099 Clidinium bromide:  D00716 Cyclopentolate (DG01141):  D01002<JP/US> D07759 Darifenacin (DG00482):  D01699<US> D03654 Darotropium bromide:  D09402 Desfesoterodine:  D10853 Dexetimide (DG00856):  D03711 D07804 Dexpanthenol:  D00193<JP> Dicycloverine (DG00032):  D00717<US> D07820 Diethazine (DG01921):  D02603 D07823 Difemerine:  D07079 Dihexyverine (DG00033):  D03824 D07821 Diphemanil:  D06878 Diphenidol (DG02880):  D01318<JP> D03858 D03859 Diphenylpiperidinomethyldioxolan iodide:  D01600 Diponium bromide:  D01463 Elantrine:  D03970 Elucaine:  D03979 Esoxybutynin chloride:  D04057 Etomidoline:  D01359 Etybenzatropine:  D04087 Eucatropine hydrochloride:  D04116 Fenpiverinium:  D07070 Fentonium:  D07951 Fesoterodine (DG00483):  D07226 D08923<JP/US> Flutropium bromide:  D02417 Glycopyrronium:  D00540<JP/US> Glycopyrronium (DG02467):  D10938 D10939<US> Heteronium bromide:  D04434 Hexocyclium (DG00039):  D01003 Homatropine (DG01142):  D01004 Homatropine methylbromide:  D02070 Hyoscyamine (DG00053):  D00147 D00719 D01648 D04479 Imidafenacin:  D06273<JP> Ipratropium bromide:  D02212<JP/US> Isopropamide (DG00038):  D01005 Mazaticol (DG00857):  D03264<JP> D08157 Mebeverine (DG00030):  D04868 D08160 Mepenzolate (DG00040):  D00720<JP> Methacholine:  D04970<JP/US> Methantheline (DG00036):  D00721 Methscopolamine bromide:  D00715<US> Methylatropine (DG01242):  D01077 D03814 Methylbenactyzium bromide:  D01315 Methylscopolamine:  D01976<JP> Metixene (DG00853):  D01871 D08209 Metoquizine:  D05012 Milameline hydrochloride:  D05035 Navafenterol (DG03123):  D11900 D11901 Otilonium bromide:  D07083 Oxapium iodide:  D01815 Oxitropium bromide:  D01946 Oxybutynin (DG00478):  D00465<US> D00722<JP/US> Oxyphencyclimine (DG00029):  D01006 D08325 Parapenzolate bromide:  D05360 Pentapiperium methylsulfate:  D05418 Penthienate:  D07081 Phencarbamide:  D05452 Phenglutarimide:  D07301 Pilocarpine (DG00992):  D00525 D02200<JP/US> D05478 D08376 Pipenzolate:  D07084 Piperidolate (DG00034):  D01165<JP> D08382 Pipethanate (DG01255):  D01521 D08384 Pipethanate ethobromide:  D01987 Pirenzepine (DG00026):  D01297 D05276<JP> D08389 Piroheptine (DG01272):  D01231<JP> D08395 Poldine:  D05535 Pridinol (DG00774):  D02064<JP> D08418 D08419 Prifinium bromide:  D01377 Procyclidine (DG00854):  D00782 D08425 Profenamine (DG00855):  D01118 D03276 D08426 Propantheline (DG00035):  D00481<JP/US> Propenzolate hydrochloride:  D05628 Propiverine (DG00479):  D01007<JP> D08441 Rapacuronium bromide:  D05703 Revefenacin:  D10978<US> Rociverine:  D07078 Rocuronium bromide:  D00765<JP/US> Scopolamine (DG00065):  D00138<US> D02071<JP> Sofpironium bromide:  D10989<JP> Solifenacin (DG00481):  D01269<JP/US> D08522 Tazomeline citrate:  D06015 Tematropium methylsulfate:  D06061 Tiemonium (DG01254):  D08595 Tiemonium iodide:  D01201 Timepidium bromide (DG00041):  D02535<JP> Tiotropium bromide:  D01929<JP/US> Tiquizium bromide:  D01875<JP> Tofenacin hydrochloride:  D06175 Tolterodine (DG00480):  D00646 D01148<JP/US> Toquizine:  D06192 Triampyzine sulfate:  D06217 Tridihexethyl (DG00037):  D00723 Trihexyphenidyl (DG00851):  D00787<JP/US> D08638 Tropatepine (DG00858):  D07303 D08653 Tropicamide:  D00397<JP/US> Trospium:  D01103<US> Umeclidinium (DG01253):  D10180 Umeclidinium bromide:  D10181<JP/US> Valethamate:  D01538 Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04020 Calcium signaling pathway     1131 (CHRM3)   09133 Signaling molecules and interaction    04080 Neuroactive ligand-receptor interaction     1131 (CHRM3)  09140 Cellular Processes   09142 Cell motility    04810 Regulation of actin cytoskeleton     1131 (CHRM3)  09150 Organismal Systems   09152 Endocrine system    04911 Insulin secretion     1131 (CHRM3)   09154 Digestive system    04970 Salivary secretion     1131 (CHRM3)    04971 Gastric acid secretion     1131 (CHRM3)    04972 Pancreatic secretion     1131 (CHRM3)   09156 Nervous system    04725 Cholinergic synapse     1131 (CHRM3)   09157 Sensory system    04742 Taste transduction     1131 (CHRM3)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     1131 (CHRM3)    05022 Pathways of neurodegeneration - multiple diseases     1131 (CHRM3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04030 G protein-coupled receptors [BR:hsa04030]     1131 (CHRM3) G protein-coupled receptors [BR:hsa04030]  Rhodopsin family   Biogenic amine    Acetylcholine (muscarinic)     1131 (CHRM3) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  7tm_1 7TM_GPCR_Srsx 7tm_4 7TM_GPCR_Srbc 7TM_GPCR_Srx Motif Other DBs NCBI-GeneID:  1131 NCBI-ProteinID:  NP_000731 OMIM:  118494 HGNC:  1952 Ensembl:  ENSG00000133019 Vega:  OTTHUMG00000039649 Pharos:  P20309(Tclin) UniProt:  P20309 A0A024R3W1 LinkDB All DBs Position 1q43 AA seq 590 aa AA seqDB search MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPL GGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVI SMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKR TTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAF YMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSM KRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSE TRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSF PKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKR MSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVN PVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL NT seq 1773 nt NT seq  +upstreamnt  +downstreamnt atgaccttgcacaataacagtacaacctcgcctttgtttccaaacatcagctcctcctgg atacacagcccctccgatgcagggctgcccccgggaaccgtcactcatttcggcagctac aatgtttctcgagcagctggcaatttctcctctccagacggtaccaccgatgaccctctg ggaggtcataccgtctggcaagtggtcttcatcgctttcttaacgggcatcctggccttg gtgaccatcatcggcaacatcctggtaattgtgtcatttaaggtcaacaagcagctgaag acggtcaacaactacttcctcttaagcctggcctgtgccgatctgattatcggggtcatt tcaatgaatctgtttacgacctacatcatcatgaatcgatgggccttagggaacttggcc tgtgacctctggcttgccattgactacgtagccagcaatgcctctgttatgaatcttctg gtcatcagctttgacagatacttttccatcacgaggccgctcacgtaccgagccaaacga acaacaaagagagccggtgtgatgatcggtctggcttgggtcatctcctttgtcctttgg gctcctgccatcttgttctggcaatactttgttggaaagagaactgtgcctccgggagag tgcttcattcagttcctcagtgagcccaccattacttttggcacagccatcgctgctttt tatatgcctgtcaccattatgactattttatactggaggatctataaggaaactgaaaag cgtaccaaagagcttgctggcctgcaagcctctgggacagaggcagagacagaaaacttt gtccaccccacgggcagttctcgaagctgcagcagttacgaacttcaacagcaaagcatg aaacgctccaacaggaggaagtatggccgctgccacttctggttcacaaccaagagctgg aaacccagctccgagcagatggaccaagaccacagcagcagtgacagttggaacaacaat gatgctgctgcctccctggagaactccgcctcctccgacgaggaggacattggctccgag acgagagccatctactccatcgtgctcaagcttccgggtcacagcaccatcctcaactcc accaagttaccctcatcggacaacctgcaggtgcctgaggaggagctggggatggtggac ttggagaggaaagccgacaagctgcaggcccagaagagcgtggacgatggaggcagtttt ccaaaaagcttctccaagcttcccatccagctagagtcagccgtggacacagctaagact tctgacgtcaactcctcagtgggtaagagcacggccactctacctctgtccttcaaggaa gccactctggccaagaggtttgctctgaagaccagaagtcagatcactaagcggaaaagg atgtccctggtcaaggagaagaaagcggcccagaccctcagtgcgatcttgcttgccttc atcatcacttggaccccatacaacatcatggttctggtgaacaccttttgtgacagctgc atacccaaaaccttttggaatctgggctactggctgtgctacatcaacagcaccgtgaac cccgtgtgctatgctctgtgcaacaaaacattcagaaccactttcaagatgctgctgctg tgccagtgtgacaaaaaaaagaggcgcaagcagcagtaccagcagagacagtcggtcatt tttcacaagcgcgcacccgagcaggccttgtag

Homo sapiens (human): 1133 Help Entry 1133              CDS       T01001                                  Gene name CHRM5, HM5 Definition (RefSeq) cholinergic receptor muscarinic 5   KO K04133   muscarinic acetylcholine receptor M5 Organism hsa  Homo sapiens (human) Pathway hsa04020   Calcium signaling pathway hsa04080   Neuroactive ligand-receptor interaction hsa04725   Cholinergic synapse hsa04810   Regulation of actin cytoskeleton hsa05010   Alzheimer disease hsa05022   Pathways of neurodegeneration - multiple diseases Network nt06410  Calcium signaling nt06460  Alzheimer disease   Element N01000   mAChR-Ca2+ -apoptotic pathway N01001   Mutation-caused aberrant Abeta to mAchR-Ca2+ -apoptotic pathway Drug target Acetylcholine (DG01133):  D00999<JP/US> Aclatonium (DG01291):  D01955<JP> Aclidinium bromide:  D08837<JP/US> Anisotropine methylbromide:  D00232 Atropine (DG00052):  D00113 D02069<JP/US> Atropine oxide (DG01243):  D03011 D07477 Batefenterol (DG01627):  D10545 D10546 Benapryzine hydrochloride:  D03076 Benzatropine (DG00859):  D00778<US> D07511 Benzetimide (DG01301):  D03087 D07513 Benzilone:  D03088 Bethanechol (DG00991):  D01000<JP/US> Bevonium:  D01532 Biperiden (DG00852):  D00779 D02246<JP> D02247<JP> Blarcamesine (DG03048):  D11383 D11549 Bornaprine:  D07302 Butropium bromide:  D01491<JP> Butylscopolamine:  D01451<JP> Carbachol:  D00524<US> Carpronium (DG01289):  D01175<JP> D09752<JP> Chlorpromazine (DG00867):  D00270 D00789<JP/US> D03274 D04034<JP> D09819 Choline alfoscerate:  D07349 Cimetropium bromide:  D07099 Clidinium bromide:  D00716 Cyclopentolate (DG01141):  D01002<JP/US> D07759 Darotropium bromide:  D09402 Dexetimide (DG00856):  D03711 D07804 Diethazine (DG01921):  D02603 D07823 Difemerine:  D07079 Dihexyverine (DG00033):  D03824 D07821 Diphenidol (DG02880):  D01318<JP> D03858 D03859 Diphenylpiperidinomethyldioxolan iodide:  D01600 Diponium bromide:  D01463 Elantrine:  D03970 Elucaine:  D03979 Etomidoline:  D01359 Etybenzatropine:  D04087 Eucatropine hydrochloride:  D04116 Fenpiverinium:  D07070 Fentonium:  D07951 Flutropium bromide:  D02417 Glycopyrronium (DG02467):  D10939<US> Heteronium bromide:  D04434 Homatropine (DG01142):  D01004 Homatropine methylbromide:  D02070 Hyoscyamine (DG00053):  D00147 D00719 D01648 D04479 Ipratropium bromide:  D02212<JP/US> Mazaticol (DG00857):  D03264<JP> D08157 Mebeverine (DG00030):  D04868 D08160 Mepenzolate (DG00040):  D00720<JP> Methacholine:  D04970<JP/US> Methantheline (DG00036):  D00721 Methscopolamine bromide:  D00715<US> Methylatropine (DG01242):  D01077 D03814 Methylbenactyzium bromide:  D01315 Methylscopolamine:  D01976<JP> Metixene (DG00853):  D01871 D08209 Metoquizine:  D05012 Milameline hydrochloride:  D05035 Otilonium bromide:  D07083 Oxapium iodide:  D01815 Oxitropium bromide:  D01946 Oxybutynin (DG00478):  D00465<US> D00722<JP/US> Parapenzolate bromide:  D05360 Pentapiperium methylsulfate:  D05418 Penthienate:  D07081 Phencarbamide:  D05452 Phenglutarimide:  D07301 Pipenzolate:  D07084 Piperidolate (DG00034):  D01165<JP> D08382 Pipethanate (DG01255):  D01521 D08384 Pipethanate ethobromide:  D01987 Pirenzepine (DG00026):  D01297 D05276<JP> D08389 Piroheptine (DG01272):  D01231<JP> D08395 Poldine:  D05535 Pridinol (DG00774):  D02064<JP> D08418 D08419 Prifinium bromide:  D01377 Procyclidine (DG00854):  D00782 D08425 Profenamine (DG00855):  D01118 D03276 D08426 Propantheline (DG00035):  D00481<JP/US> Propenzolate hydrochloride:  D05628 Propiverine (DG00479):  D01007<JP> D08441 Rapacuronium bromide:  D05703 Revefenacin:  D10978<US> Rocuronium bromide:  D00765<JP/US> Scopolamine (DG00065):  D00138<US> D02071<JP> Tazomeline citrate:  D06015 Tematropium methylsulfate:  D06061 Tiemonium (DG01254):  D08595 Tiemonium iodide:  D01201 Timepidium bromide (DG00041):  D02535<JP> Tofenacin hydrochloride:  D06175 Toquizine:  D06192 Triampyzine sulfate:  D06217 Trihexyphenidyl (DG00851):  D00787<JP/US> D08638 Tropatepine (DG00858):  D07303 D08653 Tropicamide:  D00397<JP/US> Umeclidinium (DG01253):  D10180 Umeclidinium bromide:  D10181<JP/US> Valethamate:  D01538 Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04020 Calcium signaling pathway     1133 (CHRM5)   09133 Signaling molecules and interaction    04080 Neuroactive ligand-receptor interaction     1133 (CHRM5)  09140 Cellular Processes   09142 Cell motility    04810 Regulation of actin cytoskeleton     1133 (CHRM5)  09150 Organismal Systems   09156 Nervous system    04725 Cholinergic synapse     1133 (CHRM5)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     1133 (CHRM5)    05022 Pathways of neurodegeneration - multiple diseases     1133 (CHRM5)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04030 G protein-coupled receptors [BR:hsa04030]     1133 (CHRM5) G protein-coupled receptors [BR:hsa04030]  Rhodopsin family   Biogenic amine    Acetylcholine (muscarinic)     1133 (CHRM5) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  7tm_1 7TM_GPCR_Srsx 7TM_GPCR_Srx 7tm_4 7TM_GPCR_Srbc Motif Other DBs NCBI-GeneID:  1133 NCBI-ProteinID:  NP_001307846 OMIM:  118496 HGNC:  1954 Ensembl:  ENSG00000184984 Vega:  OTTHUMG00000129369 Pharos:  P08912(Tclin) UniProt:  P08912 A0A024R9I2 LinkDB All DBs Position 15q14 AA seq 532 aa AA seqDB search MEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQ LKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMN LLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPL DECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAE KRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQL TTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPGEEFSAEETEETFVKAETEKSDYDTPN YLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLNP NPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLG YWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP NT seq 1599 nt NT seq  +upstreamnt  +downstreamnt atggaaggggattcttaccacaatgcaaccaccgtcaatggcaccccagtaaatcaccag cctttggaacgccacaggttgtgggaagtcatcaccattgcagctgtgactgctgtggta agcctgatcaccattgtgggcaatgtcttggtcatgatctccttcaaagtcaacagccag ctcaagacagttaacaactattacctgctcagcttagcctgtgcagatctcatcattgga atcttctccatgaacctctacaccacctacatcctcatgggacgctgggctctcgggagt ctggcttgtgacctttggcttgcactggactacgtggccagcaacgcttctgtcatgaac cttctggtgatcagttttgaccgttacttttccatcacaagacccttgacatatcgggcc aagcgtactccgaaaagggctggcatcatgattggcttggcctggctgatctccttcatc ctctgggccccagcaatcctctgctggcagtacttggttgggaagcggacagttccactg gatgagtgccagatccagtttctctctgagcccaccatcacttttggcactgccattgct gccttctacatccctgtttctgtcatgaccatcctctactgtcgaatctaccgggaaaca gagaagcgaaccaaggacctggctgacctccagggttctgactctgtgaccaaagctgag aagagaaagccagctcatagggctctgttcagatcctgcttgcgctgtcctcgacccacc ctggcccagcgggaaaggaaccaggcctcctggtcatcctcccgcaggagcacctccacc actgggaagccatcccaagccactggcccaagcgccaattgggccaaagctgagcagctc accacctgtagcagctacccttcctcagaggatgaggacaagcccgccactgaccctgtc ctccaagtggtctacaagagtcagggtaaggaaagcccaggggaagaattcagtgctgaa gagactgaggaaacttttgtgaaagctgaaactgaaaaaagtgactatgacaccccaaac taccttctgtctccagcagctgctcatagacccaagagtcagaaatgtgtggcctataag ttccgattggtggtaaaagctgacgggaaccaggagaccaacaatggctgtcacaaggtg aaaatcatgccctgccccttcccagtggccaaggaaccttcaacgaaaggcctcaatccc aaccccagccatcaaatgaccaaacgaaagagagtggtcctagtcaaagagaggaaagca gcccagacactgagtgccattctcctggccttcatcatcacatggaccccgtataacatc atggtcctggtttctaccttctgtgacaagtgtgtcccagtcaccctgtggcacttgggc tattggttgtgctatgtcaatagcactgtcaaccccatctgctatgccctctgcaacaga accttcaggaagacctttaagatgctgcttctctgccgatggaaaaagaaaaaagtggaa gagaagttgtactggcaggggaacagcaagctaccctga

Homo sapiens (human): 135 Help Entry 135               CDS       T01001                                  Gene name ADORA2A, A2aR, ADORA2, RDC8 Definition (RefSeq) adenosine A2a receptor   KO K04266   adenosine receptor A2a Organism hsa  Homo sapiens (human) Pathway hsa04015   Rap1 signaling pathway hsa04020   Calcium signaling pathway hsa04024   cAMP signaling pathway hsa04080   Neuroactive ligand-receptor interaction hsa04270   Vascular smooth muscle contraction hsa05012   Parkinson disease hsa05034   Alcoholism Drug target Adenosine (DG00243):  D00045<JP/US> D02300<JP> D02769 D08646 D08647 Apadenoson:  D03212 Binodenoson:  D03120 Caffeine (DG00974):  D00528<JP> D01453<JP> D07603<US> Choline theophyllinate:  D02017 Ciforadenant:  D11547 Doxofylline:  D03898 Enprofylline:  D04006 Evodenoson:  D10362 Inupadenant (DG03145):  D11978 D11979 Istradefylline:  D04641<JP/US> Preladenant:  D09717 Proxyphylline:  D01771<JP> Regadenoson:  D05711<US> Sonedenoson:  D09003 Tozadenant:  D10174 Vipadenant:  D09991 Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     135 (ADORA2A)    04020 Calcium signaling pathway     135 (ADORA2A)    04024 cAMP signaling pathway     135 (ADORA2A)   09133 Signaling molecules and interaction    04080 Neuroactive ligand-receptor interaction     135 (ADORA2A)  09150 Organismal Systems   09153 Circulatory system    04270 Vascular smooth muscle contraction     135 (ADORA2A)  09160 Human Diseases   09164 Neurodegenerative disease    05012 Parkinson disease     135 (ADORA2A)   09165 Substance dependence    05034 Alcoholism     135 (ADORA2A)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04030 G protein-coupled receptors [BR:hsa04030]     135 (ADORA2A) G protein-coupled receptors [BR:hsa04030]  Rhodopsin family   Base and nucleoside    Adenosine     135 (ADORA2A) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  7tm_1 7TM_GPCR_Srsx 7tm_4 7TM_GPCR_Srx GPR_Gpa2_C Ni_hydr_CYTB Motif Other DBs NCBI-GeneID:  135 NCBI-ProteinID:  NP_000666 OMIM:  102776 HGNC:  263 Ensembl:  ENSG00000128271 Vega:  OTTHUMG00000150761 Pharos:  P29274(Tclin) UniProt:  P29274 B3KVQ4 X5DNB4 LinkDB All DBs Structure PDB:  4UHR 4UG2 2YDV 3VG9 2YDO 3VGA 3UZA 3PWH 3REY 3UZC 5G53 3RFM Thumbnails Position 22q11.23 AA seq 412 aa AA seqDB search MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAI PFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTR AKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYF NFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVG LFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFR KIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNG YALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS NT seq 1239 nt NT seq  +upstreamnt  +downstreamnt atgcccatcatgggctcctcggtgtacatcacggtggagctggccattgctgtgctggcc atcctgggcaatgtgctggtgtgctgggccgtgtggctcaacagcaacctgcagaacgtc accaactactttgtggtgtcactggcggcggccgacatcgcagtgggtgtgctcgccatc ccctttgccatcaccatcagcaccgggttctgcgctgcctgccacggctgcctcttcatt gcctgcttcgtcctggtcctcacgcagagctccatcttcagtctcctggccatcgccatt gaccgctacattgccatccgcatcccgctccggtacaatggcttggtgaccggcacgagg gctaagggcatcattgccatctgctgggtgctgtcgtttgccatcggcctgactcccatg ctaggttggaacaactgcggtcagccaaaggagggcaagaaccactcccagggctgcggg gagggccaagtggcctgtctctttgaggatgtggtccccatgaactacatggtgtacttc aacttctttgcctgtgtgctggtgcccctgctgctcatgctgggtgtctatttgcggatc ttcctggcggcgcgacgacagctgaagcagatggagagccagcctctgccgggggagcgg gcacggtccacactgcagaaggaggtccatgctgccaagtcactggccatcattgtgggg ctctttgccctctgctggctgcccctacacatcatcaactgcttcactttcttctgcccc gactgcagccacgcccctctctggctcatgtacctggccatcgtcctctcccacaccaat tcggttgtgaatcccttcatctacgcctaccgtatccgcgagttccgccagaccttccgc aagatcattcgcagccacgtcctgaggcagcaagaacctttcaaggcagctggcaccagt gcccgggtcttggcagctcatggcagtgacggagagcaggtcagcctccgtctcaacggc cacccgccaggagtgtgggccaacggcagtgctccccaccctgagcggaggcccaatggc tatgccctggggctggtgagtggagggagtgcccaagagtcccaggggaacacgggcctc ccagacgtggagctccttagccatgagctcaagggagtgtgcccagagccccctggccta gatgaccccctggcccaggatggagcaggagtgtcctga

Homo sapiens (human): 136 Help Entry 136               CDS       T01001                                  Gene name ADORA2B, ADORA2 Definition (RefSeq) adenosine A2b receptor   KO K04267   adenosine receptor A2b Organism hsa  Homo sapiens (human) Pathway hsa04015   Rap1 signaling pathway hsa04020   Calcium signaling pathway hsa04080   Neuroactive ligand-receptor interaction hsa04270   Vascular smooth muscle contraction hsa05034   Alcoholism Drug target Adenosine (DG00243):  D00045<JP/US> D02300<JP> D02769 D08646 D08647 Aminophylline (DG01062):  D00227 D05429<JP> D11630<US> Diprophylline:  D00691<JP> Enprofylline:  D04006 Proxyphylline:  D01771<JP> Theophylline (DG01061):  D00371<JP/US> D01712 D06103 D06104 Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     136 (ADORA2B)    04020 Calcium signaling pathway     136 (ADORA2B)   09133 Signaling molecules and interaction    04080 Neuroactive ligand-receptor interaction     136 (ADORA2B)  09150 Organismal Systems   09153 Circulatory system    04270 Vascular smooth muscle contraction     136 (ADORA2B)  09160 Human Diseases   09165 Substance dependence    05034 Alcoholism     136 (ADORA2B)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04030 G protein-coupled receptors [BR:hsa04030]     136 (ADORA2B) G protein-coupled receptors [BR:hsa04030]  Rhodopsin family   Base and nucleoside    Adenosine     136 (ADORA2B) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  7tm_1 7TM_GPCR_Srsx 7tm_4 7TM_GPCR_Srx GPR_Gpa2_C 7TM_GPCR_Sri Motif Other DBs NCBI-GeneID:  136 NCBI-ProteinID:  NP_000667 OMIM:  600446 HGNC:  264 Ensembl:  ENSG00000170425 Vega:  OTTHUMG00000059140 Pharos:  P29275(Tclin) UniProt:  P29275 LinkDB All DBs Position 17p12 AA seq 332 aa AA seqDB search MLLETQDALYVALELVIAALSVAGNVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGLFA IPFAITISLGFCTDFYGCLFLACFVLVLTQSSIFSLLAVAVDRYLAICVPLRYKSLVTGT RARGVIAVLWVLAFGIGLTPFLGWNSKDSATNNCTEPWDGTTNESCCLVKCLFENVVPMS YMVYFNFFGCVLPPLLIMLVIYIKIFLVACRQLQRTELMDHSRTTLQREIHAAKSLAMIV GIFALCWLPVHAVNCVTLFQPAQGKNKPKWAMNMAILLSHANSVVNPIVYAYRNRDFRYT FHKIISRYLLCQADVKSGNGQAGVQPALGVGL NT seq 999 nt NT seq  +upstreamnt  +downstreamnt atgctgctggagacacaggacgcgctgtacgtggcgctggagctggtcatcgccgcgctt tcggtggcgggcaacgtgctggtgtgcgccgcggtgggcacggcgaacactctgcagacg cccaccaactacttcctggtgtccctggctgcggccgacgtggccgtggggctcttcgcc atcccctttgccatcaccatcagcctgggcttctgcactgacttctacggctgcctcttc ctcgcctgcttcgtgctggtgctcacgcagagctccatcttcagccttctggccgtggca gtcgacagatacctggccatctgtgtcccgctcaggtataaaagtttggtcacggggacc cgagcaagaggggtcattgctgtcctctgggtccttgcctttggcatcggattgactcca ttcctggggtggaacagtaaagacagtgccaccaacaactgcacagaaccctgggatgga accacgaatgaaagctgctgccttgtgaagtgtctctttgagaatgtggtccccatgagc tacatggtatatttcaatttctttgggtgtgttctgcccccactgcttataatgctggtg atctacattaagatcttcctggtggcctgcaggcagcttcagcgcactgagctgatggac cactcgaggaccaccctccagcgggagatccatgcagccaagtcactggccatgattgtg gggatttttgccctgtgctggttacctgtgcatgctgttaactgtgtcactcttttccag ccagctcagggtaaaaataagcccaagtgggcaatgaatatggccattcttctgtcacat gccaattcagttgtcaatcccattgtctatgcttaccggaaccgagacttccgctacact tttcacaaaattatctccaggtatcttctctgccaagcagatgtcaagagtgggaatggt caggctggggtacagcctgctctcggtgtgggcctatga

Homo sapiens (human): 153 Help Entry 153               CDS       T01001                                  Gene name ADRB1, ADRB1R, B1AR, BETA1AR, FNSS2, RHR Definition (RefSeq) adrenoceptor beta 1   KO K04141   adrenergic receptor beta-1 Organism hsa  Homo sapiens (human) Pathway hsa04020   Calcium signaling pathway hsa04022   cGMP-PKG signaling pathway hsa04024   cAMP signaling pathway hsa04080   Neuroactive ligand-receptor interaction hsa04261   Adrenergic signaling in cardiomyocytes hsa04540   Gap junction hsa04923   Regulation of lipolysis in adipocytes hsa04924   Renin secretion hsa04970   Salivary secretion hsa05414   Dilated cardiomyopathy Drug target Acebutolol (DG00314):  D00597<JP/US> D02338 Adaprolol maleate:  D02765 Alprenolol (DG00303):  D01182 D07156 Alprenoxime hydrochloride:  D02834 Amiodarone (DG00204):  D00636<JP/US> D02910 Amosulalol (DG01302):  D01469<JP> D07451 Arbutamine:  D02976 Arotinolol (DG01303):  D01830<JP> D07465 Atenolol:  D00235<JP/US> Befunolol (DG01138):  D01512 D07496 Beradilol monoethyl maleate:  D09843 Betaxolol (DG00315):  D00598<JP/US> D07526 Bevantolol:  D01369<JP> Bisoprolol (DG00316):  D00634<JP/US> D02342<JP> Bopindolol (DG00310):  D01794 D07537 Bucumolol hydrochloride:  D01492 Bufetolol hydrochloride:  D01504<JP> Bunitrolol hydrochloride:  D01444 Bunolol hydrochloride:  D03177 Bupranolol (DG00311):  D01454 D07590 Butopamine:  D03195 Carteolol (DG00308):  D00599<JP/US> D07624 Carvedilol (DG00321):  D00255<JP/US> D03415<US> Celiprolol (DG00317):  D01741<JP> D07660 Cetamolol hydrochloride:  D03449 Cicloprolol hydrochloride:  D03490 Cimaterol:  D03502 Cloranolol:  D07183 Denopamine:  D02614<JP> Dexpropranolol hydrochloride:  D03729 Diacetolol hydrochloride:  D03759 Dilevalol hydrochloride:  D01906 Dipivefrine (DG01129):  D01017<JP> D02349 Dobutamine (DG00216):  D00632<JP/US> D03879 D03880 D03881 Docarpamine:  D01903<JP> Dronedarone (DG00207):  D02537 D03914<US> Droxidopa:  D01277<JP/US> Epanolol:  D06646 Ephedrine (DG00227):  D00124 D01386<JP> D04018<US> Epinephrine (DG00013):  D00095<JP/US> D00996 D02149 Epinephryl borate:  D04026 Esmolol (DG00318):  D00644<JP/US> D07916 Etilefrine (DG00210):  D01573<JP> D07931 Exaprolol hydrochloride:  D04120 Flestolol sulfate:  D04190 Indenolol (DG01323):  D01958 D08078 Isoprenaline (DG00211):  D01390<JP/US> D02066 D02150<JP> D08090 Labetalol (DG00320):  D00600<JP/US> D08106<US> Landiolol:  D01847<JP> Levdobutamine lactobionate:  D04708 Levobetaxolol hydrochloride:  D04710 Levobunolol (DG01136):  D01025<JP/US> D08115 Medroxalol (DG01317):  D04888 D04889 Mepindolol:  D07181 Methylephedrine (DG01229):  D01952 D02109<JP> D08206 D09842 Metipranolol (DG01137):  D02081 D02374 Metoprolol (DG00313):  D00601<JP/US> D00635<US> D02358 D05011 Nadolol:  D00432<JP/US> Nebivolol (DG00319):  D05127 D06622<US> Nipradilol:  D01691<JP> Norepinephrine (DG00212):  D00076<JP> D05206<US> D08284 D09794 Octodrine:  D05228 Oxprenolol (DG00304):  D01806 D08318 Pamatolol sulfate:  D05345 Penbutolol (DG00312):  D00602 D08074 Phenylpropanolamine (DG01041):  D01224 D05466 D08368 Pindolol:  D00513<JP/US> Practolol:  D05587 Primidolol:  D02389 Propranolol (DG00305):  D00483<JP/US> D08443 Pseudoephedrine (DG01042):  D00485 D05648 D05649 D08449 Racephedrine Hydrochloride:  D08982 Racepinephrine (DG01444):  D05688 D05689 S-atenolol:  D01471 Sotalol (DG00307):  D01026<JP/US> D08525 Talinolol:  D07184 Tazolol hydrochloride:  D06014 Tertatolol (DG00309):  D07182 D08572 Tilisolol (DG01322):  D01795 D08598 Timolol (DG00306):  D00378<US> D00603<JP/US> D08600 Tiprenolol hydrochloride:  D06162 Tolamolol:  D06176 Xamoterol (DG00231):  D06328 D06329 Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04020 Calcium signaling pathway     153 (ADRB1)    04024 cAMP signaling pathway     153 (ADRB1)    04022 cGMP-PKG signaling pathway     153 (ADRB1)   09133 Signaling molecules and interaction    04080 Neuroactive ligand-receptor interaction     153 (ADRB1)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04540 Gap junction     153 (ADRB1)  09150 Organismal Systems   09152 Endocrine system    04923 Regulation of lipolysis in adipocytes     153 (ADRB1)    04924 Renin secretion     153 (ADRB1)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     153 (ADRB1)   09154 Digestive system    04970 Salivary secretion     153 (ADRB1)  09160 Human Diseases   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     153 (ADRB1)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04030 G protein-coupled receptors [BR:hsa04030]     153 (ADRB1) G protein-coupled receptors [BR:hsa04030]  Rhodopsin family   Biogenic amine    Adrenaline     153 (ADRB1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  7tm_1 7TM_GPCR_Srsx 7TM_GPCR_Srx 7TM_GPCR_Srv 7tm_4 Motif Other DBs NCBI-GeneID:  153 NCBI-ProteinID:  NP_000675 OMIM:  109630 HGNC:  285 Ensembl:  ENSG00000043591 Vega:  OTTHUMG00000019079 Pharos:  P08588(Tclin) UniProt:  P08588 LinkDB All DBs Position 10q25.3 AA seq 477 aa AA seqDB search MGAGVLVLGASEPGNLSSAAPLPDGAATAARLLVPASPPASLLPPASESPEPLSQQWTAG MGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVV WGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVC TVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIM AFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATAP LANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRLFV FFNWLGYANSAFNPIIYCRSPDFRKAFQGLLCCARRAARRRHATHGDRPRASGCLARPGP PPSPGAASDDDDDDVVGATPPARLLEPWAGCNGGAAADSDSSLDEPCRPGFASESKV NT seq 1434 nt NT seq  +upstreamnt  +downstreamnt atgggcgcgggggtgctcgtcctgggcgcctccgagcccggtaacctgtcgtcggccgca ccgctccccgacggcgcggccaccgcggcgcggctgctggtgcccgcgtcgccgcccgcc tcgttgctgcctcccgccagcgaaagccccgagccgctgtctcagcagtggacagcgggc atgggtctgctgatggcgctcatcgtgctgctcatcgtggcgggcaatgtgctggtgatc gtggccatcgccaagacgccgcggctgcagacgctcaccaacctcttcatcatgtccctg gccagcgccgacctggtcatggggctgctggtggtgccgttcggggccaccatcgtggtg tggggccgctgggagtacggctccttcttctgcgagctgtggacctcagtggacgtgctg tgcgtgacggccagcatcgagaccctgtgtgtcattgccctggaccgctacctcgccatc acctcgcccttccgctaccagagcctgctgacgcgcgcgcgggcgcggggcctcgtgtgc accgtgtgggccatctcggccctggtgtccttcctgcccatcctcatgcactggtggcgg gcggagagcgacgaggcgcgccgctgctacaacgaccccaagtgctgcgacttcgtcacc aaccgggcctacgccatcgcctcgtccgtagtctccttctacgtgcccctgtgcatcatg gccttcgtgtacctgcgggtgttccgcgaggcccagaagcaggtgaagaagatcgacagc tgcgagcgccgtttcctcggcggcccagcgcggccgccctcgccctcgccctcgcccgtc cccgcgcccgcgccgccgcccggacccccgcgccccgccgccgccgccgccaccgccccg ctggccaacgggcgtgcgggtaagcggcggccctcgcgcctcgtggccctgcgcgagcag aaggcgctcaagacgctgggcatcatcatgggcgtcttcacgctctgctggctgcccttc ttcctggccaacgtggtgaaggccttccaccgcgagctggtgcccgaccgcctcttcgtc ttcttcaactggctgggctacgccaactcggccttcaaccccatcatctactgccgcagc cccgacttccgcaaggccttccagggactgctctgctgcgcgcgcagggctgcccgccgg cgccacgcgacccacggagaccggccgcgcgcctcgggctgtctggcccggcccggaccc ccgccatcgcccggggccgcctcggacgacgacgacgacgatgtcgtcggggccacgccg cccgcgcgcctgctggagccctgggccggctgcaacggcggggcggcggcggacagcgac tcgagcctggacgagccgtgccgccccggcttcgcctcggaatccaaggtgtag

Homo sapiens (human): 154 Help Entry 154               CDS       T01001                                  Gene name ADRB2, ADRB2R, ADRBR, B2AR, BAR, BETA2AR Definition (RefSeq) adrenoceptor beta 2   KO K04142   adrenergic receptor beta-2 Organism hsa  Homo sapiens (human) Pathway hsa04020   Calcium signaling pathway hsa04022   cGMP-PKG signaling pathway hsa04024   cAMP signaling pathway hsa04080   Neuroactive ligand-receptor interaction hsa04261   Adrenergic signaling in cardiomyocytes hsa04923   Regulation of lipolysis in adipocytes hsa04924   Renin secretion hsa04970   Salivary secretion Disease H00079   Asthma H02106   Genetic obesity Drug target Abediterol (DG01232):  D10219 D10220 Adaprolol maleate:  D02765 Alprenolol (DG00303):  D01182 D07156 Alprenoxime hydrochloride:  D02834 Amosulalol (DG01302):  D01469<JP> D07451 Arformoterol (DG01233):  D02981<US> D07463 Arotinolol (DG01303):  D01830<JP> D07465 Bambuterol (DG01060):  D07377 D07489 Batefenterol (DG01627):  D10545 D10546 Bedoradrine sulfate:  D06562 Befunolol (DG01138):  D01512 D07496 Beradilol monoethyl maleate:  D09843 Bitolterol (DG01056):  D00684 D07534 Bopindolol (DG00310):  D01794 D07537 Bucindolol hydrochloride:  D03170 Bucumolol hydrochloride:  D01492 Bufetolol hydrochloride:  D01504<JP> Bunitrolol hydrochloride:  D01444 Bunolol hydrochloride:  D03177 Bupranolol (DG00311):  D01454 D07590 Butoxamine hydrochloride:  D03198 Carazolol:  D07608 Carbuterol:  D03402 Carteolol (DG00308):  D00599<JP/US> D07624 Carvedilol (DG00321):  D00255<JP/US> D03415<US> Cimaterol:  D03502 Clenbuterol (DG01053):  D01360<JP> D07713 Cloranolol:  D07183 Clorprenaline hydrochloride:  D01835 Colterol mesylate:  D03587 Dexpropranolol hydrochloride:  D03729 Diacetolol hydrochloride:  D03759 Dilevalol hydrochloride:  D01906 Dipivefrine (DG01129):  D01017<JP> D02349 Dopexamine (DG00222):  D03891 D03892 Droxidopa:  D01277<JP/US> Ephedrine (DG00227):  D00124 D01386<JP> D04018<US> Epinephrine (DG00013):  D00095<JP/US> D00996 D02149 Epinephryl borate:  D04026 Etafedrine hydrochloride:  D04072 Etilefrine (DG00210):  D01573<JP> D07931 Exaprolol hydrochloride:  D04120 Fenoterol (DG00451):  D01428<JP> D04157 Flestolol sulfate:  D04190 Formoterol (DG01052):  D01373 D05277<JP/US> D07990 Hexoprenaline (DG01047):  D02396 D08039 Indacaterol (DG01057):  D09318 D09319<JP> D11009 Indenolol (DG01323):  D01958 D08078 Isoetarine (DG01234):  D02093 D04625 D04626 Isoprenaline (DG00211):  D01390<JP/US> D02066 D02150<JP> D08090 Isoxsuprine (DG00277):  D01748<JP> D08092 D08093 Labetalol (DG00320):  D00600<JP/US> D08106<US> Levalbuterol    Levosalbutamol (DG01235):  D02281<US> D04701 D04703<US> D08124 Levobunolol (DG01136):  D01025<JP/US> D08115 Mabuterol hydrochloride:  D01589 Medroxalol (DG01317):  D04888 D04889 Mepindolol:  D07181 Metalol hydrochloride:  D04953 Methoxyphenamine:  D01635 Methylephedrine (DG01229):  D01952 D02109<JP> D08206 D09842 Metipranolol (DG01137):  D02081 D02374 Milveterol hydrochloride:  D08945 Nadolol:  D00432<JP/US> Navafenterol (DG03123):  D11900 D11901 Nipradilol:  D01691<JP> Norepinephrine (DG00212):  D00076<JP> D05206<US> D08284 D09794 Octodrine:  D05228 Olodaterol (DG01058):  D10020<US> D10145 Orciprenaline (DG01044):  D00685<US> D04954 D08300 Oxprenolol (DG00304):  D01806 D08318 Pamatolol sulfate:  D05345 Penbutolol (DG00312):  D00602 D08074 Phenylpropanolamine (DG01041):  D01224 D05466 D08368 Picumeterol fumarate:  D05476 Pindolol:  D00513<JP/US> Pirbuterol (DG01048):  D00686 D01349 D08387 Primidolol:  D02389 Procaterol (DG01055):  D02404 D05366<JP> D08424 Propranolol (DG00305):  D00483<JP/US> D08443 Pseudoephedrine (DG01042):  D00485 D05648 D05649 D08449 Racephedrine Hydrochloride:  D08982 Racepinephrine (DG01444):  D05688 D05689 Ractopamine hydrochloride:  D05691 Reproterol (DG01054):  D05718 D08474 Rimiterol:  D05730 Ritodrine (DG00450):  D01263<JP> D02359 Salbutamol (DG01045):  D00683<JP/US> D02147 Salmeterol (DG01051):  D00687<JP/US> D05792 Sibenadet hydrochloride:  D05832 Sotalol (DG00307):  D01026<JP/US> D08525 Soterenol hydrochloride:  D05902 Talinolol:  D07184 Tazolol hydrochloride:  D06014 Terbutaline (DG01046):  D00688<JP/US> D08570 Tertatolol (DG00309):  D07182 D08572 Tilisolol (DG01322):  D01795 D08598 Timolol (DG00306):  D00378<US> D00603<JP/US> D08600 Tiprenolol hydrochloride:  D06162 Tolamolol:  D06176 Tretoquinol (DG01049):  D01978 D05037<JP> D08629 Tulobuterol (DG01050):  D01362<JP> D02151<JP> Vilanterol (DG01236):  D09696 D09697 Zinterol hydrochloride:  D06374 Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04020 Calcium signaling pathway     154 (ADRB2)    04024 cAMP signaling pathway     154 (ADRB2)    04022 cGMP-PKG signaling pathway     154 (ADRB2)   09133 Signaling molecules and interaction    04080 Neuroactive ligand-receptor interaction     154 (ADRB2)  09150 Organismal Systems   09152 Endocrine system    04923 Regulation of lipolysis in adipocytes     154 (ADRB2)    04924 Renin secretion     154 (ADRB2)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     154 (ADRB2)   09154 Digestive system    04970 Salivary secretion     154 (ADRB2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04030 G protein-coupled receptors [BR:hsa04030]     154 (ADRB2) G protein-coupled receptors [BR:hsa04030]  Rhodopsin family   Biogenic amine    Adrenaline     154 (ADRB2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  7tm_1 7TM_GPCR_Srsx 7TM_GPCR_Srx 7TM_GPCR_Srv 7tm_4 Motif Other DBs NCBI-GeneID:  154 NCBI-ProteinID:  NP_000015 OMIM:  109690 HGNC:  286 Ensembl:  ENSG00000169252 Vega:  OTTHUMG00000129933 Pharos:  P07550(Tclin) UniProt:  P07550 X5DQM5 LinkDB All DBs Structure PDB:  3KJ6 2R4R 2R4S 4GBR Thumbnails Position 5q32 AA seq 413 aa AA seqDB search MGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAK FERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTAS IETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQE AINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRF HVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQD NLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNT GEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL NT seq 1242 nt NT seq  +upstreamnt  +downstreamnt atggggcaacccgggaacggcagcgccttcttgctggcacccaatggaagccatgcgccg gaccacgacgtcacgcaggaaagggacgaggtgtgggtggtgggcatgggcatcgtcatg tctctcatcgtcctggccatcgtgtttggcaatgtgctggtcatcacagccattgccaag ttcgagcgtctgcagacggtcaccaactacttcatcacttcactggcctgtgctgatctg gtcatgggcctggcagtggtgccctttggggccgcccatattcttatgaaaatgtggact tttggcaacttctggtgcgagttttggacttccattgatgtgctgtgcgtcacggccagc attgagaccctgtgcgtgatcgcagtggatcgctactttgccattacttcacctttcaag taccagagcctgctgaccaagaataaggcccgggtgatcattctgatggtgtggattgtg tcaggccttacctccttcttgcccattcagatgcactggtaccgggccacccaccaggaa gccatcaactgctatgccaatgagacctgctgtgacttcttcacgaaccaagcctatgcc attgcctcttccatcgtgtccttctacgttcccctggtgatcatggtcttcgtctactcc agggtctttcaggaggccaaaaggcagctccagaagattgacaaatctgagggccgcttc catgtccagaaccttagccaggtggagcaggatgggcggacggggcatggactccgcaga tcttccaagttctgcttgaaggagcacaaagccctcaagacgttaggcatcatcatgggc actttcaccctctgctggctgcccttcttcatcgttaacattgtgcatgtgatccaggat aacctcatccgtaaggaagtttacatcctcctaaattggataggctatgtcaattctggt ttcaatccccttatctactgccggagcccagatttcaggattgccttccaggagcttctg tgcctgcgcaggtcttctttgaaggcctatgggaatggctactccagcaacggcaacaca ggggagcagagtggatatcacgtggaacaggagaaagaaaataaactgctgtgtgaagac ctcccaggcacggaagactttgtgggccatcaaggtactgtgcctagcgataacattgat tcacaagggaggaattgtagtacaaatgactcactgctgtaa

Homo sapiens (human): 155 Help Entry 155               CDS       T01001                                  Gene name ADRB3, BETA3AR Definition (RefSeq) adrenoceptor beta 3   KO K04143   adrenergic receptor beta-3 Organism hsa  Homo sapiens (human) Pathway hsa04020   Calcium signaling pathway hsa04022   cGMP-PKG signaling pathway hsa04080   Neuroactive ligand-receptor interaction hsa04714   Thermogenesis hsa04923   Regulation of lipolysis in adipocytes hsa04924   Renin secretion hsa04970   Salivary secretion Disease H02106   Genetic obesity Drug target Adaprolol maleate:  D02765 Alprenolol (DG00303):  D01182 D07156 Alprenoxime hydrochloride:  D02834 Amibegron (DG01237):  D08850 D08851 Befunolol (DG01138):  D01512 D07496 Beradilol monoethyl maleate:  D09843 Bopindolol (DG00310):  D01794 D07537 Bufetolol hydrochloride:  D01504<JP> Bunitrolol hydrochloride:  D01444 Bunolol hydrochloride:  D03177 Bupranolol (DG00311):  D01454 D07590 Carteolol (DG00308):  D00599<JP/US> D07624 Cimaterol:  D03502 Cloranolol:  D07183 Dexpropranolol hydrochloride:  D03729 Diacetolol hydrochloride:  D03759 Dilevalol hydrochloride:  D01906 Dipivefrine (DG01129):  D01017<JP> D02349 Droxidopa:  D01277<JP/US> Ephedrine (DG00227):  D00124 D01386<JP> D04018<US> Epinephrine (DG00013):  D00095<JP/US> D00996 D02149 Epinephryl borate:  D04026 Etilefrine (DG00210):  D01573<JP> D07931 Exaprolol hydrochloride:  D04120 Fasobegron:  D09344 Flestolol sulfate:  D04190 Isoprenaline (DG00211):  D01390<JP/US> D02066 D02150<JP> D08090 Levobunolol (DG01136):  D01025<JP/US> D08115 Medroxalol (DG01317):  D04888 D04889 Mepindolol:  D07181 Methylephedrine (DG01229):  D01952 D02109<JP> D08206 D09842 Metipranolol (DG01137):  D02081 D02374 Mirabegron:  D09535<JP/US> Nipradilol:  D01691<JP> Norepinephrine (DG00212):  D00076<JP> D05206<US> D08284 D09794 Octodrine:  D05228 Oxprenolol (DG00304):  D01806 D08318 Pamatolol sulfate:  D05345 Penbutolol (DG00312):  D00602 D08074 Phenylpropanolamine (DG01041):  D01224 D05466 D08368 Pindolol:  D00513<JP/US> Primidolol:  D02389 Propranolol (DG00305):  D00483<JP/US> D08443 Pseudoephedrine (DG01042):  D00485 D05648 D05649 D08449 Racephedrine Hydrochloride:  D08982 Racepinephrine (DG01444):  D05688 D05689 Ritobegron ethyl hydrochloride:  D09732 Solabegron hydrochloride:  D05879 Talibegron hydrochloride:  D02702 Talinolol:  D07184 Tazolol hydrochloride:  D06014 Tertatolol (DG00309):  D07182 D08572 Tilisolol (DG01322):  D01795 D08598 Tiprenolol hydrochloride:  D06162 Tolamolol:  D06176 Vibegron:  D10433<JP/US> Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04020 Calcium signaling pathway     155 (ADRB3)    04022 cGMP-PKG signaling pathway     155 (ADRB3)   09133 Signaling molecules and interaction    04080 Neuroactive ligand-receptor interaction     155 (ADRB3)  09150 Organismal Systems   09152 Endocrine system    04923 Regulation of lipolysis in adipocytes     155 (ADRB3)    04924 Renin secretion     155 (ADRB3)   09154 Digestive system    04970 Salivary secretion     155 (ADRB3)   09159 Environmental adaptation    04714 Thermogenesis     155 (ADRB3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04030 G protein-coupled receptors [BR:hsa04030]     155 (ADRB3) G protein-coupled receptors [BR:hsa04030]  Rhodopsin family   Biogenic amine    Adrenaline     155 (ADRB3) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  7tm_1 7TM_GPCR_Srsx 7tm_4 7TM_GPCR_Srx 7TM_GPCR_Srv Motif Other DBs NCBI-GeneID:  155 NCBI-ProteinID:  NP_000016 OMIM:  109691 HGNC:  288 Ensembl:  ENSG00000188778 Vega:  OTTHUMG00000164028 Pharos:  P13945(Tclin) UniProt:  P13945 A8KAG8 LinkDB All DBs Position 8p11.23 AA seq 408 aa AA seqDB search MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIV AIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLC VTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRV GADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRG ELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGT FTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLL CRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS NT seq 1227 nt NT seq  +upstreamnt  +downstreamnt atggctccgtggcctcacgagaacagctctcttgccccatggccggacctccccaccctg gcgcccaataccgccaacaccagtgggctgccaggggttccgtgggaggcggccctagcc ggggccctgctggcgctggcggtgctggccaccgtgggaggcaacctgctggtcatcgtg gccatcgcctggactccgagactccagaccatgaccaacgtgttcgtgacttcgctggcc gcagccgacctggtgatgggactcctggtggtgccgccggcggccaccttggcgctgact ggccactggccgttgggcgccactggctgcgagctgtggacctcggtggacgtgctgtgt gtgaccgccagcatcgaaaccctgtgcgccctggccgtggaccgctacctggctgtgacc aacccgctgcgttacggcgcactggtcaccaagcgctgcgcccggacagctgtggtcctg gtgtgggtcgtgtcggccgcggtgtcgtttgcgcccatcatgagccagtggtggcgcgta ggggccgacgccgaggcgcagcgctgccactccaacccgcgctgctgtgccttcgcctcc aacatgccctacgtgctgctgtcctcctccgtctccttctaccttcctcttctcgtgatg ctcttcgtctacgcgcgggttttcgtggtggctacgcgccagctgcgcttgctgcgcggg gagctgggccgctttccgcccgaggagtctccgccggcgccgtcgcgctctctggccccg gccccggtggggacgtgcgctccgcccgaaggggtgcccgcctgcggccggcggcccgcg cgcctcctgcctctccgggaacaccgggccctgtgcaccttgggtctcatcatgggcacc ttcactctctgctggttgcccttctttctggccaacgtgctgcgcgccctggggggcccc tctctagtcccgggcccggctttccttgccctgaactggctaggttatgccaattctgcc ttcaacccgctcatctactgccgcagcccggactttcgcagcgccttccgccgtcttctg tgccgctgcggccgtcgcctgcctccggagccctgcgccgccgcccgcccggccctcttc ccctcgggcgttcctgcggcccggagcagcccagcgcagcccaggctttgccaacggctc gacggggcttcttggggagtttcttag

Homo sapiens (human): 1812 Help Entry 1812              CDS       T01001                                  Gene name DRD1, DADR, DRD1A Definition (RefSeq) dopamine receptor D1   KO K04144   dopamine receptor D1 Organism hsa  Homo sapiens (human) Pathway hsa04020   Calcium signaling pathway hsa04024   cAMP signaling pathway hsa04080   Neuroactive ligand-receptor interaction hsa04540   Gap junction hsa04728   Dopaminergic synapse hsa05012   Parkinson disease hsa05030   Cocaine addiction hsa05031   Amphetamine addiction hsa05032   Morphine addiction hsa05034   Alcoholism Network nt06124  Chemokine signaling (viruses) nt06167  Human cytomegalovirus (HCMV)   Element N00410   DRD1-GNAS-AC-PKA signaling pathway Drug target Acepromazine (DG00870):  D02604 D07065 Acetophenazine (DG00878):  D00788 Adrogolide hydrochloride:  D02775 Apomorphine (DG00486):  D02004<JP/US> D07460 Butaclamol hydrochloride:  D02641 Carphenazine maleate:  D02644 Chlorprothixene (DG00894):  D00790 D02162 D07686 D07687 Ciladopa hydrochloride:  D03494 Clopenthixol:  D02613 Dexpramipexole (DG01331):  D09886 D09887 Docarpamine:  D01903<JP> Dopamine (DG00213):  D00633<JP/US> D07870 Dopexamine (DG00222):  D03891 D03892 Ecopipam hydrochloride:  D03937 Etilevodopa:  D04097 Fenoldopam (DG00226):  D00613<US> D07946 Flupentixol (DG00893):  D01044 D02236 D07976 Foslevodopa:  D11839 Ibopamine (DG00223):  D04488 D08057 Levodopa:  D00059<JP/US> Mevidalen (DG03111):  D11822 D11826 Oxiperomide:  D02676 Pergolide (DG00861):  D00502<JP> D08339 Pipotiazine (DG00884):  D02680 D08385 Tavapadon:  D11431 Tiotixene (DG00895):  D00374<US> D02612 Zicronapine (DG01539):  D10329 D10495 Zuclopenthixol (DG00896):  D03556 D08691 D08692 D08693 Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04020 Calcium signaling pathway     1812 (DRD1)    04024 cAMP signaling pathway     1812 (DRD1)   09133 Signaling molecules and interaction    04080 Neuroactive ligand-receptor interaction     1812 (DRD1)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04540 Gap junction     1812 (DRD1)  09150 Organismal Systems   09156 Nervous system    04728 Dopaminergic synapse     1812 (DRD1)  09160 Human Diseases   09164 Neurodegenerative disease    05012 Parkinson disease     1812 (DRD1)   09165 Substance dependence    05030 Cocaine addiction     1812 (DRD1)    05031 Amphetamine addiction     1812 (DRD1)    05032 Morphine addiction     1812 (DRD1)    05034 Alcoholism     1812 (DRD1)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04030 G protein-coupled receptors [BR:hsa04030]     1812 (DRD1) G protein-coupled receptors [BR:hsa04030]  Rhodopsin family   Biogenic amine    Dopamine     1812 (DRD1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  7tm_1 7TM_GPCR_Srsx 7TM_GPCR_Srx Motif Other DBs NCBI-GeneID:  1812 NCBI-ProteinID:  NP_000785 OMIM:  126449 HGNC:  3020 Ensembl:  ENSG00000184845 Vega:  OTTHUMG00000130557 Pharos:  P21728(Tclin) UniProt:  P21728 LinkDB All DBs Position 5q35.2 AA seq 446 aa AA seqDB search MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTN FFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVD RYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLA ETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKN CQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGS GETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIET VSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPAL SVILDYDTDVSLEKIQPITQNGQHPT NT seq 1341 nt NT seq  +upstreamnt  +downstreamnt atgaggactctgaacacctctgccatggacgggactgggctggtggtggagagggacttc tctgttcgtatcctcactgcctgtttcctgtcgctgctcatcctgtccacgctcctgggg aacacgctggtctgtgctgccgttatcaggttccgacacctgcggtccaaggtgaccaac ttctttgtcatctccttggctgtgtcagatctcttggtggccgtcctggtcatgccctgg aaggcagtggctgagattgctggcttctggccctttgggtccttctgtaacatctgggtg gcctttgacatcatgtgctccactgcatccatcctcaacctctgtgtgatcagcgtggac aggtattgggctatctccagccctttccggtatgagagaaagatgacccccaaggcagcc ttcatcctgatcagtgtggcatggaccttgtctgtactcatctccttcatcccagtgcag ctcagctggcacaaggcaaaacccacaagcccctctgatggaaatgccacttccctggct gagaccatagacaactgtgactccagcctcagcaggacatatgccatctcatcctctgta ataagcttttacatccctgtggccatcatgattgtcacctacaccaggatctacaggatt gctcagaaacaaatacggcgcattgcggccttggagagggcagcagtccacgccaagaat tgccagaccaccacaggtaatggaaagcctgtcgaatgttctcaaccggaaagttctttt aagatgtccttcaaaagagaaactaaagtcctgaagactctgtcggtgatcatgggtgtg tttgtgtgctgttggctacctttcttcatcttgaactgcattttgcccttctgtgggtct ggggagacgcagcccttctgcattgattccaacacctttgacgtgtttgtgtggtttggg tgggctaattcatccttgaaccccatcatttatgcctttaatgctgattttcggaaggca ttttcaaccctcttaggatgctacagactttgccctgcgacgaataatgccatagagacg gtgagtatcaataacaatggggccgcgatgttttccagccatcatgagccacgaggctcc atctccaaggagtgcaatctggtttacctgatcccacatgctgtgggctcctctgaggac ctgaaaaaggaggaggcagctggcatcgccagacccttggagaagctgtccccagcccta tcagtcatattggactatgacactgacgtctctctggagaagatccaacccatcacacaa aacggtcagcacccaacctga

Homo sapiens (human): 1816 Help Entry 1816              CDS       T01001                                  Gene name DRD5, DBDR, DRD1B, DRD1L2 Definition (RefSeq) dopamine receptor D5   KO K05840   dopamine receptor D5 Organism hsa  Homo sapiens (human) Pathway hsa04020   Calcium signaling pathway hsa04024   cAMP signaling pathway hsa04080   Neuroactive ligand-receptor interaction hsa04728   Dopaminergic synapse Disease H01895   Attention deficit hyperactivity disorder (ADHD) Drug target Dexpramipexole (DG01331):  D09886 D09887 Dopamine (DG00213):  D00633<JP/US> D07870 Dopexamine (DG00222):  D03891 D03892 Ecopipam hydrochloride:  D03937 Etilevodopa:  D04097 Foslevodopa:  D11839 Levodopa:  D00059<JP/US> Oxiperomide:  D02676 Tavapadon:  D11431 Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04020 Calcium signaling pathway     1816 (DRD5)    04024 cAMP signaling pathway     1816 (DRD5)   09133 Signaling molecules and interaction    04080 Neuroactive ligand-receptor interaction     1816 (DRD5)  09150 Organismal Systems   09156 Nervous system    04728 Dopaminergic synapse     1816 (DRD5)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04030 G protein-coupled receptors [BR:hsa04030]     1816 (DRD5) G protein-coupled receptors [BR:hsa04030]  Rhodopsin family   Biogenic amine    Dopamine     1816 (DRD5) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  7tm_1 7TM_GPCR_Srsx 7TM_GPCR_Srx Motif Other DBs NCBI-GeneID:  1816 NCBI-ProteinID:  NP_000789 OMIM:  126453 HGNC:  3026 Ensembl:  ENSG00000169676 Vega:  OTTHUMG00000128489 Pharos:  P21918(Tchem) UniProt:  P21918 LinkDB All DBs Position 4p16.1 AA seq 477 aa AA seqDB search MLPPGSNGTAYPGQFALYQQLAQGNAVGGSAGAPPLGPSQVVTACLLTLLIIWTLLGNVL VCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFGAFCDVWVAFD IMCSTASILNLCVISVDRYWAISRPFRYKRKMTQRMALVMVGLAWTLSILISFIPVQLNW HRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAENCDSSLNRTYAISSSLISFYIPVAI MIVTYTRIYRIAQVQIRRISSLERAAEHAQSCRSSAACAPDTSLRASIKKETKVLKTLSV IMGVFVCCWLPFFILNCMVPFCSGHPEGPPAGFPCVSETTFDVFVWFGWANSSLNPVIYA FNADFQKVFAQLLGCSHFCSRTPVETVNISNELISYNQDIVFHKEIAAAYIHMMPNAVTP GNREVDNDEEEGPFDRMFQIYQTSPDGDPVAESVWELDCEGEISLDKITPFTPNGFH NT seq 1434 nt NT seq  +upstreamnt  +downstreamnt atgctgccgccaggcagcaacggcaccgcgtacccggggcagttcgctctataccagcag ctggcgcaggggaacgccgtggggggctcggcgggggcaccgccactggggccctcacag gtggtcaccgcctgcctgctgaccctactcatcatctggaccctgctgggcaacgtgctg gtgtgcgcagccatcgtgcggagccgccacctgcgcgccaacatgaccaacgtcttcatc gtgtctctggccgtgtcagaccttttcgtggcgctgctggtcatgccctggaaggcagtc gccgaggtggccggttactggccctttggagcgttctgcgacgtctgggtggccttcgac atcatgtgctccactgcctccatcctgaacctgtgcgtcatcagcgtggaccgctactgg gccatctccaggcccttccgctacaagcgcaagatgactcagcgcatggccttggtcatg gtcggcctggcatggaccttgtccatcctcatctccttcattccggtccagctcaactgg cacagggaccaggcggcctcttggggcgggctggacctgccaaacaacctggccaactgg acgccctgggaggaggacttttgggagcccgacgtgaatgcagagaactgtgactccagc ctgaatcgaacctacgccatctcttcctcgctcatcagcttctacatccccgttgccatc atgatcgtgacctacacgcgcatctaccgcatcgcccaggtgcagatccgcaggatttcc tccctggagagggccgcagagcacgcgcagagctgccggagcagcgcagcctgcgcgccc gacaccagcctgcgcgcttccatcaagaaggagaccaaggttctcaagaccctgtcggtg atcatgggggtcttcgtgtgttgctggctgcccttcttcatccttaactgcatggtccct ttctgcagtggacaccccgaaggccctccggccggcttcccctgcgtcagtgagaccacc ttcgacgtcttcgtctggttcggctgggctaactcctcactcaaccccgtcatctatgcc ttcaacgccgactttcagaaggtgtttgcccagctgctggggtgcagccacttctgctcc cgcacgccggtggagacggtgaacatcagcaatgagctcatctcctacaaccaagacatc gtcttccacaaggaaatcgcagctgcctacatccacatgatgcccaacgccgttaccccc ggcaaccgggaggtggacaacgacgaggaggagggtcctttcgatcgcatgttccagatc tatcagacgtccccagatggtgaccctgttgctgagtctgtctgggagctggactgcgag ggggagatttctttagacaaaataacacctttcaccccgaatggattccattaa

Homo sapiens (human): 3274 Help Entry 3274              CDS       T01001                                  Gene name HRH2, H2R, HH2R Definition (RefSeq) histamine receptor H2   KO K04150   histamine receptor H2 Organism hsa  Homo sapiens (human) Pathway hsa04020   Calcium signaling pathway hsa04080   Neuroactive ligand-receptor interaction hsa04971   Gastric acid secretion Drug target Betazole:  D01187 Cimetidine (DG00017):  D00295<JP/US> D03503<US> Dalcotidine:  D01698 Donetidine:  D03889 Etintidine hydrochloride:  D04098 Famotidine:  D00318<JP/US> Histamine:  D08040<US> Histamine phosphate:  D04445<US> Icotidine:  D04494 Impromidine hydrochloride:  D04517 Lafutidine:  D01131<JP> Lavoltidine succinate:  D04680 Lupitidine hydrochloride:  D04794 Methantheline (DG00036):  D00721 Metiamide:  D05004 Niperotidine:  D07072 Nizatidine:  D00440<JP/US> Osutidine:  D01193 Oxmetidine (DG01225):  D05306 D05307 Pibutidine hydrochloride:  D01861 Ranitidine (DG00018):  D00422 D00673<JP/US> Ranitidine bismuth citrate:  D05699 Roxatidine (DG00019):  D01467<JP> D08494 D08495 Sufotidine:  D05939 Tiotidine:  D06157 Zaltidine hydrochloride:  D06355 Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04020 Calcium signaling pathway     3274 (HRH2)   09133 Signaling molecules and interaction    04080 Neuroactive ligand-receptor interaction     3274 (HRH2)  09150 Organismal Systems   09154 Digestive system    04971 Gastric acid secretion     3274 (HRH2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04030 G protein-coupled receptors [BR:hsa04030]     3274 (HRH2) G protein-coupled receptors [BR:hsa04030]  Rhodopsin family   Biogenic amine    Histamine     3274 (HRH2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  7tm_1 7TM_GPCR_Srsx 7tm_4 Motif Other DBs NCBI-GeneID:  3274 NCBI-ProteinID:  NP_001124527 OMIM:  142703 HGNC:  5183 Ensembl:  ENSG00000113749 Vega:  OTTHUMG00000130660 Pharos:  P25021(Tclin) UniProt:  P25021 LinkDB All DBs Position 5q35.2 AA seq 397 aa AA seqDB search MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSL AITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAV MDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNE VYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVM GAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQ QLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDRP WLCLPECWSVELTHSFIHLFIHSFANIHPIPTTCQEL NT seq 1194 nt NT seq  +upstreamnt  +downstreamnt atggcacccaatggcacagcctcttccttttgcctggactctaccgcatgcaagatcacc atcaccgtggtccttgcggtcctcatcctcatcaccgttgctggcaatgtggtcgtctgt ctggccgtgggcttgaaccgccggctccgcaacctgaccaattgtttcatcgtgtccttg gctatcactgacctgctcctcggcctcctggtgctgcccttctctgccatctaccagctg tcctgcaagtggagctttggcaaggtcttctgcaatatctacaccagcctggatgtgatg ctctgcacagcctccattcttaacctcttcatgatcagcctcgaccggtactgcgctgtc atggacccactgcggtaccctgtgctggtcaccccagttcgggtcgccatctctctggtc ttaatttgggtcatctccattaccctgtcctttctgtctatccacctggggtggaacagc aggaacgagaccagcaagggcaatcataccacctctaagtgcaaagtccaggtcaatgaa gtgtacgggctggtggatgggctggtcaccttctacctcccgctactgatcatgtgcatc acctactaccgcatcttcaaggtcgcccgggatcaggccaagaggatcaatcacattagc tcctggaaggcagccaccatcagggagcacaaagccacagtgacactggccgccgtcatg ggggccttcatcatctgctggtttccctacttcaccgcgtttgtgtaccgtgggctgaga ggggatgatgccatcaatgaggtgttagaagccatcgttctgtggctgggctatgccaac tcagccctgaaccccatcctgtatgctgcgctgaacagagacttccgcaccgggtaccaa cagctcttctgctgcaggctggccaaccgcaactcccacaaaacttctctgaggtccaac gcctctcagctgtccaggacccaaagccgagaacccaggcaacaggaagagaaacccctg aagctccaggtgtggagtgggacagaagtcacggccccccagggagccacagacagacca tggctttgccttccagaatgctggtctgtggaactgacccattcattcattcatttgttc attcattcatttgcaaacattcatccaattcccaccacatgccaggaattatga

Homo sapiens (human): 3360 Help Entry 3360              CDS       T01001                                  Gene name HTR4, 5-HT4, 5-HT4R Definition (RefSeq) 5-hydroxytryptamine receptor 4   KO K04160   5-hydroxytryptamine receptor 4 Organism hsa  Homo sapiens (human) Pathway hsa04020   Calcium signaling pathway hsa04024   cAMP signaling pathway hsa04080   Neuroactive ligand-receptor interaction hsa04726   Serotonergic synapse Drug target Cinitapride (DG01520):  D07700 D07701 Cisapride (DG00056):  D00274 D02092 Fabesetron hydrochloride:  D01838 Mosapride (DG01285):  D01994<JP> D08236 Naronapride (DG01335):  D09933 D09934 Piboserod hydrochloride:  D05471 Prucalopride (DG00080):  D09205 D10152<US> Relenopride (DG02948):  D11220 D11221 Renzapride:  D06396 Sulamserod hydrochloride:  D05941 Tegaserod (DG00081):  D02730<US> D06056 Velusetrag (DG01336):  D09693 D09694 Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04020 Calcium signaling pathway     3360 (HTR4)    04024 cAMP signaling pathway     3360 (HTR4)   09133 Signaling molecules and interaction    04080 Neuroactive ligand-receptor interaction     3360 (HTR4)  09150 Organismal Systems   09156 Nervous system    04726 Serotonergic synapse     3360 (HTR4)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04030 G protein-coupled receptors [BR:hsa04030]     3360 (HTR4) G protein-coupled receptors [BR:hsa04030]  Rhodopsin family   Biogenic amine    Serotonin     3360 (HTR4) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  7tm_1 Motif Other DBs NCBI-GeneID:  3360 NCBI-ProteinID:  NP_000861 OMIM:  602164 HGNC:  5299 Ensembl:  ENSG00000164270 Vega:  OTTHUMG00000129931 Pharos:  Q13639(Tclin) UniProt:  Q13639 A0A2D3FAF9 LinkDB All DBs Position 5q32 AA seq 388 aa AA seqDB search MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIV SLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYY AICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSN STYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRP QSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWL GYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRD AVECGGQWESQCHPPATSPLVAAQPSDT NT seq 1167 nt NT seq  +upstreamnt  +downstreamnt atggacaaacttgatgctaatgtgagttctgaggagggtttcgggtcagtggagaaggtg gtgctgctcacgtttctctcgacggttatcctgatggccatcttggggaacctgctggtg atggtggctgtgtgctgggacaggcagctcaggaaaataaaaacaaattatttcattgta tctcttgcttttgcggatctgctggtttcggtgctggtgatgccctttggtgccattgag ctggttcaagacatctggatttatggggaggtgttttgtcttgttcggacatctctggac gtcctgctcacaacggcatcgatttttcacctgtgctgcatttctctggataggtattac gccatctgctgccagcctttggtctataggaacaagatgacccctctgcgcatcgcatta atgctgggaggctgctgggtcatccccacgtttatttcttttctccctataatgcaaggc tggaataacattggcataattgatttgatagaaaagaggaagttcaaccagaactctaac tctacgtactgtgtcttcatggtcaacaagccctacgccatcacctgctctgtggtggcc ttctacatcccatttctcctcatggtgctggcctattaccgcatctatgtcacagctaag gagcatgcccatcagatccagatgttacaacgggcaggagcctcctccgagagcaggcct cagtcggcagaccagcatagcactcatcgcatgaggacagagaccaaagcagccaagacc ctgtgcatcatcatgggttgcttctgcctctgctgggcaccattctttgtcaccaatatt gtggatcctttcatagactacactgtccctgggcaggtgtggactgctttcctctggctc ggctatatcaattccgggttgaacccttttctctacgccttcttgaataagtcttttaga cgtgccttcctcatcatcctctgctgtgatgatgagcgctaccgaagaccttccattctg ggccagactgtcccttgttcaaccacaaccattaatggatccacacatgtactaagggat gcagtggagtgtggtggccagtgggagagtcagtgtcacccgccagcaacttctcctttg gtggctgctcagcccagtgacacttag

Homo sapiens (human): 3361 Help Entry 3361              CDS       T01001                                  Gene name HTR5A, 5-HT5A Definition (RefSeq) 5-hydroxytryptamine receptor 5A   KO K04161   5-hydroxytryptamine receptor 5 Organism hsa  Homo sapiens (human) Pathway hsa04020   Calcium signaling pathway hsa04080   Neuroactive ligand-receptor interaction hsa04726   Serotonergic synapse Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04020 Calcium signaling pathway     3361 (HTR5A)   09133 Signaling molecules and interaction    04080 Neuroactive ligand-receptor interaction     3361 (HTR5A)  09150 Organismal Systems   09156 Nervous system    04726 Serotonergic synapse     3361 (HTR5A)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04030 G protein-coupled receptors [BR:hsa04030]     3361 (HTR5A) G protein-coupled receptors [BR:hsa04030]  Rhodopsin family   Biogenic amine    Serotonin     3361 (HTR5A) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  7tm_1 7TM_GPCR_Srx 7TM_GPCR_Srv Motif Other DBs NCBI-GeneID:  3361 NCBI-ProteinID:  NP_076917 OMIM:  601305 HGNC:  5300 Ensembl:  ENSG00000157219 Vega:  OTTHUMG00000151327 Pharos:  P47898(Tchem) UniProt:  P47898 A4D2N2 LinkDB All DBs Position 7q36.2 AA seq 357 aa AA seqDB search MDLPVNLTSFSLSTPSPLETNHSLGKDDLRPSSPLLSVFGVLILTLLGFLVAATFAWNLL VLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSGRRWQLGRRLCQLWIAC DVLCCTASIWNVTAIALDRYWSITRHMEYTLRTRKCVSNVMIALTWALSAVISLAPLLFG WGETYSEGSEECQVSREPSYAVFSTVGAFYLPLCVVLFVYWKIYKAAKFRVGSRKTNSVS PISEAVEVKDSAKQPQMVFTVRHATVTFQPEGDTWREQKEQRAALMVGILIGVFVLCWIP FFLTELISPLCSCDIPAIWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAFKNFFSRQH NT seq 1074 nt NT seq  +upstreamnt  +downstreamnt atggatttacctgtgaacctaacctccttttccctctccaccccctcccctttggagacc aaccacagcctcggcaaagacgacctgcgccccagctcgcccctgctctcggtcttcgga gtgcttattctcaccttgctgggctttctggtggcggcgacgttcgcctggaacctgctg gtgctggcgaccatcctccgtgtacgcaccttccaccgcgtgccccacaacctggtggca tccatggccgtctcggatgtcctggtggccgcgctggtcatgccgctgagcctggtgcac gagctgtccgggcgccgctggcagctaggtcggaggctgtgccagctttggatcgcgtgc gacgtgctttgctgcacggccagcatctggaacgtgacggccatagccctggaccgctac tggtccatcacgcgccacatggaatacacgctccgcacccgcaagtgcgtctccaacgtc atgatcgcgctcacctgggcactctccgctgtcatctctctggccccgctgctttttggc tggggagagacgtactctgagggcagcgaggagtgccaggtaagccgcgagccttcctac gccgtgttctccaccgtaggcgccttctacctgccgctctgtgtggtgctcttcgtgtac tggaagatctacaaggctgccaagttccgcgtgggctccaggaagaccaatagcgtctca cccatatccgaagctgtggaggtgaaggactctgccaaacagccccagatggtgttcacg gtccgccacgccaccgtcaccttccagccagaaggggacacgtggcgggagcagaaggag cagcgggccgccctcatggtgggcatcctcattggcgtgttcgtgctctgctggatcccc ttctttctcaccgagctcatcagtcccctctgctcctgtgacatccccgccatctggaaa agcatcttcctgtggcttggctactccaactccttctttaaccccctgatctatacggct ttcaacaagaactacaacagcgccttcaagaacttcttttctaggcaacactga

Homo sapiens (human): 3362 Help Entry 3362              CDS       T01001                                  Gene name HTR6, 5-HT6, 5-HT6R Definition (RefSeq) 5-hydroxytryptamine receptor 6   KO K04162   5-hydroxytryptamine receptor 6 Organism hsa  Homo sapiens (human) Pathway hsa04020   Calcium signaling pathway hsa04024   cAMP signaling pathway hsa04080   Neuroactive ligand-receptor interaction hsa04726   Serotonergic synapse Drug target Asenapine (DG03100):  D02995<JP/US> Cerlapirdine (DG01337):  D10099 D10100 Idalopirdine (DG01878):  D10710 D10747 Olanzapine (DG00898):  D00454<JP/US> D06623<US> Tiospirone hydrochloride:  D02688 Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04020 Calcium signaling pathway     3362 (HTR6)    04024 cAMP signaling pathway     3362 (HTR6)   09133 Signaling molecules and interaction    04080 Neuroactive ligand-receptor interaction     3362 (HTR6)  09150 Organismal Systems   09156 Nervous system    04726 Serotonergic synapse     3362 (HTR6)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04030 G protein-coupled receptors [BR:hsa04030]     3362 (HTR6) G protein-coupled receptors [BR:hsa04030]  Rhodopsin family   Biogenic amine    Serotonin     3362 (HTR6) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  7tm_1 7TM_GPCR_Srsx 7tm_4 Motif Other DBs NCBI-GeneID:  3362 NCBI-ProteinID:  NP_000862 OMIM:  601109 HGNC:  5301 Ensembl:  ENSG00000158748 Vega:  OTTHUMG00000002713 Pharos:  P50406(Tchem) UniProt:  P50406 LinkDB All DBs Position 1p36.13 AA seq 440 aa AA seqDB search MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNT SNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLI SLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQC RLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVP RTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPG LFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGP RPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNF FNIDPAEPELRPHPLGIPTN NT seq 1323 nt NT seq  +upstreamnt  +downstreamnt atggtcccagagccgggcccaaccgccaatagcaccccggcctggggggcagggccgccg tcggccccggggggcagcggctgggtggcggccgcgctgtgcgtggtcatcgcgctgacg gcggcggccaactcgctgctgatcgcgctcatctgcactcagcccgcgctgcgcaacacg tccaacttcttcctggtgtcgctcttcacgtctgacctgatggtggggctggtggtgatg ccgccggccatgctgaacgcgctgtacgggcgctgggtgctggcgcgcggcctctgcctg ctctggaccgccttcgacgtgatgtgctgcagcgcctccatcctcaacctctgcctcatc agcctggaccgctacctgctcatcctctcgccgctgcgctacaagctgcgcatgacgccc ctgcgtgccctggccctagtcctgggcgcctggagcctcgccgctctcgcctccttcctg cccctgctgctgggctggcacgagctgggccacgcacggccacccgtccctggccagtgc cgcctgctggccagcctgccttttgtccttgtggcgtcgggcctcaccttcttcctgccc tcgggtgccatatgcttcacctactgcaggatcctgctagctgcccgcaagcaggccgtg caggtggcctccctcaccaccggcatggccagtcaggcctcggagacgctgcaggtgccc aggaccccacgcccaggggtggagtctgctgacagcaggcgtctagccacgaagcacagc aggaaggccctgaaggccagcctgacgctgggcatcctgctgggcatgttctttgtgacc tggttgcccttctttgtggccaacatagtccaggccgtgtgcgactgcatctccccaggc ctcttcgatgtcctcacatggctgggttactgtaacagcaccatgaaccccatcatctac ccactcttcatgcgggacttcaagcgggcgctgggcaggttcctgccatgtccacgctgt ccccgggagcgccaggccagcctggcctcgccatcactgcgcacctctcacagcggcccc cggcccggccttagcctacagcaggtgctgccgctgcccctgccgccggactcagattcg gactcagacgcaggctcaggcggctcctcgggcctgcggctcacggcccagctgctgctt cctggcgaggccacccaggaccccccgctgcccaccagggccgctgccgccgtcaatttc ttcaacatcgaccccgcggagcccgagctgcggccgcatccacttggcatccccacgaac tga

Homo sapiens (human): 3363 Help Entry 3363              CDS       T01001                                  Gene name HTR7, 5-HT7 Definition (RefSeq) 5-hydroxytryptamine receptor 7   KO K04163   5-hydroxytryptamine receptor 7 Organism hsa  Homo sapiens (human) Pathway hsa04014   Ras signaling pathway hsa04020   Calcium signaling pathway hsa04080   Neuroactive ligand-receptor interaction hsa04726   Serotonergic synapse Drug target Asenapine (DG03100):  D02995<JP/US> Methysergide (DG00835):  D00681 D02357 Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04014 Ras signaling pathway     3363 (HTR7)    04020 Calcium signaling pathway     3363 (HTR7)   09133 Signaling molecules and interaction    04080 Neuroactive ligand-receptor interaction     3363 (HTR7)  09150 Organismal Systems   09156 Nervous system    04726 Serotonergic synapse     3363 (HTR7)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04030 G protein-coupled receptors [BR:hsa04030]     3363 (HTR7) G protein-coupled receptors [BR:hsa04030]  Rhodopsin family   Biogenic amine    Serotonin     3363 (HTR7) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  7tm_1 7TM_GPCR_Srsx 7tm_4 7TM_GPCR_Srx Motif Other DBs NCBI-GeneID:  3363 NCBI-ProteinID:  NP_062873 OMIM:  182137 HGNC:  5302 Ensembl:  ENSG00000148680 Vega:  OTTHUMG00000018732 Pharos:  P34969(Tclin) UniProt:  P34969 LinkDB All DBs Position 10q23.31 AA seq 479 aa AA seqDB search MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTW DAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLI VSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDR YLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYT IYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVE ECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSC IPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALK LAERPERPEFVLRACTRRVLLRPEKRPPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD NT seq 1440 nt NT seq  +upstreamnt  +downstreamnt atgatggacgttaacagcagcggccgcccggacctctacgggcacctccgctctttcctt ctgccagaagtggggcgcgggctgcccgacttgagccccgacggtggcgccgacccggtc gcgggctcctgggcgccgcacctgctgagcgaggtgacagccagcccggcgcccacctgg gacgcgcccccggacaatgcctccggctgtggggaacagatcaactacggcagagtcgag aaagttgtgatcggctccatcctgacgctcatcacgctgctgacgatcgcgggcaactgc ctggtggtgatctccgtgtgcttcgtcaagaagctccgccagccctccaactacctgatc gtgtccctggcgctggccgacctctcggtggctgtggcggtcatgcccttcgtcagcgtc accgacctcatcgggggcaagtggatctttggacactttttctgtaatgtcttcatcgcc atggacgtcatgtgctgcacggcctcgatcatgaccctgtgcgtgatcagcattgacagg taccttgggatcacaaggcccctcacataccctgtgaggcagaatgggaaatgcatggcg aagatgattctctccgtctggcttctctccgcctccatcaccttacctccactctttgga tgggctcagaatgtaaatgatgataaggtgtgcttgatcagccaggactttggctatacg atttactctaccgcagtggcattttatatccccatgtccgtcatgcttttcatgtactac cagatttacaaggctgccaggaagagtgctgccaaacacaagtttcctggcttccctcga gtggagccagacagcgtcatcgccctgaatggcatagtgaagctccagaaggaggtggaa gagtgtgcaaacctttcgagactcctcaagcatgaaaggaaaaacatctccatctttaag cgagaacagaaagcagccaccaccctggggatcatcgtcggggcctttaccgtgtgctgg ctgccatttttcctcctctcgacagccagacccttcatctgtggcacttcctgcagctgc atcccactgtgggtggagaggacatttctgtggctaggctatgcaaactctctcattaac ccttttatatatgccttcttcaaccgggacctgaggaccacctatcgcagcctgctccag tgccagtaccggaatatcaaccggaagctctcagctgcaggcatgcatgaagccctgaag cttgctgagaggccagagagacctgagtttgtgctgagggcctgcacaaggagggtgctg ttgagaccagaaaagaggccaccggtatctgtgtgggtgctacaatctccagaccatcac aattggttagcagacaaaatgctgactactgtagaaaaaaaggtcatgattcatgattga

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