KEGG   Homo sapiens (human): 1134
Entry
1134              CDS       T01001                                 
Symbol
CHRNA1, ACHRA, ACHRD, CHRNA, CMS1A, CMS1B, CMS2A, FCCMS, SCCMS
Name
(RefSeq) cholinergic receptor nicotinic alpha 1 subunit
  KO
K04803  nicotinic acetylcholine receptor alpha-1
Organism
hsa  Homo sapiens (human)
Pathway
hsa03265  Virion - Ebolavirus, Lyssavirus and Morbillivirus
hsa04080  Neuroactive ligand-receptor interaction
Disease
H00770  Congenital myasthenic syndrome
H00986  Multiple pterygium syndrome
Drug target
Acetylcholine (DG01133): D00999<JP/US>
Cytisinicline: D07770
Gantacurium chloride: D04303
Lobeline (DG01287): D02202 D02364 D08138
Mecamylamine (DG00252): D00611<US>
Metocurine iodide: D00761
Nicotine (DG00994): D03365<JP/US> D05156 D05157
Suxamethonium (DG00768): D00766<US> D02275<JP>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09125 Information processing in viruses
   03265 Virion - Ebolavirus, Lyssavirus and Morbillivirus
    1134 (CHRNA1)
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    1134 (CHRNA1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    1134 (CHRNA1)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  Acetylcholine (nicotinic)
   1134 (CHRNA1)
SSDB
Motif
Pfam: Neur_chan_LBD Neur_chan_memb Claudin_2
Other DBs
NCBI-GeneID: 1134
NCBI-ProteinID: NP_000070
OMIM: 100690
HGNC: 1955
Ensembl: ENSG00000138435
UniProt: P02708 Q53SH4
Structure
LinkDB
Position
2:complement(174747592..174764472)
AA seq 457 aa
MEPWPLLLLFSLCSAGLVLGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQL
INVDEVNQIVTTNVRLKQQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNADGDF
AIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINP
ESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFIVNVII
PCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLF
TMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKVFIDTIPNIMFFSTMKRPSREKQDKK
IFTEDIDISDISGKPGPPPMGFHSPLIKHPEVKSAIEGIKYIAETMKSDQESNNAAAEWK
YVAMVMDHILLGVFMLVCIIGTLAVFAGRLIELNQQG
NT seq 1374 nt   +upstreamnt  +downstreamnt
atggagccctggcctctcctcctgctctttagcctttgctcagctggcctcgtcctgggc
tccgaacatgagacccgtctggtggcaaagctatttaaagactacagcagcgtggtgcgg
ccagtggaagaccaccgccaggtcgtggaggtcaccgtgggcctgcagctgatacagctc
atcaatgtggatgaagtaaatcagatcgtgacaaccaatgtgcgtctgaaacagcaatgg
gtggattacaacctaaaatggaatccagatgactatggcggtgtgaaaaaaattcacatt
ccttcagaaaagatctggcgcccagaccttgttctctataacaatgcagatggtgacttt
gctattgtcaagttcaccaaagtgctcctgcagtacactggccacatcacgtggacacct
ccagccatctttaaaagctactgtgagatcatcgtcacccactttccctttgatgaacag
aactgcagcatgaagctgggcacctggacctacgacggctctgtcgtggccatcaacccg
gaaagcgaccagccagacctgagcaacttcatggagagcggggagtgggtgatcaaggag
tcccggggctggaagcactccgtgacctattcctgctgccccgacaccccctacctggac
atcacctaccacttcgtcatgcagcgcctgcccctctacttcatcgtcaacgtcatcatc
ccctgcctgctcttctccttcttaactggcctggtattctacctgcccacagactcaggg
gagaagatgactctgagcatctctgtcttactgtctttgactgtgttccttctggtcatc
gtggagctgatcccctccacgtccagtgctgtgcccttgattggaaaatacatgctgttc
accatggtgttcgtcattgcctccatcatcatcactgtcatcgtcatcaacacacaccac
cgctcacccagcacccatgtcatgcccaactgggtgcggaaggtttttatcgacactatc
ccaaatatcatgtttttctccacaatgaaaagaccatccagagaaaagcaagacaaaaag
atttttacagaagacattgatatctctgacatttctggaaagccagggcctccacccatg
ggcttccactctcccctgatcaaacaccccgaggtgaaaagtgccatcgagggcatcaag
tacatcgcagagaccatgaagtcagaccaggagtctaacaatgcggcggcagagtggaag
tacgttgcaatggtgatggaccacatactcctcggagtcttcatgcttgtttgcatcatc
ggaaccctagccgtgtttgcaggtcgactcattgaattaaatcagcaaggatga

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