KEGG   Homo sapiens (human): 146
Entry
146               CDS       T01001                                 

Gene name
ADRA1D, ADRA1, ADRA1A, ADRA1R, ALPHA1, DAR, dJ779E11.2
Definition
(RefSeq) adrenoceptor alpha 1D
  KO
K04137  adrenergic receptor alpha-1D
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04022  cGMP-PKG signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04270  Vascular smooth muscle contraction
hsa04970  Salivary secretion
Drug target
Adrenalone (DG00016): D02774 D07560
Amidephrine mesylate: D02901
Amiodarone (DG00204): D00636<JP/US> D02910
Amosulalol (DG01302): D01469<JP> D07451
Arotinolol (DG01303): D01830<JP> D07465
Bevantolol: D01369<JP>
Bunazosin (DG01316): D01887<JP> D07550
Bunitrolol hydrochloride: D01444
Carvedilol (DG00321): D00255<JP/US> D03415<US>
Dapiprazole (DG01140): D03648<US> D07775
Dihydroergocristine (DG00284): D07833 D07834
Dipivefrine (DG01129): D01017<JP> D02349
Domazoline fumarate: D03887
Doxazosin (DG00256): D00608<JP/US> D07874
Dronedarone (DG00207): D02537 D03914<US>
Droperidol: D00308<JP/US>
Droxidopa: D01277<JP/US>
Ephedrine (DG00227): D00124 D01386<JP> D04018<US>
Epinephrine (DG00013): D00095<JP/US> D00996 D02149
Epinephryl borate: D04026
Ergoloid mesylates: D02268
Ergometrine (DG00446): D01163<JP> D07905
Ergot alkaloids: D07906
Ergotamine (DG00834): D00679<US>
Etilefrine (DG00210): D01573<JP> D07931
Flesinoxan: D02568
Guanadrel: D08029
Guanadrel sulfate: D00607
Ifenprodil (DG00292): D01445<JP> D08064
Indoramin (DG00254): D04531 D04532
Labetalol (DG00320): D00600<JP/US> D08106<US>
Levobunolol (DG01136): D01025<JP/US> D08115
Metaraminol (DG00218): D01019 D08192
Methoxamine (DG00219): D01020 D08201
Methylephedrine (DG01229): D01952 D02109<JP> D08206 D09842
Methylergometrine (DG00445): D00680<JP/US> D08207
Midodrine (DG00224): D01307<JP/US> D08220
Monatepil maleate: D01171
Moxisylyte (DG00287): D01571 D08239
Naftopidil: D01674<JP>
Naphazoline (DG01032): D00743 D01021<JP> D08253
Nefazodone (DG00953): D00819<US> D08257
Nicergoline (DG00283): D01290<JP> D08271
Nipradilol: D01691<JP>
Norepinephrine (DG00212): D00076<JP> D05206<US> D08284 D09794
Octodrine: D05228
Olanzapine (DG00898): D00454<JP/US> D06623<US>
Pelanserin hydrochloride: D05395
Periciazine: D01485<JP>
Phenoxybenzamine (DG00285): D00507<US> D08358
Phentolamine (DG00280): D00509<JP/US> D08362
Phenylephrine (DG00215): D00511<JP/US> D08365 D08366 D08966
Phenylpropanolamine (DG01041): D01224 D05466 D08368
Prazosin (DG00253): D00609<JP/US> D08411
Propylhexedrine (DG01919): D05637 D08444
Pseudoephedrine (DG01042): D00485 D05648 D05649 D08449
Racephedrine Hydrochloride: D08982
Racepinephrine (DG01444): D05688 D05689
Tamsulosin (DG00490): D01024<JP/US> D08560
Terazosin (DG00491): D00610<JP/US> D08569 D11585<US>
Tetryzoline (DG01030): D00756 D01023 D08578
Tolazoline (DG00281): D00997 D08614
Tramazoline (DG01033): D01347<JP> D08624
Trimazosin (DG00255): D06234 D08212
Urapidil (DG00257): D01333<JP> D08662
Xylometazoline (DG01031): D00757 D08684
Zolertine hydrochloride: D06380
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    146 (ADRA1D)
   04022 cGMP-PKG signaling pathway
    146 (ADRA1D)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    146 (ADRA1D)
 09150 Organismal Systems
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    146 (ADRA1D)
   04270 Vascular smooth muscle contraction
    146 (ADRA1D)
  09154 Digestive system
   04970 Salivary secretion
    146 (ADRA1D)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    146 (ADRA1D)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Biogenic amine
   Adrenaline
    146 (ADRA1D)
SSDB
Motif
Pfam: 7tm_1 7TM_GPCR_Srsx 7TM_GPCR_Srx 7tm_4 7TM_GPCR_Srv
Other DBs
NCBI-GeneID: 146
NCBI-ProteinID: NP_000669
OMIM: 104219
HGNC: 280
Ensembl: ENSG00000171873
Vega: OTTHUMG00000031779
Pharos: P25100(Tclin)
UniProt: P25100 B0ZBE0
LinkDB
Position
20p13
AA seq 572 aa
MTFRDLLSVSFEGPRPDSSAGGSSAGGGGGSAGGAAPSEGPAVGGVPGGAGGGGGVVGAG
SGEDNRSSAGEPGSAGAGGDVNGTAAVGGLVVSAQGVGVGVFLAAFILMAVAGNLLVILS
VACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEVLGFWAFGRAFCDVWAAVDVLCC
TASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWVVALVVSVGPLLGWKEPVP
PDERFCGITEEAGYAVFSSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGVKRERGKAS
EVVLRIHCRGAATGADGAHGMRSAKGHTFRSSLSVRLLKFSREKKAAKTLAIVVGVFVLC
WFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQ
CRRRRRRRPLWRVYGHHWRASTSGLRQDCAPSSGDAPPGAPLALTALPDPDPEPPGTPEM
QAPVASRRKPPSAFREWRLLGPFRRPTTQLRAKVSSLSHKIRAGGAQRAEAACAQRSEVE
AVSLGVPHEVAEGATCQAYELADYSNLRETDI
NT seq 1719 nt   +upstreamnt  +downstreamnt
atgactttccgcgatctcctgagcgtcagtttcgagggaccccgcccggacagcagcgca
gggggctccagcgcgggcggcggcgggggcagcgcgggcggcgcggccccctcggagggc
ccggcggtgggcggcgtgccggggggcgcgggcggcggcggcggcgtggtgggcgcaggc
agcggcgaggacaaccggagctccgcgggggagccggggagcgcgggcgcgggcggcgac
gtgaatggcacggcggccgtcgggggactggtggtgagcgcgcagggcgtgggcgtgggc
gtcttcctggcagccttcatccttatggccgtggcaggtaacctgcttgtcatcctctca
gtggcctgcaaccgccacctgcagaccgtcaccaactatttcatcgtgaacctggccgtg
gccgacctgctgctgagcgccaccgtactgcccttctcggccaccatggaggttctgggc
ttctgggcctttggccgcgccttctgcgacgtatgggccgccgtggacgtgctgtgctgc
acggcctccatcctcagcctctgcaccatctccgtggaccggtacgtgggcgtgcgccac
tcactcaagtacccagccatcatgaccgagcgcaaggcggccgccatcctggccctgctc
tgggtcgtagccctggtggtgtccgtagggcccctgctgggctggaaggagcccgtgccc
cctgacgagcgcttctgcggtatcaccgaggaggcgggctacgctgtcttctcctccgtg
tgctccttctacctgcccatggcggtcatcgtggtcatgtactgccgcgtgtacgtggtc
gcgcgcagcaccacgcgcagcctcgaggcgggcgtcaagcgcgagcgaggcaaggcctcc
gaggtggtgctgcgcatccactgtcgcggcgcggccacgggcgccgacggggcgcacggc
atgcgcagcgccaagggccacaccttccgcagctcgctctccgtgcgcctgctcaagttc
tcccgtgagaagaaagcggccaagactctggccatcgtcgtgggtgtcttcgtgctctgc
tggttccctttcttctttgtcctgccgctcggctccttgttcccgcagctgaagccatcg
gagggcgtcttcaaggtcatcttctggctcggctacttcaacagctgcgtgaacccgctc
atctacccctgttccagccgcgagttcaagcgcgccttcctccgtctcctgcgctgccag
tgccgtcgtcgccggcgccgccgccctctctggcgtgtctacggccaccactggcgggcc
tccaccagcggcctgcgccaggactgcgccccgagttcgggcgacgcgccccccggagcg
ccgctggccctcaccgcgctccccgaccccgaccccgaacccccaggcacgcccgagatg
caggctccggtcgccagccgtcgaaagccacccagcgccttccgcgagtggaggctgctg
gggccgttccggagacccacgacccagctgcgcgccaaagtctccagcctgtcgcacaag
atccgcgccgggggcgcgcagcgcgcagaggcagcgtgcgcccagcgctcagaggtggag
gctgtgtccctaggcgtcccacacgaggtggccgagggcgccacctgccaggcctacgaa
ttggccgactacagcaacctacgggagaccgatatttaa

KEGG   Homo sapiens (human): 147
Entry
147               CDS       T01001                                 

Gene name
ADRA1B, ADRA1, ALPHA1BAR
Definition
(RefSeq) adrenoceptor alpha 1B
  KO
K04136  adrenergic receptor alpha-1B
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04022  cGMP-PKG signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04270  Vascular smooth muscle contraction
hsa04970  Salivary secretion
Drug target
Adrenalone (DG00016): D02774 D07560
Amidephrine mesylate: D02901
Amiodarone (DG00204): D00636<JP/US> D02910
Amosulalol (DG01302): D01469<JP> D07451
Arotinolol (DG01303): D01830<JP> D07465
Bevantolol: D01369<JP>
Bunazosin (DG01316): D01887<JP> D07550
Bunitrolol hydrochloride: D01444
Carvedilol (DG00321): D00255<JP/US> D03415<US>
Dapiprazole (DG01140): D03648<US> D07775
Dihydroergocristine (DG00284): D07833 D07834
Dipivefrine (DG01129): D01017<JP> D02349
Domazoline fumarate: D03887
Doxazosin (DG00256): D00608<JP/US> D07874
Dronedarone (DG00207): D02537 D03914<US>
Droperidol: D00308<JP/US>
Droxidopa: D01277<JP/US>
Ephedrine (DG00227): D00124 D01386<JP> D04018<US>
Epinephrine (DG00013): D00095<JP/US> D00996 D02149
Epinephryl borate: D04026
Ergoloid mesylates: D02268
Ergometrine (DG00446): D01163<JP> D07905
Ergot alkaloids: D07906
Ergotamine (DG00834): D00679<US>
Etilefrine (DG00210): D01573<JP> D07931
Flesinoxan: D02568
Guanadrel: D08029
Guanadrel sulfate: D00607
Ifenprodil (DG00292): D01445<JP> D08064
Indoramin (DG00254): D04531 D04532
Labetalol (DG00320): D00600<JP/US> D08106<US>
Levobunolol (DG01136): D01025<JP/US> D08115
Metaraminol (DG00218): D01019 D08192
Methoxamine (DG00219): D01020 D08201
Methylephedrine (DG01229): D01952 D02109<JP> D08206 D09842
Methylergometrine (DG00445): D00680<JP/US> D08207
Midodrine (DG00224): D01307<JP/US> D08220
Monatepil maleate: D01171
Moxisylyte (DG00287): D01571 D08239
Naftopidil: D01674<JP>
Naphazoline (DG01032): D00743 D01021<JP> D08253
Nefazodone (DG00953): D00819<US> D08257
Nicergoline (DG00283): D01290<JP> D08271
Nipradilol: D01691<JP>
Norepinephrine (DG00212): D00076<JP> D05206<US> D08284 D09794
Octodrine: D05228
Olanzapine (DG00898): D00454<JP/US> D06623<US>
Pelanserin hydrochloride: D05395
Periciazine: D01485<JP>
Phenoxybenzamine (DG00285): D00507<US> D08358
Phentolamine (DG00280): D00509<JP/US> D08362
Phenylephrine (DG00215): D00511<JP/US> D08365 D08366 D08966
Phenylpropanolamine (DG01041): D01224 D05466 D08368
Prazosin (DG00253): D00609<JP/US> D08411
Propylhexedrine (DG01919): D05637 D08444
Pseudoephedrine (DG01042): D00485 D05648 D05649 D08449
Racephedrine Hydrochloride: D08982
Racepinephrine (DG01444): D05688 D05689
Tamsulosin (DG00490): D01024<JP/US> D08560
Terazosin (DG00491): D00610<JP/US> D08569 D11585<US>
Tetryzoline (DG01030): D00756 D01023 D08578
Tolazoline (DG00281): D00997 D08614
Tramazoline (DG01033): D01347<JP> D08624
Trimazosin (DG00255): D06234 D08212
Urapidil (DG00257): D01333<JP> D08662
Xylometazoline (DG01031): D00757 D08684
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    147 (ADRA1B)
   04022 cGMP-PKG signaling pathway
    147 (ADRA1B)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    147 (ADRA1B)
 09150 Organismal Systems
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    147 (ADRA1B)
   04270 Vascular smooth muscle contraction
    147 (ADRA1B)
  09154 Digestive system
   04970 Salivary secretion
    147 (ADRA1B)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    147 (ADRA1B)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Biogenic amine
   Adrenaline
    147 (ADRA1B)
SSDB
Motif
Pfam: 7tm_1 7TM_GPCR_Srsx 7tm_4 7TM_GPCR_Srx 7TM_GPCR_Srv Shisa GTP_cyclohydro2
Other DBs
NCBI-GeneID: 147
NCBI-ProteinID: NP_000670
OMIM: 104220
HGNC: 278
Ensembl: ENSG00000170214
Vega: OTTHUMG00000130327
Pharos: P35368(Tclin)
UniProt: P35368
LinkDB
Position
5q33.3
AA seq 520 aa
MNPDLDTGHNTSAPAHWGELKNANFTGPNQTSSNSTLPQLDITRAISVGLVLGAFILFAI
VGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVLGYWVLGRIFCDI
WAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGP
LLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAG
VMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVV
GMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFV
RILGCQCRGRGRRRRRRRRRLGGCAYTYRPWTRGGSLERSQSRKDSLDDSGSCLSGSQRT
LPSASPSPGYLGRGAPPPVELCAFPEWKAPGALLSLPAPEPPGRRGRHDSGPLFTFKLLT
EPESPGTDGGASNGGCEAAADVANGQPGFKSNMPLAPGQF
NT seq 1563 nt   +upstreamnt  +downstreamnt
atgaatcccgacctggacaccggccacaacacatcagcacctgcccactggggagagttg
aaaaatgccaacttcactggccccaaccagacctcgagcaactccacactgccccagctg
gacatcaccagggccatctctgtgggcctggtgctgggcgccttcatcctctttgccatc
gtgggcaacatcctagtcatcttgtctgtggcctgcaaccggcacctgcggacgcccacc
aactacttcattgtcaacctggccatggccgacctgctgttgagcttcaccgtcctgccc
ttctcagcggccctagaggtgctcggctactgggtgctggggcggatcttctgtgacatc
tgggcagccgtggatgtcctgtgctgcacagcgtccattctgagcctgtgcgccatctcc
atcgatcgctacatcggggtgcgctactctctgcagtatcccacgctggtcacccggagg
aaggccatcttggcgctgctcagtgtctgggtcttgtccaccgtcatctccatcgggcct
ctccttgggtggaaggagccggcacccaacgatgacaaggagtgcggggtcaccgaagaa
cccttctatgccctcttctcctctctgggctccttctacatccctctggcggtcattcta
gtcatgtactgccgtgtctatatagtggccaagagaaccaccaagaacctagaggcagga
gtcatgaaggagatgtccaactccaaggagctgaccctgaggatccattccaagaacttt
cacgaggacacccttagcagtaccaaggccaagggccacaaccccaggagttccatagct
gtcaaactttttaagttctccagggaaaagaaagcagctaagacgttgggcattgtggtc
ggtatgttcatcttgtgctggctacccttcttcatcgctctaccgcttggctccttgttc
tccaccctgaagccccccgacgccgtgttcaaggtggtgttctggctgggctacttcaac
agctgcctcaaccccatcatctacccatgctccagcaaggagttcaagcgcgctttcgtg
cgcatcctcgggtgccagtgccgcggccgcggccgccgccgacgccgccgccgccgtcgc
ctgggcggctgcgcctacacctaccggccgtggacgcgcggcggctcgctggagcgctcg
cagtcgcgcaaggactcgctggacgacagcggcagctgcctgagcggcagccagcggacc
ctgccctcggcctcgccgagcccgggctacctgggccgcggcgcgccaccgccagtcgag
ctgtgcgccttccccgagtggaaggcgcccggcgccctcctgagcctgcccgcgcctgag
ccccccggccgccgcggccgccacgactcgggcccgctcttcaccttcaagctcctgacc
gagcccgagagccccgggaccgacggcggcgccagcaacggaggctgcgaggccgcggcc
gacgtggccaacgggcagccgggcttcaaaagcaacatgcccctggcgcccgggcagttt
tag

KEGG   Homo sapiens (human): 148
Entry
148               CDS       T01001                                 

Gene name
ADRA1A, ADRA1C, ADRA1L1, ALPHA1AAR
Definition
(RefSeq) adrenoceptor alpha 1A
  KO
K04135  adrenergic receptor alpha-1A
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04022  cGMP-PKG signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04152  AMPK signaling pathway
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04270  Vascular smooth muscle contraction
hsa04970  Salivary secretion
Drug target
Adrenalone (DG00016): D02774 D07560
Alfuzosin (DG00489): D01692<US> D07124
Amidephrine mesylate: D02901
Amiodarone (DG00204): D00636<JP/US> D02910
Amosulalol (DG01302): D01469<JP> D07451
Arotinolol (DG01303): D01830<JP> D07465
Bevantolol: D01369<JP>
Bunazosin (DG01316): D01887<JP> D07550
Bunitrolol hydrochloride: D01444
Carvedilol (DG00321): D00255<JP/US> D03415<US>
Dabuzalgron hydrochloride: D06394
Dapiprazole (DG01140): D03648<US> D07775
Dihydroergocristine (DG00284): D07833 D07834
Dipivefrine (DG01129): D01017<JP> D02349
Domazoline fumarate: D03887
Doxazosin (DG00256): D00608<JP/US> D07874
Dronedarone (DG00207): D02537 D03914<US>
Droperidol: D00308<JP/US>
Droxidopa: D01277<JP/US>
Ephedrine (DG00227): D00124 D01386<JP> D04018<US>
Epinephrine (DG00013): D00095<JP/US> D00996 D02149
Epinephryl borate: D04026
Ergoloid mesylates: D02268
Ergometrine (DG00446): D01163<JP> D07905
Ergot alkaloids: D07906
Ergotamine (DG00834): D00679<US>
Etilefrine (DG00210): D01573<JP> D07931
Fiduxosin hydrochloride: D04184
Flesinoxan: D02568
Garomefrine hydrochloride: D09784
Guanadrel: D08029
Guanadrel sulfate: D00607
Ifenprodil (DG00292): D01445<JP> D08064
Indoramin (DG00254): D04531 D04532
Isometheptene: D07097
Labetalol (DG00320): D00600<JP/US> D08106<US>
Levobunolol (DG01136): D01025<JP/US> D08115
Metaraminol (DG00218): D01019 D08192
Methoxamine (DG00219): D01020 D08201
Methylephedrine (DG01229): D01952 D02109<JP> D08206 D09842
Methylergometrine (DG00445): D00680<JP/US> D08207
Midodrine (DG00224): D01307<JP/US> D08220
Monatepil maleate: D01171
Moxisylyte (DG00287): D01571 D08239
Naftopidil: D01674<JP>
Naphazoline (DG01032): D00743 D01021<JP> D08253
Nefazodone (DG00953): D00819<US> D08257
Nicergoline (DG00283): D01290<JP> D08271
Nipradilol: D01691<JP>
Norepinephrine (DG00212): D00076<JP> D05206<US> D08284 D09794
Octodrine: D05228
Olanzapine (DG00898): D00454<JP/US> D06623<US>
Oxymetazoline (DG01029): D01022<JP/US> D08322
Pelanserin hydrochloride: D05395
Periciazine: D01485<JP>
Phenoxybenzamine (DG00285): D00507<US> D08358
Phentolamine (DG00280): D00509<JP/US> D08362
Phenylephrine (DG00215): D00511<JP/US> D08365 D08366 D08966
Phenylpropanolamine (DG01041): D01224 D05466 D08368
Prazosin (DG00253): D00609<JP/US> D08411
Propylhexedrine (DG01919): D05637 D08444
Pseudoephedrine (DG01042): D00485 D05648 D05649 D08449
Racephedrine Hydrochloride: D08982
Racepinephrine (DG01444): D05688 D05689
Silodosin: D01965<JP/US>
Tamsulosin (DG00490): D01024<JP/US> D08560
Terazosin (DG00491): D00610<JP/US> D08569 D11585<US>
Tetryzoline (DG01030): D00756 D01023 D08578
Tolazoline (DG00281): D00997 D08614
Tramazoline (DG01033): D01347<JP> D08624
Trimazosin (DG00255): D06234 D08212
Urapidil (DG00257): D01333<JP> D08662
Xylometazoline (DG01031): D00757 D08684
Zolertine hydrochloride: D06380
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    148 (ADRA1A)
   04022 cGMP-PKG signaling pathway
    148 (ADRA1A)
   04152 AMPK signaling pathway
    148 (ADRA1A)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    148 (ADRA1A)
 09150 Organismal Systems
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    148 (ADRA1A)
   04270 Vascular smooth muscle contraction
    148 (ADRA1A)
  09154 Digestive system
   04970 Salivary secretion
    148 (ADRA1A)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    148 (ADRA1A)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Biogenic amine
   Adrenaline
    148 (ADRA1A)
SSDB
Motif
Pfam: 7tm_1 7TM_GPCR_Srsx 7TM_GPCR_Srx 7tm_4
Other DBs
NCBI-GeneID: 148
NCBI-ProteinID: NP_000671
OMIM: 104221
HGNC: 277
Ensembl: ENSG00000120907
Vega: OTTHUMG00000099459
Pharos: P35348(Tclin)
UniProt: P35348
LinkDB
Position
8p21.2
AA seq 466 aa
MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV
THYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCII
SIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINE
EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN
APAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPD
FKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTL
HPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCT
TARVRSKSFLQVCCCVGPSTPSLDKNHQVPTIKVHTISLSENGEEV
NT seq 1401 nt   +upstreamnt  +downstreamnt
atggtgtttctctcgggaaatgcttccgacagctccaactgcacccaaccgccggcaccg
gtgaacatttccaaggccattctgctcggggtgatcttggggggcctcattcttttcggg
gtgctgggtaacatcctagtgatcctctccgtagcctgtcaccgacacctgcactcagtc
acgcactactacatcgtcaacctggcggtggccgacctcctgctcacctccacggtgctg
cccttctccgccatcttcgaggtcctaggctactgggccttcggcagggtcttctgcaac
atctgggcggcagtggatgtgctgtgctgcaccgcgtccatcatgggcctctgcatcatc
tccatcgaccgctacatcggcgtgagctacccgctgcgctacccaaccatcgtcacccag
aggaggggtctcatggctctgctctgcgtctgggcactctccctggtcatatccattgga
cccctgttcggctggaggcagccggcccccgaggacgagaccatctgccagatcaacgag
gagccgggctacgtgctcttctcagcgctgggctccttctacctgcctctggccatcatc
ctggtcatgtactgccgcgtctacgtggtggccaagagggagagccggggcctcaagtct
ggcctcaagaccgacaagtcggactcggagcaagtgacgctccgcatccatcggaaaaac
gccccggcaggaggcagcgggatggccagcgccaagaccaagacgcacttctcagtgagg
ctcctcaagttctcccgggagaagaaagcggccaaaacgctgggcatcgtggtcggctgc
ttcgtcctctgctggctgccttttttcttagtcatgcccattgggtctttcttccctgat
ttcaagccctctgaaacagtttttaaaatagtattttggctcggatatctaaacagctgc
atcaaccccatcatatacccatgctccagccaagagttcaaaaaggcctttcagaatgtc
ttgagaatccagtgtctctgcagaaagcagtcttccaaacatgccctgggctacaccctg
cacccgcccagccaggccgtggaagggcaacacaaggacatggtgcgcatccccgtggga
tcaagagagaccttctacaggatctccaagacggatggcgtttgtgaatggaaatttttc
tcttccatgccccgtggatctgccaggattacagtgtccaaagaccaatcctcctgtacc
acagcccgggtgagaagtaaaagctttttgcaggtctgctgctgtgtagggccctcaacc
cccagccttgacaagaaccatcaagttccaaccattaaggtccacaccatctccctcagt
gagaacggggaggaagtctag

KEGG   Homo sapiens (human): 150
Entry
150               CDS       T01001                                 

Gene name
ADRA2A, ADRA2, ADRA2R, ADRAR, ALPHA2AAR, ZNF32
Definition
(RefSeq) adrenoceptor alpha 2A
  KO
K04138  adrenergic receptor alpha-2A
Organism
hsa  Homo sapiens (human)
Pathway
hsa04022  cGMP-PKG signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
Drug target
Apraclonidine (DG01130): D01008<JP/US> D07461
Aptazapine maleate: D02972
Atipamezole: D03002
Betanidine: D01603
Brimonidine (DG00442): D02076<JP/US> D07540
Chlorpromazine (DG00867): D00270 D00789<JP/US> D03274 D04034<JP> D09819
Clonidine (DG00249): D00281<US> D00604<JP/US>
Clozapine: D00283<JP/US>
Delequamine hydrochloride: D03672
Detomidine (DG01318): D03702 D07795
Dexmedetomidine (DG00926): D00514 D01205<JP/US>
Dihydroergocristine (DG00284): D07833 D07834
Dipivefrine (DG01129): D01017<JP> D02349
Domazoline fumarate: D03887
Droxidopa: D01277<JP/US>
Ephedrine (DG00227): D00124 D01386<JP> D04018<US>
Epinephrine (DG00013): D00095<JP/US> D00996 D02149
Epinephryl borate: D04026
Ergoloid mesylates: D02268
Ergometrine (DG00446): D01163<JP> D07905
Etilefrine (DG00210): D01573<JP> D07931
Fadolmidine hydrochloride: D04124
Fluparoxan hydrochloride: D04223
Guanabenz (DG01230): D00605<JP> D04375
Guanadrel: D08029
Guanadrel sulfate: D00607
Guanfacine (DG00250): D00606<JP/US> D08031
Levonordefrin: D02388
Lidamidine (DG02870): D02407 D08126
Lofexidine (DG01001): D04765<US> D08141
Medetomidine (DG01320): D04883 D08165
Metaraminol (DG00218): D01019 D08192
Methyldopa (levorotatory) (DG00248): D00405<JP/US> D08205
Methylephedrine (DG01229): D01952 D02109<JP> D08206 D09842
Methylergometrine (DG00445): D00680<JP/US> D08207
Mianserin (DG00951): D01358<JP> D08216
Mirtazapine (DG02838): D00563<JP/US> D11056
Moxonidine: D05087
Napamezole hydrochloride: D05119
Norepinephrine (DG00212): D00076<JP> D05206<US> D08284 D09794
Octodrine: D05228
Phenoxybenzamine (DG00285): D00507<US> D08358
Phentolamine (DG00280): D00509<JP/US> D08362
Phenylpropanolamine (DG01041): D01224 D05466 D08368
Propylhexedrine (DG01919): D05637 D08444
Pseudoephedrine (DG01042): D00485 D05648 D05649 D08449
Racephedrine Hydrochloride: D08982
Racepinephrine (DG01444): D05688 D05689
Rilmenidine: D08482
Romifidine: D08487
Setiptiline (DG01231): D02034<JP> D08511
Sunepitron hydrochloride: D02569
Tizanidine (DG00773): D00776<JP/US> D08611
Tolazoline (DG00281): D00997 D08614
Tramazoline (DG01033): D01347<JP> D08624
Vatinoxan (DG02987): D11320 D11321
Xylazine (DG01321): D06344 D08683
Xylometazoline (DG01031): D00757 D08684
Yohimbin (DG00485): D06671 D08685
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04022 cGMP-PKG signaling pathway
    150 (ADRA2A)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    150 (ADRA2A)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    150 (ADRA2A)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Biogenic amine
   Adrenaline
    150 (ADRA2A)
SSDB
Motif
Pfam: 7tm_1 7tm_4 7TM_GPCR_Srsx T2SSM
Other DBs
NCBI-GeneID: 150
NCBI-ProteinID: NP_000672
OMIM: 104210
HGNC: 281
Ensembl: ENSG00000150594
Vega: OTTHUMG00000019050
Pharos: P08913(Tclin)
UniProt: P08913
LinkDB
Position
10q25.2
AA seq 465 aa
MFRQEQPLAEGSFAPMGSLQPDAGNASWNGTEAPGGGARATPYSLQVTLTLVCLAGLLML
LTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAW
CEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIITVWVISAVIS
FPPLISIEKKGGGGGPQPAEPRCEINDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKR
RTRVPPSRRGPDAVAAPPGGTERRPNGLGPERSAGPGGAEAEPLPTQLNGAPGEPAPAGP
RDTDALDLEESSSSDHAERPPGPRRPERGPRGKGKARASQVKPGDSLPRRGPGATGIGTP
AAGPGEERVGAAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVGCSVPR
TLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV
NT seq 1398 nt   +upstreamnt  +downstreamnt
atgttccgccaggagcagccgttggccgagggcagctttgcgcccatgggctccctgcag
ccggacgcgggcaacgcgagctggaacgggaccgaggcgccggggggcggcgcccgggcc
accccttactccctgcaggtgacgctgacgctggtgtgcctggccggcctgctcatgctg
ctcaccgtgttcggcaacgtgctcgtcatcatcgccgtgttcacgagccgcgcgctcaag
gcgccccaaaacctcttcctggtgtctctggcctcggccgacatcctggtggccacgctc
gtcatccctttctcgctggccaacgaggtcatgggctactggtacttcggcaaggcttgg
tgcgagatctacctggcgctcgacgtgctcttctgcacgtcgtccatcgtgcacctgtgc
gccatcagcctggaccgctactggtccatcacacaggccatcgagtacaacctgaagcgc
acgccgcgccgcatcaaggccatcatcatcaccgtgtgggtcatctcggccgtcatctcc
ttcccgccgctcatctccatcgagaagaagggcggcggcggcggcccgcagccggccgag
ccgcgctgcgagatcaacgaccagaagtggtacgtcatctcgtcgtgcatcggctccttc
ttcgctccctgcctcatcatgatcctggtctacgtgcgcatctaccagatcgccaagcgt
cgcacccgcgtgccacccagccgccggggtccggacgccgtcgccgcgccgccggggggc
accgagcgcaggcccaacggtctgggccccgagcgcagcgcgggcccggggggcgcagag
gccgaaccgctgcccacccagctcaacggcgcccctggcgagcccgcgccggccgggccg
cgcgacaccgacgcgctggacctggaggagagctcgtcttccgaccacgccgagcggcct
ccagggccccgcagacccgagcgcggtccccggggcaaaggcaaggcccgagcgagccag
gtgaagccgggcgacagcctgccgcggcgcgggccgggggcgacggggatcgggacgccg
gctgcagggccgggggaggagcgcgtcggggctgccaaggcgtcgcgctggcgcgggcgg
cagaaccgcgagaagcgcttcacgttcgtgctggccgtggtcatcggagtgttcgtggtg
tgctggttccccttcttcttcacctacacgctcacggccgtcgggtgctccgtgccacgc
acgctcttcaaattcttcttctggttcggctactgcaacagctcgttgaacccggtcatc
tacaccatcttcaaccacgatttccgccgcgccttcaagaagatcctctgtcggggggac
aggaagcggatcgtgtga

KEGG   Homo sapiens (human): 151
Entry
151               CDS       T01001                                 

Gene name
ADRA2B, ADRA2L1, ADRA2RL1, ADRARL1, ALPHA2BAR, FAME2, alpha-2BAR
Definition
(RefSeq) adrenoceptor alpha 2B
  KO
K04139  adrenergic receptor alpha-2B
Organism
hsa  Homo sapiens (human)
Pathway
hsa04022  cGMP-PKG signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
Drug target
Apraclonidine (DG01130): D01008<JP/US> D07461
Aptazapine maleate: D02972
Atipamezole: D03002
Betanidine: D01603
Brimonidine (DG00442): D02076<JP/US> D07540
Chlorpromazine (DG00867): D00270 D00789<JP/US> D03274 D04034<JP> D09819
Clonidine (DG00249): D00281<US> D00604<JP/US>
Clozapine: D00283<JP/US>
Delequamine hydrochloride: D03672
Detomidine (DG01318): D03702 D07795
Dexmedetomidine (DG00926): D00514 D01205<JP/US>
Dihydroergocristine (DG00284): D07833 D07834
Dipivefrine (DG01129): D01017<JP> D02349
Domazoline fumarate: D03887
Droxidopa: D01277<JP/US>
Ephedrine (DG00227): D00124 D01386<JP> D04018<US>
Epinephrine (DG00013): D00095<JP/US> D00996 D02149
Epinephryl borate: D04026
Ergoloid mesylates: D02268
Ergometrine (DG00446): D01163<JP> D07905
Etilefrine (DG00210): D01573<JP> D07931
Fadolmidine hydrochloride: D04124
Fluparoxan hydrochloride: D04223
Guanabenz (DG01230): D00605<JP> D04375
Guanadrel: D08029
Guanadrel sulfate: D00607
Imiloxan hydrochloride: D04514
Levonordefrin: D02388
Lidamidine (DG02870): D02407 D08126
Lofexidine (DG01001): D04765<US> D08141
Medetomidine (DG01320): D04883 D08165
Metaraminol (DG00218): D01019 D08192
Methyldopa (levorotatory) (DG00248): D00405<JP/US> D08205
Methylephedrine (DG01229): D01952 D02109<JP> D08206 D09842
Methylergometrine (DG00445): D00680<JP/US> D08207
Mianserin (DG00951): D01358<JP> D08216
Mirtazapine (DG02838): D00563<JP/US> D11056
Moxonidine: D05087
Napamezole hydrochloride: D05119
Norepinephrine (DG00212): D00076<JP> D05206<US> D08284 D09794
Octodrine: D05228
Phenoxybenzamine (DG00285): D00507<US> D08358
Phentolamine (DG00280): D00509<JP/US> D08362
Phenylpropanolamine (DG01041): D01224 D05466 D08368
Propylhexedrine (DG01919): D05637 D08444
Pseudoephedrine (DG01042): D00485 D05648 D05649 D08449
Racephedrine Hydrochloride: D08982
Racepinephrine (DG01444): D05688 D05689
Rilmenidine: D08482
Romifidine: D08487
Setiptiline (DG01231): D02034<JP> D08511
Sunepitron hydrochloride: D02569
Tizanidine (DG00773): D00776<JP/US> D08611
Tolazoline (DG00281): D00997 D08614
Tramazoline (DG01033): D01347<JP> D08624
Vatinoxan (DG02987): D11320 D11321
Xylazine (DG01321): D06344 D08683
Xylometazoline (DG01031): D00757 D08684
Yohimbin (DG00485): D06671 D08685
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04022 cGMP-PKG signaling pathway
    151 (ADRA2B)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    151 (ADRA2B)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    151 (ADRA2B)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Biogenic amine
   Adrenaline
    151 (ADRA2B)
SSDB
Motif
Pfam: 7tm_1 7TM_GPCR_Srsx 7tm_4 7TM_GPCR_Srx Na_Ca_ex DUF4632
Other DBs
NCBI-GeneID: 151
NCBI-ProteinID: NP_000673
OMIM: 104260
HGNC: 282
Ensembl: ENSG00000274286
Vega: OTTHUMG00000188276
Pharos: P18089(Tclin)
UniProt: P18089
LinkDB
Position
2q11.2
AA seq 450 aa
MDHQDPYSVQATAAIAAAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADIL
VATLIIPFSLANELLGYWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEY
NSKRTPRRIKCIILTVWLIAAVISLPPLIYKGDQGPQPRGRPQCKLNQEAWYILASSIGS
FFAPCLIMILVYLRIYLIAKRSNRRGPRAKGGPGQGESKQPRPDHGGALASAKLPALASV
ASAREVNGHSKSTGEKEEGETPEDTGTRALPPSWAALPNSGQGQKEGVCGASPEDEAEEE
EEEEEEEEECEPQAVPVSPASACSPPLQQPQGSRVLATLRGQVLLGRGVGAIGGQWWRRR
AQLTREKRFTFVLAVVIGVFVLCWFPFFFSYSLGAICPKHCKVPHGLFQFFFWIGYCNSS
LNPVIYTIFNQDFRRAFRRILCRPWTQTAW
NT seq 1353 nt   +upstreamnt  +downstreamnt
atggaccaccaggacccctactccgtgcaggccacagcggccatagcggcggccatcacc
ttcctcattctctttaccatcttcggcaacgctctggtcatcctggctgtgttgaccagc
cgctcgctgcgcgcccctcagaacctgttcctggtgtcgctggccgccgccgacatcctg
gtggccacgctcatcatccctttctcgctggccaacgagctgctgggctactggtacttc
cggcgcacgtggtgcgaggtgtacctggcgctcgacgtgctcttctgcacctcgtccatc
gtgcacctgtgcgccatcagcctggaccgctactgggccgtgagccgcgcgctggagtac
aactccaagcgcaccccgcgccgcatcaagtgcatcatcctcactgtgtggctcatcgcc
gccgtcatctcgctgccgcccctcatctacaagggcgaccagggcccccagccgcgcggg
cgcccccagtgcaagctcaaccaggaggcctggtacatcctggcctccagcatcggatct
ttctttgctccttgcctcatcatgatccttgtctacctgcgcatctacctgatcgccaaa
cgcagcaaccgcagaggtcccagggccaagggggggcctgggcagggtgagtccaagcag
ccccgacccgaccatggtggggctttggcctcagccaaactgccagccctggcctctgtg
gcttctgccagagaggtcaacggacactcgaagtccactggggagaaggaggagggggag
acccctgaagatactgggacccgggccttgccacccagttgggctgcccttcccaactca
ggccagggccagaaggagggtgtttgtggggcatctccagaggatgaagctgaagaggag
gaagaggaggaggaggaggaggaagagtgtgaaccccaggcagtgccagtgtctccggcc
tcagcttgcagccccccgctgcagcagccacagggctcccgggtgctggccaccctacgt
ggccaggtgctcctgggcaggggcgtgggtgctataggtgggcagtggtggcgtcgacgg
gcgcagctgacccgggagaagcgcttcaccttcgtgctggctgtggtcattggcgttttt
gtgctctgctggttccccttcttcttcagctacagcctgggagccatctgcccgaagcac
tgcaaggtgccccatggcctcttccagttcttcttctggatcggctactgcaacagctca
ctgaaccctgttatctacaccatcttcaaccaggacttccgccgtgccttccggaggatc
ctgtgccgcccgtggacccagacggcctggtga

KEGG   Homo sapiens (human): 152
Entry
152               CDS       T01001                                 

Gene name
ADRA2C, ADRA2L2, ADRA2RL2, ADRARL2, ALPHA2CAR
Definition
(RefSeq) adrenoceptor alpha 2C
  KO
K04140  adrenergic receptor alpha-2C
Organism
hsa  Homo sapiens (human)
Pathway
hsa04022  cGMP-PKG signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
Drug target
Apraclonidine (DG01130): D01008<JP/US> D07461
Aptazapine maleate: D02972
Atipamezole: D03002
Betanidine: D01603
Brimonidine (DG00442): D02076<JP/US> D07540
Chlorpromazine (DG00867): D00270 D00789<JP/US> D03274 D04034<JP> D09819
Clonidine (DG00249): D00281<US> D00604<JP/US>
Clozapine: D00283<JP/US>
Delequamine hydrochloride: D03672
Detomidine (DG01318): D03702 D07795
Dexmedetomidine (DG00926): D00514 D01205<JP/US>
Dihydroergocristine (DG00284): D07833 D07834
Dipivefrine (DG01129): D01017<JP> D02349
Domazoline fumarate: D03887
Droxidopa: D01277<JP/US>
Ephedrine (DG00227): D00124 D01386<JP> D04018<US>
Epinephrine (DG00013): D00095<JP/US> D00996 D02149
Epinephryl borate: D04026
Ergoloid mesylates: D02268
Ergometrine (DG00446): D01163<JP> D07905
Etilefrine (DG00210): D01573<JP> D07931
Fadolmidine hydrochloride: D04124
Fluparoxan hydrochloride: D04223
Guanabenz (DG01230): D00605<JP> D04375
Guanadrel: D08029
Guanadrel sulfate: D00607
Levonordefrin: D02388
Lidamidine (DG02870): D02407 D08126
Lofexidine (DG01001): D04765<US> D08141
Medetomidine (DG01320): D04883 D08165
Metaraminol (DG00218): D01019 D08192
Methyldopa (levorotatory) (DG00248): D00405<JP/US> D08205
Methylephedrine (DG01229): D01952 D02109<JP> D08206 D09842
Methylergometrine (DG00445): D00680<JP/US> D08207
Mianserin (DG00951): D01358<JP> D08216
Mirtazapine (DG02838): D00563<JP/US> D11056
Moxonidine: D05087
Napamezole hydrochloride: D05119
Norepinephrine (DG00212): D00076<JP> D05206<US> D08284 D09794
Octodrine: D05228
Phenoxybenzamine (DG00285): D00507<US> D08358
Phentolamine (DG00280): D00509<JP/US> D08362
Phenylpropanolamine (DG01041): D01224 D05466 D08368
Propylhexedrine (DG01919): D05637 D08444
Pseudoephedrine (DG01042): D00485 D05648 D05649 D08449
Racephedrine Hydrochloride: D08982
Racepinephrine (DG01444): D05688 D05689
Rilmenidine: D08482
Romifidine: D08487
Setiptiline (DG01231): D02034<JP> D08511
Sunepitron hydrochloride: D02569
Tizanidine (DG00773): D00776<JP/US> D08611
Tolazoline (DG00281): D00997 D08614
Tramazoline (DG01033): D01347<JP> D08624
Vatinoxan (DG02987): D11320 D11321
Xylazine (DG01321): D06344 D08683
Xylometazoline (DG01031): D00757 D08684
Yohimbin (DG00485): D06671 D08685
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04022 cGMP-PKG signaling pathway
    152 (ADRA2C)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    152 (ADRA2C)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    152 (ADRA2C)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Biogenic amine
   Adrenaline
    152 (ADRA2C)
SSDB
Motif
Pfam: 7tm_1 7TM_GPCR_Srsx 7tm_4
Other DBs
NCBI-GeneID: 152
NCBI-ProteinID: NP_000674
OMIM: 104250
HGNC: 283
Ensembl: ENSG00000184160
Vega: OTTHUMG00000159830
Pharos: P18825(Tclin)
UniProt: P18825 Q4W594
LinkDB
Position
4p16.3
AA seq 462 aa
MASPALAAALAVAAAAGPNASGAGERGSGGVANASGASWGPPRGQYSAGAVAGLAAVVGF
LIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFG
QVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISA
VISFPPLVSLYRQPDGAAYPQCGLNDETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLR
TRTLSEKRAPVGPDGASPTTENGLGAAAGAGENGHCAPPPADVEPDESSAAAERRRRRGA
LRRGGRRRAGAEGGAGGADGQGAGPGAAESGALTASRSPGPGGRLSRASSRSVEFFLSRR
RRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQVPGPLFK
FFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRRRGFRQ
NT seq 1389 nt   +upstreamnt  +downstreamnt
atggcgtccccggcgctggcggcggcgctggcggtggcggcagcggcgggccccaatgcg
agcggcgcgggcgagaggggcagcggcggggttgccaatgcctcgggggcttcctggggg
ccgccgcgcggccagtactcggcgggcgcggtggcagggctggctgccgtggtgggcttc
ctcatcgtcttcaccgtggtgggcaacgtgctggtggtgatcgccgtgctgaccagccgg
gcgctgcgcgcgccacagaacctcttcctggtgtcgctggcctcggccgacatcctggtg
gccacgctggtcatgcccttctcgttggccaacgagctcatggcctactggtacttcggg
caggtgtggtgcggcgtgtacctggcgctcgatgtgctgttttgcacctcgtcgatcgtg
catctgtgtgccatcagcctggaccgctactggtcggtgacgcaggccgtcgagtacaac
ctgaagcgcacaccacgccgcgtcaaggccaccatcgtggccgtgtggctcatctcggcc
gtcatctccttcccgccgctggtctcgctctaccgccagcccgacggcgccgcctacccg
cagtgcggcctcaacgacgagacctggtacatcctgtcctcctgcatcggctccttcttc
gcgccctgcctcatcatgggcctggtctacgcgcgcatctaccgagtggccaagctgcgc
acgcgcacgctcagcgagaagcgcgcccccgtgggccccgacggtgcgtccccgactacc
gaaaacgggctgggcgcggcggcaggcgcaggcgagaacgggcactgcgcgcccccgccc
gccgacgtggagccggacgagagcagcgcagcggccgagaggcggcggcgccggggcgcg
ttgcggcggggcgggcggcggcgagcgggcgcggaggggggcgcgggcggtgcggacggg
cagggggcggggccgggggcggctgagtcgggggcgctgaccgcctccaggtccccgggg
cccggtggccgcctgtcgcgcgccagctcgcgctccgtcgagttcttcctgtcgcgccgg
cgccgggcgcgcagcagcgtgtgccgccgcaaggtggcccaggcgcgcgagaagcgcttc
acctttgtgctggctgtggtcatgggcgtgttcgtgctctgctggttccccttcttcttc
agctacagcctgtacggcatctgccgcgaggcctgccaggtgcccggcccgctcttcaag
ttcttcttctggatcggctactgcaacagctcgctcaacccggtcatctacacggtcttc
aaccaggatttccggcgatcctttaagcacatcctcttccgacggaggagaaggggcttc
aggcagtga

KEGG   Homo sapiens (human): 185
Entry
185               CDS       T01001                                 

Gene name
AGTR1, AG2S, AGTR1B, AT1, AT1AR, AT1B, AT1BR, AT1R, AT2R1, HAT1R
Definition
(RefSeq) angiotensin II receptor type 1
  KO
K04166  angiotensin II receptor type 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04022  cGMP-PKG signaling pathway
hsa04072  Phospholipase D signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04270  Vascular smooth muscle contraction
hsa04371  Apelin signaling pathway
hsa04614  Renin-angiotensin system
hsa04924  Renin secretion
hsa04925  Aldosterone synthesis and secretion
hsa04927  Cortisol synthesis and secretion
hsa04933  AGE-RAGE signaling pathway in diabetic complications
hsa04934  Cushing syndrome
hsa05171  Coronavirus disease - COVID-19
hsa05200  Pathways in cancer
hsa05415  Diabetic cardiomyopathy
Network
nt06171  Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
nt06316  Angiotensin-aldosterone signaling
  Element
N00301  Angiotensin-aldosterone signaling pathway
N01306  AngII-AT1R-NOX2 signaling pathway
N01307  SARS-CoV-2 S to AngII-AT1R-NOX2 signaling pathway
Disease
H00575  Renal tubular dysgenesis
Drug target
Angiotensin II: D00150 D02014 D11142<US>
Angiotensinamide: D02939
Azilsartan (DG00351): D08864<JP>
Azilsartan medoxomil (DG00351): D08067 D08865<US>
Candesartan (DG00350): D00522 D00626<JP/US>
Eprosartan (DG00349): D02082 D04040
Fimasartan: D10556
Forasartan: D04243
Irbesartan: D00523<JP/US>
Losartan (DG00348): D00357<JP/US> D08146
Olmesartan (DG01544): D05246
Olmesartan medoxomil: D01204<JP/US>
Pratosartan: D01922
Saprisartan potassium: D05801
Saralasin acetate: D04126
Sparsentan: D11776
Tasosartan: D06010
Telmisartan: D00627<JP/US>
Valsartan: D00400<JP/US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    185 (AGTR1)
   04020 Calcium signaling pathway
    185 (AGTR1)
   04072 Phospholipase D signaling pathway
    185 (AGTR1)
   04022 cGMP-PKG signaling pathway
    185 (AGTR1)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    185 (AGTR1)
 09150 Organismal Systems
  09152 Endocrine system
   04924 Renin secretion
    185 (AGTR1)
   04614 Renin-angiotensin system
    185 (AGTR1)
   04925 Aldosterone synthesis and secretion
    185 (AGTR1)
   04927 Cortisol synthesis and secretion
    185 (AGTR1)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    185 (AGTR1)
   04270 Vascular smooth muscle contraction
    185 (AGTR1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    185 (AGTR1)
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    185 (AGTR1)
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    185 (AGTR1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    185 (AGTR1)
   04934 Cushing syndrome
    185 (AGTR1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    185 (AGTR1)
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    185 (AGTR1)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    185 (AGTR1)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Peptide
   Angiotensin
    185 (AGTR1)
SSDB
Motif
Pfam: 7tm_1 7TM_GPCR_Srsx 7TM_GPCR_Srx
Other DBs
NCBI-GeneID: 185
NCBI-ProteinID: NP_000676
OMIM: 106165
HGNC: 336
Ensembl: ENSG00000144891
Vega: OTTHUMG00000159503
Pharos: P30556(Tclin)
UniProt: P30556 Q53YY0
LinkDB
Position
3q24
AA seq 359 aa
MILNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLK
TVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLT
CLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVC
AFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFK
IIMAIVLFFFFSWIPHQIFTFLDVLIQLGIIRDCRIADIVDTAMPITICIAYFNNCLNPL
FYGFLGKKFKRYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSTKKPAPCFEVE
NT seq 1080 nt   +upstreamnt  +downstreamnt
atgattctcaactcttctactgaagatggtattaaaagaatccaagatgattgtcccaaa
gctggaaggcataattacatatttgtcatgattcctactttatacagtatcatctttgtg
gtgggaatatttggaaacagcttggtggtgatagtcatttacttttatatgaagctgaag
actgtggccagtgtttttcttttgaatttagcactggctgacttatgctttttactgact
ttgccactatgggctgtctacacagctatggaataccgctggccctttggcaattaccta
tgtaagattgcttcagccagcgtcagtttcaacctgtacgctagtgtgtttctactcacg
tgtctcagcattgatcgatacctggctattgttcacccaatgaagtcccgccttcgacgc
acaatgcttgtagccaaagtcacctgcatcatcatttggctgctggcaggcttggccagt
ttgccagctataatccatcgaaatgtatttttcattgagaacaccaatattacagtttgt
gctttccattatgagtcccaaaattcaaccctcccgatagggctgggcctgaccaaaaat
atactgggtttcctgtttccttttctgatcattcttacaagttatactcttatttggaag
gccctaaagaaggcttatgaaattcagaagaacaaaccaagaaatgatgatatttttaag
ataattatggcaattgtgcttttctttttcttttcctggattccccaccaaatattcact
tttctggatgtattgattcaactaggcatcatacgtgactgtagaattgcagatattgtg
gacacggccatgcctatcaccatttgtatagcttattttaacaattgcctgaatcctctt
ttttatggctttctggggaaaaaatttaaaagatattttctccagcttctaaaatatatt
cccccaaaagccaaatcccactcaaacctttcaacaaaaatgagcacgctttcctaccgc
ccctcagataatgtaagctcatccaccaagaagcctgcaccatgttttgaggttgagtga

KEGG   Homo sapiens (human): 1909
Entry
1909              CDS       T01001                                 

Gene name
EDNRA, ET-A, ETA, ETA-R, ETAR, ETRA, MFDA, hET-AR
Definition
(RefSeq) endothelin receptor type A
  KO
K04197  endothelin receptor type A
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04022  cGMP-PKG signaling pathway
hsa04024  cAMP signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
hsa04924  Renin secretion
hsa05200  Pathways in cancer
Disease
H02126  Mandibulofacial dysostosis with alopecia
Drug target
Ambrisentan: D07077<JP/US>
Aprocitentan: D11441
Atrasentan hydrochloride: D03009
Bosentan (DG00266): D01227<JP/US> D07538
Centhaquine (DG03144): D11974 D11975
Clazosentan (DG03076): D07682 D11664
Edonentan: D03953
Fandosentan potassium: D04128
Macitentan: D10135<JP/US>
Sitaxentan (DG00267): D07171 D08517
Sparsentan: D11776
Zibotentan: D07741
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    1909 (EDNRA)
   04024 cAMP signaling pathway
    1909 (EDNRA)
   04022 cGMP-PKG signaling pathway
    1909 (EDNRA)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    1909 (EDNRA)
 09150 Organismal Systems
  09152 Endocrine system
   04924 Renin secretion
    1909 (EDNRA)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    1909 (EDNRA)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    1909 (EDNRA)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    1909 (EDNRA)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Peptide
   Endothelin
    1909 (EDNRA)
SSDB
Motif
Pfam: 7tm_1 7TM_GPCR_Srsx
Other DBs
NCBI-GeneID: 1909
NCBI-ProteinID: NP_001948
OMIM: 131243
HGNC: 3179
Ensembl: ENSG00000151617
Vega: OTTHUMG00000161354
Pharos: P25101(Tclin)
UniProt: P25101
LinkDB
Position
4q31.22-q31.23
AA seq 427 aa
METLCLRASFWLALVGCVISDNPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLVLP
SNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYRGEQHKTCM
LNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHDQNNHNTDRS
SHKDSMN
NT seq 1284 nt   +upstreamnt  +downstreamnt
atggaaaccctttgcctcagggcatccttttggctggcactggttggatgtgtaatcagt
gataatcctgagagatacagcacaaatctaagcaatcatgtggatgatttcaccactttt
cgtggcacagagctcagcttcctggttaccactcatcaacccactaatttggtcctaccc
agcaatggctcaatgcacaactattgcccacagcagactaaaattacttcagctttcaaa
tacattaacactgtgatatcttgtactattttcatcgtgggaatggtggggaatgcaact
ctgctcaggatcatttaccagaacaaatgtatgaggaatggccccaacgcgctgatagcc
agtcttgcccttggagaccttatctatgtggtcattgatctccctatcaatgtatttaag
ctgctggctgggcgctggccttttgatcacaatgactttggcgtatttctttgcaagctg
ttcccctttttgcagaagtcctcggtggggatcaccgtcctcaacctctgcgctcttagt
gttgacaggtacagagcagttgcctcctggagtcgtgttcagggaattgggattcctttg
gtaactgccattgaaattgtctccatctggatcctgtcctttatcctggccattcctgaa
gcgattggcttcgtcatggtaccctttgaatataggggtgaacagcataaaacctgtatg
ctcaatgccacatcaaaattcatggagttctaccaagatgtaaaggactggtggctcttc
gggttctatttctgtatgcccttggtgtgcactgcgatcttctacaccctcatgacttgt
gagatgttgaacagaaggaatggcagcttgagaattgccctcagtgaacatcttaagcag
cgtcgagaagtggcaaaaacagttttctgcttggttgtaatttttgctctttgctggttc
cctcttcatttaagccgtatattgaagaaaactgtgtataacgagatggacaagaaccga
tgtgaattacttagtttcttactgctcatggattacatcggtattaacttggcaaccatg
aattcatgtataaaccccatagctctgtattttgtgagcaagaaatttaaaaattgtttc
cagtcatgcctctgctgctgctgttaccagtccaaaagtctgatgacctcggtccccatg
aacggaacaagcatccagtggaagaaccacgatcaaaacaaccacaacacagaccggagc
agccataaggacagcatgaactga

KEGG   Homo sapiens (human): 1910
Entry
1910              CDS       T01001                                 

Gene name
EDNRB, ABCDS, ET-B, ET-BR, ETB, ETB1, ETBR, ETRB, HSCR, HSCR2, WS4A
Definition
(RefSeq) endothelin receptor type B
  KO
K04198  endothelin receptor type B
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04022  cGMP-PKG signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04916  Melanogenesis
hsa04926  Relaxin signaling pathway
hsa05200  Pathways in cancer
Disease
H00054  Nasopharyngeal cancer
H00759  Waardenburg syndrome
H00823  ABCD syndrome
H00910  Hirschsprung disease
Drug target
Aprocitentan: D11441
Bosentan (DG00266): D01227<JP/US> D07538
Centhaquine (DG03144): D11974 D11975
Macitentan: D10135<JP/US>
Sovatelitide: D11964
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    1910 (EDNRB)
   04022 cGMP-PKG signaling pathway
    1910 (EDNRB)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    1910 (EDNRB)
 09150 Organismal Systems
  09152 Endocrine system
   04926 Relaxin signaling pathway
    1910 (EDNRB)
   04916 Melanogenesis
    1910 (EDNRB)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    1910 (EDNRB)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    1910 (EDNRB)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Peptide
   Endothelin
    1910 (EDNRB)
SSDB
Motif
Pfam: 7tm_1 7TM_GPCR_Srsx 7TM_GPCR_Srx 7tm_4 7TM_GPCR_Srw
Other DBs
NCBI-GeneID: 1910
NCBI-ProteinID: NP_000106
OMIM: 131244
HGNC: 3180
Ensembl: ENSG00000136160
Vega: OTTHUMG00000017111
Pharos: P24530(Tclin)
UniProt: P24530
LinkDB
Structure
PDB: 
5GLI 5GLH

Position
13q22.3
AA seq 442 aa
MQPPPSLCGRALVALVLACGLSRIWGEERGFPPDRATPLLQTAEIMTPPTKTLWPKGSNA
SLARSLAPAEVPKGDRTAGSPPRTISPPPCQGPIEIKETFKYINTVVSCLVFVLGIIGNS
TLLRIIYKNKCMRNGPNILIASLALGDLLHIVIDIPINVYKLLAEDWPFGAEMCKLVPFI
QKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGF
DIITMDYKGSYLRICLLHPVQKTAFMQFYKTAKDWWLFSFYFCLPLAITAFFYTLMTCEM
LRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYNQNDPNRCEL
LSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQSFEEKQSLEEKQSC
LKFKANDHGYDNFRSSNKYSSS
NT seq 1329 nt   +upstreamnt  +downstreamnt
atgcagccgcctccaagtctgtgcggacgcgccctggttgcgctggttcttgcctgcggc
ctgtcgcggatctggggagaggagagaggcttcccgcctgacagggccactccgcttttg
caaaccgcagagataatgacgccacccactaagaccttatggcccaagggttccaacgcc
agtctggcgcggtcgttggcacctgcggaggtgcctaaaggagacaggacggcaggatct
ccgccacgcaccatctcccctcccccgtgccaaggacccatcgagatcaaggagactttc
aaatacatcaacacggttgtgtcctgccttgtgttcgtgctggggatcatcgggaactcc
acacttctgagaattatctacaagaacaagtgcatgcgaaacggtcccaatatcttgatc
gccagcttggctctgggagacctgctgcacatcgtcattgacatccctatcaatgtctac
aagctgctggcagaggactggccatttggagctgagatgtgtaagctggtgcctttcata
cagaaagcctctgtgggaatcactgtgctgagtctatgtgctctgagtattgacagatat
cgagctgttgcttcttggagtagaattaaaggaattggggttccaaaatggacagcagta
gaaattgttttgatttgggtggtctctgtggttctggctgtccctgaagccataggtttt
gatataattacgatggactacaaaggaagttatctgcgaatctgcttgcttcatcccgtt
cagaagacagctttcatgcagttttacaagacagcaaaagattggtggctattcagtttc
tatttctgcttgccattggccatcactgcatttttttatacactaatgacctgtgaaatg
ttgagaaagaaaagtggcatgcagattgctttaaatgatcacctaaagcagagacgggaa
gtggccaaaaccgtcttttgcctggtccttgtctttgccctctgctggcttccccttcac
ctcagcaggattctgaagctcactctttataatcagaatgatcccaatagatgtgaactt
ttgagctttctgttggtattggactatattggtatcaacatggcttcactgaattcctgc
attaacccaattgctctgtatttggtgagcaaaagattcaaaaactgctttaagtcatgc
ttatgctgctggtgccagtcatttgaagaaaaacagtccttggaggaaaagcagtcgtgc
ttaaagttcaaagctaatgatcacggatatgacaacttccgttccagtaataaatacagc
tcatcttga

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