KEGG   Homo sapiens (human): 116443
Entry
116443            CDS       T01001                                 

Gene name
GRIN3A, GluN3A, NMDAR-L, NMDAR3A, NR3A
Definition
(RefSeq) glutamate ionotropic receptor NMDA type subunit 3A
  KO
K05213  glutamate receptor ionotropic, NMDA 3A
Organism
hsa  Homo sapiens (human)
Pathway
hsa04024  cAMP signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04724  Glutamatergic synapse
hsa05017  Spinocerebellar ataxia
hsa05020  Prion disease
hsa05030  Cocaine addiction
hsa05031  Amphetamine addiction
hsa05033  Nicotine addiction
hsa05034  Alcoholism
Drug target
Felbamate: D00536<US>
Orphenadrine (DG01252): D08305
Orphenadrine (chloride): D02599
Orphenadrine (citrate): D00774<US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04024 cAMP signaling pathway
    116443 (GRIN3A)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    116443 (GRIN3A)
 09150 Organismal Systems
  09156 Nervous system
   04724 Glutamatergic synapse
    116443 (GRIN3A)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05017 Spinocerebellar ataxia
    116443 (GRIN3A)
   05020 Prion disease
    116443 (GRIN3A)
  09165 Substance dependence
   05030 Cocaine addiction
    116443 (GRIN3A)
   05031 Amphetamine addiction
    116443 (GRIN3A)
   05033 Nicotine addiction
    116443 (GRIN3A)
   05034 Alcoholism
    116443 (GRIN3A)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    116443 (GRIN3A)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  Glutamate (ionotropic)
   116443 (GRIN3A)
SSDB
Motif
Pfam: Lig_chan Lig_chan-Glu_bd SBP_bac_3 ANF_receptor DUF5446
Other DBs
NCBI-GeneID: 116443
NCBI-ProteinID: NP_597702
OMIM: 606650
HGNC: 16767
Ensembl: ENSG00000198785
Vega: OTTHUMG00000020387
Pharos: Q8TCU5(Tclin)
UniProt: Q8TCU5
LinkDB
Position
9q31.1
AA seq 1115 aa
MRRLSLWWLLSRVCLLLPPPCALVLAGVPSSSSHPQPCQILKRIGHAVRVGAVHLQPWTT
APRAASRAPDDSRAGAQRDEPEPGTRRSPAPSPGARWLGSTLHGRGPPGSRKPGEGARAE
ALWPRDALLFAVDNLNRVEGLLPYNLSLEVVMAIEAGLGDLPLLPFSSPSSPWSSDPFSF
LQSVCHTVVVQGVSALLAFPQSQGEMMELDLVSLVLHIPVISIVRHEFPRESQNPLHLQL
SLENSLSSDADVTVSILTMNNWYNFSLLLCQEDWNITDFLLLTQNNSKFHLGSIINITAN
LPSTQDLLSFLQIQLESIKNSTPTVVMFGCDMESIRRIFEITTQFGVMPPELRWVLGDSQ
NVEELRTEGLPLGLIAHGKTTQSVFEHYVQDAMELVARAVATATMIQPELALIPSTMNCM
EVETTNLTSGQYLSRFLANTTFRGLSGSIRVKGSTIVSSENNFFIWNLQHDPMGKPMWTR
LGSWQGGKIVMDYGIWPEQAQRHKTHFQHPSKLHLRVVTLIEHPFVFTREVDDEGLCPAG
QLCLDPMTNDSSTLDSLFSSLHSSNDTVPIKFKKCCYGYCIDLLEKIAEDMNFDFDLYIV
GDGKYGAWKNGHWTGLVGDLLRGTAHMAVTSFSINTARSQVIDFTSPFFSTSLGILVRTR
DTAAPIGAFMWPLHWTMWLGIFVALHITAVFLTLYEWKSPFGLTPKGRNRSKVFSFSSAL
NICYALLFGRTVAIKPPKCWTGRFLMNLWAIFCMFCLSTYTANLAAVMVGEKIYEELSGI
HDPKLHHPSQGFRFGTVRESSAEDYVRQSFPEMHEYMRRYNVPATPDGVEYLKNDPEKLD
AFIMDKALLDYEVSIDADCKLLTVGKPFAIEGYGIGLPPNSPLTANISELISQYKSHGFM
DMLHDKWYRVVPCGKRSFAVTETLQMGIKHFSGLFVLLCIGFGLSILTTIGEHIVYRLLL
PRIKNKSKLQYWLHTSQRLHRAINTSFIEEKQQHFKTKRVEKRSNVGPRQLTVWNTSNLS
HDNRRKYIFSDEEGQNQLGIRIHQDIPLPPRRRELPALRTTNGKADSLNVSRNSVMQELS
ELEKQIQVIRQELQLAVSRKTELEEYQRTSRTCES
NT seq 3348 nt   +upstreamnt  +downstreamnt
atgaggagactgagtttgtggtggctgctgagcagggtctgtctgctgttgccgccgccc
tgcgcactggtgctggccggggtgcccagctcctcctcgcacccgcagccctgccagatc
ctcaagcgcatcgggcacgcggtgagggtgggcgcggtgcacttgcagccctggaccacc
gccccccgcgcggccagccgcgctccggacgacagccgagcaggagcccagagggatgag
ccggagccagggactaggcggtccccggcgccctcgccgggcgcacgctggttggggagc
accctgcatggccgggggccgccgggctcccgtaagcccggggagggcgccagggcggag
gccctgtggccacgggacgccctcctatttgccgtggacaacctgaaccgcgtggaaggg
ctgctaccctacaacctgtctttggaagtagtgatggccatcgaggcaggcctgggcgat
ctgccacttttgcccttctcctcccctagttcgccatggagcagtgaccctttctccttc
ctgcaaagtgtgtgccataccgtggtggtgcaaggggtgtcggcgctgctcgccttcccc
cagagccagggcgaaatgatggagctcgacttggtcagcttagtcctgcacattccagtg
atcagcatcgtgcgccacgagtttccacgggagagtcagaatccccttcacctacaactg
agtttagaaaattcattaagttctgatgctgatgtcactgtctcaatcctgaccatgaac
aactggtacaattttagcttgttgctgtgccaggaagactggaacatcaccgacttcctc
ctccttacccagaataattccaagttccaccttggttctatcatcaacatcaccgctaac
ctcccctccacccaggacctcttgagcttcctacagatccagcttgagagtattaagaac
agcacacccacagtggtgatgtttggctgcgacatggaaagtatccggcggattttcgaa
attacaacccagtttggggtcatgccccctgaacttcgttgggtgctgggagattcccag
aatgtggaggaactgaggacagagggtctgcccttagggctcattgctcatggaaaaaca
acacagtctgtctttgagcactacgtacaagatgctatggagctggtcgcaagagctgta
gccacagccaccatgatccaaccagaacttgctctcattcccagcacgatgaactgcatg
gaggtggaaactacaaatctcacttcaggacaatatttatcaaggtttctagccaatacc
actttcagaggcctcagtggttccatcagagtaaaaggttccaccatcgtcagctcagaa
aacaactttttcatctggaatcttcaacatgaccccatgggaaagccaatgtggacccgc
ttgggcagctggcaggggggaaagattgtcatggactatggaatatggccagagcaggcc
cagagacacaaaacccacttccaacatccaagtaagctacacttgagagtggttaccctg
attgagcatccttttgtcttcacaagggaggtagatgatgaaggcttgtgccctgctggc
caactctgtctagaccccatgactaatgactcttccacattggacagcctttttagcagc
ctccatagcagtaatgatacagtgcccattaaattcaagaagtgctgctatggatattgc
attgatctgctggaaaagatagcagaagacatgaactttgacttcgacctctatattgta
ggggatggaaagtatggagcatggaaaaatgggcactggactgggctagtgggtgatctc
ctgagagggactgcccacatggcagtcacttcctttagcatcaatactgcacggagccag
gtgatagatttcaccagccctttcttctccaccagcttgggcatcttagtgaggacccga
gatacagcagctcccattggagccttcatgtggccactccactggacaatgtggctgggg
atttttgtggctctgcacatcactgccgtcttcctcactctgtatgaatggaagagtcca
tttggtttgactcccaaggggcgaaatagaagtaaagtcttctccttttcttcagccttg
aacatctgttatgccctcttgtttggcagaacagtggccatcaaacctccaaaatgttgg
actggaaggtttctaatgaacctttgggccattttctgtatgttttgcctttccacatac
acggcaaacttggctgctgtcatggtaggtgagaagatctatgaagagctttctggaata
catgaccccaagttacatcatccttcccaaggattccgctttggaactgtccgagaaagc
agtgctgaagattatgtgagacaaagtttcccagagatgcatgaatatatgagaaggtac
aatgttccagccacccctgatggagtggagtatctgaagaatgatccagagaaactagac
gccttcatcatggacaaagcccttctggattatgaagtgtcaatagatgctgactgcaaa
cttctcactgtggggaagccatttgccatagaaggatacggcattggcctcccacccaac
tctccattgaccgccaacatatccgagctaatcagtcaatacaagtcacatgggtttatg
gatatgctccatgacaagtggtacagggtggttccctgtggcaagagaagttttgctgtc
acggagactttgcaaatgggcatcaaacacttctctgggctctttgtgctgctgtgcatt
ggatttggtctgtccattttgaccaccattggtgagcacatagtatacaggctgctgcta
ccacgaatcaaaaacaaatccaagctgcaatactggctccacaccagccagagattacac
agagcaataaatacatcatttatagaggaaaagcagcagcatttcaagaccaaacgtgtg
gaaaagaggtctaatgtgggaccccgtcagcttaccgtatggaatacttccaatctgagt
catgacaaccgacggaaatacatctttagtgatgaggaaggacaaaaccagctgggcatc
cggatccaccaggacatccccctccctccaaggagaagagagctccctgccttgcggacc
accaatgggaaagcagactccctaaatgtatctcggaactcagtgatgcaggaactctca
gagctcgagaagcagattcaggtgatccgtcaggagctgcagctggctgtgagcaggaaa
acggagctggaggagtatcaaaggacaagtcggacttgtgagtcctag

KEGG   Homo sapiens (human): 116444
Entry
116444            CDS       T01001                                 

Gene name
GRIN3B, GluN3B, NR3B
Definition
(RefSeq) glutamate ionotropic receptor NMDA type subunit 3B
  KO
K05214  glutamate receptor ionotropic, NMDA 3B
Organism
hsa  Homo sapiens (human)
Pathway
hsa04024  cAMP signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04724  Glutamatergic synapse
hsa05017  Spinocerebellar ataxia
hsa05020  Prion disease
hsa05030  Cocaine addiction
hsa05031  Amphetamine addiction
hsa05033  Nicotine addiction
hsa05034  Alcoholism
Drug target
Felbamate: D00536<US>
Orphenadrine (DG01252): D08305
Orphenadrine (chloride): D02599
Orphenadrine (citrate): D00774<US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04024 cAMP signaling pathway
    116444 (GRIN3B)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    116444 (GRIN3B)
 09150 Organismal Systems
  09156 Nervous system
   04724 Glutamatergic synapse
    116444 (GRIN3B)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05017 Spinocerebellar ataxia
    116444 (GRIN3B)
   05020 Prion disease
    116444 (GRIN3B)
  09165 Substance dependence
   05030 Cocaine addiction
    116444 (GRIN3B)
   05031 Amphetamine addiction
    116444 (GRIN3B)
   05033 Nicotine addiction
    116444 (GRIN3B)
   05034 Alcoholism
    116444 (GRIN3B)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    116444 (GRIN3B)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  Glutamate (ionotropic)
   116444 (GRIN3B)
SSDB
Motif
Pfam: Lig_chan Lig_chan-Glu_bd SBP_bac_3 ANF_receptor
Other DBs
NCBI-GeneID: 116444
NCBI-ProteinID: NP_619635
OMIM: 606651
HGNC: 16768
Ensembl: ENSG00000116032
Vega: OTTHUMG00000181904
Pharos: O60391(Tclin)
UniProt: O60391 Q5F0I5
LinkDB
Position
19p13.3
AA seq 1043 aa
MEFVRALWLGLALALGPGSAGGHPQPCGVLARLGGSVRLGALLPRAPLARARARAALARA
ALAPRLPHNLSLELVVAAPPARDPASLTRGLCQALVPPGVAALLAFPEARPELLQLHFLA
AATETPVLSLLRREARAPLGAPNPFHLQLHWASPLETLLDVLVAVLQAHAWEDVGLALCR
TQDPGGLVALWTSRAGRPPQLVLDLSRRDTGDAGLRARLAPMAAPVGGEAPVPAAVLLGC
DIARARRVLEAVPPGPHWLLGTPLPPKALPTAGLPPGLLALGEVARPPLEAAIHDIVQLV
ARALGSAAQVQPKRALLPAPVNCGDLQPAGPESPGRFLARFLANTSFQGRTGPVWVTGSS
QVHMSRHFKVWSLRRDPRGAPAWATVGSWRDGQLDLEPGGASARPPPPQGAQVWPKLRVV
TLLEHPFVFARDPDEDGQCPAGQLCLDPGTNDSATLDALFAALANGSAPRALRKCCYGYC
IDLLERLAEDTPFDFELYLVGDGKYGALRDGRWTGLVGDLLAGRAHMAVTSFSINSARSQ
VVDFTSPFFSTSLGIMVRARDTASPIGAFMWPLHWSTWLGVFAALHLTALFLTVYEWRSP
YGLTPRGRNRSTVFSYSSALNLCYAILFRRTVSSKTPKCPTGRLLMNLWAIFCLLVLSSY
TANLAAVMVGDKTFEELSGIHDPKLHHPAQGFRFGTVWESSAEAYIKKSFPDMHAHMRRH
SAPTTPRGVAMLTSDPPKLNAFIMDKSLLDYEVSIDADCKLLTVGKPFAIEGYGIGLPQN
SPLTSNLSEFISRYKSSGFIDLLHDKWYKMVPCGKRVFAVTETLQMSIYHFAGLFVLLCL
GLGSALLSSLGEHAFFRLALPRIRKGSRLQYWLHTSQKIHRALNTEPPEGSKEETAEAEP
SGPEVEQQQQQQDQPTAPEGWKRARRAVDKERRVRFLLEPAVVVAPEADAEAEAAPREGP
VWLCSYGRPPAARPTGAPQPGELQELERRIEVARERLRQALVRRGQLLAQLGDSARHRPR
RLLQARAAPAEAPPHSGRPGSQE
NT seq 3132 nt   +upstreamnt  +downstreamnt
atggagtttgtgcgggcgctgtggctgggcctggcgctggcgctggggccggggtccgcg
gggggccaccctcagccgtgcggcgtcctggcgcgcctcgggggctccgtgcgcctgggc
gccctcctgccccgcgcgcctctcgcccgcgcccgcgcccgcgccgccctggcccgggcc
gccctggcgccgcggctgccgcacaacctgagcttggagctggtggtcgccgcgcccccc
gcccgcgaccccgcctcgctgacccgcggcctgtgccaggcgctggtgcctccgggcgtg
gcggccctgctcgcctttcccgaggctcggcccgagctgctgcagctgcacttcctggcg
gcggccaccgagacccccgtgctcagcctgctgcggcgggaggcgcgcgcgcccctcgga
gccccgaacccattccacctgcagctgcactgggccagccccctggagacgctgctggat
gtgctggtggcggtgctgcaggcgcacgcctgggaagacgtcggcctggccctgtgccgc
actcaggaccccggcggcctggtggccctctggacaagccgggctggccggcccccacag
ctggtcctggacctaagccggcgggacacgggagatgcaggactgcgggcacgcctggcc
ccgatggcggcgccagtggggggtgaagcaccggtacccgcggcggtcctcctcggctgt
gacatcgcccgtgcccgtcgggtgctggaggccgtacctcccggcccccactggctgttg
gggacaccactgccgcccaaggccctgcccaccgcggggctgccaccagggctgctggcg
ctgggcgaggtggcacgacccccgctggaggccgccatccatgacattgtgcaactggtg
gcccgggcgctgggcagtgcggcccaggtgcagccgaagcgagccctcctccccgccccg
gtcaactgcggggacctgcagccggccgggcccgagtccccggggcgcttcttggcacgg
ttcctggccaacacgtccttccagggccgcacgggccccgtgtgggtgacaggcagctcc
caggtacacatgtctcggcactttaaggtgtggagccttcgccgggacccacggggcgcc
ccggcctgggccacggtgggcagctggcgggacggccagctggacttggaaccgggaggt
gcctctgcacggcccccgcccccacagggtgcccaggtctggcccaagctgcgtgtggta
acgctgttggaacacccatttgtgtttgcccgtgatccagacgaagacgggcagtgccca
gcggggcagctgtgcctggaccctggcaccaacgactcggccaccctggacgcactgttc
gccgcgctggccaacggctcagcgccccgtgccctgcgcaagtgctgctacggctactgc
attgacctgctggagcggctggcggaggacacgcccttcgacttcgagctgtacctcgtg
ggtgacggcaagtacggcgccctgcgggacggccgctggaccggcctggtcggggacctg
ctggccggccgggcccacatggcggtcaccagcttcagtatcaactccgcccgctcacag
gtggtggacttcaccagccccttcttctccaccagcctgggcatcatggtgcgggcacgg
gacacggcctcacccatcggtgcctttatgtggcccctgcactggtccacgtggctgggc
gtctttgcggccctgcacctcaccgcgctcttcctcaccgtgtacgagtggcgtagcccc
tacggcctcacgccacgtggccgcaaccgcagcaccgtcttctcctactcctcagccctc
aacctgtgctacgccatcctcttcagacgcaccgtgtccagcaagacgcccaagtgcccc
acgggccgcctgctcatgaacctctgggccatcttctgcctgctggtgctgtccagctac
acggccaacctggctgccgtcatggtcggggacaagaccttcgaggagctgtcggggatc
cacgaccccaagctgcaccacccggcgcagggcttccgcttcggcaccgtgtgggagagc
agcgccgaggcgtacatcaagaagagcttccccgacatgcacgcacacatgcggcgccac
agcgcgcccaccacgccccgcggcgtcgccatgctcacgagcgacccccccaagctcaac
gccttcatcatggacaagtcgctcctggactacgaggtctccatcgacgccgactgcaaa
ctgctgaccgtgggaaagcccttcgccattgagggctatgggatcggactgccccagaac
tcgccgctcacctccaacctgtccgagttcatcagccgctacaagtcctccggcttcatc
gacctgctccacgacaagtggtacaagatggtgccttgcggcaagcgggtctttgcggtt
acagagaccctgcagatgagcatctaccacttcgcgggcctcttcgtgttgctgtgcctg
ggcctgggcagcgctctgctcagctcgctgggcgagcacgccttcttccgcctggcgctg
ccgcgcatccgcaaggggagcaggctgcagtactggctgcacaccagccagaaaatccac
cgcgccctcaacacggagccaccagaggggtcgaaggaggagacggcagaggcggagccc
agcggccccgaggtggagcagcagcagcagcagcaggaccagccaacggctccggagggc
tggaaacgggcgcgccgggccgtggacaaggagcgccgcgtgcgcttcctgctggagccc
gccgtggttgtggcacccgaagcggacgcggaggcggaggctgcgccgcgagagggcccc
gtctggctgtgctcctacggccgcccgcccgccgcaaggcccacgggggccccccagccc
ggggagctgcaggagctggagcgccgcatcgaagtcgcgcgtgagcggctccgccaggcc
ctggtgcggcgcggccagctcctggcacagctcggggacagcgcacgtcaccggcctcgg
cgcttgcttcaggccagagcggcccccgcggaggccccaccacactctggccgaccgggg
agccaggaatga

KEGG   Homo sapiens (human): 2890
Entry
2890              CDS       T01001                                 

Gene name
GRIA1, GLUH1, GLUR1, GLURA, GluA1, HBGR1
Definition
(RefSeq) glutamate ionotropic receptor AMPA type subunit 1
  KO
K05197  glutamate receptor 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04024  cAMP signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04713  Circadian entrainment
hsa04720  Long-term potentiation
hsa04723  Retrograde endocannabinoid signaling
hsa04724  Glutamatergic synapse
hsa04728  Dopaminergic synapse
hsa04730  Long-term depression
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05017  Spinocerebellar ataxia
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05031  Amphetamine addiction
hsa05033  Nicotine addiction
Drug target
Dasolampanel: D10107
Dasolampanel etibutil: D10108
Dasolampanel etibutil tosylate: D10109
Farampator: D04131
Mibampator: D09931
Perampanel (DG01901): D08964<US> D10780<JP>
Riluzole: D00775<JP/US>
Talampanel: D02696
Tezampanel: D06656
Topiramate: D00537<JP/US>
Troriluzole (DG03011): D11414
Zonampanel: D09035
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04024 cAMP signaling pathway
    2890 (GRIA1)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2890 (GRIA1)
 09150 Organismal Systems
  09156 Nervous system
   04724 Glutamatergic synapse
    2890 (GRIA1)
   04728 Dopaminergic synapse
    2890 (GRIA1)
   04720 Long-term potentiation
    2890 (GRIA1)
   04730 Long-term depression
    2890 (GRIA1)
   04723 Retrograde endocannabinoid signaling
    2890 (GRIA1)
  09159 Environmental adaptation
   04713 Circadian entrainment
    2890 (GRIA1)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    2890 (GRIA1)
   05016 Huntington disease
    2890 (GRIA1)
   05017 Spinocerebellar ataxia
    2890 (GRIA1)
   05022 Pathways of neurodegeneration - multiple diseases
    2890 (GRIA1)
  09165 Substance dependence
   05031 Amphetamine addiction
    2890 (GRIA1)
   05033 Nicotine addiction
    2890 (GRIA1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2890 (GRIA1)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  Glutamate (ionotropic)
   2890 (GRIA1)
SSDB
Motif
Pfam: ANF_receptor Lig_chan Lig_chan-Glu_bd SBP_bac_3 DUF659 Peripla_BP_6 DUF2061
Other DBs
NCBI-GeneID: 2890
NCBI-ProteinID: NP_000818
OMIM: 138248
HGNC: 4571
Ensembl: ENSG00000155511
Vega: OTTHUMG00000130148
Pharos: P42261(Tclin)
UniProt: P42261 Q59GL5
LinkDB
Position
5q33.2
AA seq 906 aa
MQHIFAFFCTGFLGAVVGANFPNNIQIGGLFPNQQSQEHAAFRFALSQLTEPPKLLPQID
IVNISDSFEMTYRFCSQFSKGVYAIFGFYERRTVNMLTSFCGALHVCFITPSFPVDTSNQ
FVLQLRPELQDALISIIDHYKWQKFVYIYDADRGLSVLQKVLDTAAEKNWQVTAVNILTT
TEEGYRMLFQDLEKKKERLVVVDCESERLNAILGQIIKLEKNGIGYHYILANLGFMDIDL
NKFKESGANVTGFQLVNYTDTIPAKIMQQWKNSDARDHTRVDWKRPKYTSALTYDGVKVM
AEAFQSLRRQRIDISRRGNAGDCLANPAVPWGQGIDIQRALQQVRFEGLTGNVQFNEKGR
RTNYTLHVIEMKHDGIRKIGYWNEDDKFVPAATDAQAGGDNSSVQNRTYIVTTILEDPYV
MLKKNANQFEGNDRYEGYCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDTKAWNGMVGE
LVYGRADVAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIW
MCIVFAYIGVSVVLFLVSRFSPYEWHSEEFEEGRDQTTSDQSNEFGIFNSLWFSLGAFMQ
QGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIA
YGTLEAGSTKEFFRRSKIAVFEKMWTYMKSAEPSVFVRTTEEGMIRVRKSKGKYAYLLES
TMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSALRNPVNLAVLKLNEQGLLDKLKNKW
WYDKGECGSGGGDSKDKTSALSLSNVAGVFYILIGGLGLAMLVALIEFCYKSRSESKRMK
GFCLIPQQSINEAIRTSTLPRNSGAGASSGGSGENGRVVSHDFPKSMQSIPCMSHSSGMP
LGATGL
NT seq 2721 nt   +upstreamnt  +downstreamnt
atgcagcacatttttgccttcttctgcaccggtttcctaggcgcggtagtaggtgccaat
ttccccaacaatatccagatcgggggattatttccaaaccagcagtcacaggaacatgct
gcttttagatttgctttgtcgcaactcacagagcccccgaagctgctcccccagattgat
attgtgaacatcagcgacagctttgagatgacctatagattctgttcccagttctccaaa
ggagtctatgccatctttgggttttatgaacgtaggactgtcaacatgctgacctccttt
tgtggggccctccacgtctgcttcattacgccgagctttcccgttgatacatccaatcag
tttgtccttcagctgcgccctgaactgcaggatgccctcatcagcatcattgaccattac
aagtggcagaaatttgtctacatttatgatgccgaccggggcttatccgtcctgcagaaa
gtcctggatacagctgctgagaagaactggcaggtgacagcagtcaacattttgacaacc
acagaggagggataccggatgctctttcaggacctggagaagaaaaaggagcggctggtg
gtggtggactgtgaatcagaacgcctcaatgctatcttgggccagattataaagctagag
aagaatggcatcggctaccactacattcttgcaaatctgggcttcatggacattgactta
aacaaattcaaggagagtggcgccaatgtgacaggtttccagctggtgaactacacagac
actattccggccaagatcatgcagcagtggaagaatagtgatgctcgagaccacacacgg
gtggactggaagagacccaagtacacctctgcgctcacctacgatggggtgaaggtgatg
gctgaggctttccagagcctgcggaggcagagaattgatatatctcgccgggggaatgct
ggggattgtctggctaacccagctgttccctggggccaagggatcgacatccagagagct
ctgcagcaggtgcgatttgaaggtttaacaggaaacgtgcagtttaatgagaaaggacgc
cggaccaactacacgctccacgtgattgaaatgaaacatgacggcatccgaaagattggt
tactggaatgaagatgataagtttgtccctgcagccaccgatgcccaagctgggggcgat
aattcaagtgttcagaacagaacatacatcgtcacaacaatcctagaagatccttatgtg
atgctcaagaagaacgccaatcagtttgagggcaatgaccgttacgagggctactgtgta
gagctggcggcagagattgccaagcacgtgggctactcctaccgtctggagattgtcagt
gatggaaaatacggagcccgagaccctgacacgaaggcctggaatggcatggtgggagag
ctggtctatggaagagcagatgtggctgtggctcccttaactatcactttggtccgggaa
gaagttatagatttctccaaaccatttatgagtttggggatctccatcatgattaaaaaa
ccacagaaatccaagccgggtgtcttctccttccttgatcctttggcttatgagatttgg
atgtgcattgtttttgcctacattggagtgagtgttgtcctcttcctggtcagccgcttc
agtccctatgaatggcacagtgaagagtttgaggaaggacgggaccagacaaccagtgac
cagtccaatgagtttgggatattcaacagtttgtggttctccctgggagccttcatgcag
caaggatgtgacatttctcccaggtccctgtctggtcgcatcgttggtggcgtctggtgg
ttcttcaccttaatcatcatctcctcatatacagccaatctggccgccttcctgaccgtg
gagaggatggtgtctcccattgagagtgcagaggacctagcgaagcagacagaaattgcc
tacgggacgctggaagcaggatctactaaggagttcttcaggaggtctaaaattgctgtg
tttgagaagatgtggacatacatgaagtcagcagagccatcagtttttgtgcggaccaca
gaggaggggatgattcgagtgaggaaatccaaaggcaaatatgcctacctcctggagtcc
accatgaatgagtacattgagcagcggaaaccctgtgacaccatgaaggtgggaggtaac
ttggattccaaaggctatggcattgcaacacccaaggggtctgccctgagaaatccagta
aacctggcagtgttaaaactgaacgagcaggggcttttggacaaattgaaaaacaaatgg
tggtacgacaagggcgagtgcggcagcgggggaggtgattccaaggacaagacaagcgct
ctgagcctcagcaatgtggcaggcgtgttctacatcctgatcggaggacttggactagcc
atgctggttgccttaatcgagttctgctacaaatcccgtagtgaatccaagcggatgaag
ggtttttgtttgatcccacagcaatccatcaacgaagccatacggacatcgaccctcccc
cgcaacagcggggcaggagccagcagcggcggcagtggagagaatggtcgggtggtcagc
catgacttccccaagtccatgcaatcgattccttgcatgagccacagttcagggatgccc
ttgggagccacgggattgtaa

KEGG   Homo sapiens (human): 2891
Entry
2891              CDS       T01001                                 

Gene name
GRIA2, GLUR2, GLURB, GluA2, GluR-K2, HBGR2, NEDLIB, gluR-2, gluR-B
Definition
(RefSeq) glutamate ionotropic receptor AMPA type subunit 2
  KO
K05198  glutamate receptor 2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04024  cAMP signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04713  Circadian entrainment
hsa04720  Long-term potentiation
hsa04723  Retrograde endocannabinoid signaling
hsa04724  Glutamatergic synapse
hsa04728  Dopaminergic synapse
hsa04730  Long-term depression
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05017  Spinocerebellar ataxia
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05030  Cocaine addiction
hsa05031  Amphetamine addiction
hsa05033  Nicotine addiction
Drug target
Dasolampanel: D10107
Dasolampanel etibutil: D10108
Dasolampanel etibutil tosylate: D10109
Farampator: D04131
Mibampator: D09931
Perampanel (DG01901): D08964<US> D10780<JP>
Riluzole: D00775<JP/US>
Talampanel: D02696
Tezampanel: D06656
Topiramate: D00537<JP/US>
Troriluzole (DG03011): D11414
Zonampanel: D09035
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04024 cAMP signaling pathway
    2891 (GRIA2)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2891 (GRIA2)
 09150 Organismal Systems
  09156 Nervous system
   04724 Glutamatergic synapse
    2891 (GRIA2)
   04728 Dopaminergic synapse
    2891 (GRIA2)
   04720 Long-term potentiation
    2891 (GRIA2)
   04730 Long-term depression
    2891 (GRIA2)
   04723 Retrograde endocannabinoid signaling
    2891 (GRIA2)
  09159 Environmental adaptation
   04713 Circadian entrainment
    2891 (GRIA2)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    2891 (GRIA2)
   05016 Huntington disease
    2891 (GRIA2)
   05017 Spinocerebellar ataxia
    2891 (GRIA2)
   05022 Pathways of neurodegeneration - multiple diseases
    2891 (GRIA2)
  09165 Substance dependence
   05030 Cocaine addiction
    2891 (GRIA2)
   05031 Amphetamine addiction
    2891 (GRIA2)
   05033 Nicotine addiction
    2891 (GRIA2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2891 (GRIA2)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  Glutamate (ionotropic)
   2891 (GRIA2)
SSDB
Motif
Pfam: ANF_receptor Lig_chan Lig_chan-Glu_bd SBP_bac_3 Peripla_BP_6 DUF2061
Other DBs
NCBI-GeneID: 2891
NCBI-ProteinID: NP_000817
OMIM: 138247
HGNC: 4572
Ensembl: ENSG00000120251
Vega: OTTHUMG00000133836
Pharos: P42262(Tclin)
UniProt: P42262
LinkDB
Structure
PDB: 

Position
4q32.1
AA seq 883 aa
MQKIMHISVLLSPVLWGLIFGVSSNSIQIGGLFPRGADQEYSAFRVGMVQFSTSEFRLTP
HIDNLEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTDG
THPFVIQMRPDLKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINV
GNINNDKKDEMYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANL
GFTDGDLLKIQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTTTIKYTSALT
YDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNI
KFDQNGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTLTELPSGNDTSGLENKTVVVTT
ILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKI
WNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLD
PLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWF
SLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDL
SKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGK
YAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRTPVNLAVLKLSEQGVL
DKLKNKWWYDKGECGAKDSGSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSR
AEAKRMKVAKNAQNINPSSSQNSQNFATYKEGYNVYGIESVKI
NT seq 2652 nt   +upstreamnt  +downstreamnt
atgcaaaagattatgcatatttctgtcctcctttctcctgttttatggggactgattttt
ggtgtctcttctaacagcatacagataggggggctatttcctaggggcgccgatcaagaa
tacagtgcatttcgagtagggatggttcagttttccacttcggagttcagactgacaccc
cacatcgacaatttggaggtggcaaacagcttcgcagtcactaatgctttctgctcccag
ttttcgagaggagtctatgctatttttggattttatgacaagaagtctgtaaataccatc
acatcattttgcggaacactccacgtctccttcatcactcccagcttcccaacagatggc
acacatccatttgtcattcagatgagacccgacctcaaaggagctctccttagcttgatt
gaatactatcaatgggacaagtttgcatacctctatgacagtgacagaggcttatcaaca
ctgcaagctgtgctggattctgctgctgaaaagaaatggcaagtgactgctatcaatgtg
ggaaacattaacaatgacaagaaagatgagatgtaccgatcactttttcaagatctggag
ttaaaaaaggaacggcgtgtaattctggactgtgaaagggataaagtaaacgacattgta
gaccaggttattaccattggaaaacatgttaaagggtaccactacatcattgcaaatctg
ggatttactgatggagacctattaaaaatccagtttggaggtgcaaatgtctctggattt
cagatagtggactatgatgattcgttggtatctaaatttatagaaagatggtcaacactg
gaagaaaaagaataccctggagctcacacaacaacaattaagtatacttctgctctgacc
tatgatgccgttcaagtgatgactgaagccttccgcaacctaaggaagcaaagaattgaa
atctcccgaagggggaatgcaggagactgtctggcaaacccagcagtgccctggggacaa
ggtgtagaaatagaaagggccctcaaacaggttcaggttgaaggtctctcaggaaatata
aagtttgaccagaatggaaaaagaataaactatacaattaacatcatggagctcaaaact
aatgggccccggaagattggctactggagtgaagtggacaaaatggttgttacccttact
gagctcccttctggaaatgacacctctgggcttgagaataagactgttgttgtcaccaca
attttggaatctccgtatgttatgatgaagaaaaatcatgaaatgcttgaaggcaatgag
cgctatgagggctactgtgttgacctggctgcagaaatcgccaaacattgtgggttcaag
tacaagttgacaattgttggtgatggcaagtatggggccagggatgcagacacgaaaatt
tggaatgggatggttggagaacttgtatatgggaaagctgatattgcaattgctccatta
actattacccttgtgagagaagaggtgattgacttctcaaagcccttcatgagcctcggg
atatctatcatgatcaagaagcctcagaagtccaaaccaggagtgttttcctttcttgat
cctttagcctatgagatctggatgtgcattgtttttgcctacattggggtcagtgtagtt
ttattcctggtcagcagatttagcccctacgagtggcacactgaggagtttgaagatgga
agagaaacacaaagtagtgaatcaactaatgaatttgggatttttaatagtctctggttt
tccttgggtgcctttatgcagcaaggatgcgatatttcgccaagatccctctctgggcgc
attgttggaggtgtgtggtggttctttaccctgatcataatctcctcctacacggctaac
ttagctgccttcctgactgtagagaggatggtgtctcccatcgaaagtgctgaggatctt
tctaagcaaacagaaattgcttatggaacattagactctggctccactaaagagtttttc
aggagatctaaaattgcagtgtttgataaaatgtggacctacatgcggagtgcggagccc
tctgtgtttgtgaggactacggccgaaggggtggctagagtgcggaagtccaaagggaaa
tatgcctacttgttggagtccacgatgaacgagtacattgagcaaaggaagccttgcgac
accatgaaagttggtggaaacctggattccaaaggctatggcatcgcaacacctaaagga
tcctcattaagaaccccagtaaatcttgcagtattgaaactcagtgagcaaggcgtctta
gacaagctgaaaaacaaatggtggtacgataaaggtgaatgtggagccaaggactctgga
agtaaggaaaagaccagtgccctcagtctgagcaacgttgctggagtattctacatcctt
gtcgggggccttggtttggcaatgctggtggctttgattgagttctgttacaagtcaagg
gccgaggcgaaacgaatgaaggtggcaaagaatgcacagaatattaacccatcttcctcg
cagaattcacagaattttgcaacttataaggaaggttacaacgtatatggcatcgaaagt
gttaaaatttag

KEGG   Homo sapiens (human): 2892
Entry
2892              CDS       T01001                                 

Gene name
GRIA3, GLUR-C, GLUR-K3, GLUR3, GLURC, GluA3, MRX94, MRXSW
Definition
(RefSeq) glutamate ionotropic receptor AMPA type subunit 3
  KO
K05199  glutamate receptor 3
Organism
hsa  Homo sapiens (human)
Pathway
hsa04024  cAMP signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04713  Circadian entrainment
hsa04723  Retrograde endocannabinoid signaling
hsa04724  Glutamatergic synapse
hsa04728  Dopaminergic synapse
hsa04730  Long-term depression
hsa05016  Huntington disease
hsa05017  Spinocerebellar ataxia
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05031  Amphetamine addiction
hsa05033  Nicotine addiction
hsa05202  Transcriptional misregulation in cancer
Network
nt06240  Transcription
  Element
N00120  MLL-ENL fusion to transcriptional activation
Disease
H00658  Syndromic X-linked mental retardation
Drug target
Dasolampanel: D10107
Dasolampanel etibutil: D10108
Dasolampanel etibutil tosylate: D10109
Farampator: D04131
Mibampator: D09931
Perampanel (DG01901): D08964<US> D10780<JP>
Riluzole: D00775<JP/US>
Talampanel: D02696
Tezampanel: D06656
Topiramate: D00537<JP/US>
Troriluzole (DG03011): D11414
Zonampanel: D09035
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04024 cAMP signaling pathway
    2892 (GRIA3)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2892 (GRIA3)
 09150 Organismal Systems
  09156 Nervous system
   04724 Glutamatergic synapse
    2892 (GRIA3)
   04728 Dopaminergic synapse
    2892 (GRIA3)
   04730 Long-term depression
    2892 (GRIA3)
   04723 Retrograde endocannabinoid signaling
    2892 (GRIA3)
  09159 Environmental adaptation
   04713 Circadian entrainment
    2892 (GRIA3)
 09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    2892 (GRIA3)
  09164 Neurodegenerative disease
   05016 Huntington disease
    2892 (GRIA3)
   05017 Spinocerebellar ataxia
    2892 (GRIA3)
   05022 Pathways of neurodegeneration - multiple diseases
    2892 (GRIA3)
  09165 Substance dependence
   05031 Amphetamine addiction
    2892 (GRIA3)
   05033 Nicotine addiction
    2892 (GRIA3)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2892 (GRIA3)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  Glutamate (ionotropic)
   2892 (GRIA3)
SSDB
Motif
Pfam: ANF_receptor Lig_chan Lig_chan-Glu_bd SBP_bac_3 NusG_add DUF2061
Other DBs
NCBI-GeneID: 2892
NCBI-ProteinID: NP_000819
OMIM: 305915
HGNC: 4573
Ensembl: ENSG00000125675
Vega: OTTHUMG00000022685
Pharos: P42263(Tclin)
UniProt: P42263 Q17R51
LinkDB
Position
Xq25
AA seq 894 aa
MARQKKMGQSVLRAVFFLVLGLLGHSHGGFPNTISIGGLFMRNTVQEHSAFRFAVQLYNT
NQNTTEKPFHLNYHVDHLDSSNSFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSFCGAL
HTSFVTPSFPTDADVQFVIQMRPALKGAILSLLGHYKWEKFVYLYDTERGFSILQAIMEA
AVQNNWQVTARSVGNIKDVQEFRRIIEEMDRRQEKRYLIDCEVERINTILEQVVILGKHS
RGYHYMLANLGFTDILLERVMHGGANITGFQIVNNENPMVQQFIQRWVRLDEREFPEAKN
APLKYTSALTHDAILVIAEAFRYLRRQRVDVSRRGSAGDCLANPAVPWSQGIDIERALKM
VQVQGMTGNIQFDTYGRRTNYTIDVYEMKVSGSRKAGYWNEYERFVPFSDQQISNDSASS
ENRTIVVTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVGDGKY
GARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKS
KPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDPQSPPDPP
NEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVER
MVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTAD
GVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALRNAVNL
AVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKDKTSALSLSNVAGVFYILVGGLGLAMM
VALIEFCYKSRAESKRMKLTKNTQNFKPAPATNTQNYATYREGYNVYGTESVKI
NT seq 2685 nt   +upstreamnt  +downstreamnt
atggccaggcagaagaaaatggggcaaagcgtgctccgggcggtcttctttttagtcctg
gggcttttgggtcattctcacggaggattccccaacaccatcagcataggtggacttttc
atgagaaacacagtgcaggagcacagcgctttccgctttgccgtgcagttatacaacacc
aaccagaacaccaccgagaagcccttccatttgaattaccacgtagatcacttggattcc
tccaatagtttttccgtgacaaatgctttctgctcccagttctcgagaggggtgtatgcc
atctttggattctatgaccagatgtcaatgaacaccctgacctccttctgtggggccctg
cacacatcctttgttacgcctagcttccccactgacgcagatgtgcagtttgtcatccag
atgcgcccagccttgaagggcgctattctgagtcttctgggtcattacaagtgggagaag
tttgtgtacctctatgacacagaacgaggattttccatcctccaagcgattatggaagca
gcagtgcaaaacaactggcaagtaacagcaaggtctgtgggaaacataaaggacgtccaa
gaattcaggcgcatcattgaagaaatggacaggaggcaggaaaagcgatacttgattgac
tgcgaagtcgaaaggattaacacaattttggaacaggttgtgatcctagggaaacactca
agaggttatcactacatgctcgctaacctgggttttactgatattttactggaaagagtc
atgcatgggggagccaacattacaggtttccagattgtcaacaatgaaaaccctatggtt
cagcagttcatacagcgctgggtgaggctggatgaaagggaattccctgaagccaagaat
gcaccactaaagtatacatctgcattgacacacgacgcaatactggtcatagcagaagct
ttccgctacctgaggaggcagcgagtagatgtgtcccggagaggaagtgctggagactgc
ttagcaaatcctgctgtgccctggagtcaaggaattgatattgagagagctctgaaaatg
gtgcaagtacaaggaatgactggaaatattcaatttgacacttatggacgtaggacaaat
tataccatcgatgtgtatgaaatgaaagtcagtggctctcgaaaagctggctactggaat
gagtatgaaaggtttgtgcctttctcagatcagcaaatcagcaatgacagtgcatcctca
gagaatcggaccatagtagtgactaccattctggaatcaccatatgtaatgtacaagaag
aaccatgagcaactggaaggaaatgaacgatatgaaggctattgtgtagacctagcctat
gaaatagccaaacatgtaaggatcaaatacaaattgtccatcgttggtgacgggaaatat
ggtgcaagggatccagagactaaaatatggaacggcatggttggggaacttgtctatggg
agagctgatatagctgttgctccactcactataacattggtccgtgaagaagtcatagat
ttttcaaagccattcatgagcctgggcatctccatcatgataaagaagcctcagaaatca
aaaccaggcgtattctcatttctggatcccctggcttatgaaatctggatgtgcattgtc
tttgcttacattggagtcagcgtagttcttttcctagtcagcaggttcagtccttatgaa
tggcacttggaagacaacaatgaagaacctcgtgacccacaaagtcctcctgatcctcca
aatgaatttggaatatttaacagtctttggttttccttgggtgcctttatgcagcaagga
tgtgatatttctccaagatcactctccgggcgcattgttggaggggtttggtggttcttc
accctgatcataatttcttcctatactgccaatctcgctgctttcctgactgtggagagg
atggtttctcccatagagagtgctgaagacttagctaaacagactgaaattgcatatggg
accctggactccggttcaacaaaagaatttttcagaagatccaaaattgctgtgtacgag
aaaatgtggtcttacatgaaatcagcggagccatctgtgtttaccaaaacaacagcagac
ggagtggcccgagtgcgaaagtccaagggaaagttcgccttcctgctggagtcaaccatg
aatgagtacattgagcagagaaaaccatgtgatacgatgaaagttggtggaaatctggat
tccaaaggctatggtgtggcaacccctaaaggctcagcattaagaaatgctgttaacctg
gcagtattaaaactgaatgagcaaggcctcttggacaaattgaaaaacaaatggtggtac
gacaaaggagagtgcggcagcgggggcggtgactccaaggacaagaccagcgctctgagc
ctgagcaatgtggcaggcgttttctatatacttgtcggaggtctggggctggccatgatg
gtggctttgatagaattctgttacaaatcacgggcagagtccaaacgcatgaaactcaca
aagaacacccaaaactttaagcctgctcctgccaccaacactcagaattatgctacatac
agagaaggctacaacgtgtatggaacagagagtgttaagatctag

KEGG   Homo sapiens (human): 2893
Entry
2893              CDS       T01001                                 

Gene name
GRIA4, GLUR4, GLUR4C, GLURD, GluA4, NEDSGA
Definition
(RefSeq) glutamate ionotropic receptor AMPA type subunit 4
  KO
K05200  glutamate receptor 4
Organism
hsa  Homo sapiens (human)
Pathway
hsa04024  cAMP signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04713  Circadian entrainment
hsa04723  Retrograde endocannabinoid signaling
hsa04724  Glutamatergic synapse
hsa04728  Dopaminergic synapse
hsa05016  Huntington disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05031  Amphetamine addiction
hsa05033  Nicotine addiction
Drug target
Dasolampanel: D10107
Dasolampanel etibutil: D10108
Dasolampanel etibutil tosylate: D10109
Farampator: D04131
Mibampator: D09931
Perampanel (DG01901): D08964<US> D10780<JP>
Riluzole: D00775<JP/US>
Talampanel: D02696
Tezampanel: D06656
Topiramate: D00537<JP/US>
Troriluzole (DG03011): D11414
Zonampanel: D09035
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04024 cAMP signaling pathway
    2893 (GRIA4)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2893 (GRIA4)
 09150 Organismal Systems
  09156 Nervous system
   04724 Glutamatergic synapse
    2893 (GRIA4)
   04728 Dopaminergic synapse
    2893 (GRIA4)
   04723 Retrograde endocannabinoid signaling
    2893 (GRIA4)
  09159 Environmental adaptation
   04713 Circadian entrainment
    2893 (GRIA4)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05016 Huntington disease
    2893 (GRIA4)
   05022 Pathways of neurodegeneration - multiple diseases
    2893 (GRIA4)
  09165 Substance dependence
   05031 Amphetamine addiction
    2893 (GRIA4)
   05033 Nicotine addiction
    2893 (GRIA4)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2893 (GRIA4)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  Glutamate (ionotropic)
   2893 (GRIA4)
SSDB
Motif
Pfam: ANF_receptor Lig_chan Lig_chan-Glu_bd SBP_bac_3 Peripla_BP_6 DUF2061
Other DBs
NCBI-GeneID: 2893
NCBI-ProteinID: NP_000820
OMIM: 138246
HGNC: 4574
Ensembl: ENSG00000152578
Vega: OTTHUMG00000166236
Pharos: P48058(Tclin)
UniProt: P48058 Q1WWK6
LinkDB
Position
11q22.3
AA seq 902 aa
MRIISRQIVLLFSGFWGLAMGAFPSSVQIGGLFIRNTDQEYTAFRLAIFLHNTSPNASEA
PFNLVPHVDNIETANSFAVTNAFCSQYSRGVFAIFGLYDKRSVHTLTSFCSALHISLITP
SFPTEGESQFVLQLRPSLRGALLSLLDHYEWNCFVFLYDTDRGYSILQAIMEKAGQNGWH
VSAICVENFNDVSYRQLLEELDRRQEKKFVIDCEIERLQNILEQIVSVGKHVKGYHYIIA
NLGFKDISLERFIHGGANVTGFQLVDFNTPMVIKLMDRWKKLDQREYPGSETPPKYTSAL
TYDGVLVMAETFRSLRRQKIDISRRGNAGDCLANPAAPWGQGIDMERTLKQVRIQGLTGN
VQFDHYGRRVNYTMDVFELKSTGPRKVGYWNDMDKLVLIQDVPTLGNDTAAIENRTVVVT
TIMESPYVMYKKNHEMFEGNDKYEGYCVDLASEIAKHIGIKYKIAIVPDGKYGARDADTK
IWNGMVGELVYGKAEIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFL
DPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEPEDGKEGPSDQPPNEFGIFNSLW
FSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAED
LAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWTYMRSAEPSVFTRTTAEGVARVRKSKG
KFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSSLRTPVNLAVLKLSEAGV
LDKLKNKWWYDKGECGPKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKS
RAEAKRMKLTFSEAIRNKARLSITGSVGENGRVLTPDCPKAVHTGTAIRQSSGLAVIASD
LP
NT seq 2709 nt   +upstreamnt  +downstreamnt
atgaggattatttccagacagattgtcttgttattttctggattttggggactcgccatg
ggagcctttccgagcagcgtgcaaataggtggtctcttcatccgaaacacagatcaggaa
tacactgcttttcgattagcaatttttcttcataacaccagccccaatgcgtcggaagct
ccttttaatttggtacctcatgtggacaacattgagacagccaacagttttgctgtaaca
aacgccttctgttcccagtattctagaggagtatttgccatttttggactctatgataag
aggtcggtacataccttgacctcattctgcagcgccttacatatctccctcatcacacca
agtttccctactgagggggagagccagtttgtgctgcaactaagaccttcgttacgagga
gcactcttgagtttgctggatcactacgaatggaactgttttgtcttcctgtatgacaca
gacaggggatactcgatactccaagctattatggaaaaagcaggacaaaatggttggcat
gtcagcgctatatgtgtggaaaattttaatgatgtcagctataggcaacttctagaagaa
cttgacagaagacaagagaagaagtttgtaatagactgtgagatagagagacttcaaaac
atattagaacagattgtaagtgttggaaagcatgttaaaggctaccattatatcattgca
aacttgggattcaaggatatttctcttgagaggtttatacatggtggagccaatgttact
ggattccagttggtggattttaatacacctatggtaatcaaactaatggatcgctggaag
aaactagatcagagagagtatccaggatctgagactcctccaaagtacacctctgctctg
acttatgatggagtccttgtgatggctgaaactttccgaagtcttaggaggcagaaaatt
gatatctcaaggagaggaaatgctggggattgtctggcaaatcctgctgctccatggggc
cagggaattgacatggagaggacactcaaacaggttcgaattcaagggctgacagggaat
gttcagtttgaccactatggacgtagagtcaattacacaatggatgtgtttgagctgaaa
agcacaggacctagaaaggttggttactggaatgatatggataagttagtcttgattcaa
gatgtaccaactcttggcaatgacacagctgctattgagaacagaacagtggttgtaacc
acaattatggaatccccatatgttatgtacaagaaaaatcatgaaatgtttgaaggaaat
gacaagtatgaaggatactgtgtagatttggcatctgaaattgcaaaacatattggtatc
aagtataaaattgccattgtccctgatggaaaatatggagcaagggatgcagacacaaaa
atctggaatgggatggtaggagaacttgtttatgggaaagcagagattgctattgcccct
ctgacaatcactttggtacgagaggaggtcattgacttttctaagcccttcatgagtttg
ggcatatctatcatgatcaaaaagcctcagaaatccaaaccaggagtgttttccttcttg
gatcctctggcctatgagatttggatgtgcatagtctttgcctacattggtgtcagcgtg
gtcttattcctagttagtagatttagtccatatgagtggcacacagaagagccagaggac
ggaaaggaaggacccagcgaccagcctcccaatgagtttggcatctttaacagcctctgg
ttttccctgggtgcttttatgcagcaaggatgtgacatttcacccagatccctctcaggt
cgaattgttggaggtgtttggtggttctttacactcatcattatatcatcttatactgct
aacctcgctgctttcctgacggttgagcgaatggtctctcccatagaaagtgcagaagac
ctggccaaacaaacagaaattgcctatggaacactggattcaggatcaacaaaagaattc
ttcagaagatcaaaaatagcagtgtatgaaaagatgtggacctacatgcgatcagcagag
ccatcagtattcactaggactacagctgagggagtagctcgtgtccgcaaatccaagggc
aaatttgcctttctcctggagtccactatgaatgaatacattgagcagcgaaagccatgt
gacacgatgaaagtgggaggaaatctggattccaaaggctatggagtagcaacgcccaag
ggttcctcattaagaactcctgtaaaccttgccgttttgaaactcagtgaggcaggcgtc
ttagacaagctgaaaaacaaatggtggtacgataaaggtgaatgtggacccaaggactct
ggaagcaaggacaagacgagtgccttgagcctgagcaatgtagcaggcgtcttctacatt
ctggttggcggcttgggcttggcaatgctggtggctttgatagagttctgttacaagtcc
agggcagaagcgaagagaatgaagctgaccttttctgaagccataagaaacaaagccaga
ttatccatcactgggagtgtgggagagaatggccgcgtcttgacgcctgactgcccaaag
gctgtacacactggaactgcaatcagacaaagttcaggattggctgtcattgcatcggac
ctaccataa

KEGG   Homo sapiens (human): 2894
Entry
2894              CDS       T01001                                 

Gene name
GRID1, GluD1
Definition
(RefSeq) glutamate ionotropic receptor delta type subunit 1
  KO
K05206  glutamate receptor delta-1 subunit
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2894 (GRID1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2894 (GRID1)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  Glutamate (ionotropic)
   2894 (GRID1)
SSDB
Motif
Pfam: ANF_receptor Lig_chan Lig_chan-Glu_bd SBP_bac_3 Peripla_BP_6
Other DBs
NCBI-GeneID: 2894
NCBI-ProteinID: NP_060021
OMIM: 610659
HGNC: 4575
Ensembl: ENSG00000182771
Vega: OTTHUMG00000018650
Pharos: Q9ULK0(Tbio)
UniProt: Q9ULK0 A8KAN9
LinkDB
Position
10q23.1-q23.2
AA seq 1009 aa
MEALTLWLLPWICQCVSVRADSIIHIGAIFEENAAKDDRVFQLAVSDLSLNDDILQSEKI
TYSIKVIEANNPFQAVQEACDLMTQGILALVTSTGCASANALQSLTDAMHIPHLFVQRNP
GGSPRTACHLNPSPDGEAYTLASRPPVRLNDVMLRLVTELRWQKFVMFYDSEYDIRGLQS
FLDQASRLGLDVSLQKVDKNISHVFTSLFTTMKTEELNRYRDTLRRAILLLSPQGAHSFI
NEAVETNLASKDSHWVFVNEEISDPEILDLVHSALGRMTVVRQIFPSAKDNQKCTRNNHR
ISSLLCDPQEGYLQMLQISNLYLYDSVLMLANAFHRKLEDRKWHSMASLNCIRKSTKPWN
GGRSMLDTIKKGHITGLTGVMEFREDSSNPYVQFEILGTTYSETFGKDMRKLATWDSEKG
LNGSLQERPMGSRLQGLTLKVVTVLEEPFVMVAENILGQPKRYKGFSIDVLDALAKALGF
KYEIYQAPDGRYGHQLHNTSWNGMIGELISKRADLAISAITITPERESVVDFSKRYMDYS
VGILIKKPEEKISIFSLFAPFDFAVWACIAAAIPVVGVLIFVLNRIQAVRAQSAAQPRPS
ASATLHSAIWIVYGAFVQQGGESSVNSMAMRIVMGSWWLFTLIVCSSYTANLAAFLTVSR
MDNPIRTFQDLSKQVEMSYGTVRDSAVYEYFRAKGTNPLEQDSTFAELWRTISKNGGADN
CVSSPSEGIRKAKKGNYAFLWDVAVVEYAALTDDDCSVTVIGNSISSKGYGIALQHGSPY
RDLFSQRILELQDTGDLDVLKQKWWPHMGRCDLTSHASAQADGKSLKLHSFAGVFCILAI
GLLLACLVAALELWWNSNRCHQETPKEDKEVNLEQVHRRMNSLMDEDIAHKQISPASIEL
SALEMGGLAPTQTLEPTREYQNTQLSVSTFLPEQSSHGTSRTLSSGPSSNLPLPLSSSAT
MPSMQCKHRSPNGGLFRQSPVKTPIPMSFQPVPGGVLPEALDTSHGTSI
NT seq 3030 nt   +upstreamnt  +downstreamnt
atggaagcgctgacgctgtggcttctcccctggatatgccagtgcgtgtcggtgcgggcc
gactccatcatccacatcggtgccatcttcgaggagaacgcggccaaggacgacagggtg
ttccagttggcggtatccgacctgagcctcaacgatgacatcctgcagagcgagaagatc
acctactccatcaaggtcatcgaggccaacaacccattccaggctgtgcaggaagcctgt
gacctcatgacccaggggattttggccttggtcacgtccactggctgtgcatctgccaat
gccctgcagtccctcacggatgccatgcacatcccacacctctttgtccagcgcaacccg
ggagggtcgccacgcaccgcatgccacctgaaccccagccccgatggtgaggcctacaca
ctggcttcgagaccacccgtccgcctcaatgatgtcatgctcaggctggtgacggagctg
cgctggcagaagttcgtcatgttctacgacagcgagtatgatatccgtgggcttcaaagc
tttctggaccaggcctcgcggctgggccttgacgtctctttacaaaaggtggacaagaac
attagccacgtattcaccagcctcttcaccacgatgaagacagaggagctgaatcgctac
cgggacacgcttcgccgcgccatcctgctgctcagcccacagggagcccactccttcatc
aacgaggccgtggagaccaacctggcttccaaggacagccactgggtctttgtgaatgag
gaaatcagtgacccggagatcctggatctggtccatagtgcccttggaaggatgaccgtg
gtccggcaaatctttccgtctgcaaaggacaatcagaaatgcacgaggaacaaccaccgc
atctcctccctgctctgcgacccccaggaaggctacctccagatgctgcagatctccaac
ctctatctgtatgacagtgttctgatgctggccaacgcctttcacaggaagctggaggac
cggaagtggcatagcatggcgagcctcaactgcatacggaaatccactaagccatggaat
ggtgggaggtccatgctggataccatcaaaaagggccacatcactggcctcactggggtg
atggagtttcgggaggacagttcgaatccctatgtccagtttgaaatccttggcactacc
tatagtgagacttttggcaaagacatgcgcaagttggcgacatgggactcagagaagggc
ttgaatggcagcttgcaagagaggcccatgggcagccgcctccaaggattgactcttaaa
gtggtgactgtcttggaagagcctttcgtgatggtggctgagaacatcctaggacagccc
aagcgctacaaagggttctccatagatgtcctggatgcactggccaaggctctgggcttt
aaatatgagatttaccaagcccctgatggcaggtacggtcaccagctccataacacctcc
tggaacgggatgatcggggagctcatcagcaagagagcagacttggccatctctgccatc
accatcaccccagagagggagagcgttgtggacttcagcaagcggtacatggactattca
gtggggattctaattaagaagcccgaggagaaaatcagcatcttctccctctttgctcca
tttgatttcgctgtgtgggcctgcattgcagcagccatccctgtggttggtgtgctgata
tttgtgttgaacaggatacaggctgtgagggctcagagtgctgcccagcccaggccgtca
gcttctgccactctgcacagcgccatctggattgtctatggagccttcgtacagcaaggt
ggcgaatcttccgtgaactccatggccatgcgcatcgtgatgggcagctggtggctcttc
acgctcattgtgtgctcctcctacacagccaaccttgctgccttcctcacagtgtccagg
atggacaaccccataaggactttccaggacctgtccaaacaagtggaaatgtcttatggc
actgtccgggattctgctgtatatgagtacttccgagccaagggcaccaaccccctggag
caggacagcacgtttgctgaactctggcggaccatcagcaagaacggaggggctgacaac
tgcgtgtccagtccttcagaaggcatcaggaaggcaaagaaggggaactacgccttcctg
tgggatgtggccgtggtggaatacgcagccctgacggatgacgactgctcggtgactgtc
atcggcaacagcatcagcagcaagggttacgggattgccctgcagcatggcagcccctac
agggacctcttctcccagaggatcctggagctgcaggacacaggggacctggatgtgctg
aagcagaagtggtggccgcacatgggccgctgtgacctcaccagccatgccagcgcccag
gccgacggcaaatccctcaagctgcacagcttcgccggggtcttctgcatcctggccatt
ggcctgctcctggcctgcctggtggctgccctggagttgtggtggaacagcaaccggtgc
caccaggagacccccaaggaggacaaagaagtgaacttggagcaggtccaccggcgcatg
aacagcctcatggatgaagacattgctcacaagcagatttccccagcgtcgattgagctc
tcggccctggagatggggggcctggctcccacccagaccttggagccgacacgggagtac
cagaacacccagctctcggtcagcacctttctgccagagcagagcagccatggcaccagc
cggacactctcatcagggcccagcagcaacctgccgctgccgctgagcagctcggcgacc
atgccctccatgcagtgcaaacacaggtcacccaacggggggctgttccggcagagcccg
gtgaagacccccatccccatgtccttccagcccgtgcctggaggcgtccttccagaggct
ctggacacctcccacgggacctccatctga

KEGG   Homo sapiens (human): 2895
Entry
2895              CDS       T01001                                 

Gene name
GRID2, GluD2, SCAR18
Definition
(RefSeq) glutamate ionotropic receptor delta type subunit 2
  KO
K05207  glutamate receptor delta-2 subunit
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04730  Long-term depression
Disease
H01891  Autosomal recessive spinocerebellar ataxias
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2895 (GRID2)
 09150 Organismal Systems
  09156 Nervous system
   04730 Long-term depression
    2895 (GRID2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2895 (GRID2)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  Glutamate (ionotropic)
   2895 (GRID2)
SSDB
Motif
Pfam: ANF_receptor Lig_chan Lig_chan-Glu_bd SBP_bac_3 Desmo_N RNase_H
Other DBs
NCBI-GeneID: 2895
NCBI-ProteinID: NP_001501
OMIM: 602368
HGNC: 4576
Ensembl: ENSG00000152208
Vega: OTTHUMG00000130975
Pharos: O43424(Tbio)
UniProt: O43424
LinkDB
Structure
PDB: 
5KC8 5KCA

Position
4q22.1-q22.2
AA seq 1007 aa
MEVFPFLLVLSVWWSRTWDSANADSIIHIGAIFDESAKKDDEVFRTAVGDLNQNEEILQT
EKITFSVTFVDGNNPFQAVQEACELMNQGILALVSSIGCTSAGSLQSLADAMHIPHLFIQ
RSTAGTPRSGCGLTRSNRNDDYTLSVRPPVYLHDVILRVVTEYAWQKFIIFYDSEYDIRG
IQEFLDKVSQQGMDVALQKVENNINKMITTLFDTMRIEELNRYRDTLRRAILVMNPATAK
SFITEVVETNLVAFDCHWIIINEEINDVDVQELVRRSIGRLTIIRQTFPVPQNISQRCFR
GNHRISSTLCDPKDPFAQNMEISNLYIYDTVLLLANAFHKKLEDRKWHSMASLSCIRKNS
KPWQGGRSMLETIKKGGVSGLTGELEFGENGGNPNVHFEILGTNYGEELGRGVRKLGCWN
PVTGLNGSLTDKKLENNMRGVVLRVVTVLEEPFVMVSENVLGKPKKYQGFSIDVLDALSN
YLGFNYEIYVAPDHKYGSPQEDGTWNGLVGELVFKRADIGISALTITPDRENVVDFTTRY
MDYSVGVLLRRAEKTVDMFACLAPFDLSLWACIAGTVLLVGLLVYLLNWLNPPRLQMGSM
TSTTLYNSMWFVYGSFVQQGGEVPYTTLATRMMMGAWWLFALIVISSYTANLAAFLTITR
IESSIQSLQDLSKQTEIPYGTVLDSAVYEHVRMKGLNPFERDSMYSQMWRMINRSNGSEN
NVLESQAGIQKVKYGNYAFVWDAAVLEYVAINDPDCSFYTIGNTVADRGYGIALQHGSPY
RDVFSQRILELQQNGDMDILKHKWWPKNGQCDLYSSVDTKQKGGALDIKSFAGVFCILAA
GIVLSCFIAMLETWWNKRKGSRVPSKEDDKEIDLEHLHRRVNSLCTDDDSPHKQFSTSSI
DLTPLDIDTLPTRQALEQISDFRNTHITTTTFIPEQIQTLSRTLSAKAASGFTFGNVPEH
RTGPFRHRAPNGGFFRSPIKTMSSIPYQPTPTLGLNLGNDPDRGTSI
NT seq 3024 nt   +upstreamnt  +downstreamnt
atggaagttttcccctttctcttggttttgtccgtctggtggtctcgaacctgggactcg
gcgaatgcggattcgatcattcacatcggagcaatttttgatgaatctgccaaaaaggat
gatgaggtatttcgcactgcggttggtgaccttaaccagaatgaggagatcttacagact
gagaaaatcacattttcagtgacgtttgttgatggcaacaaccctttccaagcagttcaa
gaagcctgtgaacttatgaatcaaggcatcttggccctggtcagctccattggctgcacg
tcagcaggatccctccagtctttggcagacgccatgcatatcccccacctcttcattcag
cgctcaacagctgggaccccaaggagtggctgtggactcacccggagcaacaggaatgat
gactacactctctcagttcgcccacctgtctacttgcatgatgttatcctaagagtggtc
acagagtatgcctggcagaaattcattatattctatgatagtgaatacgatatccgtgga
atacaggagttcttggacaaagtctctcagcagggaatggatgttgcacttcagaaggta
gaaaacaacatcaataaaatgattaccactctctttgacaccatgagaatagaagaactg
aatcgctatcgagacactcttaggcgagcgatccttgttatgaatcctgctacagccaaa
tccttcattactgaggttgtggagactaatttggttgcttttgactgtcactggatcatt
ataaatgaggaaataaacgatgtggacgtacaggaacttgtaagaaggtcaattggaagg
ttaacgattattcggcagacatttccagttccccagaacataagtcagcggtgtttccgt
ggcaaccatcgaatatcttcaacattgtgtgatccaaaggatccatttgctcagaatatg
gagatttccaacctttacatatatgacacggtgcttctgcttgctaatgcttttcataag
aagctggaggaccgaaagtggcacagcatggcaagtctgtcatgtatcagaaagaactca
aagccctggcagggtgggcgctccatgttggagaccatcaagaagggtggagttagtggg
ttgactggagagctagaatttggagaaaatggaggcaatcccaatgtccactttgaaatc
cttggaaccaactatggagaagagcttggcagaggtgttcgaaaacttggttgctggaat
cctgtcacaggtctgaatgggtcactgactgacaagaaattggagaataacatgcgtgga
gtggttctacgtgtagtaactgttctggaagaaccttttgtgatggtctctgaaaatgtc
ttgggtaagccgaagaaataccagggcttctccattgatgttttggatgccttatctaac
tacctgggttttaactacgaaatttacgtagcaccggatcacaaatacggaagcccacaa
gaagatgggacatggaatggcttggtaggagaacttgtctttaagagagccgacataggg
atttctgctttaaccatcactccagatcgtgaaaatgtggtggactttacgacacgttac
atggactactcagtgggggtactacttcgaagggctgaaaagacagtggatatgtttgcc
tgtcttgcaccatttgatctctctctatgggcttgcattgctggcacagtccttctggtg
ggtctactggtctacctcttgaactggcttaatcccccacgattacaaatgggatcaatg
acgtctactactctctacaactccatgtggtttgtgtatggatcttttgtacaacaaggc
ggggaagtcccgtacacgactctggctacccgaatgatgatgggggcttggtggctattt
gctttgattgttatctcatcttacacggcaaacctcgctgctttcctcactattacacgc
attgaaagttccatccagtctctccaggacctttccaagcaaacagaaatcccttatggc
acagtcctagactctgcggtatatgagcatgtccgcatgaaaggactgaatccttttgag
agggacagcatgtattcccaaatgtggcggatgatcaaccgaagcaatggatcggagaac
aatgttctggagtcccaggcaggcattcaaaaggtaaaatatggaaattatgctttcgta
tgggatgcagctgtattggaatatgtggctatcaatgacccagattgttccttttacacc
attggaaatactgttgctgatcggggatatggaattgcattacaacatggcagtccttac
cgagatgttttttcacaaaggatcctggagcttcagcagaatggtgacatggacatcctg
aagcacaaatggtggcctaagaatggccagtgtgacctgtactcgtcagtggacacaaag
cagaaaggaggcgccctggacataaagagctttgcaggggtcttttgtatcctggctgct
ggaattgtcctctcctgcttcatagccatgctggagacgtggtggaacaagaggaaaggc
tcccgggttccatcaaaagaggatgacaaggaaattgacctggagcacctccatagacgt
gtaaatagcttgtgcacagatgacgacagcccccataaacagttttccacctcgtcaatt
gatttgacccctctggacattgacactttgccaacacgacaagcactggagcaaatcagt
gatttcaggaacactcatattaccacaacaacctttatcccagagcagatccagactctt
agccgcacactgtcagctaaagctgcttctggtttcacttttggcaacgtgcctgagcac
cgaactggcccttttaggcacagggcacctaatgggggctttttcaggagtcctataaaa
acaatgtcatctattccttatcaaccaactcctaccctggggctcaatctgggtaatgat
ccagaccgaggcacctccatatga

KEGG   Homo sapiens (human): 2897
Entry
2897              CDS       T01001                                 

Gene name
GRIK1, EAA3, EEA3, GLR5, GLUR5, GluK1, gluR-5
Definition
(RefSeq) glutamate ionotropic receptor kainate type subunit 1
  KO
K05201  glutamate receptor, ionotropic kainate 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04724  Glutamatergic synapse
Drug target
Dasolampanel: D10107
Dasolampanel etibutil: D10108
Dasolampanel etibutil tosylate: D10109
Riluzole: D00775<JP/US>
Tezampanel: D06656
Topiramate: D00537<JP/US>
Troriluzole (DG03011): D11414
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2897 (GRIK1)
 09150 Organismal Systems
  09156 Nervous system
   04724 Glutamatergic synapse
    2897 (GRIK1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2897 (GRIK1)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  Glutamate (ionotropic)
   2897 (GRIK1)
SSDB
Motif
Pfam: ANF_receptor Lig_chan Lig_chan-Glu_bd SBP_bac_3 Peripla_BP_6
Other DBs
NCBI-GeneID: 2897
NCBI-ProteinID: NP_000821
OMIM: 138245
HGNC: 4579
Ensembl: ENSG00000171189
Vega: OTTHUMG00000078879
Pharos: P39086(Tclin)
UniProt: P39086
LinkDB
Structure
PDB: 

Position
21q21.3
AA seq 918 aa
MEHGTLLAQPGLWTRDTSWALLYFLCYILPQTAPQVLRIGGIFETVENEPVNVEELAFKF
AVTSINRNRTLMPNTTLTYDIQRINLFDSFEASRRACDQLALGVAALFGPSHSSSVSAVQ
SICNALEVPHIQTRWKHPSVDNKDLFYINLYPDYAAISRAILDLVLYYNWKTVTVVYEDS
TGLIRLQELIKAPSRYNIKIKIRQLPSGNKDAKPLLKEMKKGKEFYVIFDCSHETAAEIL
KQILFMGMMTEYYHYFFTTLDLFALDLELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSME
RLQAPPRPETGLLDGMMTTEAALMYDAVYMVAIASHRASQLTVSSLQCHRHKPWRLGPRF
MNLIKEARWDGLTGHITFNKTNGLRKDFDLDIISLKEEGTEKAAGEVSKHLYKVWKKIGI
WNSNSGLNMTDSNKDKSSNITDSLANRTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCL
DLLKELSNILGFIYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREK
VIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFT
PYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTL
IIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKM
WAFMSSRQQTALVRNSDEGIQRVLTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYG
VGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEDNKEASALGVENIGGIFI
VLAAGLVLSVFVAIGEFIYKSRKNNDIEQAFCFFYGLQCKQTHPTNSTSGTTLSTDLECG
KLIREERGIRKQSSVHTV
NT seq 2757 nt   +upstreamnt  +downstreamnt
atggagcacggcacactcctcgcccagcccgggctctggaccagggacaccagctgggca
ctcctctatttcctctgctatatcctccctcagaccgccccgcaagtactcaggatcgga
gggatttttgaaacagtggaaaatgagcctgttaatgttgaagaattagctttcaagttt
gcagtcaccagcattaacagaaaccgaaccctgatgcctaacaccacattaacctatgac
atccagagaattaacctttttgatagttttgaagcctcgcggagagcatgtgaccagctg
gctcttggtgtggctgctctctttggcccttcccatagctcctccgtcagtgctgtgcag
tctatttgcaatgctctcgaagttccacacatacagacccgctggaaacacccctcggtg
gacaacaaagatttgttttacatcaacctttacccagattatgcagctatcagcagggcg
atcctggatctggtcctctattacaactggaaaacagtgacagtggtgtatgaagacagc
acaggtctaattcgtctacaagagctcatcaaagctccctccagatataatattaaaatc
aaaatccgccagctgccctctgggaataaagatgccaagcctttactcaaggagatgaag
aaaggcaaggagttctatgtgatatttgattgttcacatgaaacagccgctgaaatcctt
aagcagattctgttcatgggcatgatgaccgagtactatcactactttttcacaaccctg
gacttatttgctttggatctggaactctataggtacagtggcgtaaacatgaccgggttt
cggctgcttaacattgacaaccctcacgtgtcatccatcattgagaagtggtccatggag
agactgcaggccccacccaggcccgagactggccttttggatggcatgatgacaactgaa
gcggctctgatgtacgatgctgtgtacatggtggccattgcctcgcaccgggcatcccag
ctgaccgtcagctccctgcagtgccatagacataagccatggcgcctcggacccagattt
atgaacctgatcaaagaggcccggtgggatggcttgactgggcatatcacctttaataaa
accaatggcttgaggaaggattttgatctggacattattagtctcaaagaggaaggaact
gaaaaggctgctggcgaagtgtctaaacacttgtataaagtgtggaagaagattgggatt
tggaattccaacagtgggcttaacatgacggacagcaacaaagacaagtccagcaatatc
actgattcattggccaacagaacactcattgtcaccaccattctggaagaaccctatgtt
atgtacaggaaatctgataagcctctatatggaaatgacagatttgaaggatattgccta
gacctgttgaaagaattgtcaaacatcctgggtttcatttatgatgttaaactagttccc
gatggcaaatatggggcccagaatgacaaaggggagtggaacgggatggttaaagaactc
atagatcacagggctgacctggcagtggctcctcttaccatcacctacgtgcgggagaaa
gtcattgacttctccaaacccttcatgaccctaggcatcagcattctctaccggaagccc
aatggtaccaatccaggcgttttctccttcctcaaccccctgtctccagatatttggatg
tatgtgctcttagcctgcttgggagtcagctgtgtactctttgtgattgcaaggtttaca
ccctacgagtggtataacccccacccatgcaaccctgactcagacgtggtggaaaacaat
tttactttactaaatagtttctggtttggagttggagctctcatgcagcaaggatcagag
ctgatgcccaaagctctatcgaccagaatagttggagggatatggtggtttttcacccta
atcatcatttcatcctacacggccaatctggctgccttcttgacagtagagagaatggaa
tcccccatagattcggcagatgatctggcaaagcaaaccaagatagaatatggggcggtt
agagatggatcaacaatgaccttcttcaagaaatcaaaaatctccacctatgagaagatg
tgggctttcatgagcagcaggcagcagaccgccctggtaagaaacagtgatgaggggatc
cagagagtgctcaccacagactacgcgctgctgatggagtccaccagcattgagtatgtg
acgcagagaaactgcaacctcactcagatcgggggcctcattgactccaaaggttacgga
gtgggaacacctattggttctccttaccgggataaaattactattgctattcttcaactc
caagaagaagggaagctgcatatgatgaaagagaagtggtggcgtgggaatggctgcccc
gaggaagacaacaaagaagccagtgccctgggagtggaaaatattggaggcatcttcatt
gttctggctgccggactggtcctttctgtatttgtagctattggagaattcatatacaaa
tcacggaagaataatgatattgaacaggctttttgtttcttttatggactgcaatgtaag
caaacccatccaaccaactccacttctggaactactttatctacggatttagaatgtggt
aaattaattcgagaggagagagggattcgaaaacagtcctcagttcatactgtgtaa

KEGG   Homo sapiens (human): 2898
Entry
2898              CDS       T01001                                 

Gene name
GRIK2, EAA4, GLR6, GLUK6, GLUR6, GluK2, MRT6
Definition
(RefSeq) glutamate ionotropic receptor kainate type subunit 2
  KO
K05202  glutamate receptor, ionotropic kainate 2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04724  Glutamatergic synapse
Disease
H00768  Autosomal recessive mental retardation
Drug target
Dasolampanel: D10107
Dasolampanel etibutil: D10108
Dasolampanel etibutil tosylate: D10109
Riluzole: D00775<JP/US>
Tezampanel: D06656
Topiramate: D00537<JP/US>
Troriluzole (DG03011): D11414
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2898 (GRIK2)
 09150 Organismal Systems
  09156 Nervous system
   04724 Glutamatergic synapse
    2898 (GRIK2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2898 (GRIK2)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  Glutamate (ionotropic)
   2898 (GRIK2)
SSDB
Motif
Pfam: ANF_receptor Lig_chan Lig_chan-Glu_bd SBP_bac_3 Peripla_BP_6
Other DBs
NCBI-GeneID: 2898
NCBI-ProteinID: NP_068775
OMIM: 138244
HGNC: 4580
Ensembl: ENSG00000164418
Vega: OTTHUMG00000016328
Pharos: Q13002(Tclin)
UniProt: Q13002 A8K0H7 Q8IY40
LinkDB
Structure
PDB: 
3QXM

Position
6q16.3
AA seq 908 aa
MKIIFPILSNPVFRRTVKLLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFA
VNTINRNRTLLPNTTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQS
ICNALGVPHIQTRWKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDST
GLIRLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILK
QALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMER
LQAPPKPDSGLLDGFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKPWRFGTRFM
SLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGK
PANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEI
RLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISI
LYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSD
VVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLT
VERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKS
NEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITI
AILQLQEEGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVG
EFLYKSKKNAQLEKRSFCSAMVEELRMSLKCQRRLKHKPQAPVIVKTEEVINMHTFNDRR
LPGKETMA
NT seq 2727 nt   +upstreamnt  +downstreamnt
atgaagattattttcccgattctaagtaatccagtcttcaggcgcaccgttaaactcctg
ctctgtttactgtggattggatattctcaaggaaccacacatgtattaagatttggtggt
atttttgaatatgtggaatctggcccaatgggagctgaggaacttgcattcagatttgct
gtgaacacaattaacagaaacagaacattgctacccaatactacccttacctatgatacc
cagaagataaacctttatgatagttttgaagcatccaagaaagcctgtgatcagctgtct
cttggggtggctgccatcttcgggccttcacacagctcatcagcaaacgcagtgcagtcc
atctgcaatgctctgggagttccccacatacagacccgctggaagcaccaggtgtcagac
aacaaagattccttctatgtcagtctctacccagacttctcttcactcagccgtgccatt
ttagacctggtgcagtttttcaagtggaaaaccgtcacggttgtgtatgatgacagcact
ggtctcattcgtttgcaagagctcatcaaagctccatcaaggtataatcttcgactcaaa
attcgtcagttacctgctgatacaaaggatgcaaaacccttactaaaagaaatgaaaaga
ggcaaggagtttcatgtaatctttgattgtagccatgaaatggcagcaggcattttaaaa
caggcattagctatgggaatgatgacagaatactatcattatatctttaccactctggac
ctctttgctcttgatgttgagccctaccgatacagtggtgttaacatgacagggttcaga
atattaaatacagaaaatacccaagtctcctccatcattgaaaagtggtcgatggaacga
ttgcaggcacctccgaaacccgattcaggtttgctggatggatttatgacgactgatgct
gctctaatgtatgatgctgtgcatgtggtgtctgtggccgttcaacagtttccccagatg
acagtcagttccttgcagtgtaatcgacataaaccctggcgcttcgggacccgctttatg
agtctaattaaagaggcacattgggaaggcctcacaggcagaataactttcaacaaaacc
aatggcttgagaacagattttgatttggatgtgatcagtctgaaggaagaaggtctagaa
aagattggaacgtgggatccagccagtggcctgaatatgacagaaagtcaaaagggaaag
ccagcgaacatcacagattccttatccaatcgttctttgattgttaccaccattttggaa
gagccttatgtcctttttaagaagtctgacaaacctctctatggtaatgatcgatttgaa
ggctattgcattgatctcctcagagagttatctacaatccttggctttacatatgaaatt
agacttgtggaagatgggaaatatggagcccaggatgatgccaatggacaatggaatgga
atggttcgtgaactaattgatcataaagctgaccttgcagttgctccactggctattacc
tatgttcgagagaaggtcatcgacttttccaagccctttatgacacttggaataagtatt
ttgtaccgcaagcccaatggtacaaacccaggcgtcttctccttcctgaatcctctctcc
cctgatatctggatgtatattctgctggcttacttgggtgtcagttgtgtgctctttgtc
atagccaggtttagtccttatgagtggtataatccacacccttgcaaccctgactcagac
gtggtggaaaacaattttaccttgctaaatagtttctggtttggagttggagctctcatg
cagcaaggttctgagctcatgcccaaagcactgtccaccaggatagtgggaggcatttgg
tggtttttcacacttatcatcatttcttcgtatactgctaacttagccgcctttctgaca
gtggaacgcatggaatcccctattgactctgctgatgatttagctaaacaaaccaagata
gaatatggagcagtagaggatggtgcaaccatgacttttttcaagaaatcaaaaatctcc
acgtatgacaaaatgtgggcctttatgagtagcagaaggcagtcagtgctggtcaaaagt
aatgaagaaggaatccagcgagtcctcacctctgattatgctttcctaatggagtcaaca
accatcgagtttgttacccagcggaactgtaacctgacacagattggcggccttatagac
tctaaaggttatggcgttggcactcccatgggttctccatatcgagacaaaattaccata
gcaattcttcagctgcaagaggaaggcaaactgcatatgatgaaggagaaatggtggagg
ggcaatggttgcccagaagaggagagcaaagaggccagtgccctgggggttcagaatatt
ggtggcatcttcattgttctggcagccggcttggtgctttcagtttttgtggcagtggga
gaatttttatacaaatccaaaaaaaacgctcaattggaaaagaggtccttctgtagtgcc
atggtagaagaattgaggatgtccctgaagtgccagcgtcggttaaaacataagccacag
gccccagttattgtgaaaacagaagaagttatcaacatgcacacatttaacgacagaagg
ttgccaggtaaagaaaccatggcataa

KEGG   Homo sapiens (human): 2899
Entry
2899              CDS       T01001                                 

Gene name
GRIK3, EAA5, GLR7, GLUR7, GluK3, GluR7a
Definition
(RefSeq) glutamate ionotropic receptor kainate type subunit 3
  KO
K05203  glutamate receptor, ionotropic kainate 3
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04724  Glutamatergic synapse
Drug target
Dasolampanel: D10107
Dasolampanel etibutil: D10108
Dasolampanel etibutil tosylate: D10109
Riluzole: D00775<JP/US>
Tezampanel: D06656
Topiramate: D00537<JP/US>
Troriluzole (DG03011): D11414
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2899 (GRIK3)
 09150 Organismal Systems
  09156 Nervous system
   04724 Glutamatergic synapse
    2899 (GRIK3)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2899 (GRIK3)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  Glutamate (ionotropic)
   2899 (GRIK3)
SSDB
Motif
Pfam: ANF_receptor Lig_chan Lig_chan-Glu_bd SBP_bac_3 Peripla_BP_6
Other DBs
NCBI-GeneID: 2899
NCBI-ProteinID: NP_000822
OMIM: 138243
HGNC: 4581
Ensembl: ENSG00000163873
Vega: OTTHUMG00000004189
Pharos: Q13003(Tclin)
UniProt: Q13003
LinkDB
Position
1p34.3
AA seq 919 aa
MTAPWRRLRSLVWEYWAGLLVCAFWIPDSRGMPHVIRIGGIFEYADGPNAQVMNAEEHAF
RFSANIINRNRTLLPNTTLTYDIQRIHFHDSFEATKKACDQLALGVVAIFGPSQGSCTNA
VQSICNALEVPHIQLRWKHHPLDNKDTFYVNLYPDYASLSHAILDLVQYLKWRSATVVYD
DSTGLIRLQELIMAPSRYNIRLKIRQLPIDSDDSRPLLKEMKRGREFRIIFDCSHTMAAQ
ILKQAMAMGMMTEYYHFIFTTLDLYALDLEPYRYSGVNLTGFRILNVDNPHVSAIVEKWS
MERLQAAPRSESGLLDGVMMTDAALLYDAVHIVSVCYQRAPQMTVNSLQCHRHKAWRFGG
RFMNFIKEAQWEGLTGRIVFNKTSGLRTDFDLDIISLKEDGLEKVGVWSPADGLNITEVA
KGRGPNVTDSLTNRSLIVTTVLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFS
YEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGV
SILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPG
SEVVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAF
LTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVK
NNEEGIQRALTADYALLMESTTIEYVTQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKIT
IAILQLQEEDKLHIMKEKWWRGSGCPEEENKEASALGIQKIGGIFIVLAAGLVLSVLVAV
GEFVYKLRKTAEREQRSFCSTVADEIRFSLTCQRRVKHKPQPPMMVKTDAVINMHTFNDR
RLPGKDSMACSTSLAPVFP
NT seq 2760 nt   +upstreamnt  +downstreamnt
atgaccgctccctggcggcgcctccggagtctggtttgggaatactgggccgggctcctc
gtgtgcgccttctggatcccggactcgcgcgggatgccccacgtcatccggatcggagga
atcttcgagtatgcggacggccccaacgcccaggtcatgaatgccgaggagcatgccttt
cgattttctgccaacatcatcaacaggaacaggactctgctgcccaacacaaccttgacc
tatgacatacagaggattcacttccatgacagcttcgaggcgaccaaaaaggcctgtgac
cagctggcactgggcgtggtggcgatcttcggcccatcacagggctcctgcaccaatgcc
gtccagtccatctgcaatgccctggaggtgccccacatccagctgcgttggaagcaccac
ccgctggacaacaaggacaccttctacgtgaacctctaccccgactacgcctcgctcagc
catgccatcctcgacctggtccagtacctcaagtggcggtcagccaccgtggtctatgac
gacagtacagggctcatccgactgcaggagctcatcatggccccatcaagatacaacatc
cgcctgaagatccgtcagctccccatcgactctgacgactcgcgccccttgctcaaggag
atgaagcgaggccgggaattccgcattatcttcgactgcagccacactatggcggcccag
atcctcaagcaggccatggccatgggcatgatgactgagtactaccacttcatcttcacc
actctggatctctacgctttagacctggagccctaccgctactcaggcgtgaacctgaca
ggattccggattctcaatgtggacaacccacacgtctcggccattgtggagaagtggtcc
atggagcggctgcaggcagctccccggtccgagtctggcctgctggatggagtgatgatg
actgatgcagccttactgtacgacgccgtccatatcgtgtccgtgtgctaccagcgggca
ccacagatgaccgtgaactccctgcagtgccatcggcacaaggcctggcgctttggcggc
cgcttcatgaacttcatcaaggaggctcaatgggaaggattaactggacgaattgttttc
aacaaaactagtggcttgcggacggattttgatctggacatcatcagcctgaaagaggat
ggcctggagaaggttggggtgtggagtcctgccgacgggctcaacatcactgaggttgcc
aaaggccgaggccctaatgtcaccgactctctgacaaacagatcactcattgtcaccaca
gtgctggaggagcccttcgtcatgtttcggaaatcagacaggacgctatacgggaatgac
cggttcgagggctactgcatcgacctgctaaaggagctggcccacatccttggtttctcc
tatgagatccggctggtggaggacggcaagtacggggcacaggatgacaagggccagtgg
aacggcatggtcaaggagctcatcgaccacaaggcagatctggccgtggcccccctgacc
atcacccatgttcgagagaaggccatcgacttctccaagcccttcatgacacttggtgtg
agcatcctgtatcgaaagcccaatggcaccaaccccagcgtcttctccttcctcaatccc
ctgtccccagacatctggatgtatgttctcctcgcctacctgggggtcagctgtgtcctc
ttcgtcatcgccaggttcagcccttatgagtggtacgatgctcacccctgcaaccctggc
tccgaggtggtggaaaataacttcactctgcttaacagcttctggtttggaatgggatcc
ctgatgcagcaagggtctgagctgatgcccaaagccctgtccacacgcatcattggtggc
atctggtggttcttcacgctcatcatcatctcttcctacacggccaacctggctgccttt
ctgaccgtggagcgcatggaatcacccattgactctgctgatgacctggccaagcaaacc
aaaatcgagtatggggctgtcaaggatggggccaccatgaccttcttcaagaaatccaag
atctccaccttcgagaagatgtgggccttcatgagcagcaagccatcggcgctggtgaag
aacaacgaggagggcatccagagggccctgacggccgactacgcgctgctcatggagtcc
accaccatcgagtacgtcacgcagaggaactgcaacctcacccagatcgggggcctcatt
gactccaagggctacggcatcggcacgcccatgggctccccataccgggacaagatcacc
atcgccatcctgcagcttcaggaggaggacaagctgcatatcatgaaggagaagtggtgg
cggggcagcgggtgtcctgaggaggaaaacaaagaggccagtgccctggggatccagaag
atcgggggcatcttcattgtcctggccgccgggctggtcctctctgtgctggtggccgtg
ggcgagtttgtgtacaagctccgcaaaacagcagagagagagcagcgttccttctgcagc
accgtggccgatgagatccgtttctcccttacctgccagcgtcgagtcaagcacaagcct
cagcctcccatgatggtcaagactgacgccgtcatcaacatgcacacattcaatgaccgc
cggcttcccggcaaggacagcatggcctgcagcacatccttagcccctgtgttcccctag

KEGG   Homo sapiens (human): 2900
Entry
2900              CDS       T01001                                 

Gene name
GRIK4, EAA1, GRIK, GluK4, KA1
Definition
(RefSeq) glutamate ionotropic receptor kainate type subunit 4
  KO
K05204  glutamate receptor, ionotropic kainate 4
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04724  Glutamatergic synapse
Drug target
Dasolampanel: D10107
Dasolampanel etibutil: D10108
Dasolampanel etibutil tosylate: D10109
Riluzole: D00775<JP/US>
Tezampanel: D06656
Topiramate: D00537<JP/US>
Troriluzole (DG03011): D11414
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2900 (GRIK4)
 09150 Organismal Systems
  09156 Nervous system
   04724 Glutamatergic synapse
    2900 (GRIK4)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2900 (GRIK4)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  Glutamate (ionotropic)
   2900 (GRIK4)
SSDB
Motif
Pfam: ANF_receptor Lig_chan Lig_chan-Glu_bd SBP_bac_3
Other DBs
NCBI-GeneID: 2900
NCBI-ProteinID: NP_001269399
OMIM: 600282
HGNC: 4582
Ensembl: ENSG00000149403
Vega: OTTHUMG00000048255
Pharos: Q16099(Tclin)
UniProt: Q16099 B2RAP6
LinkDB
Position
11q23.3
AA seq 956 aa
MPRVSAPLVLLPAWLVMVACSPHSLRIAAILDDPMECSRGERLSITLAKNRINRAPERLG
KAKVEVDIFELLRDSEYETAETMCQILPKGVVAVLGPSSSPASSSIISNICGEKEVPHFK
VAPEEFVKFQFQRFTTLNLHPSNTDISVAVAGILNFFNCTTACLICAKAECLLNLEKLLR
QFLISKDTLSVRMLDDTRDPTPLLKEIRDDKTATIIIHANASMSHTILLKAAELGMVSAY
YTYIFTNLEFSLQRMDSLVDDRVNILGFSIFNQSHAFFQEFAQSLNQSWQENCDHVPFTG
PALSSALLFDAVYAVVTAVQELNRSQEIGVKPLSCGSAQIWQHGTSLMNYLRMVELEGLT
GHIEFNSKGQRSNYALKILQFTRNGFRQIGQWHVAEGLSMDSHLYASNISDTLFNTTLVV
TTILENPYLMLKGNHQEMEGNDRYEGFCVDMLKELAEILRFNYKIRLVGDGVYGVPEANG
TWTGMVGELIARKADLAVAGLTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFL
DPFSPGVWLFMLLAYLAVSCVLFLVARLTPYEWYSPHPCAQGRCNLLVNQYSLGNSLWFP
VGGFMQQGSTIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMDVPIESVDDLA
DQTAIEYGTIHGGSSMTFFQNSRYQTYQRMWNYMYSKQPSVFVKSTEEGIARVLNSNYAF
LLESTMNEYYRQRNCNLTQIGGLLDTKGYGIGMPVGSVFRDEFDLAILQLQENNRLEILK
RKWWEGGKCPKEEDHRAKGLGMENIGGIFVVLICGLIVAIFMAMLEFLWTLRHSEATEVS
VCQEMVTELRSIILCQDSIHPRRRRAAVPPPRPPIPEERRPRGTATLSNGKLCGAGEPDQ
LAQRLAQEAALVARGCTHIRVCPECRRFQGLRARPSPARSEESLEWEKTTNSSEPE
NT seq 2871 nt   +upstreamnt  +downstreamnt
atgccccgcgtctcggcgcctttggtgctgcttcctgcgtggctcgtgatggtcgcctgc
agcccgcactccttgaggatcgctgctatcttggacgaccccatggagtgcagcagaggg
gagcggctctccatcaccctggccaagaaccgcatcaaccgcgctcctgagaggctgggc
aaggccaaggtcgaagtggacatctttgagcttctcagagacagcgagtacgagactgca
gaaaccatgtgtcagatcctccccaagggggtggtcgctgtcctcggaccatcgtccagc
ccagcctccagctccatcatcagcaacatctgtggagagaaggaggtccctcacttcaaa
gtggccccagaggagttcgtcaagttccagttccagagattcacaaccctgaacctccac
cccagcaacactgacatcagcgtggctgtagctgggatcctgaacttcttcaactgcacc
accgcctgcctcatctgtgccaaagcagaatgccttttaaacctagagaagctgctccgg
caattccttatctccaaggacacgctgtccgtccgcatgctggatgacacccgggacccc
accccgctcctcaaggagatccgggacgacaagaccgccaccatcatcatccacgccaac
gcctccatgtcccacaccatcctcctgaaggcagccgaacttgggatggtgtcagcctat
tacacatacatcttcactaatctggagttctcactccagagaatggacagccttgtggat
gatcgtgtcaacatcctgggattttccattttcaaccaatcccatgctttcttccaagag
tttgcccagagcctcaaccagtcctggcaggagaactgtgaccatgtgcccttcactggg
cctgcgctctcctcggccctgctgtttgatgctgtctatgctgtggtgactgcggtgcag
gaactgaaccggagccaagagatcggcgtgaagcccttgtcctgcggctcggcccagatc
tggcagcacggcaccagcctcatgaactacctgcgcatggtagaattggaaggtcttacc
ggccacattgaattcaacagcaaaggccagaggtccaactacgctttgaaaatcttacag
ttcacaaggaatggttttcggcagatcggccagtggcacgtggcagagggcctcagcatg
gacagccacctctatgcctccaacatctcggacactctcttcaacaccaccctggtcgtc
accaccatcctggagaacccatatttaatgctgaaggggaaccaccaggagatggaaggc
aatgaccgctacgagggcttctgtgtggacatgctcaaggagctggcagagatcctccga
ttcaactacaagatccgcctggttggggatggcgtgtacggcgttcccgaggccaacggc
acctggacgggaatggtcggggagctgatcgctaggaaagcagatctggctgtggcaggc
ctcaccattacagctgaacgggagaaggtgattgatttctctaagccattcatgactctg
ggaattagcattctttaccgcgttcatatgggacgcaaacccggctatttctccttcctg
gacccattttctccgggcgtctggctcttcatgcttctagcctatctggccgtcagctgt
gtcctcttcctggtggctcggttgacgccctacgagtggtacagcccacacccatgtgcc
cagggccggtgcaacctcctggtgaaccagtactccctgggcaacagcctctggtttccg
gtcggggggttcatgcagcaaggctccaccatcgcccctcgcgccttatccacccgctgt
gtcagtggcgtctggtgggcattcacgctgatcatcatctcatcctacacggccaacctg
gcagccttcctgaccgtgcagcgcatggatgtgcccattgagtcagtggatgacctggct
gaccagaccgccattgaatatggcacaattcacggaggctccagcatgaccttcttccaa
aattcccgctaccagacctaccaacgcatgtggaattacatgtattccaagcagcccagc
gtgttcgtgaagagcacagaggagggaatcgccagggtgttgaattccaactacgccttc
ctcctggaatccaccatgaacgagtactatcggcagcgaaactgcaacctcactcagatt
gggggcctgctggacaccaagggctatgggattggcatgccagtcggctcggttttccgg
gacgagtttgatctggccattctccagctgcaggagaacaaccgcctggagatcctgaag
cgcaaatggtgggaaggagggaagtgccccaaggaggaagatcacagagctaaaggcctg
ggaatggagaatattggtggaatctttgtggttcttatttgtggcttaatcgtggccatt
tttatggctatgttggagtttttatggactctcagacactcagaagcaactgaggtgtcc
gtctgccaggagatggtgaccgagctgcgcagcattatcctgtgtcaggacagtatccac
ccccgccggcggcgcgccgcagtcccgccgccccggccccccatccccgaggagcgccga
ccgcggggcacggcgacgctcagcaacgggaagctgtgcggggcaggggagcccgaccag
ctcgcgcagagactggcgcaggaggccgccctggtggcccgcggctgcacgcacatccgc
gtctgccccgagtgccgccgcttccagggcctgcgggcacggccgtcgcccgcccgcagc
gaggagagcctggagtgggagaaaaccaccaacagcagcgagcccgagtag

KEGG   Homo sapiens (human): 2901
Entry
2901              CDS       T01001                                 

Gene name
GRIK5, EAA2, GRIK2, GluK5, KA2
Definition
(RefSeq) glutamate ionotropic receptor kainate type subunit 5
  KO
K05205  glutamate receptor, ionotropic kainate 5
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04724  Glutamatergic synapse
Drug target
Dasolampanel: D10107
Dasolampanel etibutil: D10108
Dasolampanel etibutil tosylate: D10109
Riluzole: D00775<JP/US>
Tezampanel: D06656
Topiramate: D00537<JP/US>
Troriluzole (DG03011): D11414
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2901 (GRIK5)
 09150 Organismal Systems
  09156 Nervous system
   04724 Glutamatergic synapse
    2901 (GRIK5)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2901 (GRIK5)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  Glutamate (ionotropic)
   2901 (GRIK5)
SSDB
Motif
Pfam: ANF_receptor Lig_chan Lig_chan-Glu_bd SBP_bac_3 Peripla_BP_6
Other DBs
NCBI-GeneID: 2901
NCBI-ProteinID: NP_002079
OMIM: 600283
HGNC: 4583
Ensembl: ENSG00000105737
Vega: OTTHUMG00000044573
Pharos: Q16478(Tclin)
UniProt: Q16478
LinkDB
Position
19q13.2
AA seq 980 aa
MPAELLLLLIVAFASPSCQVLSSLRMAAILDDQTVCGRGERLALALAREQINGIIEVPAK
ARVEVDIFELQRDSQYETTDTMCQILPKGVVSVLGPSSSPASASTVSHICGEKEIPHIKV
GPEETPRLQYLRFASVSLYPSNEDVSLAVSRILKSFNYPSASLICAKAECLLRLEELVRG
FLISKETLSVRMLDDSRDPTPLLKEIRDDKVSTIIIDANASISHLILRKASELGMTSAFY
KYILTTMDFPILHLDGIVEDSSNILGFSMFNTSHPFYPEFVRSLNMSWRENCEASTYLGP
ALSAALMFDAVHVVVSAVRELNRSQEIGVKPLACTSANIWPHGTSLMNYLRMVEYDGLTG
RVEFNSKGQRTNYTLRILEKSRQGHREIGVWYSNRTLAMNATTLDINLSQTLANKTLVVT
TILENPYVMRRPNFQALSGNERFEGFCVDMLRELAELLRFRYRLRLVEDGLYGAPEPNGS
WTGMVGELINRKADLAVAAFTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLD
PFSPAVWLFMLLAYLAVSCVLFLAARLSPYEWYNPHPCLRARPHILENQYTLGNSLWFPV
GGFMQQGSEIMPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLAD
QTNIEYGTIHAGSTMTFFQNSRYQTYQRMWNYMQSKQPSVFVKSTEEGIARVLNSRYAFL
LESTMNEYHRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILKR
KWWEGGRCPKEEDHRAKGLGMENIGGIFIVLICGLIIAVFVAVMEFIWSTRRSAESEEVS
VCQEMLQELRHAVSCRKTSRSRRRRRPGGPSRALLSLRAVREMRLSNGKLYSAGAGGDAG
SAHGGPQRLLDDPGPPSGARPAAPTPCTHVRVCQECRRIQALRASGAGAPPRGLGVPAEA
TSPPRPRPGPAGPRELAEHE
NT seq 2943 nt   +upstreamnt  +downstreamnt
atgccggctgagctgctgctgctgctgattgttgccttcgccagccccagctgccaggtg
ctctcatcactgcgcatggctgcaatcctggatgatcagacagtgtgtggccgcggtgag
cgtctggccttggccttggcccgggagcagatcaacgggatcatcgaggtcccagccaag
gcccgagtggaagtagacatctttgagctgcagcgggacagccagtacgagaccacggac
accatgtgtcagatcttacccaaaggggttgtgtctgtccttgggccctcctctagccca
gcatctgcctccaccgtgagccatatctgtggagagaaggagatcccccacatcaaggtg
ggtcccgaggagacaccccgccttcagtaccttcgcttcgcgtctgtcagcctgtacccc
agtaacgaggacgtcagcttggcggtctcccgaatcctcaagtccttcaactacccctcg
gccagcctcatctgcgccaaggctgagtgcctgctgcgattggaggaactggtgcgtggc
ttcctcatctccaaggagacgctgtcagtgaggatgttggacgacagccgggaccccaca
ccactgctcaaggagatccgtgatgacaaggtgtccaccatcatcatcgacgccaacgcc
tccatctcccacctcatcctccgtaaggcctcggaactgggaatgacctcagcgttttac
aagtacatcctcaccaccatggacttccccatcctgcatctggacggtattgtggaggac
tcctccaacatcctgggcttctccatgttcaacacgtcccaccccttctaccctgagttt
gtccgcagcctcaacatgtcctggagggagaactgtgaagccagcacctacctgggccct
gcgctgtcagccgccctgatgtttgacgccgtgcacgtggtggtgagcgctgtccgagag
ctgaaccgcagccaggagatcggtgtgaagcctctggcctgtacatcggccaacatttgg
ccccacgggaccagcctcatgaactacctgcgcatggtagagtatgatgggctgaccggg
cgggtcgagttcaacagcaaagggcagagaaccaactacaccctgcgcatcctagaaaag
tcccggcagggccaccgtgagattggggtgtggtactctaaccgcaccctggccatgaat
gccaccaccctggacatcaacctgtcgcagacactggccaacaagaccctggtggtcaca
accatcctggagaacccatacgtcatgcgccggcccaacttccaggccctgtcggggaac
gaacgcttcgagggcttctgcgtggacatgctgcgggagctggccgagctgctgcgcttc
cgctaccgcctgcggttggtggaggatgggctgtacggggcgcccgagcccaacggctcc
tggacgggcatggttggcgagctcatcaaccggaaggcagacctggctgtggccgccttc
accatcacagctgagcgggagaaggtcatcgacttttccaagccctttatgaccctgggg
atcagcatcctctaccgagtgcacatgggccgcaagcctggctacttctccttcctggac
cccttctcccctgctgtgtggctcttcatgcttcttgcctacctggctgtcagctgcgtc
ctgtttctggctgccaggctgagcccctatgagtggtataacccacacccatgcctgcgg
gcacgcccccacatcctggagaaccagtacacgctgggcaacagcctgtggtttcccgtg
gggggcttcatgcagcagggctcggagatcatgccccgggcgctgtccacgcgctgtgtc
agcggagtctggtgggccttcaccttgatcatcatctcctcctacacggccaacctggcc
gccttcctcaccgtgcagcgcatggaggtgcctgtggagtcggccgatgacctggcagat
cagaccaacatcgagtatggcaccatccacgccggctccaccatgaccttcttccagaat
tcacggtaccaaacgtaccagcgcatgtggaactacatgcagtcgaagcagcccagcgtg
ttcgtcaagagcacagaagagggcattgcccgcgtcctcaactcccgctacgccttcctg
ctcgagtccaccatgaacgaataccaccggcgcctcaactgcaacctcacccagatcggg
ggactcctcgacaccaagggctacggcattggcatgccgctgggctccccgttccgggat
gagatcacactggccatcctgcagcttcaggagaacaaccggctggagatcctgaagcgc
aagtggtgggaggggggccggtgccccaaggaggaggaccatcgagctaaaggtttgggc
atggagaacattggtggcatttttatcgtgctcatctgtggcctcatcattgctgtcttc
gtggcggtcatggaattcatatggtccacacggaggtcagctgagtccgaggaggtgtcg
gtgtgccaggagatgctgcaggagctgcgccacgccgtttcttgccgcaagacgtcgcgt
tcccgccggcgccgacgcccgggcggcccgagccgggccctgctgtcactgcgcgcggtc
cgcgagatgcgcctcagcaacggcaagctctactcggccggcgcgggcggggatgcgggc
agcgcgcacgggggcccgcagcgcctcctggacgacccggggccccccagcggagcccga
cccgccgcccccaccccctgcacccacgtgcgcgtctgccaggagtgccggcgcatccag
gcgctgcgggcctcgggggccggcgcgcctccgcgtggcctgggcgtccccgccgaagcc
accagcccgccccggccgcggcctggccccgccggcccccgggagctggcggagcacgag
tga

KEGG   Homo sapiens (human): 2902
Entry
2902              CDS       T01001                                 

Gene name
GRIN1, GluN1, MRD8, NDHMSD, NDHMSR, NMD-R1, NMDA1, NMDAR1, NR1
Definition
(RefSeq) glutamate ionotropic receptor NMDA type subunit 1
  KO
K05208  glutamate receptor ionotropic, NMDA 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04014  Ras signaling pathway
hsa04015  Rap1 signaling pathway
hsa04020  Calcium signaling pathway
hsa04024  cAMP signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04713  Circadian entrainment
hsa04720  Long-term potentiation
hsa04724  Glutamatergic synapse
hsa05010  Alzheimer disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05017  Spinocerebellar ataxia
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05030  Cocaine addiction
hsa05031  Amphetamine addiction
hsa05033  Nicotine addiction
hsa05034  Alcoholism
Network
nt06410  Calcium signaling
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06462  Spinocerebellar ataxia
nt06465  Prion disease
  Element
N00970  Transport of calcium
N00971  Mutation-caused aberrant PDYN to transport of calcium
N00987  Mutation-caused aberrant Htt to transport of calcium
N01003  Mutation-caused aberrant Abeta to transport of calcium
N01200  Scrapie conformation PrPSc to transport of calcium
Disease
H00773  Autosomal dominant mental retardation
Drug target
Acamprosate (DG00996): D02780<JP/US> D07058
Amantadine (DG00860): D00777<JP/US> D07441
Apimostinel: D11299
Aptiganel hydrochloride: D02973
Budipine (DG00866): D07306 D07589
Delucemine hydrochloride: D03679
Dextromethorphan (DG01078): D00848<JP> D03742 D03744
Dextrorphan hydrochloride: D03746
Dizocilpine maleate: D03878
Esketamine (DG01829): D07283 D10627<US>
Felbamate: D00536<US>
Gavestinel: D04308
Ketamine (DG00796): D00711<JP/US> D08098
Latrepirdine (DG01379): D09917 D09918
Levomethadone (DG01002): D08121 D08122
Licostinel: D04728
Memantine (DG00986): D04905<JP/US> D08174
Methadone (DG00999): D02102<JP/US> D08195
Orphenadrine (DG01252): D08305
Orphenadrine (chloride): D02599
Orphenadrine (citrate): D00774<US>
Perzinfotel: D05447
Phencyclidine hydrochloride: D05453
Remacemide hydrochloride: D05714
Riluzole: D00775<JP/US>
Selfotel: D02410
Tiletamine (DG01380): D06146 D08596
Troriluzole (DG03011): D11414
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    2902 (GRIN1)
   04015 Rap1 signaling pathway
    2902 (GRIN1)
   04020 Calcium signaling pathway
    2902 (GRIN1)
   04024 cAMP signaling pathway
    2902 (GRIN1)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2902 (GRIN1)
 09150 Organismal Systems
  09156 Nervous system
   04724 Glutamatergic synapse
    2902 (GRIN1)
   04720 Long-term potentiation
    2902 (GRIN1)
  09159 Environmental adaptation
   04713 Circadian entrainment
    2902 (GRIN1)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    2902 (GRIN1)
   05014 Amyotrophic lateral sclerosis
    2902 (GRIN1)
   05016 Huntington disease
    2902 (GRIN1)
   05017 Spinocerebellar ataxia
    2902 (GRIN1)
   05020 Prion disease
    2902 (GRIN1)
   05022 Pathways of neurodegeneration - multiple diseases
    2902 (GRIN1)
  09165 Substance dependence
   05030 Cocaine addiction
    2902 (GRIN1)
   05031 Amphetamine addiction
    2902 (GRIN1)
   05033 Nicotine addiction
    2902 (GRIN1)
   05034 Alcoholism
    2902 (GRIN1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2902 (GRIN1)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  Glutamate (ionotropic)
   2902 (GRIN1)
SSDB
Motif
Pfam: Lig_chan ANF_receptor Lig_chan-Glu_bd SBP_bac_3 CaM_bdg_C0 Peripla_BP_6 Ion_trans_2
Other DBs
NCBI-GeneID: 2902
NCBI-ProteinID: NP_015566
OMIM: 138249
HGNC: 4584
Ensembl: ENSG00000176884
Vega: OTTHUMG00000020976
Pharos: Q05586(Tclin)
UniProt: Q05586
LinkDB
Structure
PDB: 

Position
9q34.3
AA seq 938 aa
MSTMRLLTLALLFSCSVARAACDPKIVNIGAVLSTRKHEQMFREAVNQANKRHGSWKIQL
NATSVTHKPNAIQMALSVCEDLISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLG
LTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEGRAAQKRL
ETLLEERESKAEKVLQFDPGTKNVTALLMEAKELEARVIILSASEDDAATVYRAAAMLNM
TGSGYVWLVGEREISGNALRYAPDGILGLQLINGKNESAHISDAVGVVAQAVHELLEKEN
ITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFANYSIMNLQNRK
LVQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQEPFVYVKPTLSDGTC
KEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVA
DGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTI
LVKKEIPRSTLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDA
LTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRP
EERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELSTMYRHMEKHNYESAAEAIQA
VRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSH
ENGFMEDLDKTWVRYQECDSRSNAPATLTFENMAGVFMLVAGGIVAGIFLIFIEIAYKRH
KDARRKQMQLAFAAVNVWRKNLQDRKSGRAEPDPKKKATFRAITSTLASSFKRRRSSKDT
STGGGRGALQNQKDTVLPRRAIEREEGQLQLCSRHRES
NT seq 2817 nt   +upstreamnt  +downstreamnt
atgagcaccatgcgcctgctgacgctcgccctgctgttctcctgctccgtcgcccgtgcc
gcgtgcgaccccaagatcgtcaacattggcgcggtgctgagcacgcggaagcacgagcag
atgttccgcgaggccgtgaaccaggccaacaagcggcacggctcctggaagattcagctc
aatgccacctccgtcacgcacaagcccaacgccatccagatggctctgtcggtgtgcgag
gacctcatctccagccaggtctacgccatcctagttagccatccacctacccccaacgac
cacttcactcccacccctgtctcctacacagccggcttctaccgcatacccgtgctgggg
ctgaccacccgcatgtccatctactcggacaagagcatccacctgagcttcctgcgcacc
gtgccgccctactcccaccagtccagcgtgtggtttgagatgatgcgtgtctacagctgg
aaccacatcatcctgctggtcagcgacgaccacgagggccgggcggctcagaaacgcctg
gagacgctgctggaggagcgtgagtccaaggcagagaaggtgctgcagtttgacccaggg
accaagaacgtgacggccctgctgatggaggcgaaagagctggaggcccgggtcatcatc
ctttctgccagcgaggacgatgctgccactgtataccgcgcagccgcgatgctgaacatg
acgggctccgggtacgtgtggctggtcggcgagcgcgagatctcggggaacgccctgcgc
tacgccccagacggcatcctcgggctgcagctcatcaacggcaagaacgagtcggcccac
atcagcgacgccgtgggcgtggtggcccaggccgtgcacgagctcctcgagaaggagaac
atcaccgacccgccgcggggctgcgtgggcaacaccaacatctggaagaccgggccgctc
ttcaagagagtgctgatgtcttccaagtatgcggatggggtgactggtcgcgtggagttc
aatgaggatggggaccggaagttcgccaactacagcatcatgaacctgcagaaccgcaag
ctggtgcaagtgggcatctacaatggcacccacgtcatccctaatgacaggaagatcatc
tggccaggcggagagacagagaagcctcgagggtaccagatgtccaccagactgaagatt
gtgacgatccaccaggagcccttcgtgtacgtcaagcccacgctgagtgatgggacatgc
aaggaggagttcacagtcaacggcgacccagtcaagaaggtgatctgcaccgggcccaac
gacacgtcgccgggcagcccccgccacacggtgcctcagtgttgctacggcttttgcatc
gacctgctcatcaagctggcacggaccatgaacttcacctacgaggtgcacctggtggca
gatggcaagttcggcacacaggagcgggtgaacaacagcaacaagaaggagtggaatggg
atgatgggcgagctgctcagcgggcaggcagacatgatcgtggcgccgctaaccataaac
aacgagcgcgcgcagtacatcgagttttccaagcccttcaagtaccagggcctgactatt
ctggtcaagaaggagattccccggagcacgctggactcgttcatgcagccgttccagagc
acactgtggctgctggtggggctgtcggtgcacgtggtggccgtgatgctgtacctgctg
gaccgcttcagccccttcggccggttcaaggtgaacagcgaggaggaggaggaggacgca
ctgaccctgtcctcggccatgtggttctcctggggcgtcctgctcaactccggcatcggg
gaaggcgcccccagaagcttctcagcgcgcatcctgggcatggtgtgggccggctttgcc
atgatcatcgtggcctcctacaccgccaacctggcggccttcctggtgctggaccggccg
gaggagcgcatcacgggcatcaacgaccctcggctgaggaacccctcggacaagtttatc
tacgccacggtgaagcagagctccgtggatatctacttccggcgccaggtggagctgagc
accatgtaccggcatatggagaagcacaactacgagagtgcggcggaggccatccaggcc
gtgagagacaacaagctgcatgccttcatctgggactcggcggtgctggagttcgaggcc
tcgcagaagtgcgacctggtgacgactggagagctgtttttccgctcgggcttcggcata
ggcatgcgcaaagacagcccctggaagcagaacgtctccctgtccatcctcaagtcccac
gagaatggcttcatggaagacctggacaagacgtgggttcggtatcaggaatgtgactcg
cgcagcaacgcccctgcgacccttacttttgagaacatggccggggtcttcatgctggta
gctgggggcatcgtggccgggatcttcctgattttcatcgagattgcctacaagcggcac
aaggatgctcgccggaagcagatgcagctggcctttgccgccgttaacgtgtggcggaag
aacctgcaggatagaaagagtggtagagcagagcctgaccctaaaaagaaagccacattt
agggctatcacctccaccctggcttccagcttcaagaggcgtaggtcctccaaagacacg
agcaccgggggtggacgcggcgctttgcaaaaccaaaaagacacagtgctgccgcgacgc
gctattgagagggaggagggccagctgcagctgtgttcccgtcatagggagagctga

KEGG   Homo sapiens (human): 2903
Entry
2903              CDS       T01001                                 

Gene name
GRIN2A, EPND, FESD, GluN2A, LKS, NMDAR2A, NR2A
Definition
(RefSeq) glutamate ionotropic receptor NMDA type subunit 2A
  KO
K05209  glutamate receptor ionotropic, NMDA 2A
Organism
hsa  Homo sapiens (human)
Pathway
hsa04014  Ras signaling pathway
hsa04015  Rap1 signaling pathway
hsa04020  Calcium signaling pathway
hsa04024  cAMP signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04713  Circadian entrainment
hsa04720  Long-term potentiation
hsa04724  Glutamatergic synapse
hsa04728  Dopaminergic synapse
hsa05010  Alzheimer disease
hsa05014  Amyotrophic lateral sclerosis
hsa05017  Spinocerebellar ataxia
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05030  Cocaine addiction
hsa05031  Amphetamine addiction
hsa05033  Nicotine addiction
hsa05034  Alcoholism
hsa05322  Systemic lupus erythematosus
Network
nt06410  Calcium signaling
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06462  Spinocerebellar ataxia
nt06465  Prion disease
  Element
N00970  Transport of calcium
N00971  Mutation-caused aberrant PDYN to transport of calcium
N00987  Mutation-caused aberrant Htt to transport of calcium
N01003  Mutation-caused aberrant Abeta to transport of calcium
N01200  Scrapie conformation PrPSc to transport of calcium
Disease
H01514  Landau-Kleffner syndrome
H01827  Rolandic epilepsy, mental retardation, and speech dyspraxia
Drug target
Acamprosate (DG00996): D02780<JP/US> D07058
Amantadine (DG00860): D00777<JP/US> D07441
Apimostinel: D11299
Aptiganel hydrochloride: D02973
Budipine (DG00866): D07306 D07589
Delucemine hydrochloride: D03679
Dextromethorphan (DG01078): D00848<JP> D03742 D03744
Dextrorphan hydrochloride: D03746
Dizocilpine maleate: D03878
Esketamine (DG01829): D07283 D10627<US>
Felbamate: D00536<US>
Gavestinel: D04308
Ketamine (DG00796): D00711<JP/US> D08098
Latrepirdine (DG01379): D09917 D09918
Levomethadone (DG01002): D08121 D08122
Licostinel: D04728
Memantine (DG00986): D04905<JP/US> D08174
Methadone (DG00999): D02102<JP/US> D08195
Orphenadrine (DG01252): D08305
Orphenadrine (chloride): D02599
Orphenadrine (citrate): D00774<US>
Perzinfotel: D05447
Phencyclidine hydrochloride: D05453
Remacemide hydrochloride: D05714
Riluzole: D00775<JP/US>
Selfotel: D02410
Tiletamine (DG01380): D06146 D08596
Troriluzole (DG03011): D11414
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    2903 (GRIN2A)
   04015 Rap1 signaling pathway
    2903 (GRIN2A)
   04020 Calcium signaling pathway
    2903 (GRIN2A)
   04024 cAMP signaling pathway
    2903 (GRIN2A)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2903 (GRIN2A)
 09150 Organismal Systems
  09156 Nervous system
   04724 Glutamatergic synapse
    2903 (GRIN2A)
   04728 Dopaminergic synapse
    2903 (GRIN2A)
   04720 Long-term potentiation
    2903 (GRIN2A)
  09159 Environmental adaptation
   04713 Circadian entrainment
    2903 (GRIN2A)
 09160 Human Diseases
  09163 Immune disease
   05322 Systemic lupus erythematosus
    2903 (GRIN2A)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    2903 (GRIN2A)
   05014 Amyotrophic lateral sclerosis
    2903 (GRIN2A)
   05017 Spinocerebellar ataxia
    2903 (GRIN2A)
   05020 Prion disease
    2903 (GRIN2A)
   05022 Pathways of neurodegeneration - multiple diseases
    2903 (GRIN2A)
  09165 Substance dependence
   05030 Cocaine addiction
    2903 (GRIN2A)
   05031 Amphetamine addiction
    2903 (GRIN2A)
   05033 Nicotine addiction
    2903 (GRIN2A)
   05034 Alcoholism
    2903 (GRIN2A)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2903 (GRIN2A)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  Glutamate (ionotropic)
   2903 (GRIN2A)
SSDB
Motif
Pfam: NMDAR2_C Lig_chan Lig_chan-Glu_bd SBP_bac_3 ANF_receptor
Other DBs
NCBI-GeneID: 2903
NCBI-ProteinID: NP_000824
OMIM: 138253
HGNC: 4585
Ensembl: ENSG00000183454
Vega: OTTHUMG00000129721
Pharos: Q12879(Tclin)
UniProt: Q12879 Q547U9
LinkDB
Structure
PDB: 

Position
16p13.2
AA seq 1464 aa
MGRVGYWTLLVLPALLVWRGPAPSAAAEKGPPALNIAVMLGHSHDVTERELRTLWGPEQA
AGLPLDVNVVALLMNRTDPKSLITHVCDLMSGARIHGLVFGDDTDQEAVAQMLDFISSHT
FVPILGIHGGASMIMADKDPTSTFFQFGASIQQQATVMLKIMQDYDWHVFSLVTTIFPGY
REFISFVKTTVDNSFVGWDMQNVITLDTSFEDAKTQVQLKKIHSSVILLYCSKDEAVLIL
SEARSLGLTGYDFFWIVPSLVSGNTELIPKEFPSGLISVSYDDWDYSLEARVRDGIGILT
TAASSMLEKFSYIPEAKASCYGQMERPEVPMHTLHPFMVNVTWDGKDLSFTEEGYQVHPR
LVVIVLNKDREWEKVGKWENHTLSLRHAVWPRYKSFSDCEPDDNHLSIVTLEEAPFVIVE
DIDPLTETCVRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTVKFTYDLYLV
TNGKHGKKVNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSRS
NGTVSPSAFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYNRNLAKGKAPHGPSFT
IGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEFVD
QVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNNYPYMHQYMTKFNQKGVEDALVSL
KTGKLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALL
QFVGDGEMEELETLWLTGICHNEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHL
FYWKLRFCFTGVCSDRPGLLFSISRGIYSCIHGVHIEEKKKSPDFNLTGSQSNMLKLLRS
AKNISSMSNMNSSRMDSPKRAADFIQRGSLIMDMVSDKGNLMYSDNRSFQGKESIFGDNM
NELQTFVANRQKDNLNNYVFQGQHPLTLNESNPNTVEVAVSTESKANSRPRQLWKKSVDS
IRQDSLSQNPVSQRDEATAENRTHSLKSPRYLPEEMAHSDISETSNRATCHREPDNSKNH
KTKDNFKRSVASKYPKDCSEVERTYLKTKSSSPRDKIYTIDGEKEPGFHLDPPQFVENVT
LPENVDFPDPYQDPSENFRKGDSTLPMNRNPLHNEEGLSNNDQYKLYSKHFTLKDKGSPH
SETSERYRQNSTHCRSCLSNMPTYSGHFTMRSPFKCDACLRMGNLYDIDEDQMLQETGNP
ATGEQVYQQDWAQNNALQLQKNKLRISRQHSYDNIVDKPRELDLSRPSRSISLKDRERLL
EGNFYGSLFSVPSSKLSGKKSSLFPQGLEDSKRSKSLLPDHTSDNPFLHSHRDDQRLVIG
RCPSDPYKHSLPSQAVNDSYLRSSLRSTASYCSRDSRGHNDVYISEHVMPYAANKNNMYS
TPRVLNSCSNRRVYKKMPSIESDV
NT seq 4395 nt   +upstreamnt  +downstreamnt
atgggcagagtgggctattggaccctgctggtgctgccggcccttctggtctggcgcggt
ccggcgccgagcgcggcggcggagaagggtccccccgcgctaaatattgcggtgatgctg
ggtcacagccacgacgtgacagagcgcgaacttcgaacactgtggggccccgagcaggcg
gcggggctgcccctggacgtgaacgtggtagctctgctgatgaaccgcaccgaccccaag
agcctcatcacgcacgtgtgcgacctcatgtccggggcacgcatccacggcctcgtgttt
ggggacgacacggaccaggaggccgtagcccagatgctggattttatctcctcccacacc
ttcgtccccatcttgggcattcatgggggcgcatctatgatcatggctgacaaggatccg
acgtctaccttcttccagtttggagcgtccatccagcagcaagccacggtcatgctgaag
atcatgcaggattatgactggcatgtcttctccctggtgaccactatcttccctggctac
agggaattcatcagcttcgtcaagaccacagtggacaacagctttgtgggctgggacatg
cagaatgtgatcacactggacacttcctttgaggatgcaaagacacaagtccagctgaag
aagatccactcttctgtcatcttgctctactgttccaaagacgaggctgttctcattctg
agtgaggcccgctcccttggcctcaccgggtatgatttcttctggattgtccccagcttg
gtctctgggaacacggagctcatcccaaaagagtttccatcgggactcatttctgtctcc
tacgatgactgggactacagcctggaggcgagagtgagggacggcattggcatcctaacc
accgctgcatcttctatgctggagaagttctcctacatccccgaggccaaggccagctgc
tacgggcagatggagaggccagaggtcccgatgcacaccttgcacccatttatggtcaat
gttacatgggatggcaaagacttatccttcactgaggaaggctaccaggtgcaccccagg
ctggtggtgattgtgctgaacaaagaccgggaatgggaaaaggtgggcaagtgggagaac
catacgctgagcctgaggcacgccgtgtggcccaggtacaagtccttctccgactgtgag
ccggatgacaaccatctcagcatcgtcaccctggaggaggccccattcgtcatcgtggaa
gacatagaccccctgaccgagacgtgtgtgaggaacaccgtgccatgtcggaagttcgtc
aaaatcaacaattcaaccaatgaggggatgaatgtgaagaaatgctgcaaggggttctgc
attgatattctgaagaagctttccagaactgtgaagtttacttacgacctctatctggtg
accaatgggaagcatggcaagaaagttaacaatgtgtggaatggaatgatcggtgaagtg
gtctatcaacgggcagtcatggcagttggctcgctcaccatcaatgaggaacgttctgaa
gtggtggacttctctgtgccctttgtggaaacgggaatcagtgtcatggtttcaagaagt
aatggcaccgtctcaccttctgcttttctagaaccattcagcgcctctgtctgggtgatg
atgtttgtgatgctgctcattgtttctgccatagctgtttttgtctttgaatacttcagc
cctgttggatacaacagaaacttagccaaagggaaagcaccccatgggccttcttttaca
attggaaaagctatatggcttctttggggcctggtgttcaataactccgtgcctgtccag
aatcctaaagggaccaccagcaagatcatggtatctgtatgggccttcttcgctgtcata
ttcctggctagctacacagccaatctggctgccttcatgatccaagaggaatttgtggac
caagtgaccggcctcagtgacaaaaagtttcagagacctcatgactattccccacctttt
cgatttgggacagtgcctaatggaagcacggagagaaacattcggaataactatccctac
atgcatcagtacatgaccaaatttaatcagaaaggagtagaggacgccttggtcagcctg
aaaacggggaagctggacgctttcatctacgatgccgcagtcttgaattacaaggctggg
agggatgaaggctgcaagctggtgaccatcgggagtgggtacatctttgccaccaccggt
tatggaattgcccttcagaaaggctctccttggaagaggcagatcgacctggccttgctt
cagtttgtgggtgatggtgagatggaggagctggagaccctgtggctcactgggatctgc
cacaacgagaagaacgaggtgatgagcagccagctggacattgacaacatggcgggcgta
ttctacatgctggctgccgccatggcccttagcctcatcaccttcatctgggagcacctc
ttctactggaagctgcgcttctgtttcacgggcgtgtgctccgaccggcctgggttgctc
ttctccatcagcaggggcatctacagctgcattcatggagtgcacattgaagaaaagaag
aagtctccagacttcaatctgacgggatcccagagcaacatgttaaaactcctccggtca
gccaaaaacatttccagcatgtccaacatgaactcctcaagaatggactcacccaaaaga
gctgctgacttcatccaaagaggttccctcatcatggacatggtttcagataaggggaat
ttgatgtactcagacaacaggtcctttcaggggaaagagagcatttttggagacaacatg
aacgaactccaaacatttgtggccaaccggcagaaggataacctcaataactatgtattc
cagggacaacatcctcttactctcaatgagtccaaccctaacacggtggaggtggccgtg
agcacagaatccaaagcgaactctagaccccggcagctgtggaagaaatccgtggattcc
atacgccaggattcactatcccagaatccagtctcccagagggatgaggcaacagcagag
aataggacccactccctaaagagccctaggtatcttccagaagagatggcccactctgac
atttcagaaacgtcaaatcgggccacgtgccacagggaacctgacaacagtaagaaccac
aaaaccaaggacaactttaaaaggtcagtggcctccaaataccccaaggactgtagtgag
gtcgagcgcacctacctgaaaaccaaatcaagctcccctagagacaagatctacactata
gatggtgagaaggagcctggtttccacttagatccaccccagtttgttgaaaatgtgacc
ctgcccgagaacgtggacttcccggacccctaccaggatcccagtgaaaacttccgcaag
ggggactccacgctgccaatgaaccggaaccccttgcataatgaagaggggctttccaac
aacgaccagtataaactctactccaagcacttcaccttgaaagacaagggttccccgcac
agtgagaccagcgagcgataccggcagaactccacgcactgcagaagctgcctttccaac
atgcccacctattcaggccacttcaccatgaggtcccccttcaagtgcgatgcctgcctg
cggatggggaacctctatgacatcgatgaagaccagatgcttcaggagacaggtaaccca
gccaccggggagcaggtctaccagcaggactgggcacagaacaatgcccttcaattacaa
aagaacaagctaaggattagccgtcagcattcctacgataacattgtcgacaaacctagg
gagctagaccttagcaggccctcccggagcataagcctcaaggacagggaacggcttctg
gagggaaatttttacggcagcctgtttagtgtcccctcaagcaaactctcggggaaaaaa
agctcccttttcccccaaggtctggaggacagcaagaggagcaagtctctcttgccagac
cacacctccgataaccctttcctccactcccacagggatgaccaacgcttggttattggg
agatgcccctcggacccttacaaacactcgttgccatcccaggcggtgaatgacagctat
cttcggtcgtccttgaggtcaacggcatcgtactgttccagggacagtcggggccacaat
gatgtgtatatttcggagcatgttatgccttatgctgcaaataagaataatatgtactct
acccccagggttttaaattcctgcagcaatagacgcgtgtacaagaaaatgcctagtatc
gaatctgatgtttaa

KEGG   Homo sapiens (human): 2904
Entry
2904              CDS       T01001                                 

Gene name
GRIN2B, EIEE27, GluN2B, MRD6, NMDAR2B, NR2B, NR3, hNR3
Definition
(RefSeq) glutamate ionotropic receptor NMDA type subunit 2B
  KO
K05210  glutamate receptor ionotropic, NMDA 2B
Organism
hsa  Homo sapiens (human)
Pathway
hsa04014  Ras signaling pathway
hsa04015  Rap1 signaling pathway
hsa04024  cAMP signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04713  Circadian entrainment
hsa04720  Long-term potentiation
hsa04724  Glutamatergic synapse
hsa04728  Dopaminergic synapse
hsa05010  Alzheimer disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05017  Spinocerebellar ataxia
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05030  Cocaine addiction
hsa05031  Amphetamine addiction
hsa05033  Nicotine addiction
hsa05034  Alcoholism
hsa05322  Systemic lupus erythematosus
Network
nt06410  Calcium signaling
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06462  Spinocerebellar ataxia
nt06465  Prion disease
  Element
N00970  Transport of calcium
N00971  Mutation-caused aberrant PDYN to transport of calcium
N00987  Mutation-caused aberrant Htt to transport of calcium
N01003  Mutation-caused aberrant Abeta to transport of calcium
N01200  Scrapie conformation PrPSc to transport of calcium
Disease
H00606  Early infantile epileptic encephalopathy
H00773  Autosomal dominant mental retardation
Drug target
Acamprosate (DG00996): D02780<JP/US> D07058
Amantadine (DG00860): D00777<JP/US> D07441
Apimostinel: D11299
Aptiganel hydrochloride: D02973
Besonprodil: D03100
Budipine (DG00866): D07306 D07589
Delucemine hydrochloride: D03679
Dextromethorphan (DG01078): D00848<JP> D03742 D03744
Dextrorphan hydrochloride: D03746
Dizocilpine maleate: D03878
Esketamine (DG01829): D07283 D10627<US>
Felbamate: D00536<US>
Gavestinel: D04308
Ketamine (DG00796): D00711<JP/US> D08098
Latrepirdine (DG01379): D09917 D09918
Levomethadone (DG01002): D08121 D08122
Licostinel: D04728
Memantine (DG00986): D04905<JP/US> D08174
Methadone (DG00999): D02102<JP/US> D08195
Neramexane mesylate: D05145
Orphenadrine (DG01252): D08305
Orphenadrine (chloride): D02599
Orphenadrine (citrate): D00774<US>
Perzinfotel: D05447
Phencyclidine hydrochloride: D05453
Remacemide hydrochloride: D05714
Riluzole: D00775<JP/US>
Rislenemdaz: D11340
Selfotel: D02410
Tiletamine (DG01380): D06146 D08596
Traxoprodil mesylate: D06204
Troriluzole (DG03011): D11414
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    2904 (GRIN2B)
   04015 Rap1 signaling pathway
    2904 (GRIN2B)
   04024 cAMP signaling pathway
    2904 (GRIN2B)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2904 (GRIN2B)
 09150 Organismal Systems
  09156 Nervous system
   04724 Glutamatergic synapse
    2904 (GRIN2B)
   04728 Dopaminergic synapse
    2904 (GRIN2B)
   04720 Long-term potentiation
    2904 (GRIN2B)
  09159 Environmental adaptation
   04713 Circadian entrainment
    2904 (GRIN2B)
 09160 Human Diseases
  09163 Immune disease
   05322 Systemic lupus erythematosus
    2904 (GRIN2B)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    2904 (GRIN2B)
   05014 Amyotrophic lateral sclerosis
    2904 (GRIN2B)
   05016 Huntington disease
    2904 (GRIN2B)
   05017 Spinocerebellar ataxia
    2904 (GRIN2B)
   05020 Prion disease
    2904 (GRIN2B)
   05022 Pathways of neurodegeneration - multiple diseases
    2904 (GRIN2B)
  09165 Substance dependence
   05030 Cocaine addiction
    2904 (GRIN2B)
   05031 Amphetamine addiction
    2904 (GRIN2B)
   05033 Nicotine addiction
    2904 (GRIN2B)
   05034 Alcoholism
    2904 (GRIN2B)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2904 (GRIN2B)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  Glutamate (ionotropic)
   2904 (GRIN2B)
SSDB
Motif
Pfam: NMDAR2_C Lig_chan Lig_chan-Glu_bd SBP_bac_3 ANF_receptor
Other DBs
NCBI-GeneID: 2904
NCBI-ProteinID: NP_000825
OMIM: 138252
HGNC: 4586
Ensembl: ENSG00000273079
Vega: OTTHUMG00000137373
Pharos: Q13224(Tclin)
UniProt: Q13224
LinkDB
Structure
PDB: 
5EWM 5EWJ 5EWL

Position
12p13.1
AA seq 1484 aa
MKPRAECCSPKFWLVLAVLAVSGSRARSQKSPPSIGIAVILVGTSDEVAIKDAHEKDDFH
HLSVVPRVELVAMNETDPKSIITRICDLMSDRKIQGVVFADDTDQEAIAQILDFISAQTL
TPILGIHGGSSMIMADKDESSMFFQFGPSIEQQASVMLNIMEEYDWYIFSIVTTYFPGYQ
DFVNKIRSTIENSFVGWELEEVLLLDMSLDDGDSKIQNQLKKLQSPIILLYCTKEEATYI
FEVANSVGLTGYGYTWIVPSLVAGDTDTVPAEFPTGLISVSYDEWDYGLPARVRDGIAII
TTAASDMLSEHSFIPEPKSSCYNTHEKRIYQSNMLNRYLINVTFEGRNLSFSEDGYQMHP
KLVIILLNKERKWERVGKWKDKSLQMKYYVWPRMCPETEEQEDDHLSIVTLEEAPFVIVE
SVDPLSGTCMRNTVPCQKRIVTENKTDEEPGYIKKCCKGFCIDILKKISKSVKFTYDLYL
VTNGKHGKKINGTWNGMIGEVVMKRAYMAVGSLTINEERSEVVDFSVPFIETGISVMVSR
SNGTVSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGYNRCLADGREPGGPSF
TIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEYV
DQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIRNNYAEMHAYMGKFNQRGVDDALLS
LKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAIQKDSGWKRQVDLAI
LQLFGDGEMEELEALWLTGICHNEKNEVMSSQLDIDNMAGVFYMLGAAMALSLITFICEH
LFYWQFRHCFMGVCSGKPGMVFSISRGIYSCIHGVAIEERQSVMNSPTATMNNTHSNILR
LLRTAKNMANLSGVNGSPQSALDFIRRESSVYDISEHRRSFTHSDCKSYNNPPCEENLFS
DYISEVERTFGNLQLKDSNVYQDHYHHHHRPHSIGSASSIDGLYDCDNPPFTTQSRSISK
KPLDIGLPSSKHSQLSDLYGKFSFKSDRYSGHDDLIRSDVSDISTHTVTYGNIEGNAAKR
RKQQYKDSLKKRPASAKSRREFDEIELAYRRRPPRSPDHKRYFRDKEGLRDFYLDQFRTK
ENSPHWEHVDLTDIYKERSDDFKRDSVSGGGPCTNRSHIKHGTGDKHGVVSGVPAPWEKN
LTNVEWEDRSGGNFCRSCPSKLHNYSTTVTGQNSGRQACIRCEACKKAGNLYDISEDNSL
QELDQPAAPVAVTSNASTTKYPQSPTNSKAQKKNRNKLRRQHSYDTFVDLQKEEAALAPR
SVSLKDKGRFMDGSPYAHMFEMSAGESTFANNKSSVPTAGHHHHNNPGGGYMLSKSLYPD
RVTQNPFIPTFGDDQCLLHGSKSYFFRQPTVAGASKARPDFRALVTNKPVVSALHGAVPA
RFQKDICIGNQSNPCVPNNKNPRAFNGSSNGHVYEKLSSIESDV
NT seq 4455 nt   +upstreamnt  +downstreamnt
atgaagcccagagcggagtgctgttctcccaagttctggttggtgttggccgtcctggcc
gtgtcaggcagcagagctcgttctcagaagagcccccccagcattggcattgctgtcatc
ctcgtgggcacttccgacgaggtggccatcaaggatgcccacgagaaagatgatttccac
catctctccgtggtaccccgggtggaactggtagccatgaatgagaccgacccaaagagc
atcatcacccgcatctgtgatctcatgtctgaccggaagatccagggggtggtgtttgct
gatgacacagaccaggaagccatcgcccagatcctcgatttcatttcagcacagactctc
acccccatcctgggcatccacgggggctcctctatgataatggcagataaggatgaatcc
tccatgttcttccagtttggcccatcaattgaacagcaagcttccgtaatgctcaacatc
atggaagaatatgactggtacatcttttctatcgtcaccacctatttccctggctaccag
gactttgtaaacaagatccgcagcaccattgagaatagctttgtgggctgggagctagag
gaggtcctcctactggacatgtccctggacgatggagattctaagatccagaatcagctc
aagaaacttcaaagccccatcattcttctttactgtaccaaggaagaagccacctacatc
tttgaagtggccaactcagtagggctgactggctatggctacacgtggatcgtgcccagt
ctggtggcaggggatacagacacagtgcctgcggagttccccactgggctcatctctgta
tcatatgatgaatgggactatggcctccccgccagagtgagagatggaattgccataatc
accactgctgcttctgacatgctgtctgagcacagcttcatccctgagcccaaaagcagt
tgttacaacacccacgagaagagaatctaccagtccaatatgctaaataggtatctgatc
aatgtcacttttgaggggaggaatttgtccttcagtgaagatggctaccagatgcacccg
aaactggtgataattcttctgaacaaggagaggaagtgggaaagggtggggaagtggaaa
gacaagtccctgcagatgaagtactatgtgtggccccgaatgtgtccagagactgaagag
caggaggatgaccatctgagcattgtgaccctggaggaggcaccatttgtcattgtggaa
agtgtggaccctctgagtggaacctgcatgaggaacacagtcccctgccaaaaacgcata
gtcactgagaataaaacagacgaggagccgggttacatcaaaaaatgctgcaaggggttc
tgtattgacatccttaagaaaatttctaaatctgtgaagttcacctatgacctttacctg
gttaccaatggcaagcatgggaagaaaatcaatggaacctggaatggtatgattggagag
gtggtcatgaagagggcctacatggcagtgggctcactcaccatcaatgaggaacgatcg
gaggtggtcgacttctctgtgcccttcatagagacaggcatcagtgtcatggtgtcacgc
agcaatgggactgtctcaccttctgccttcttagagccattcagcgctgacgtatgggtg
atgatgtttgtgatgctgctcatcgtctcagccgtggctgtctttgtctttgagtacttc
agccctgtgggttataacaggtgcctcgctgatggcagagagcctggtggaccctctttc
accatcggcaaagctatttggttgctctggggtctggtgtttaacaactccgtacctgtg
cagaacccaaaggggaccacctccaagatcatggtgtcagtgtgggccttctttgctgtc
atcttcctggccagctacactgccaacttagctgccttcatgatccaagaggaatatgtg
gaccaggtttctggcctgagcgacaaaaagttccagagacctaatgacttctcaccccct
ttccgctttgggaccgtgcccaacggcagcacagagagaaatattcgcaataactatgca
gaaatgcatgcctacatgggaaagttcaaccagaggggtgtagatgatgcattgctctcc
ctgaaaacagggaaactggatgccttcatctatgatgcagcagtgctgaactatatggca
ggcagagatgaaggctgcaagctggtgaccattggcagtgggaaggtctttgcttccact
ggctatggcattgccatccaaaaagattctgggtggaagcgccaggtggaccttgctatc
ctgcagctctttggagatggggagatggaagaactggaagctctctggctcactggcatt
tgtcacaatgagaagaatgaggtcatgagcagccagctggacattgacaacatggcaggg
gtcttctacatgttgggggcggccatggctctcagcctcatcaccttcatctgcgaacac
cttttctattggcagttccgacattgctttatgggtgtctgttctggcaagcctggcatg
gtcttctccatcagcagaggtatctacagctgcatccatggggtggcgatcgaggagcgc
cagtctgtaatgaactcccccaccgcaaccatgaacaacacacactccaacatcctgcgc
ctgctgcgcacggccaagaacatggctaacctgtctggtgtgaatggctcaccgcagagc
gccctggacttcatccgacgggagtcatccgtctatgacatctcagagcaccgccgcagc
ttcacgcattctgactgcaaatcctacaacaacccgccctgtgaggagaacctcttcagt
gactacatcagtgaggtagagagaacgttcgggaacctgcagctgaaggacagcaacgtg
taccaagatcactaccaccatcaccaccggccccatagtattggcagtgccagctccatc
gatgggctctacgactgtgacaacccacccttcaccacccagtccaggtccatcagcaag
aagcccctggacatcggcctcccctcctccaagcacagccagctcagtgacctgtacggc
aaattctccttcaagagcgaccgctacagtggccacgacgacttgatccgctccgatgtc
tctgacatctcaacccacaccgtcacctatgggaacatcgagggcaatgccgccaagagg
cgtaagcagcaatataaggacagcctgaagaagcggcctgcctcggccaagtcccgcagg
gagtttgacgagatcgagctggcctaccgtcgccgaccgccccgctcccctgaccacaag
cgctacttcagggacaaggaagggctacgggacttctacctggaccagttccgaacaaag
gagaactcaccccactgggagcacgtagacctgaccgacatctacaaggagcggagtgat
gactttaagcgcgactccgtcagcggaggagggccctgtaccaacaggtctcacatcaag
cacgggacgggcgacaaacacggcgtggtcagcggggtacctgcaccttgggagaagaac
ctgaccaacgtggagtgggaggaccggtccgggggcaacttctgccgcagctgtccctcc
aagctgcacaactactccacgacggtgacgggtcagaactcgggcaggcaggcgtgcatc
cggtgtgaggcttgcaagaaagcaggcaacctgtatgacatcagtgaggacaactccctg
caggaactggaccagccggctgccccagtggcggtgacgtcaaacgcctccaccactaag
taccctcagagcccgactaattccaaggcccagaagaagaaccggaacaaactgcgccgg
cagcactcctacgacaccttcgtggacctgcagaaggaagaagccgccctggccccgcgc
agcgtaagcctgaaagacaagggccgattcatggatgggagcccctacgcccacatgttt
gagatgtcagctggcgagagcacctttgccaacaacaagtcctcagtgcccactgccgga
catcaccaccacaacaaccccggcggcgggtacatgctcagcaagtcgctctaccctgac
cgggtcacgcaaaaccctttcatccccacttttggggacgaccagtgcttgctccatggc
agcaaatcctacttcttcaggcagcccacggtggcgggggcgtcgaaagccaggccggac
ttccgggcccttgtcaccaacaagccggtggtctcggcccttcatggggccgtgccagcc
cgtttccagaaggacatctgtatagggaaccagtccaacccctgtgtgcctaacaacaaa
aaccccagggctttcaatggctccagcaatgggcatgtttatgagaaactttctagtatt
gagtctgatgtctga

KEGG   Homo sapiens (human): 2905
Entry
2905              CDS       T01001                                 

Gene name
GRIN2C, GluN2C, NMDAR2C, NR2C
Definition
(RefSeq) glutamate ionotropic receptor NMDA type subunit 2C
  KO
K05211  glutamate receptor ionotropic, NMDA 2C
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04024  cAMP signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04713  Circadian entrainment
hsa04720  Long-term potentiation
hsa04724  Glutamatergic synapse
hsa05010  Alzheimer disease
hsa05014  Amyotrophic lateral sclerosis
hsa05017  Spinocerebellar ataxia
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05030  Cocaine addiction
hsa05031  Amphetamine addiction
hsa05033  Nicotine addiction
hsa05034  Alcoholism
Network
nt06410  Calcium signaling
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06462  Spinocerebellar ataxia
nt06465  Prion disease
  Element
N00970  Transport of calcium
N00971  Mutation-caused aberrant PDYN to transport of calcium
N00987  Mutation-caused aberrant Htt to transport of calcium
N01003  Mutation-caused aberrant Abeta to transport of calcium
N01200  Scrapie conformation PrPSc to transport of calcium
Drug target
Acamprosate (DG00996): D02780<JP/US> D07058
Amantadine (DG00860): D00777<JP/US> D07441
Apimostinel: D11299
Aptiganel hydrochloride: D02973
Budipine (DG00866): D07306 D07589
Delucemine hydrochloride: D03679
Dextromethorphan (DG01078): D00848<JP> D03742 D03744
Dextrorphan hydrochloride: D03746
Dizocilpine maleate: D03878
Esketamine (DG01829): D07283 D10627<US>
Felbamate: D00536<US>
Gavestinel: D04308
Ketamine (DG00796): D00711<JP/US> D08098
Latrepirdine (DG01379): D09917 D09918
Levomethadone (DG01002): D08121 D08122
Licostinel: D04728
Memantine (DG00986): D04905<JP/US> D08174
Methadone (DG00999): D02102<JP/US> D08195
Orphenadrine (DG01252): D08305
Orphenadrine (chloride): D02599
Orphenadrine (citrate): D00774<US>
Perzinfotel: D05447
Phencyclidine hydrochloride: D05453
Remacemide hydrochloride: D05714
Riluzole: D00775<JP/US>
Selfotel: D02410
Tiletamine (DG01380): D06146 D08596
Troriluzole (DG03011): D11414
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    2905 (GRIN2C)
   04024 cAMP signaling pathway
    2905 (GRIN2C)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2905 (GRIN2C)
 09150 Organismal Systems
  09156 Nervous system
   04724 Glutamatergic synapse
    2905 (GRIN2C)
   04720 Long-term potentiation
    2905 (GRIN2C)
  09159 Environmental adaptation
   04713 Circadian entrainment
    2905 (GRIN2C)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    2905 (GRIN2C)
   05014 Amyotrophic lateral sclerosis
    2905 (GRIN2C)
   05017 Spinocerebellar ataxia
    2905 (GRIN2C)
   05020 Prion disease
    2905 (GRIN2C)
   05022 Pathways of neurodegeneration - multiple diseases
    2905 (GRIN2C)
  09165 Substance dependence
   05030 Cocaine addiction
    2905 (GRIN2C)
   05031 Amphetamine addiction
    2905 (GRIN2C)
   05033 Nicotine addiction
    2905 (GRIN2C)
   05034 Alcoholism
    2905 (GRIN2C)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2905 (GRIN2C)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  Glutamate (ionotropic)
   2905 (GRIN2C)
SSDB
Motif
Pfam: Lig_chan Lig_chan-Glu_bd SBP_bac_3 ANF_receptor NMDAR2_C
Other DBs
NCBI-GeneID: 2905
NCBI-ProteinID: NP_000826
OMIM: 138254
HGNC: 4587
Ensembl: ENSG00000161509
Vega: OTTHUMG00000044524
Pharos: Q14957(Tclin)
UniProt: Q14957 O15398
LinkDB
Position
17q25.1
AA seq 1233 aa
MGGALGPALLLTSLFGAWAGLGPGQGEQGMTVAVVFSSSGPPQAQFRARLTPQSFLDLPL
EIQPLTVGVNTTNPSSLLTQICGLLGAAHVHGIVFEDNVDTEAVAQILDFISSQTHVPIL
SISGGSAVVLTPKEPGSAFLQLGVSLEQQLQVLFKVLEEYDWSAFAVITSLHPGHALFLE
GVRAVADASHVSWRLLDVVTLELGPGGPRARTQRLLRQLDAPVFVAYCSREEAEVLFAEA
AQAGLVGPGHVWLVPNLALGSTDAPPATFPVGLISVVTESWRLSLRQKVRDGVAILALGA
HSYWRQHGTLPAPAGDCRVHPGPVSPAREAFYRHLLNVTWEGRDFSFSPGGYLVQPTMVV
IALNRHRLWEMVGRWEHGVLYMKYPVWPRYSASLQPVVDSRHLTVATLEERPFVIVESPD
PGTGGCVPNTVPCRRQSNHTFSSGDVAPYTKLCCKGFCIDILKKLARVVKFSYDLYLVTN
GKHGKRVRGVWNGMIGEVYYKRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSNG
TVSPSAFLEPYSPAVWVMMFVMCLTVVAITVFMFEYFSPVSYNQNLTRGKKSGGPAFTIG
KSVWLLWALVFNNSVPIENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEQYIDTV
SGLSDKKFQRPQDQYPPFRFGTVPNGSTERNIRSNYRDMHTHMVKFNQRSVEDALTSLKM
GKLDAFIYDAAVLNYMAGKDEGCKLVTIGSGKVFATTGYGIAMQKDSHWKRAIDLALLQF
LGDGETQKLETVWLSGICQNEKNEVMSSKLDIDNMAGVFYMLLVAMGLALLVFAWEHLVY
WKLRHSVPNSSQLDFLLAFSRGIYSCFSGVQSLASPPRQASPDLTASSAQASVLKMLQAA
RDMVTTAGVSSSLDRATRTIENWGGGRRAPPPSPCPTPRSGPSPCLPTPDPPPEPSPTGW
GPPDGGRAALVRRAPQPPGRPPTPGPPLSDVSRVSRRPAWEARWPVRTGHCGRHLSASER
PLSPARCHYSSFPRADRSGRPFLPLFPELEDLPLLGPEQLARREALLHAAWARGSRPRHA
SLPSSVAEAFARPSSLPAGCTGPACARPDGHSACRRLAQAQSMCLPIYREACQEGEQAGA
PAWQHRQHVCLHAHAHLPFCWGAVCPHLPPCASHGSWLSGAWGPLGHRGRTLGLGTGYRD
SGGLDEISRVARGTQGFPGPCTWRRISSLESEV
NT seq 3702 nt   +upstreamnt  +downstreamnt
atgggtggggccctggggccggccctgttgctcacctcgctcttcggtgcctgggcaggg
ctgggtccggggcagggcgagcagggcatgacggtggccgtggtgtttagcagctcaggg
ccgccccaggcccagttccgtgcccgcctcaccccccagagcttcctggacctacccctg
gagatccagccgctcacagttggggtcaacaccaccaaccccagcagcctcctcacccag
atctgcggcctcctgggtgctgcccacgtccacggcattgtctttgaggacaacgtggac
accgaggcggtggcccagatccttgacttcatctcctcccagacccatgtgcccatcctc
agcatcagcggaggctctgctgtggtcctcacccccaaggagccgggctccgccttcctg
cagctgggcgtgtccctggagcagcagctgcaggtgctgttcaaggtgctggaagagtac
gactggagcgccttcgccgtcatcaccagcctgcacccgggccacgcgctcttcctggag
ggcgtgcgcgccgtcgccgacgccagccacgtgagttggcggctgctggacgtggtcacg
ctggagctgggcccgggagggccgcgcgcgcgcacgcagcgcctgctgcgccagctcgac
gcgcccgtgtttgtggcctactgctcgcgcgaggaggccgaggtgctcttcgccgaggcg
gcgcaggccggtctggtggggcccggccacgtgtggctggtgcccaacctggcgctgggc
agcaccgatgcgccccccgccaccttccccgtgggcctcatcagcgtcgtcaccgagagc
tggcgcctcagcctgcgccagaaggtgcgcgacggcgtggccattctggccctgggcgcc
cacagctactggcgccagcatggaaccctgccagccccggccggggactgccgtgttcac
cctgggcccgtcagccctgcccgggaggccttctacaggcacctactgaatgtcacctgg
gagggccgagacttctccttcagccctggtgggtacctggtccagcccaccatggtggtg
atcgccctcaaccggcaccgcctctgggagatggtggggcgctgggagcatggcgtccta
tacatgaagtaccccgtgtggcctcgctacagtgcctctctgcagcctgtggtggacagt
cggcacctgacggtggccacgctggaagagcggccctttgtcatcgtggagagccctgac
cctggcacaggaggctgtgtccccaacaccgtgccctgccgcaggcagagcaaccacacc
ttcagcagcggggacgtggccccctacaccaagctctgctgtaagggattctgcatcgac
atcctcaagaagctggccagagtggtcaaattctcctacgacctgtacctggtgaccaac
ggcaagcatggcaagcgggtgcgcggcgtatggaacggcatgattggggaggtgtactac
aagcgggcagacatggccatcggctccctcaccatcaatgaggaacgctccgagatcgta
gacttctctgtaccctttgtggagacgggcatcagtgtgatggtggctcgcagcaatggc
accgtctccccctcggccttcttggagccatatagccctgcagtgtgggtgatgatgttt
gtcatgtgcctcactgtggtggccatcaccgtcttcatgttcgagtacttcagccctgtc
agctacaaccagaacctcaccagaggcaagaagtccgggggcccagctttcactatcggc
aagtccgtgtggctgctgtgggcgctggtcttcaacaactcagtgcccatcgagaacccg
cggggcaccaccagcaagatcatggttctggtctgggccttctttgctgtcatcttcctc
gccagctacacggccaacctggccgccttcatgatccaagagcaatacatcgacactgtg
tcgggcctcagtgacaagaagtttcagcggcctcaagatcagtacccacctttccgcttc
ggcacggtgcccaacggcagcacggagcggaacatccgcagtaactaccgtgacatgcac
acccacatggtcaagttcaaccagcgctcggtggaggacgcgctcaccagcctcaagatg
gggaagctggatgccttcatctatgatgctgctgtcctcaactacatggcaggcaaggac
gagggctgcaagctggtcaccattgggtctggcaaggtctttgctaccactggctacggc
atcgccatgcagaaggactcccactggaagcgggccatagacctggcgctcttgcagttc
ctgggggacggagagacacagaaactggagacagtgtggctctcagggatctgccagaat
gagaagaacgaggtgatgagcagcaagctggacatcgacaacatggcaggcgtcttctac
atgctgctggtggccatggggctggccctgctggtcttcgcctgggagcacctggtctac
tggaagctgcgccactcggtgcccaactcatcccagctggacttcctgctggctttcagc
aggggcatctacagctgcttcagcggggtgcagagcctcgccagcccaccgcggcaggcc
agcccggacctcacggccagctcggcccaggccagcgtgctcaagatgctgcaggcagcc
cgcgacatggtgaccacggcgggcgtaagcagctccctggaccgcgccactcgcaccatc
gagaattggggtggcggccgccgtgcgcccccaccgtccccctgcccgaccccgcggtct
ggccccagcccatgcctgcccacccccgacccgcccccagagccgagccccacgggctgg
ggaccgccagacgggggtcgcgcggcgcttgtgcgcagggctccgcagcccccgggccgc
cccccgacgccggggccgcccctgtccgacgtctcccgagtgtcgcgccgcccagcctgg
gaggcgcggtggccggtgcggaccgggcactgcgggaggcacctctcggcctccgagcgg
cccctgtcgcccgcgcgctgtcactacagctcctttcctcgagccgaccgatccggccgc
cccttcctcccgctcttcccggagctggaggacctgccgctgctcggtccggagcagctg
gcccggcgggaggccctgctgcacgcggcctgggcccggggctcgcgcccgcgtcacgct
tccctgcccagctccgtggccgaggccttcgctcggcccagctcgctgcccgctgggtgc
accggccccgcctgcgcccgccccgacggccactcggcctgcaggcgcttggcgcaggcg
cagtcgatgtgcttgccgatctaccgggaggcctgccaggagggcgagcaggcaggggcc
cccgcctggcagcacagacagcacgtctgcctgcacgcccacgcccacctgccattttgc
tggggggctgtctgtcctcaccttccaccctgtgccagccacggctcctggctctccggg
gcctgggggcctctggggcacaggggcaggactctggggctgggcacaggctacagagac
agtgggggactggacgagatcagcagggtagcccgtgggacgcaaggcttcccgggaccc
tgcacctggagacggatctccagtctggagtcagaagtgtga

KEGG   Homo sapiens (human): 2906
Entry
2906              CDS       T01001                                 

Gene name
GRIN2D, EB11, EIEE46, GluN2D, NMDAR2D, NR2D
Definition
(RefSeq) glutamate ionotropic receptor NMDA type subunit 2D
  KO
K05212  glutamate receptor ionotropic, NMDA 2D
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04024  cAMP signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04713  Circadian entrainment
hsa04720  Long-term potentiation
hsa04724  Glutamatergic synapse
hsa05010  Alzheimer disease
hsa05014  Amyotrophic lateral sclerosis
hsa05017  Spinocerebellar ataxia
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05030  Cocaine addiction
hsa05031  Amphetamine addiction
hsa05033  Nicotine addiction
hsa05034  Alcoholism
Network
nt06410  Calcium signaling
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06462  Spinocerebellar ataxia
nt06465  Prion disease
  Element
N00970  Transport of calcium
N00971  Mutation-caused aberrant PDYN to transport of calcium
N00987  Mutation-caused aberrant Htt to transport of calcium
N01003  Mutation-caused aberrant Abeta to transport of calcium
N01200  Scrapie conformation PrPSc to transport of calcium
Disease
H00606  Early infantile epileptic encephalopathy
Drug target
Acamprosate (DG00996): D02780<JP/US> D07058
Amantadine (DG00860): D00777<JP/US> D07441
Apimostinel: D11299
Aptiganel hydrochloride: D02973
Budipine (DG00866): D07306 D07589
Delucemine hydrochloride: D03679
Dextromethorphan (DG01078): D00848<JP> D03742 D03744
Dextrorphan hydrochloride: D03746
Dizocilpine maleate: D03878
Esketamine (DG01829): D07283 D10627<US>
Felbamate: D00536<US>
Gavestinel: D04308
Ketamine (DG00796): D00711<JP/US> D08098
Latrepirdine (DG01379): D09917 D09918
Levomethadone (DG01002): D08121 D08122
Licostinel: D04728
Memantine (DG00986): D04905<JP/US> D08174
Methadone (DG00999): D02102<JP/US> D08195
Orphenadrine (DG01252): D08305
Orphenadrine (chloride): D02599
Orphenadrine (citrate): D00774<US>
Perzinfotel: D05447
Phencyclidine hydrochloride: D05453
Remacemide hydrochloride: D05714
Riluzole: D00775<JP/US>
Selfotel: D02410
Tiletamine (DG01380): D06146 D08596
Troriluzole (DG03011): D11414
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    2906 (GRIN2D)
   04024 cAMP signaling pathway
    2906 (GRIN2D)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2906 (GRIN2D)
 09150 Organismal Systems
  09156 Nervous system
   04724 Glutamatergic synapse
    2906 (GRIN2D)
   04720 Long-term potentiation
    2906 (GRIN2D)
  09159 Environmental adaptation
   04713 Circadian entrainment
    2906 (GRIN2D)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    2906 (GRIN2D)
   05014 Amyotrophic lateral sclerosis
    2906 (GRIN2D)
   05017 Spinocerebellar ataxia
    2906 (GRIN2D)
   05020 Prion disease
    2906 (GRIN2D)
   05022 Pathways of neurodegeneration - multiple diseases
    2906 (GRIN2D)
  09165 Substance dependence
   05030 Cocaine addiction
    2906 (GRIN2D)
   05031 Amphetamine addiction
    2906 (GRIN2D)
   05033 Nicotine addiction
    2906 (GRIN2D)
   05034 Alcoholism
    2906 (GRIN2D)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2906 (GRIN2D)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  Glutamate (ionotropic)
   2906 (GRIN2D)
SSDB
Motif
Pfam: Lig_chan Lig_chan-Glu_bd SBP_bac_3 ANF_receptor NMDAR2_C MatE
Other DBs
NCBI-GeneID: 2906
NCBI-ProteinID: NP_000827
OMIM: 602717
HGNC: 4588
Ensembl: ENSG00000105464
Vega: OTTHUMG00000183304
Pharos: O15399(Tclin)
UniProt: O15399 Q59G17
LinkDB
Position
19q13.33
AA seq 1336 aa
MRGAGGPRGPRGPAKMLLLLALACASPFPEEAPGPGGAGGPGGGLGGARPLNVALVFSGP
AYAAEAARLGPAVAAAVRSPGLDVRPVALVLNGSDPRSLVLQLCDLLSGLRVHGVVFEDD
SRAPAVAPILDFLSAQTSLPIVAVHGGAALVLTPKEKGSTFLQLGSSTEQQLQVIFEVLE
EYDWTSFVAVTTRAPGHRAFLSYIEVLTDGSLVGWEHRGALTLDPGAGEAVLSAQLRSVS
AQIRLLFCAREEAEPVFRAAEEAGLTGSGYVWFMVGPQLAGGGGSGAPGEPPLLPGGAPL
PAGLFAVRSAGWRDDLARRVAAGVAVVARGAQALLRDYGFLPELGHDCRAQNRTHRGESL
HRYFMNITWDNRDYSFNEDGFLVNPSLVVISLTRDRTWEVVGSWEQQTLRLKYPLWSRYG
RFLQPVDDTQHLTVATLEERPFVIVEPADPISGTCIRDSVPCRSQLNRTHSPPPDAPRPE
KRCCKGFCIDILKRLAHTIGFSYDLYLVTNGKHGKKIDGVWNGMIGEVFYQRADMAIGSL
TINEERSEIVDFSVPFVETGISVMVARSNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAVT
VFIFEYLSPVGYNRSLATGKRPGGSTFTIGKSIWLLWALVFNNSVPVENPRGTTSKIMVL
VWAFFAVIFLASYTANLAAFMIQEEYVDTVSGLSDRKFQRPQEQYPPLKFGTVPNGSTEK
NIRSNYPDMHSYMVRYNQPRVEEALTQLKAGKLDAFIYDAAVLNYMARKDEGCKLVTIGS
GKVFATTGYGIALHKGSRWKRPIDLALLQFLGDDEIEMLERLWLSGICHNDKIEVMSSKL
DIDNMAGVFYMLLVAMGLSLLVFAWEHLVYWRLRHCLGPTHRMDFLLAFSRGMYSCCSAE
AAPPPAKPPPPPQPLPSPAYPAPRPAPGPAPFVPRERASVDRWRRTKGAGPPGGAGLADG
FHRYYGPIEPQGLGLGLGEARAAPRGAAGRPLSPPAAQPPQKPPPSYFAIVRDKEPAEPP
AGAFPGFPSPPAPPAAAATAVGPPLCRLAFEDESPPAPARWPRSDPESQPLLGPGAGGAG
GTGGAGGGAPAAPPPCRAAPPPCPYLDLEPSPSDSEDSESLGGASLGGLEPWWFADFPYP
YAERLGPPPGRYWSVDKLGGWRAGSWDYLPPRSGPAAWHCRHCASLELLPPPRHLSCSHD
GLDGGWWAPPPPPWAAGPLPRRRARCGCPRSHPHRPRASHRTPAAAAPHHHRHRRAAGGW
DLPPPAPTSRSLEDLSSCPRAAPARRLTGPSRHARRCPHAAHWGPPLPTASHRRHRGGDL
GTRRGSAHFSSLESEV
NT seq 4011 nt   +upstreamnt  +downstreamnt
atgcgcggcgccggtggcccccgcggccctcggggccccgctaagatgctgctgctgctg
gcgctggcctgcgccagcccgttcccggaggaggcgccggggccgggcggggccggtggg
cccggcggcggcctcggcggggcgcggccgctcaacgtggcgctcgtgttctcggggccc
gcgtacgcggccgaggcggcacgcctgggcccggccgtggcggcggcggtgcgcagcccg
ggcctagacgtgcggcccgtggcgctggtgctcaacggctcggacccgcgcagcctcgtg
ctgcagctctgcgacctgctgtcggggttgcgcgtgcacggcgtggtcttcgaagacgac
tcgcgcgcgcccgccgtcgcgcccatcctcgacttcctgtcggcgcagacctcgctgccc
atcgtggccgtgcacggcggcgccgcgctcgtgctcacgcccaaggagaagggctccacc
ttcctgcagctgggctcttccaccgagcaacagcttcaggtcatctttgaggtgctggag
gagtatgactggacgtcctttgtagccgtgaccactcgtgcccctggccaccgggccttc
ctgtcctacattgaggtgctgactgacggtagtctggtgggctgggagcaccgcggagcg
ctgacgctggaccctggggcgggcgaggccgtgctcagtgcccagctccgcagtgtcagc
gcgcagatccgcctgctcttctgcgcccgagaggaggccgagcccgtgttccgcgcagct
gaggaggctggcctcactggatctggctacgtctggttcatggtggggccccagctggct
ggaggcgggggctctggggcccctggtgagccccctcttctgccaggaggcgcccccctg
cctgccgggctgtttgcagtgcgctcggctggctggcgggatgacctggctcggcgagtg
gcagctggcgtggccgtagtggccagaggtgcccaggccctgctgcgtgattatggtttc
cttcctgagctcggccacgactgtcgcgcccagaaccgcacccaccgcggcgagagtctg
cataggtacttcatgaacatcacgtgggataaccgggattactccttcaatgaggacggc
ttcctagtgaacccctccctggtggtcatctccctcaccagagacaggacgtgggaggtg
gtgggcagctgggagcagcagacgctccgcctcaagtacccgctgtggtcccgctatggt
cgcttcctgcagccagtggacgacacgcagcacctcacggtggccacgctggaggaaagg
ccgtttgtcatcgtggagcctgcagaccctatcagcggcacctgcatccgagactccgtc
ccctgccggagccagctcaaccgaacccacagccctccaccggatgccccccgcccggaa
aagcgctgctgcaagggtttctgcatcgacattctgaagcggctggcgcataccatcggc
ttcagctacgacctctacctggtcaccaatggcaagcacggaaagaagatcgatggcgtc
tggaacggcatgatcggggaggtgttctaccagcgcgcagacatggccatcggctccctc
accatcaacgaggagcgctccgagatcgtggacttctccgtccccttcgtggagaccggc
atcagcgtcatggtggcgcgcagcaatggcacggtgtccccctcggccttcctcgagccc
tacagccccgccgtgtgggtgatgatgttcgtcatgtgcctcactgtggtcgccgtcact
gttttcatcttcgagtacctcagtcctgttggttacaaccgcagcctggccacgggcaag
cgccctggcggttcaaccttcaccattgggaaatccatctggctgctctgggccctggtg
ttcaataattcggtgcccgtggagaacccccggggaaccaccagcaaaatcatggtgctg
gtgtgggccttcttcgccgtcatcttcctcgccagctacacagccaacctggccgccttc
atgatccaggaggagtacgtggatactgtgtctgggctcagtgaccgcaagttccagagg
ccccaggagcagtacccgcccctgaagtttgggaccgtgcccaacggctccacggagaag
aacatccgcagcaactatcccgacatgcacagctacatggtgcgctacaaccagccccgc
gtagaggaagcgctcactcagctcaaggcagggaagctggacgccttcatctacgatgct
gcagtgctcaattacatggcccgcaaggacgagggctgcaagcttgtcaccatcggctcc
ggcaaggtcttcgccacgacaggctatggcatcgccctgcacaagggctcccgctggaag
cggcccatcgacctggcgttgctgcagttcctgggggatgatgagatcgagatgctggag
cggctgtggctctctgggatctgccacaatgacaaaatcgaggtgatgagcagcaagctg
gacatcgacaacatggcgggcgtcttctacatgctcctggtggccatgggcctgtccctg
ctggtcttcgcctgggagcacctggtgtactggcgcctgcggcactgcctggggcccacc
caccgcatggacttcctgctggccttctccaggggcatgtacagctgctgcagcgctgag
gccgccccaccgcccgccaagcccccgccgccgccacagcccctgcccagccccgcgtac
cccgcgccgcggccggctcccgggcccgcacctttcgtgccccgcgagcgcgcctcagtg
gaccgctggcgccggaccaagggcgcggggccgccggggggcgcgggcctggccgacggc
ttccaccgctactacggccccatcgagccgcagggcctaggcctcggcctgggcgaagcg
cgcgcggcaccgcggggcgcagccgggcgcccgctgtccccgccggccgctcagcccccg
cagaagccgccgccctcctatttcgccatcgtacgcgacaaggagccagccgagcccccc
gccggcgccttccccggcttcccgtcgccgcccgcgccccccgccgccgcggccaccgcc
gtcgggccgccactctgccgcttggccttcgaggacgagagcccgccggcgcccgcgcgg
tggccgcgctcggaccccgagagccaacccctgctggggccaggcgcgggcggcgcgggg
ggcacggggggcgcaggcggaggagccccggccgctccgcccccgtgccgcgccgcgccg
cccccgtgcccttacctcgatctcgagccgtcgccgtcggactcggaggactcggagagc
ctgggcggcgcgtcgctgggcggcctggagccctggtggttcgccgacttcccttacccg
tatgccgagcgcctcgggccgccgcccggccgctactggtcggtcgacaagctcgggggc
tggcgcgccgggagctgggactacctgcccccgcgcagcggtccggccgcctggcactgt
cggcactgcgccagcctggagctgctgccgccgccgcgccatctcagctgctcgcacgat
ggcctggacggcggctggtgggcgccaccgcctccaccctgggccgccgggcccctgccc
cgacgccgggcccgctgcgggtgcccgcggtcgcacccgcaccgcccgcgggcctcgcac
cgcacgcccgccgccgccgcgccccaccaccacaggcaccggcgcgccgctgggggctgg
gacctcccgccgcccgcgcccacctcgcgctcgctcgaggacctcagctcgtgccctcgc
gccgcccctgcgcgcaggcttaccgggccctcccgccacgctcgcaggtgtccgcacgcc
gcgcactgggggccgccgctgcccacagcttcccaccggagacaccggggcggggacctg
ggcacccgcaggggctcggcgcacttctctagcctcgagtccgaggtatga

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