KEGG   Homo sapiens (human): 131890Help
Entry
131890            CDS       T01001                                 

Gene name
GRK7, GPRK7
Definition
(RefSeq) G protein-coupled receptor kinase 7
  KO
K00909  rhodopsin kinase [EC:2.7.11.14]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04062  Chemokine signaling pathway
hsa04144  Endocytosis
hsa04744  Phototransduction
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    131890 (GRK7)
 09150 Organismal Systems
  09151 Immune system
   04062 Chemokine signaling pathway
    131890 (GRK7)
  09157 Sensory system
   04744 Phototransduction
    131890 (GRK7)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    131890 (GRK7)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.14  rhodopsin kinase
     131890 (GRK7)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: AGC group
  GRK family [OT]
   131890 (GRK7)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Pkinase Pkinase_Tyr RGS Kinase-like
Motif
Other DBs
NCBI-GeneID: 131890
NCBI-ProteinID: NP_631948
OMIM: 606987
HGNC: 17031
Ensembl: ENSG00000114124
Vega: OTTHUMG00000159068
Pharos: Q8WTQ7(Tchem)
UniProt: Q8WTQ7
LinkDB All DBs
Position
3q23
AA seq 553 aa AA seqDB search
MVDMGALDNLIANTAYLQARKPSDCDSKELQRRRRSLALPGLQGCAELRQKLSLNFHSLC
EQQPIGRRLFRDFLATVPTFRKAATFLEDVQNWELAEEGPTKDSALQGLVATCASAPAPG
NPQPFLSQAVATKCQAATTEEERVAAVTLAKAEAMAFLQEQPFKDFVTSAFYDKFLQWKL
FEMQPVSDKYFTEFRVLGKGGFGEVCAVQVKNTGKMYACKKLDKKRLKKKGGEKMALLEK
EILEKVSSPFIVSLAYAFESKTHLCLVMSLMNGGDLKFHIYNVGTRGLDMSRVIFYSAQI
ACGMLHLHELGIVYRDMKPENVLLDDLGNCRLSDLGLAVEMKGGKPITQRAGTNGYMAPE
ILMEKVSYSYPVDWFAMGCSIYEMVAGRTPFKDYKEKVSKEDLKQRTLQDEVKFQHDNFT
EEAKDICRLFLAKKPEQRLGSREKSDDPRKHHFFKTINFPRLEAGLIEPPFVPDPSVVYA
KDIAEIDDFSEVRGVEFDDKDKQFFKNFATGAVPIAWQEEIIETGLFEELNDPNRPTGCE
EGNSSKSGVCLLL
NT seq 1662 nt NT seq  +upstreamnt  +downstreamnt
atggtggacatgggggccctggacaacctgatcgccaacaccgcctacctgcaggcccgg
aagccctcggactgcgacagcaaagagctgcagcggcggcggcgtagcctggccctgccc
gggctgcagggctgcgcggagctccgccagaagctgtccctgaacttccacagcctgtgt
gagcagcagcccatcggtcgccgcctcttccgtgacttcctagccacagtgcccacgttc
cgcaaggcggcaaccttcctagaggacgtgcagaactgggagctggccgaggagggaccc
accaaagacagcgcgctgcaggggctggtggccacttgtgcgagtgcccctgccccgggg
aacccgcaacccttcctcagccaggccgtggccaccaagtgccaagcagccaccactgag
gaagagcgagtggctgcagtgacgctggccaaggctgaggccatggctttcttgcaagag
cagccctttaaggatttcgtgaccagcgccttctacgacaagtttctgcagtggaaactc
ttcgagatgcaaccagtgtcagacaagtacttcactgagttcagagtgctggggaaaggt
ggttttggggaggtatgtgccgtccaggtgaaaaacactgggaagatgtatgcctgtaag
aaactggacaagaagcggctgaagaagaaaggtggcgagaagatggctctcttggaaaag
gaaatcttggagaaggtcagcagccctttcattgtctctctggcctatgcctttgagagc
aagacccatctctgccttgtcatgagcctgatgaatgggggagacctcaagttccacatc
tacaacgtgggcacgcgtggcctggacatgagccgggtgatcttttactcggcccagata
gcctgtgggatgctgcacctccatgaactcggcatcgtctatcgggacatgaagcctgag
aatgtgcttctggatgacctcggcaactgcaggttatctgacctggggctggccgtggag
atgaagggtggcaagcccatcacccagagggctggaaccaatggttacatggctcctgag
atcctaatggaaaaggtaagttattcctatcctgtggactggtttgccatgggatgcagc
atttatgaaatggttgctggacgaacaccattcaaagattacaaggaaaaggtcagtaaa
gaggatctgaagcaaagaactctgcaagacgaggtcaaattccagcatgataacttcaca
gaggaagcaaaagatatttgcaggctcttcttggctaagaaaccagagcaacgcttagga
agcagagaaaagtctgatgatcccaggaaacatcatttctttaaaacgatcaactttcct
cgcctggaagctggcctaattgaacccccatttgtgccagacccttcagtggtttatgcc
aaagacatcgctgaaattgatgatttctctgaggttcggggggtggaatttgatgacaaa
gataagcagttcttcaaaaactttgcgacaggtgctgttcctatagcatggcaggaagaa
attatagaaacgggactgtttgaggaactgaatgaccccaacagacctacgggttgtgag
gagggtaattcatccaagtctggcgtgtgtttgttattgtaa

KEGG   Homo sapiens (human): 156Help
Entry
156               CDS       T01001                                 

Gene name
GRK2, ADRBK1, BARK1, BETA-ARK1
Definition
(RefSeq) G protein-coupled receptor kinase 2
  KO
K00910  beta-adrenergic-receptor kinase [EC:2.7.11.15]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04062  Chemokine signaling pathway
hsa04144  Endocytosis
hsa04340  Hedgehog signaling pathway
hsa04724  Glutamatergic synapse
hsa04740  Olfactory transduction
hsa05032  Morphine addiction
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04340 Hedgehog signaling pathway
    156 (GRK2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    156 (GRK2)
 09150 Organismal Systems
  09151 Immune system
   04062 Chemokine signaling pathway
    156 (GRK2)
  09156 Nervous system
   04724 Glutamatergic synapse
    156 (GRK2)
  09157 Sensory system
   04740 Olfactory transduction
    156 (GRK2)
 09160 Human Diseases
  09165 Substance dependence
   05032 Morphine addiction
    156 (GRK2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    156 (GRK2)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    156 (GRK2)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.15  beta-adrenergic-receptor kinase
     156 (GRK2)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: AGC group
  GRK family [OT]
   156 (GRK2)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   156 (GRK2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Pkinase Pkinase_Tyr RGS PH Kinase-like Pkinase_fungal HTH_WhiA
Motif
Other DBs
NCBI-GeneID: 156
NCBI-ProteinID: NP_001610
OMIM: 109635
HGNC: 289
Ensembl: ENSG00000173020
Vega: OTTHUMG00000167104
Pharos: P25098(Tbio)
UniProt: P25098 A0A0S2Z392
LinkDB All DBs
Structure
PDB: 

Position
11q13.2
AA seq 689 aa AA seqDB search
MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFS
QKLGYLLFRDFCLNHLEEARPLVEFYEEIKKYEKLETEEERVARSREIFDSYIMKELLAC
SHPFSKSATEHVQGHLGKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNV
ELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNER
IMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAE
IILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPE
VLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPE
LRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAA
DAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARK
KAKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSL
LTMEEIQSVEETQIKERKCLLLKIRGGKQFILQCDSDPELVQWKKELRDAYREAQQLVQR
VPKMKNKPRSPVVELSKVPLVQRGSANGL
NT seq 2070 nt NT seq  +upstreamnt  +downstreamnt
atggcggacctggaggcggtgctggccgacgtgagctacctgatggccatggagaagagc
aaggccacgccggccgcgcgcgccagcaagaagatcctgctgcccgagcccagcatccgc
agtgtcatgcagaagtacctggaggaccggggcgaggtgacctttgagaagatcttttcc
cagaagctggggtacctgctcttccgagacttctgcctgaaccacctggaggaggccagg
cccttggtggaattctatgaggagatcaagaagtacgagaagctggagacggaggaggag
cgtgtggcccgcagccgggagatcttcgactcatacatcatgaaggagctgctggcctgc
tcgcatcccttctcgaagagtgccactgagcatgtccaaggccacctggggaagaagcag
gtgcctccggatctcttccagccatacatcgaagagatttgtcaaaacctccgaggggac
gtgttccagaaattcattgagagcgataagttcacacggttttgccagtggaagaatgtg
gagctcaacatccacctgaccatgaatgacttcagcgtgcatcgcatcattgggcgcggg
ggctttggcgaggtctatgggtgccggaaggctgacacaggcaagatgtacgccatgaag
tgcctggacaaaaagcgcatcaagatgaagcagggggagaccctggccctgaacgagcgc
atcatgctctcgctcgtcagcactggggactgcccattcattgtctgcatgtcatacgcg
ttccacacgccagacaagctcagcttcatcctggacctcatgaacggtggggacctgcac
taccacctctcccagcacggggtcttctcagaggctgacatgcgcttctatgcggccgag
atcatcctgggcctggagcacatgcacaaccgcttcgtggtctaccgggacctgaagcca
gccaacatccttctggacgagcatggccacgtgcggatctcggacctgggcctggcctgt
gacttctccaagaagaagccccatgccagcgtgggcacccacgggtacatggctccggag
gtcctgcagaagggcgtggcctacgacagcagtgccgactggttctctctggggtgcatg
ctcttcaagttgctgcgggggcacagccccttccggcagcacaagaccaaagacaagcat
gagatcgaccgcatgacgctgacgatggccgtggagctgcccgactccttctcccctgaa
ctacgctccctgctggaggggttgctgcagagggatgtcaaccggagattgggctgcctg
ggccgaggggctcaggaggtgaaagagagcccctttttccgctccctggactggcagatg
gtcttcttgcagaagtaccctcccccgctgatccccccacgaggggaggtgaacgcggcc
gacgccttcgacattggctccttcgatgaggaggacacaaaaggaatcaagttactggac
agtgatcaggagctctaccgcaacttccccctcaccatctcggagcggtggcagcaggag
gtggcagagactgtcttcgacaccatcaacgctgagacagaccggctggaggctcgcaag
aaagccaagaacaagcagctgggccatgaggaagactacgccctgggcaaggactgcatc
atgcatggctacatgtccaagatgggcaaccccttcctgacccagtggcagcggcggtac
ttctacctgttccccaaccgcctcgagtggcggggcgagggcgaggccccgcagagcctg
ctgaccatggaggagatccagtcggtggaggagacgcagatcaaggagcgcaagtgcctg
ctcctcaagatccgcggtgggaaacagttcattttgcagtgcgatagcgaccctgagctg
gtgcagtggaagaaggagctgcgcgacgcctaccgcgaggcccagcagctggtgcagcgg
gtgcccaagatgaagaacaagccgcgctcgcccgtggtggagctgagcaaggtgccgctg
gtccagcgcggcagtgccaacggcctctga

KEGG   Homo sapiens (human): 157Help
Entry
157               CDS       T01001                                 

Gene name
GRK3, ADRBK2, BARK2
Definition
(RefSeq) G protein-coupled receptor kinase 3
  KO
K00910  beta-adrenergic-receptor kinase [EC:2.7.11.15]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04062  Chemokine signaling pathway
hsa04144  Endocytosis
hsa04340  Hedgehog signaling pathway
hsa04724  Glutamatergic synapse
hsa04740  Olfactory transduction
hsa05032  Morphine addiction
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04340 Hedgehog signaling pathway
    157 (GRK3)
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    157 (GRK3)
 09150 Organismal Systems
  09151 Immune system
   04062 Chemokine signaling pathway
    157 (GRK3)
  09156 Nervous system
   04724 Glutamatergic synapse
    157 (GRK3)
  09157 Sensory system
   04740 Olfactory transduction
    157 (GRK3)
 09160 Human Diseases
  09165 Substance dependence
   05032 Morphine addiction
    157 (GRK3)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    157 (GRK3)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    157 (GRK3)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.15  beta-adrenergic-receptor kinase
     157 (GRK3)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: AGC group
  GRK family [OT]
   157 (GRK3)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   157 (GRK3)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Pkinase Pkinase_Tyr RGS PH Pkinase_fungal HTH_WhiA
Motif
Other DBs
NCBI-GeneID: 157
NCBI-ProteinID: NP_005151
OMIM: 109636
HGNC: 290
Ensembl: ENSG00000100077
Vega: OTTHUMG00000150280
Pharos: P35626(Tbio)
UniProt: P35626 A0A024R1D8 Q8N433
LinkDB All DBs
Position
22q12.1
AA seq 688 aa AA seqDB search
MADLEAVLADVSYLMAMEKSKATPAARASKRIVLPEPSIRSVMQKYLAERNEITFDKIFN
QKIGFLLFKDFCLNEINEAVPQVKFYEEIKEYEKLDNEEDRLCRSRQIYDAYIMKELLSC
SHPFSKQAVEHVQSHLSKKQVTSTLFQPYIEEICESLRGDIFQKFMESDKFTRFCQWKNV
ELNIHLTMNEFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNER
IMLSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFSEKEMRFYATE
IILGLEHMHNRFVVYRDLKPANILLDEHGHARISDLGLACDFSKKKPHASVGTHGYMAPE
VLQKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTVNVELPDTFSPE
LKSLLEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPPLIPPRGEVNAA
DAFDIGSFDEEDTKGIKLLDCDQELYKNFPLVISERWQQEVTETVYEAVNADTDKIEARK
RAKNKQLGHEEDYALGKDCIMHGYMLKLGNPFLTQWQRRYFYLFPNRLEWRGEGESRQNL
LTMEQILSVEETQIKDKKCILFRIKGGKQFVLQCESDPEFVQWKKELNETFKEAQRLLRR
APKFLNKPRSGTVELPKPSLCHRNSNGL
NT seq 2067 nt NT seq  +upstreamnt  +downstreamnt
atggcggacctggaggctgtgctggccgatgtcagttacctgatggccatggagaagagc
aaggcgaccccggccgcccgcgccagcaagaggatcgtcctgccggagcccagtatccgg
agtgtgatgcagaagtaccttgcagagagaaatgaaataacctttgacaagattttcaat
cagaaaattggtttcttgctatttaaagatttttgtttgaatgaaattaatgaagctgta
cctcaggtgaagttttatgaagagataaaggaatatgaaaaacttgataatgaggaagac
cgcctttgcagaagtcgacaaatttatgatgcctacatcatgaaggaacttctttcctgt
tcacatcctttctcaaagcaagctgtagaacacgtacaaagtcatttatccaagaaacaa
gtgacatcaactctttttcagccatacatagaagaaatttgtgaaagccttcgaggtgac
atttttcaaaaatttatggaaagtgacaagttcactagattttgtcagtggaaaaacgtt
gaattaaatatccatttgaccatgaatgagttcagtgtgcataggattattggacgagga
ggattcggggaagtttatggttgcaggaaagcagacactggaaaaatgtatgcaatgaaa
tgcttagataagaagaggatcaaaatgaaacaaggagaaacattagccttaaatgaaaga
atcatgttgtctcttgtcagcacaggagactgtcctttcattgtatgtatgacctatgcc
ttccataccccagataaactctgcttcatcctggatctgatgaacgggggcgatttgcac
taccacctttcacaacacggtgtgttctctgagaaggagatgcggttttatgccactgaa
atcattctgggtctggaacacatgcacaatcggtttgttgtctacagagatttgaagcca
gcaaatattctcttggatgaacatggacacgcaagaatatcagatcttggtcttgcctgc
gatttttccaaaaagaagcctcatgcgagtgttggcacccatgggtacatggctcccgag
gtgctgcagaaggggacggcctatgacagcagtgccgactggttctccctgggctgcatg
cttttcaaacttctgagaggtcacagccctttcagacaacataaaaccaaagacaagcat
gaaattgaccgaatgacactcaccgtgaatgtggaacttccagacaccttctctcctgaa
ctgaagtcccttttggagggcttgcttcagcgagacgttagcaagcggctgggctgtcac
ggaggcggctcacaggaagtaaaagagcacagctttttcaaaggtgttgactggcagcat
gtctacttacaaaagtacccaccacccttgattcctccccggggagaagtcaatgctgct
gatgcctttgatattggctcatttgatgaagaggataccaaagggattaagctacttgat
tgcgaccaagaactctacaagaacttccctttggtcatctctgaacgctggcagcaagaa
gtaacggaaacagtttatgaagcagtaaatgcagacacagataaaatcgaggccaggaag
agagctaaaaataagcaacttggccacgaagaagattacgctctggggaaggactgtatt
atgcacgggtacatgctgaaactgggaaacccatttctgactcagtggcagcgtcgctat
ttttacctctttccaaatagacttgaatggagaggagagggagagtcccggcaaaattta
ctgacaatggaacagattctctctgtggaagaaactcaaattaaagacaaaaaatgcatt
ttgttcagaataaaaggagggaaacaatttgtcttgcaatgtgagagtgatccagagttt
gtgcagtggaagaaagagttgaacgaaaccttcaaggaggcccagcggctattgcgtcgt
gccccgaagttcctcaacaaacctcggtcaggtactgtggagctcccaaagccatccctc
tgtcacagaaacagcaacggcctctag

KEGG   Homo sapiens (human): 2868Help
Entry
2868              CDS       T01001                                 

Gene name
GRK4, GPRK2L, GPRK4, GRK4a, IT11
Definition
(RefSeq) G protein-coupled receptor kinase 4
  KO
K08291  G protein-coupled receptor kinase [EC:2.7.11.16]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04062  Chemokine signaling pathway
hsa04144  Endocytosis
hsa05032  Morphine addiction
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    2868 (GRK4)
 09150 Organismal Systems
  09151 Immune system
   04062 Chemokine signaling pathway
    2868 (GRK4)
 09160 Human Diseases
  09165 Substance dependence
   05032 Morphine addiction
    2868 (GRK4)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    2868 (GRK4)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.16  G-protein-coupled receptor kinase
     2868 (GRK4)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: AGC group
  GRK family [OT]
   2868 (GRK4)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Pkinase Pkinase_Tyr RGS Kinase-like Pkinase_fungal
Motif
Other DBs
NCBI-GeneID: 2868
NCBI-ProteinID: NP_892027
OMIM: 137026
HGNC: 4543
Ensembl: ENSG00000125388
Vega: OTTHUMG00000159914
Pharos: P32298(Tchem)
UniProt: P32298
LinkDB All DBs
Structure
PDB: 

Position
4p16.3
AA seq 578 aa AA seqDB search
MELENIVANSLLLKARQGGYGKKSGRSKKWKEILTLPPVSQCSELRHSIEKDYSSLCDKQ
PIGRRLFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAAPLPE
IPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQ
PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILE
KVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGL
EDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNN
EKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSI
CRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLD
IEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNEMIESGCFKDINKSESEEALPLDLDK
NIHTPVSRPNRGFFYRLFRRGGCLTMVPSEKEVEPKQC
NT seq 1737 nt NT seq  +upstreamnt  +downstreamnt
atggagctcgagaacatcgtggccaactcgctgctgctgaaagcgcgtcaaggaggatat
ggcaaaaaaagtggtcgtagtaaaaaatggaaggagatactgacactgcctcctgtcagc
cagtgcagtgagcttagacattccattgaaaaggattatagcagtctttgtgacaagcaa
ccgataggaagacgtctcttcaggcagttctgtgataccaaacccactctaaagaggcac
attgaattcttggatgcagtggcagaatatgaagttgccgatgatgaggaccgaagtgat
tgtggactgtcaatcttagatagattcttcaatgataagttggcagcccctttaccagaa
atacctccagatgttgtgacagaatgtagattgggactgaaggaggagaacccttccaaa
aaagcctttgaggaatgtactagagttgcccataactacctaagaggggaaccatttgaa
gaataccaagaaagctcatatttttctcagtttttacaatggaaatggctggaaaggcaa
cccgtaacaaagaacacatttagacattacagagttctaggaaaaggcggatttggagag
gtttgcgcctgtcaagtgcgagccacaggaaaaatgtatgcctgcaaaaagctacaaaaa
aaaagaataaagaagaggaaaggtgaagctatggctctaaatgagaaaagaattctggag
aaagtgcaaagtagattcgtagttagtttagcctacgcttatgaaaccaaagatgccttg
tgcttggtgctcaccattatgaatggaggggatttgaagtttcacatttacaacctgggc
aatcccggctttgatgagcagagagccgttttctatgctgcagagctgtgttgcggcttg
gaagatttacagagggaaagaattgtatacagagacttgaagcctgagaatattctcctt
gatgatcgtggacacatccggatttcagacctcggtttggccacagagatcccagaagga
cagagggttcgaggaagagttggaacagtcggctacatggcacctgaagttgtcaataat
gaaaagtatacgtttagtcccgattggtggggacttggctgtctgatctatgaaatgatt
cagggacattctccattcaaaaaatacaaagagaaagtcaaatgggaggaggtcgatcaa
agaatcaagaatgataccgaggagtattctgagaagttttcagaggatgccaaatctatc
tgcaggatgttactcaccaagaatccaagcaagcggctgggctgcaggggcgagggagcg
gctggggtgaagcagcaccccgtgttcaaggacatcaacttcaggaggctggaggcaaac
atgctggagccccctttctgtcctgatcctcatgccgtttactgtaaggacgtcctggat
atcgagcagttctcggtggtgaaagggatctacctggacaccgcagatgaagacttctat
gctcggtttgctaccgggtgtgtctccatcccctggcagaatgagatgatcgaatctggg
tgtttcaaagacatcaacaaaagtgaaagtgaggaagctttgccattagatctagacaag
aacatacataccccggtttccagaccaaacagaggcttcttctatagactcttcagaaga
gggggctgcctgaccatggtccccagtgagaaggaagtggaacccaagcaatgctga

KEGG   Homo sapiens (human): 2869Help
Entry
2869              CDS       T01001                                 

Gene name
GRK5, FP2025, GPRK5
Definition
(RefSeq) G protein-coupled receptor kinase 5
  KO
K08291  G protein-coupled receptor kinase [EC:2.7.11.16]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04062  Chemokine signaling pathway
hsa04144  Endocytosis
hsa05032  Morphine addiction
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    2869 (GRK5)
 09150 Organismal Systems
  09151 Immune system
   04062 Chemokine signaling pathway
    2869 (GRK5)
 09160 Human Diseases
  09165 Substance dependence
   05032 Morphine addiction
    2869 (GRK5)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    2869 (GRK5)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.16  G-protein-coupled receptor kinase
     2869 (GRK5)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: AGC group
  GRK family [OT]
   2869 (GRK5)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Pkinase Pkinase_Tyr RGS Kinase-like Pkinase_fungal
Motif
Other DBs
NCBI-GeneID: 2869
NCBI-ProteinID: NP_005299
OMIM: 600870
HGNC: 4544
Ensembl: ENSG00000198873
Vega: OTTHUMG00000019149
Pharos: P34947(Tbio)
UniProt: P34947
LinkDB All DBs
Structure
PDB: 

Position
10q26.11
AA seq 590 aa AA seqDB search
MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQ
PIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQ
VGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQP
VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEK
VNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLE
DLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQ
RYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSIC
KMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDI
EQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRN
HPPEPPKKGLLQRLFKRQHQNNSKSSPSSKTSFNHHINSNHVSSNSTGSS
NT seq 1773 nt NT seq  +upstreamnt  +downstreamnt
atggagctggaaaacatcgtggccaacacggtcttgctgaaagccagggaagggggcgga
ggaaagcgcaaagggaaaagcaagaagtggaaagaaatcctgaagttccctcacattagc
cagtgtgaagacctccgaaggaccatagacagagattactgcagtttatgtgacaagcag
ccaatcgggaggctgcttttccggcagttttgtgaaaccaggcctgggctggagtgttac
attcagttcctggactccgtggcagaatatgaagttactccagatgaaaaactgggagag
aaagggaaggaaattatgaccaagtacctcaccccaaagtcccctgttttcatagcccaa
gttggccaagacctggtctcccagacggaggagaagctcctacagaagccgtgcaaagaa
ctcttttctgcctgtgcacagtctgtccacgagtacctgaggggagaaccattccacgaa
tatctggacagcatgttttttgaccgctttctccagtggaagtggttggaaaggcaaccg
gtgaccaaaaacactttcaggcagtatcgagtgctaggaaaagggggcttcggggaggtc
tgtgcctgccaggttcgggccacgggtaaaatgtatgcctgcaagcgcttggagaagaag
aggatcaaaaagaggaaaggggagtccatggccctcaatgagaagcagatcctcgagaag
gtcaacagtcagtttgtggtcaacctggcctatgcctacgagaccaaggatgcactgtgc
ttggtcctgaccatcatgaatgggggtgacctgaagttccacatctacaacatgggcaac
cctggcttcgaggaggagcgggccttgttttatgcggcagagatcctctgcggcttagaa
gacctccaccgtgagaacaccgtctaccgagatctgaaacctgaaaacatcctgttagat
gattatggccacattaggatctcagacctgggcttggctgtgaagatccccgagggagac
ctgatccgcggccgggtgggcactgttggctacatggctccagaggtcctgaacaaccag
aggtacggcctgagccccgactactggggccttggctgcctcatctatgagatgatcgag
ggccagtcgccgttccgcggccgcaaggagaaggtgaagcgggaggaggtggaccgccgg
gtcctggagacggaggaggtgtactcccacaagttctccgaggaggccaagtccatctgc
aagatgctgctcacgaaagatgcgaagcagaggctgggctgccaggaggagggggctgca
gaggtcaagagacaccccttcttcaggaacatgaacttcaagcgcttagaagccgggatg
ttggaccctcccttcgttccagacccccgcgctgtgtactgtaaggacgtgctggacatc
gagcagttctccactgtgaagggcgtcaatctggaccacacagacgacgacttctactcc
aagttctccacgggctctgtgtccatcccatggcaaaacgagatgatagaaacagaatgc
tttaaggagctgaacgtgtttggacctaatggtaccctcccgccagatctgaacagaaac
caccctccggaaccgcccaagaaagggctgctccagagactcttcaagcggcagcatcag
aacaattccaagagttcgcccagctccaagaccagttttaaccaccacataaactcaaac
catgtcagctcgaactccaccggaagcagctag

KEGG   Homo sapiens (human): 2870Help
Entry
2870              CDS       T01001                                 

Gene name
GRK6, GPRK6
Definition
(RefSeq) G protein-coupled receptor kinase 6
  KO
K08291  G protein-coupled receptor kinase [EC:2.7.11.16]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04062  Chemokine signaling pathway
hsa04144  Endocytosis
hsa05032  Morphine addiction
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    2870 (GRK6)
 09150 Organismal Systems
  09151 Immune system
   04062 Chemokine signaling pathway
    2870 (GRK6)
 09160 Human Diseases
  09165 Substance dependence
   05032 Morphine addiction
    2870 (GRK6)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    2870 (GRK6)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.16  G-protein-coupled receptor kinase
     2870 (GRK6)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: AGC group
  GRK family [OT]
   2870 (GRK6)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Pkinase Pkinase_Tyr RGS Kinase-like Pkinase_fungal Haspin_kinase
Motif
Other DBs
NCBI-GeneID: 2870
NCBI-ProteinID: NP_001004106
OMIM: 600869
HGNC: 4545
Ensembl: ENSG00000198055
Vega: OTTHUMG00000163401
Pharos: P43250(Tbio)
UniProt: P43250
LinkDB All DBs
Structure
PDB: 

Position
5q35.3
AA seq 576 aa AA seqDB search
MELENIVANTVLLKAREGGGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCERQ
PIGRLLFREFCATRPELSRCVAFLDGVAEYEVTPDDKRKACGRQLTQNFLSHTGPDLIPE
VPRQLVTNCTQRLEQGPCKDLFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWLERQP
VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEK
VNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLE
DLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNE
RYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLC
SQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLDI
EQFSTVKGVELEPTDQDFYQKFATGSVPIPWQNEMVETECFQELNVFGLDGSVPPDLDWK
GQPPAPPKKGLLQRLFSRQDCCGNCSDSEEELPTRL
NT seq 1731 nt NT seq  +upstreamnt  +downstreamnt
atggagctcgagaacatcgtagcgaacacggtgctactcaaggcccgggaaggtggcggt
ggaaatcgcaaaggcaaaagcaagaaatggcggcagatgctccagttccctcacatcagc
cagtgcgaagagctgcggctcagcctcgagcgtgactatcacagcctgtgcgagcggcag
cccattgggcgcctgctgttccgagagttctgtgccacgaggccggagctgagccgctgc
gtcgccttcctggatggggtggccgagtatgaagtgaccccggatgacaagcggaaggca
tgtgggcggcagctaacgcagaattttctgagccacacgggtcctgacctcatccctgag
gtcccccggcagctggtgacgaactgcacccagcggctggagcagggtccctgcaaagac
cttttccaggaactcacccggctgacccacgagtacctgagcgtggccccttttgccgac
tacctcgacagcatctacttcaaccgtttcctgcagtggaagtggctggaaaggcagcca
gtgaccaaaaacaccttcaggcaataccgagtcctgggcaaaggtggctttggggaggtg
tgcgcctgccaggtgcgggccacaggtaagatgtatgcctgcaagaagctagagaaaaag
cggatcaagaagcggaaaggggaggccatggcgctgaacgagaagcagatcctggagaaa
gtgaacagtaggtttgtagtgagcttggcctacgcctatgagaccaaggacgcgctgtgc
ctggtgctgacactgatgaacgggggcgacctcaagttccacatctaccacatgggccag
gctggcttccccgaagcgcgggccgtcttctacgccgccgagatctgctgtggcctggag
gacctgcaccgggagcgcatcgtgtacagggacctgaagcccgagaacatcttgctggat
gaccacggccacatccgcatctctgacctgggactagctgtgcatgtgcccgagggccag
accatcaaagggcgtgtgggcaccgtgggttacatggctccggaggtggtgaagaatgaa
cggtacacgttcagccctgactggtgggcgctcggctgcctcctgtacgagatgatcgca
ggccagtcgcccttccagcagaggaagaagaagatcaagcgggaggaggtggagcggctg
gtgaaggaggtccccgaggagtattccgagcgcttttccccgcaggcccgctcactttgc
tcacagctcctctgcaaggaccctgccgaacgcctggggtgtcgtgggggcagtgcccgc
gaggtgaaggagcaccccctctttaagaagctgaacttcaagcggctgggagctggcatg
ctggagccgccgttcaagcctgacccccaggccatttactgcaaggatgttctggacatt
gaacagttctctacggtcaagggcgtggagctggagcctaccgaccaggacttctaccag
aagtttgccacaggcagtgtgcccatcccctggcagaacgagatggtggagaccgagtgc
ttccaagagctgaatgtctttgggctggatggctcagttcccccagacctggactggaag
ggccagccacctgcacctcctaaaaagggactgctgcagagactcttcagtcgccaagat
tgctgtggaaactgcagcgacagcgaggaagagctccccacccgcctctag

KEGG   Homo sapiens (human): 6011Help
Entry
6011              CDS       T01001                                 

Gene name
GRK1, GPRK1, RHOK, RK
Definition
(RefSeq) G protein-coupled receptor kinase 1
  KO
K00909  rhodopsin kinase [EC:2.7.11.14]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04062  Chemokine signaling pathway
hsa04144  Endocytosis
hsa04744  Phototransduction
Disease
H00787  Congenital stationary night blindness
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    6011 (GRK1)
 09150 Organismal Systems
  09151 Immune system
   04062 Chemokine signaling pathway
    6011 (GRK1)
  09157 Sensory system
   04744 Phototransduction
    6011 (GRK1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    6011 (GRK1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.14  rhodopsin kinase
     6011 (GRK1)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: AGC group
  GRK family [OT]
   6011 (GRK1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Pkinase Pkinase_Tyr RGS Pkinase_fungal Kinase-like
Motif
Other DBs
NCBI-GeneID: 6011
NCBI-ProteinID: NP_002920
OMIM: 180381
HGNC: 10013
Ensembl: ENSG00000185974
Vega: OTTHUMG00000185528
Pharos: Q15835(Tchem)
UniProt: Q15835
LinkDB All DBs
Structure
PDB: 

Position
13q34
AA seq 563 aa AA seqDB search
MDFGSLETVVANSAFIAARGSFDGSSSQPSRDKKYLAKLKLPPLSKCESLRDSLSLEFES
VCLEQPIGKKLFQQFLQSAEKHLPALELWKDIEDYDTADNDLQPQKAQTILAQYLDPQAK
LFCSFLDEGIVAKFKEGPVEIQDGLFQPLLQATLAHLGQAPFQEYLGSLYFLRFLQWKWL
EAQPMGEDWFLDFRVLGKGGFGEVSACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKK
ILMKVHSRFIVSLAYAFETKADLCLVMTIMNGGDIRYHIYNVNEENPGFPEPRALFYTAQ
IICGLEHLHQRRIVYRDLKPENVLLDNDGNVRISDLGLAVELLDGQSKTKGYAGTPGFMA
PELLQGEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKHRIISEPVKYPDKFS
QASKDFCEALLEKDPEKRLGFRDETCDKLRAHPLFKDLNWRQLEAGMLMPPFIPDSKTVY
AKDIQDVGAFSTVKGVAFDKTDTEFFQEFATGNCPIPWQEEMIETGIFGELNVWRSDGQM
PDDMKGISGGSSSSSKSGMCLVS
NT seq 1692 nt NT seq  +upstreamnt  +downstreamnt
atggatttcgggtctttggagaccgtggtggccaactctgccttcatcgccgcccgaggc
agctttgacggcagcagctcccaaccctcccgggacaagaagtacctggccaagctcaag
ctgcccccgctgtccaagtgtgagtccctccgcgacagcctcagcctggagtttgagagt
gtgtgcttggagcagcccatcggcaagaagctctttcagcagttcctacaatcggcagag
aagcacctgccggccctggagctctggaaagacatcgaggactatgacacggcagacaat
gacctccagccacagaaggcccagaccatcctggcccagtacctggacccccaggccaaa
ctcttctgcagcttcctggatgaggggatagtggcgaagtttaaggaggggcctgtggag
atccaggacgggctcttccagcccctgctgcaggccaccctggcacacctgggccaagcc
cccttccaggagtacctgggcagcctgtacttcctgaggttcctgcagtggaagtggctg
gaagcccagcccatgggggaggactggttcctggacttcagggtcctagggaaagggggc
ttcggggaggtgtcggcctgccagatgaaggcgaccggcaagctgtatgcctgcaagaag
ctgaacaagaagcggctgaagaagaggaagggctaccagggtgctatggtggagaagaag
attctgatgaaagtacacagcaggttcatcgtgtctctggcctatgcgtttgaaaccaaa
gccgacctctgtctggtgatgaccatcatgaacggaggtgacatcaggtaccacatctac
aacgtgaatgaggagaaccctggcttcccggagccgcgcgccctcttctacacggcgcag
atcatctgcggcctggagcacctgcaccagaggcggatcgtctaccgcgacctcaagccc
gagaacgtgctgctggacaatgacggcaatgtccggatctctgaccttgggctggccgtg
gagctgctggacggacagagcaagaccaagggctacgcagggaccccaggtttcatggcc
cccgagctcctgcagggcgaggagtacgacttctccgtggactactttgccctgggggtc
accctgtatgagatgattgcggccagaggacccttccgagcccgtggagagaaggtggag
aacaaggagctgaagcaccggatcatctcagagcccgtgaagtaccctgataagttcagc
caggccagcaaggacttctgcgaggcgctgctggagaaggacccggagaagcgcctgggg
ttcagagatgagacctgcgacaagctccgtgcccaccccctcttcaaggaccttaactgg
aggcagctggaggctgggatgctgatgccccctttcatcccagactccaaaactgtctac
gcaaaggatattcaggacgtgggtgccttttccaccgtcaaaggtgtggcctttgacaaa
acagacacagaattctttcaggaatttgccactggcaactgccccatcccctggcaggag
gagatgatcgagacgggcatctttggcgagctgaacgtgtggcgctcggacggtcagatg
ccggacgacatgaagggcatctccgggggctccagctcctcgtccaagtcagggatgtgt
ctggtttcctag

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