KEGG   Homo sapiens (human): 133
Entry
133               CDS       T01001                                 

Gene name
ADM, AM, PAMP
Definition
(RefSeq) adrenomedullin
  KO
K12333  adrenomedullin
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    133 (ADM)
 09150 Organismal Systems
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    133 (ADM)
SSDB
Motif
Pfam: Calc_CGRP_IAPP Fibrinogen_C
Other DBs
NCBI-GeneID: 133
NCBI-ProteinID: NP_001115
OMIM: 103275
HGNC: 259
Ensembl: ENSG00000148926
Vega: OTTHUMG00000165907
Pharos: P35318(Tbio)
CPD: C16127 C18198
UniProt: P35318
LinkDB
Structure
PDB: 
4RWF 2L7S 2FLY

Position
11p15.4
AA seq 185 aa
MKLVSVALMYLGSLAFLGADTARLDVASEFRKKWNKWALSRGKRELRMSSSYPTGLADVK
AGPAQTLIRPQDMKGASRSPEDSSPDAARIRVKRYRQSMNNFQGLRSFGCRFGTCTVQKL
AHQIYQFTDKDKDNVAPRSKISPQGYGRRRRRSLPEAGPGRTLVSSKPQAHGAPAPPSGS
APHFL
NT seq 558 nt   +upstreamnt  +downstreamnt
atgaagctggtttccgtcgccctgatgtacctgggttcgctcgccttcctaggcgctgac
accgctcggttggatgtcgcgtcggagtttcgaaagaagtggaataagtgggctctgagt
cgtgggaagagggaactgcggatgtccagcagctaccccaccgggctcgctgacgtgaag
gccgggcctgcccagacccttattcggccccaggacatgaagggtgcctctcgaagcccc
gaagacagcagtccggatgccgcccgcatccgagtcaagcgctaccgccagagcatgaac
aacttccagggcctccggagctttggctgccgcttcgggacgtgcacggtgcagaagctg
gcacaccagatctaccagttcacagataaggacaaggacaacgtcgcccccaggagcaag
atcagcccccagggctacggccgccggcgccggcgctccctgcccgaggccggcccgggt
cggactctggtgtcttctaagccacaagcacacggggctccagcccccccgagtggaagt
gctccccactttctttag

KEGG   Homo sapiens (human): 3375
Entry
3375              CDS       T01001                                 

Gene name
IAPP, DAP, IAP
Definition
(RefSeq) islet amyloid polypeptide
  KO
K08039  islet amyloid polypeptide
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04950  Maturity onset diabetes of the young
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    3375 (IAPP)
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04950 Maturity onset diabetes of the young
    3375 (IAPP)
SSDB
Motif
Pfam: Calc_CGRP_IAPP
Other DBs
NCBI-GeneID: 3375
NCBI-ProteinID: NP_000406
OMIM: 147940
HGNC: 5329
Ensembl: ENSG00000121351
Vega: OTTHUMG00000169128
Pharos: P10997(Tbio)
CPD: C16130
UniProt: P10997 A0A024RAU1
LinkDB
Structure
PDB: 
5MGQ 5K5G 2L86 2KB8

Position
12p12.1
AA seq 89 aa
MGILKLQVFLIVLSVALNHLKATPIESHQVEKRKCNTATCATQRLANFLVHSSNNFGAIL
SSTNVGSNTYGKRNAVEVLKREPLNYLPL
NT seq 270 nt   +upstreamnt  +downstreamnt
atgggcatcctgaagctgcaagtatttctcattgtgctctctgttgcattgaaccatctg
aaagctacacccattgaaagtcatcaggtggaaaagcggaaatgcaacactgccacatgt
gcaacgcagcgcctggcaaattttttagttcattccagcaacaactttggtgccattctc
tcatctaccaacgtgggatccaatacatatggcaagaggaatgcagtagaggttttaaag
agagagccactgaattacttgcccctttag

KEGG   Homo sapiens (human): 796
Entry
796               CDS       T01001                                 

Gene name
CALCA, CALC1, CGRP, CGRP-I, CGRP-alpha, CGRP1, CT, KC, PCT
Definition
(RefSeq) calcitonin related polypeptide alpha
  KO
K12332  calcitonin
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
Drug target
Eptinezumab: D11303<US>
Fremanezumab: D11055<US>
Galcanezumab: D10936<US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    796 (CALCA)
 09150 Organismal Systems
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    796 (CALCA)
SSDB
Motif
Pfam: Calc_CGRP_IAPP
Other DBs
NCBI-GeneID: 796
NCBI-ProteinID: NP_001029124
OMIM: 114130
HGNC: 1437
Ensembl: ENSG00000110680
Vega: OTTHUMG00000159731
Pharos: P01258(Tbio)
CPD: C15876 C16125
UniProt: P01258
LinkDB
Position
11p15.2
AA seq 141 aa
MGFQKFSPFLALSILVLLQAGSLHAAPFRSALESSPADPATLSEDEARLLLAALVQDYVQ
MKASELEQEQEREGSSLDSPRSKRCGNLSTCMLGTYTQDFNKFHTFPQTAIGVGAPGKKR
DMSSDLERDHRPHVSMPQNAN
NT seq 426 nt   +upstreamnt  +downstreamnt
atgggcttccaaaagttctcccccttcctggctctcagcatcttggtcctgttgcaggca
ggcagcctccatgcagcaccattcaggtctgccctggagagcagcccagcagacccggcc
acgctcagtgaggacgaagcgcgcctcctgctggctgcactggtgcaggactatgtgcag
atgaaggccagtgagctggagcaggagcaagagagagagggctccagcctggacagcccc
agatctaagcggtgcggtaatctgagtacttgcatgctgggcacatacacgcaggacttc
aacaagtttcacacgttcccccaaactgcaattggggttggagcacctggaaagaaaagg
gatatgtccagcgacttggagagagaccatcgccctcatgttagcatgccccagaatgcc
aactaa

KEGG   Homo sapiens (human): 797
Entry
797               CDS       T01001                                 

Gene name
CALCB, CALC2, CGRP-II, CGRP2
Definition
(RefSeq) calcitonin related polypeptide beta
  KO
K12332  calcitonin
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    797 (CALCB)
 09150 Organismal Systems
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    797 (CALCB)
SSDB
Motif
Pfam: Calc_CGRP_IAPP
Other DBs
NCBI-GeneID: 797
NCBI-ProteinID: NP_000719
OMIM: 114160
HGNC: 1438
Ensembl: ENSG00000175868
Vega: OTTHUMG00000164629
Pharos: P10092(Tbio)
CPD: C16126
UniProt: P10092
LinkDB
Position
11p15.2
AA seq 127 aa
MGFRKFSPFLALSILVLYQAGSLQAAPFRSALESSPDPATLSKEDARLLLAALVQDYVQM
KASELKQEQETQGSSSAAQKRACNTATCVTHRLAGLLSRSGGMVKSNFVPTNVGSKAFGR
RRRDLQA
NT seq 384 nt   +upstreamnt  +downstreamnt
atgggtttccggaagttctcccccttcctggctctcagtatcttggtcctgtaccaggcg
ggcagcctccaggcggcgccattcaggtctgccctggagagcagcccagacccggccaca
ctcagtaaagaggacgcgcgcctcctgctggctgcactggtgcaggactatgtgcagatg
aaggccagtgagctgaagcaggagcaggagacacagggctccagctccgctgcccagaag
agagcctgcaacactgccacctgtgtgactcatcggctggcaggcttgctgagcagatca
gggggcatggtgaagagcaacttcgtgcccaccaatgtgggttccaaagcctttggcagg
cgccgcagggaccttcaagcctga

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