Homo sapiens (human): 1312 Help Entry 1312              CDS       T01001                                  Gene name COMT, HEL-S-98n Definition (RefSeq) catechol-O-methyltransferase   KO K00545   catechol O-methyltransferase [EC:2.1.1.6] Organism hsa  Homo sapiens (human) Pathway hsa00140   Steroid hormone biosynthesis hsa00350   Tyrosine metabolism hsa01100   Metabolic pathways hsa04728   Dopaminergic synapse Disease H01450   Obsessive-compulsive disorder Drug target Entacapone:  D00781<JP/US> Flopropione:  D01259<JP> Nitecapone:  D03241 Opicapone:  D10825<JP/US> Phloroglucinol (DG00050):  D00152 D08369 Tolcapone:  D00786<US> Brite KEGG Orthology (KO) [BR:hsa00001]  09100 Metabolism   09103 Lipid metabolism    00140 Steroid hormone biosynthesis     1312 (COMT)   09105 Amino acid metabolism    00350 Tyrosine metabolism     1312 (COMT)  09150 Organismal Systems   09156 Nervous system    04728 Dopaminergic synapse     1312 (COMT)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:hsa04147]     1312 (COMT) Enzymes [BR:hsa01000]  2. Transferases   2.1  Transferring one-carbon groups    2.1.1  Methyltransferases     2.1.1.6  catechol O-methyltransferase      1312 (COMT) Exosome [BR:hsa04147]  Exosomal proteins   Exosomal proteins of breast cancer cells    1312 (COMT) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Methyltransf_3 Methyltransf_24 Methyltransf_15 CmcI PCMT Methyltransf_31 Motif Other DBs NCBI-GeneID:  1312 NCBI-ProteinID:  NP_000745 OMIM:  116790 HGNC:  2228 Ensembl:  ENSG00000093010 Vega:  OTTHUMG00000150529 Pharos:  P21964(Tclin) UniProt:  P21964 A0A140VJG8 LinkDB All DBs Structure PDB:  3BWY 6I3C 4PYI 6I3D 5LSA 4XUC 4PYJ 3BWM 4PYK 4XUE 4XUD 3A7E Thumbnails Position 22q11.21 AA seq 271 aa AA seqDB search MPEAPPLLLAAVLLGLVLLVVLLLLLRHWGWGLCLIGWNEFILQPIHNLLMGDTKEQRIL NHVLQHAEPGNAQSVLEAIDTYCEQKEWAMNVGDKKGKIVDAVIQEHQPSVLLELGAYCG YSAVRMARLLSPGARLITIEINPDCAAITQRMVDFAGVKDKVTLVVGASQDIIPQLKKKY DVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVICPGAPDFLAHVRGSSCFE CTHYQSFLEYREVVDGLEKAIYKGPGSEAGP NT seq 816 nt NT seq  +upstreamnt  +downstreamnt atgccggaggccccgcctctgctgttggcagctgtgttgctgggcctggtgctgctggtg gtgctgctgctgcttctgaggcactggggctggggcctgtgccttatcggctggaacgag ttcatcctgcagcccatccacaacctgctcatgggtgacaccaaggagcagcgcatcctg aaccacgtgctgcagcatgcggagcccgggaacgcacagagcgtgctggaggccattgac acctactgcgagcagaaggagtgggccatgaacgtgggcgacaagaaaggcaagatcgtg gacgccgtgattcaggagcaccagccctccgtgctgctggagctgggggcctactgtggc tactcagctgtgcgcatggcccgcctgctgtcaccaggggcgaggctcatcaccatcgag atcaaccccgactgtgccgccatcacccagcggatggtggatttcgctggcgtgaaggac aaggtcacccttgtggttggagcgtcccaggacatcatcccccagctgaagaagaagtat gatgtggacacactggacatggtcttcctcgaccactggaaggaccggtacctgccggac acgcttctcttggaggaatgtggcctgctgcggaaggggacagtgctactggctgacaac gtgatctgcccaggtgcgccagacttcctagcacacgtgcgcgggagcagctgctttgag tgcacacactaccaatcgttcctggaatacagggaggtggtggacggcctggagaaggcc atctacaagggcccaggcagcgaagcagggccctga

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