KEGG   Homo sapiens (human): 147700
Entry
147700            CDS       T01001                                 

Gene name
KLC3, KLC2, KLC2L, KLCt, KNS2B
Definition
(RefSeq) kinesin light chain 3
  KO
K10407  kinesin light chain
Organism
hsa  Homo sapiens (human)
Pathway
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05132  Salmonella infection
Network
nt06419  Microtubule-based transport
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06465  Prion disease
  Element
N00978  Anterograde axonal transport
N00979  Mutation-caused aberrant Htt to anterograde axonal transport
N01017  Mutation-caused aberrant PSEN1 to anterograde axonal transport
N01055  Mutation-caused aberrant SNCA to anterograde axonal transport
N01202  Oligomeric conformation PrPc to anterograde axonal transport
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    147700 (KLC3)
   05012 Parkinson disease
    147700 (KLC3)
   05014 Amyotrophic lateral sclerosis
    147700 (KLC3)
   05016 Huntington disease
    147700 (KLC3)
   05020 Prion disease
    147700 (KLC3)
   05022 Pathways of neurodegeneration - multiple diseases
    147700 (KLC3)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    147700 (KLC3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis [BR:hsa03019]
    147700 (KLC3)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    147700 (KLC3)
Messenger RNA biogenesis [BR:hsa03019]
 Eukaryotic type
  mRNA surveillance and transport factors
   mRNA cycle factors
    P-body specific factors
     147700 (KLC3)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulin-binding proteins
    Kinesins
     147700 (KLC3)
SSDB
Motif
Pfam: TPR_12 TPR_10 TPR_7 TPR_1 TPR_2 TPR_8 TPR_MalT TPR_19 TPR_17 SNAP TPR_16 ANAPC3 PPR Crescentin PPR_2 RNPP_C DUF3450 Tox-GHH YabA TPR_4
Other DBs
NCBI-GeneID: 147700
NCBI-ProteinID: NP_803136
OMIM: 601334
HGNC: 20717
Ensembl: ENSG00000104892
Vega: OTTHUMG00000143722
Pharos: Q6P597(Tbio)
UniProt: Q6P597 A0A024R0V3
LinkDB
Position
19q13.32
AA seq 504 aa
MSVQVAAPGSAGLGPERLSPEELVRQTRQVVQGLEALRAEHHGLAGHLAEALAGQGPAAG
LEMLEEKQQVVSHSLEAIELGLGEAQVLLALSAHVGALEAEKQRLRSQARRLAQENVWLR
EELEETQRRLRASEESVAQLEEEKRHLEFLGQLRQYDPPAESQQSESPPRRDSLASLFPS
EEEERKGPEAAGAAAAQQGGYEIPARLRTLHNLVIQYAGQGRYEVAVPLCRQALEDLERS
SGHCHPDVATMLNILALVYRDQNKYKEATDLLHDALQIREQTLGPEHPAVAATLNNLAVL
YGKRGRYREAEPLCQRALEIREKVLGADHPDVAKQLNNLALLCQNQGKFEDVERHYARAL
SIYEALGGPHDPNVAKTKNNLASAYLKQNKYQQAEELYKEILHKEDLPAPLGAPNTGTAG
DAEQALRRSSSLSKIRESIRRGSEKLVSRLRGEAAAGAAGMKRAMSLNTLNVDAPRAPGT
QFPSWHLDKAPRTLSASTQDLSPH
NT seq 1515 nt   +upstreamnt  +downstreamnt
atgtctgtgcaggtagcggctcctggaagtgcagggctgggcccagagcgcctgagccct
gaggagctggtgcggcagacgcggcaagtggtccaggggctggaggcgctgcgggcagag
caccatggcctggctgggcacctggcggaggccctggcgggacagggcccggcagccggc
ttggagatgctggaggaaaagcagcaggtggtgagccactcgctggaggccatcgagctg
gggctgggcgaggcccaggtgctgctggccctgtcggcacatgtgggtgcactggaggca
gagaagcagcggctgcgctcgcaggcccggcggctggcccaggagaacgtgtggctgcgg
gaggaactggaggagacgcagcggcggcttcgggccagcgaggagtccgtggcccagctg
gaggaggagaagcgccacctggagttcctggggcagctgcgacagtacgacccaccggcg
gagagccagcagtctgagtccccgcctcgccgagacagcctggcctccctgttccccagc
gaggaggaggagaggaaaggtcctgaggccgcaggagcagcagctgctcagcagggtggc
tatgagatccctgcccgccttcggaccctgcataacctcgtgatccagtacgcggggcag
ggccgctatgaggtggcggtgcctctgtgccgccaggccttggaggacctggagcgcagc
tcgggccactgccaccctgacgtggccaccatgctcaacatcctggcgctggtgtaccgg
gaccagaacaagtacaaagaagccacagaccttctccatgatgccctgcagatccgggag
cagacgctgggccctgagcaccccgcggtggccgccacgctcaacaacttggctgtcctc
tatgggaagcgtgggcgttaccgggaggcagagcccctgtgccagcgcgctttggagatc
cgagagaaggtcctgggtgctgaccacccagatgtggccaagcagctcaacaacctggcc
ctgctgtgccagaaccagggcaagtttgaggacgtggagcggcactatgcccgggccctg
agcatctatgaggcactgggcgggccccatgaccccaacgtggccaagaccaagaacaac
ctggcctcagcctacctgaaacagaacaagtatcaacaagcggaagagctgtacaaagaa
atcctccacaaggaggacctacccgcccctctcggtgcccccaacacaggcacagctggt
gacgcagaacaggcccttcgccgcagcagctcactctccaagatccgtgagtctatcagg
cgaggaagtgagaagctggtctcccggctccgaggcgaggcggcggcaggagcagccgga
atgaagagagccatgtcactcaacacactgaacgtggatgctccaagggctcctgggact
cagtttcccagctggcacctggacaaggcccctcggaccctcagcgccagcacccaggac
ctgagcccccactaa

KEGG   Homo sapiens (human): 3798
Entry
3798              CDS       T01001                                 

Gene name
KIF5A, ALS25, D12S1889, MY050, NEIMY, NKHC, SPG10
Definition
(RefSeq) kinesin family member 5A
  KO
K10396  kinesin family member 5
Organism
hsa  Homo sapiens (human)
Pathway
hsa04144  Endocytosis
hsa04728  Dopaminergic synapse
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05132  Salmonella infection
hsa05223  Non-small cell lung cancer
Network
nt06419  Microtubule-based transport
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06465  Prion disease
  Element
N00978  Anterograde axonal transport
N00979  Mutation-caused aberrant Htt to anterograde axonal transport
N01017  Mutation-caused aberrant PSEN1 to anterograde axonal transport
N01055  Mutation-caused aberrant SNCA to anterograde axonal transport
N01202  Oligomeric conformation PrPc to anterograde axonal transport
Disease
H00266  Hereditary spastic paraplegia
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    3798 (KIF5A)
 09150 Organismal Systems
  09156 Nervous system
   04728 Dopaminergic synapse
    3798 (KIF5A)
 09160 Human Diseases
  09162 Cancer: specific types
   05223 Non-small cell lung cancer
    3798 (KIF5A)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    3798 (KIF5A)
   05012 Parkinson disease
    3798 (KIF5A)
   05014 Amyotrophic lateral sclerosis
    3798 (KIF5A)
   05016 Huntington disease
    3798 (KIF5A)
   05020 Prion disease
    3798 (KIF5A)
   05022 Pathways of neurodegeneration - multiple diseases
    3798 (KIF5A)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    3798 (KIF5A)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    3798 (KIF5A)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    3798 (KIF5A)
   04147 Exosome [BR:hsa04147]
    3798 (KIF5A)
Membrane trafficking [BR:hsa04131]
 Others
  Actin-binding proteins
   Others
    3798 (KIF5A)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulin-binding proteins
    Kinesins
     3798 (KIF5A)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   3798 (KIF5A)
SSDB
Motif
Pfam: Kinesin Microtub_bd DUF3584 ATG16 Spc7
Other DBs
NCBI-GeneID: 3798
NCBI-ProteinID: NP_004975
OMIM: 602821
HGNC: 6323
Ensembl: ENSG00000155980
Vega: OTTHUMG00000170143
Pharos: Q12840(Tbio)
UniProt: Q12840
LinkDB
Structure
PDB: 
4UXY 4UXT 4UY0

Position
12q13.3
AA seq 1032 aa
MAETNNECSIKVLCRFRPLNQAEILRGDKFIPIFQGDDSVVIGGKPYVFDRVFPPNTTQE
QVYHACAMQIVKDVLAGYNGTIFAYGQTSSGKTHTMEGKLHDPQLMGIIPRIARDIFNHI
YSMDENLEFHIKVSYFEIYLDKIRDLLDVTKTNLSVHEDKNRVPFVKGCTERFVSSPEEI
LDVIDEGKSNRHVAVTNMNEHSSRSHSIFLINIKQENMETEQKLSGKLYLVDLAGSEKVS
KTGAEGAVLDEAKNINKSLSALGNVISALAEGTKSYVPYRDSKMTRILQDSLGGNCRTTM
FICCSPSSYNDAETKSTLMFGQRAKTIKNTASVNLELTAEQWKKKYEKEKEKTKAQKETI
AKLEAELSRWRNGENVPETERLAGEEAALGAELCEETPVNDNSSIVVRIAPEERQKYEEE
IRRLYKQLDDKDDEINQQSQLIEKLKQQMLDQEELLVSTRGDNEKVQRELSHLQSENDAA
KDEVKEVLQALEELAVNYDQKSQEVEEKSQQNQLLVDELSQKVATMLSLESELQRLQEVS
GHQRKRIAEVLNGLMKDLSEFSVIVGNGEIKLPVEISGAIEEEFTVARLYISKIKSEVKS
VVKRCRQLENLQVECHRKMEVTGRELSSCQLLISQHEAKIRSLTEYMQSVELKKRHLEES
YDSLSDELAKLQAQETVHEVALKDKEPDTQDADEVKKALELQMESHREAHHRQLARLRDE
INEKQKTIDELKDLNQKLQLELEKLQADYEKLKSEEHEKSTKLQELTFLYERHEQSKQDL
KGLEETVARELQTLHNLRKLFVQDVTTRVKKSAEMEPEDSGGIHSQKQKISFLENNLEQL
TKVHKQLVRDNADLRCELPKLEKRLRATAERVKALEGALKEAKEGAMKDKRRYQQEVDRI
KEAVRYKSSGKRGHSAQIAKPVRPGHYPASSPTNPYGTRSPECISYTNSLFQNYQNLYLQ
ATPSSTSDMYFANSCTSSGATSSGGPLASYQKANMDNGNATDINDNRSDLPCGYEAEDQA
KLFPLHQETAAS
NT seq 3099 nt   +upstreamnt  +downstreamnt
atggcggagaccaacaacgaatgtagcatcaaggtgctctgccgattccggcccctgaac
caggctgagattctgcggggagacaagttcatccccattttccaaggggacgacagcgtc
gttattggggggaagccatatgtttttgaccgtgtattccccccaaacacgactcaagag
caagtttatcatgcatgtgccatgcagattgtcaaagatgtccttgctggctacaatggc
accatttttgcttatggacagacatcctcagggaaaacacataccatggagggaaagctg
cacgaccctcagctgatgggaatcattcctcgaattgcccgagacatcttcaaccacatc
tactccatggatgagaaccttgagttccacatcaaggtttcttactttgaaatttacctg
gacaaaattcgtgaccttctggatgtgaccaagacaaatctgtccgtgcacgaggacaag
aaccgggtgccatttgtcaagggttgtactgaacgctttgtgtccagcccggaggagatt
ctggatgtgattgatgaagggaaatcaaatcgtcatgtggctgtcaccaacatgaatgaa
cacagctctcggagccacagcatcttcctcatcaacatcaagcaggagaacatggaaacg
gagcagaagctcagtgggaagctgtatctggtggacctggcagggagtgagaaggtcagc
aagactggagcagagggagccgtgctggacgaggcaaagaatatcaacaagtcactgtca
gctctgggcaatgtgatctccgcactggctgagggcactaaaagctatgttccatatcgt
gacagcaaaatgacaaggattctccaggactctctcgggggaaactgccggacgactatg
ttcatctgttgctcaccatccagttataatgatgcagagaccaagtccaccctgatgttt
gggcagcgggcaaagaccattaagaacactgcctcagtaaatttggagttgactgctgag
cagtggaagaagaaatatgagaaggagaaggagaagacaaaggcccagaaggagacgatt
gcgaagctggaggctgagctgagccggtggcgcaatggagagaatgtgcctgagacagag
cgcctggctggggaggaggcagccctgggagccgagctctgtgaggagacccctgtgaat
gacaactcatccatcgtggtgcgcatcgcgcccgaggagcggcagaaatacgaggaggag
atccgccgtctctataagcagcttgacgacaaggatgatgaaatcaaccaacaaagccaa
ctcatagagaagctcaagcagcaaatgctggaccaggaagagctgctggtgtccacccga
ggagacaacgagaaggtccagcgggagctgagccacctgcaatcagagaacgatgccgct
aaggatgaggtgaaggaagtgctgcaggccctggaggagctggctgtgaactatgaccag
aagtcccaggaggtggaggagaagagccagcagaaccagcttctggtggatgagctgtct
cagaaggtggccaccatgctgtccctggagtctgagttgcagcggctacaggaggtcagt
ggacaccagcgaaaacgaattgctgaggtgctgaacgggctgatgaaggatctgagcgag
ttcagtgtcattgtgggcaacggggagattaagctgccagtggagatcagtggggccatc
gaggaggagttcactgtggcccgactctacatcagcaaaatcaaatcagaagtcaagtct
gtggtcaagcggtgccggcagctggagaacctccaggtggagtgtcaccgcaagatggaa
gtgaccgggcgggagctctcatcctgccagctcctcatctctcagcatgaggccaagatc
cgctcgcttacggaatacatgcagagcgtggagctaaagaagcggcacctggaagagtcc
tatgactccttgagcgatgagctggccaagctccaggcccaggaaactgtgcatgaagtg
gccctgaaggacaaggagcctgacactcaggatgcagatgaagtgaagaaggctctggag
ctgcagatggagagtcaccgggaggcccatcaccggcagctggcccggctccgggacgag
atcaacgagaagcagaagaccattgatgagctcaaagacctaaatcagaagctccagtta
gagctagagaagcttcaggctgactacgagaagctgaagagcgaagaacacgagaagagc
accaagctgcaggagctgacatttctgtacgagcgacatgagcagtccaagcaggacctc
aagggtctggaggagacagttgcccgggaactccagaccctccacaaccttcgcaagctg
ttcgttcaagacgtcacgactcgagtcaagaaaagtgcagaaatggagcccgaagacagt
ggggggattcactcccaaaagcagaagatttcctttcttgagaacaacctggaacagctt
acaaaggttcacaaacagctggtacgtgacaatgcagatctgcgttgtgagcttcctaaa
ttggaaaaacgacttagggctacggctgagagagttaaggccctggagggtgcactgaag
gaggccaaggagggcgccatgaaggacaagcgccggtaccagcaggaggtggaccgcatc
aaggaggccgttcgctacaagagctcgggcaaacggggccattctgcccagattgccaaa
cccgtccggcctggccactacccagcatcctcacccaccaacccctatggcacccggagc
cctgagtgcatcagttacaccaacagcctcttccagaactaccagaatctctacctgcag
gccacacccagctccacctcagatatgtactttgcaaactcctgtaccagcagtggagcc
acatcttctggcggccccttggcttcctaccagaaggccaacatggacaatggaaatgcc
acagatatcaatgacaataggagtgacctgccgtgtggctatgaggctgaggaccaggcc
aagcttttccctctccaccaagagacagcagccagctaa

KEGG   Homo sapiens (human): 3799
Entry
3799              CDS       T01001                                 

Gene name
KIF5B, HEL-S-61, KINH, KNS, KNS1, UKHC
Definition
(RefSeq) kinesin family member 5B
  KO
K10396  kinesin family member 5
Organism
hsa  Homo sapiens (human)
Pathway
hsa04144  Endocytosis
hsa04728  Dopaminergic synapse
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05132  Salmonella infection
hsa05223  Non-small cell lung cancer
Network
nt06419  Microtubule-based transport
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06465  Prion disease
  Element
N00978  Anterograde axonal transport
N00979  Mutation-caused aberrant Htt to anterograde axonal transport
N01017  Mutation-caused aberrant PSEN1 to anterograde axonal transport
N01055  Mutation-caused aberrant SNCA to anterograde axonal transport
N01202  Oligomeric conformation PrPc to anterograde axonal transport
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    3799 (KIF5B)
 09150 Organismal Systems
  09156 Nervous system
   04728 Dopaminergic synapse
    3799 (KIF5B)
 09160 Human Diseases
  09162 Cancer: specific types
   05223 Non-small cell lung cancer
    3799 (KIF5B)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    3799 (KIF5B)
   05012 Parkinson disease
    3799 (KIF5B)
   05014 Amyotrophic lateral sclerosis
    3799 (KIF5B)
   05016 Huntington disease
    3799 (KIF5B)
   05020 Prion disease
    3799 (KIF5B)
   05022 Pathways of neurodegeneration - multiple diseases
    3799 (KIF5B)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    3799 (KIF5B)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    3799 (KIF5B)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    3799 (KIF5B)
   04147 Exosome [BR:hsa04147]
    3799 (KIF5B)
Membrane trafficking [BR:hsa04131]
 Others
  Actin-binding proteins
   Others
    3799 (KIF5B)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulin-binding proteins
    Kinesins
     3799 (KIF5B)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   3799 (KIF5B)
SSDB
Motif
Pfam: Kinesin Microtub_bd Crescentin
Other DBs
NCBI-GeneID: 3799
NCBI-ProteinID: NP_004512
OMIM: 602809
HGNC: 6324
Ensembl: ENSG00000170759
Vega: OTTHUMG00000017913
Pharos: P33176(Tbio)
UniProt: P33176 V9HW29 Q6P164
LinkDB
Structure
PDB: 

Position
10p11.22
AA seq 963 aa
MADLAECNIKVMCRFRPLNESEVNRGDKYIAKFQGEDTVVIASKPYAFDRVFQSSTSQEQ
VYNDCAKKIVKDVLEGYNGTIFAYGQTSSGKTHTMEGKLHDPEGMGIIPRIVQDIFNYIY
SMDENLEFHIKVSYFEIYLDKIRDLLDVSKTNLSVHEDKNRVPYVKGCTERFVCSPDEVM
DTIDEGKSNRHVAVTNMNEHSSRSHSIFLINVKQENTQTEQKLSGKLYLVDLAGSEKVSK
TGAEGAVLDEAKNINKSLSALGNVISALAEGSTYVPYRDSKMTRILQDSLGGNCRTTIVI
CCSPSSYNESETKSTLLFGQRAKTIKNTVCVNVELTAEQWKKKYEKEKEKNKILRNTIQW
LENELNRWRNGETVPIDEQFDKEKANLEAFTVDKDITLTNDKPATAIGVIGNFTDAERRK
CEEEIAKLYKQLDDKDEEINQQSQLVEKLKTQMLDQEELLASTRRDQDNMQAELNRLQAE
NDASKEEVKEVLQALEELAVNYDQKSQEVEDKTKEYELLSDELNQKSATLASIDAELQKL
KEMTNHQKKRAAEMMASLLKDLAEIGIAVGNNDVKQPEGTGMIDEEFTVARLYISKMKSE
VKTMVKRCKQLESTQTESNKKMEENEKELAACQLRISQHEAKIKSLTEYLQNVEQKKRQL
EESVDALSEELVQLRAQEKVHEMEKEHLNKVQTANEVKQAVEQQIQSHRETHQKQISSLR
DEVEAKAKLITDLQDQNQKMMLEQERLRVEHEKLKATDQEKSRKLHELTVMQDRREQARQ
DLKGLEETVAKELQTLHNLRKLFVQDLATRVKKSAEIDSDDTGGSAAQKQKISFLENNLE
QLTKVHKQLVRDNADLRCELPKLEKRLRATAERVKALESALKEAKENASRDRKRYQQEVD
RIKEAVRSKNMARRGHSAQIAKPIRPGQHPAASPTHPSAIRGGGAFVQNSQPVAVRGGGG
KQV
NT seq 2892 nt   +upstreamnt  +downstreamnt
atggcggacctggccgagtgcaacatcaaagtgatgtgtcgcttcagacctctcaacgag
tctgaagtgaaccgcggcgacaagtacatcgccaagtttcagggagaagacacggtcgtg
atcgcgtccaagccttatgcatttgatcgggtgttccagtcaagcacatctcaagagcaa
gtgtataatgactgtgcaaagaagattgttaaagatgtacttgaaggatataatggaaca
atatttgcatatggacaaacatcctctgggaagacacacacaatggagggtaaacttcat
gatccagaaggcatgggaattattccaagaatagtgcaagatatttttaattatatttac
tccatggatgaaaatttggaatttcatattaaggtttcatattttgaaatatatttggat
aagataagggacctgttagatgtttcaaagaccaacctttcagttcatgaagacaaaaac
cgagttccctatgtaaaggggtgcacagagcgttttgtatgtagtccagatgaagttatg
gataccatagatgaaggaaaatccaacagacatgtagcagttacaaatatgaatgaacat
agctctaggagtcacagtatatttcttattaatgtcaaacaagagaacacacaaacggaa
caaaagctgagtggaaaactttatctggttgatttagctggtagtgaaaaggttagtaaa
actggagctgaaggtgctgtgctggatgaagctaaaaacatcaacaagtcactttctgct
cttggaaatgttatttctgctttggctgagggtagtacatatgttccatatcgagatagt
aaaatgacaagaatccttcaagattcattaggtggcaactgtagaaccactattgtaatt
tgctgctctccatcatcatacaatgagtctgaaacaaaatctacactcttatttggccaa
agggccaaaacaattaagaacacagtttgtgtcaatgtggagttaactgcagaacagtgg
aaaaagaagtatgaaaaagaaaaagaaaaaaataagatcctgcggaacactattcagtgg
cttgaaaatgagctcaacagatggcgtaatggggagacggtgcctattgatgaacagttt
gacaaagagaaagccaacttggaagctttcacagtggataaagatattactcttaccaat
gataaaccagcaaccgcaattggagttataggaaattttactgatgctgaaagaagaaag
tgtgaagaagaaattgctaaattatacaaacagcttgatgacaaggatgaagaaattaac
cagcaaagtcaactggtagagaaactgaagacgcaaatgttggatcaggaggagcttttg
gcatctaccagaagggatcaagacaatatgcaagctgagctgaatcgccttcaagcagaa
aatgatgcctctaaagaagaagtgaaagaagttttacaggccctagaagaacttgctgtc
aattatgatcagaagtctcaggaagttgaagacaaaactaaggaatatgaattgcttagt
gatgaattgaatcagaaatcggcaactttagcgagtatagatgctgagcttcagaaactt
aaggaaatgaccaaccaccagaaaaaacgagcagctgagatgatggcatctttactaaaa
gaccttgcagaaataggaattgctgtgggaaataatgatgtaaagcagcctgagggaact
ggcatgatagatgaagagttcactgttgcaagactctacattagcaaaatgaagtcagaa
gtaaaaaccatggtgaaacgttgcaagcagttagaaagcacacaaactgagagcaacaaa
aaaatggaagaaaatgaaaaggagttagcagcatgtcagcttcgtatctctcaacatgaa
gccaaaatcaagtcattgactgaataccttcaaaatgtggaacaaaagaaaagacagttg
gaggaatctgtcgatgccctcagtgaagaactagtccagcttcgagcacaagagaaagtc
catgaaatggaaaaggagcacttaaataaggttcagactgcaaatgaagttaagcaagct
gttgaacagcagatccagagccatagagaaactcatcaaaaacagatcagtagtttgaga
gatgaagtagaagcaaaagcaaaacttattactgatcttcaagaccaaaaccagaaaatg
atgttagagcaggaacgtctaagagtagaacatgagaagttgaaagccacagatcaggaa
aagagcagaaaactacatgaacttacggttatgcaagatagacgagaacaagcaagacaa
gacttgaagggtttggaagagacagtggcaaaagaacttcagactttacacaacctgcgc
aaactctttgttcaggacctggctacaagagttaaaaagagtgctgagattgattctgat
gacaccggaggcagcgctgctcagaagcaaaaaatctcctttcttgaaaataatcttgaa
cagctcactaaagtgcacaaacagttggtacgtgataatgcagatctccgctgtgaactt
cctaagttggaaaagcgacttcgagctacagctgagagagtgaaagctttggaatcagca
ctgaaagaagctaaagaaaatgcatctcgtgatcgcaaacgctatcagcaagaagtagat
cgcataaaggaagcagtcaggtcaaagaatatggccagaagagggcattctgcacagatt
gctaaacctattcgtcccgggcaacatccagcagcttctccaactcacccaagtgcaatt
cgtggaggaggtgcatttgttcagaacagccagccagtggcagtgcgaggtggaggaggc
aaacaagtgtaa

KEGG   Homo sapiens (human): 3800
Entry
3800              CDS       T01001                                 

Gene name
KIF5C, CDCBM2, KINN, NKHC, NKHC-2, NKHC2
Definition
(RefSeq) kinesin family member 5C
  KO
K10396  kinesin family member 5
Organism
hsa  Homo sapiens (human)
Pathway
hsa04144  Endocytosis
hsa04728  Dopaminergic synapse
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05132  Salmonella infection
hsa05223  Non-small cell lung cancer
Network
nt06419  Microtubule-based transport
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06465  Prion disease
  Element
N00978  Anterograde axonal transport
N00979  Mutation-caused aberrant Htt to anterograde axonal transport
N01017  Mutation-caused aberrant PSEN1 to anterograde axonal transport
N01055  Mutation-caused aberrant SNCA to anterograde axonal transport
N01202  Oligomeric conformation PrPc to anterograde axonal transport
Disease
H01881  Complex cortical dysplasia with other brain malformations
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    3800 (KIF5C)
 09150 Organismal Systems
  09156 Nervous system
   04728 Dopaminergic synapse
    3800 (KIF5C)
 09160 Human Diseases
  09162 Cancer: specific types
   05223 Non-small cell lung cancer
    3800 (KIF5C)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    3800 (KIF5C)
   05012 Parkinson disease
    3800 (KIF5C)
   05014 Amyotrophic lateral sclerosis
    3800 (KIF5C)
   05016 Huntington disease
    3800 (KIF5C)
   05020 Prion disease
    3800 (KIF5C)
   05022 Pathways of neurodegeneration - multiple diseases
    3800 (KIF5C)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    3800 (KIF5C)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    3800 (KIF5C)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    3800 (KIF5C)
   04147 Exosome [BR:hsa04147]
    3800 (KIF5C)
Membrane trafficking [BR:hsa04131]
 Others
  Actin-binding proteins
   Others
    3800 (KIF5C)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulin-binding proteins
    Kinesins
     3800 (KIF5C)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   3800 (KIF5C)
SSDB
Motif
Pfam: Kinesin Microtub_bd
Other DBs
NCBI-GeneID: 3800
NCBI-ProteinID: NP_004513
OMIM: 604593
HGNC: 6325
Ensembl: ENSG00000168280
Vega: OTTHUMG00000153779
Pharos: O60282(Tbio)
UniProt: O60282 Q59GB8
LinkDB
Position
2q23.1-q23.2
AA seq 957 aa
MADPAECSIKVMCRFRPLNEAEILRGDKFIPKFKGDETVVIGQGKPYVFDRVLPPNTTQE
QVYNACAKQIVKDVLEGYNGTIFAYGQTSSGKTHTMEGKLHDPQLMGIIPRIAHDIFDHI
YSMDENLEFHIKVSYFEIYLDKIRDLLDVSKTNLAVHEDKNRVPYVKGCTERFVSSPEEV
MDVIDEGKANRHVAVTNMNEHSSRSHSIFLINIKQENVETEKKLSGKLYLVDLAGSEKVS
KTGAEGAVLDEAKNINKSLSALGNVISALAEGTKTHVPYRDSKMTRILQDSLGGNCRTTI
VICCSPSVFNEAETKSTLMFGQRAKTIKNTVSVNLELTAEEWKKKYEKEKEKNKTLKNVI
QHLEMELNRWRNGEAVPEDEQISAKDQKNLEPCDNTPIIDNIAPVVAGISTEEKEKYDEE
ISSLYRQLDDKDDEINQQSQLAEKLKQQMLDQDELLASTRRDYEKIQEELTRLQIENEAA
KDEVKEVLQALEELAVNYDQKSQEVEDKTRANEQLTDELAQKTTTLTTTQRELSQLQELS
NHQKKRATEILNLLLKDLGEIGGIIGTNDVKTLADVNGVIEEEFTMARLYISKMKSEVKS
LVNRSKQLESAQMDSNRKMNASERELAACQLLISQHEAKIKSLTDYMQNMEQKRRQLEES
QDSLSEELAKLRAQEKMHEVSFQDKEKEHLTRLQDAEEMKKALEQQMESHREAHQKQLSR
LRDEIEEKQKIIDEIRDLNQKLQLEQEKLSSDYNKLKIEDQEREMKLEKLLLLNDKREQA
REDLKGLEETVSRELQTLHNLRKLFVQDLTTRVKKSVELDNDDGGGSAAQKQKISFLENN
LEQLTKVHKQLVRDNADLRCELPKLEKRLRATAERVKALESALKEAKENAMRDRKRYQQE
VDRIKEAVRAKNMARRAHSAQIAKPIRPGHYPASSPTAVHAIRGGGGSSSNSTHYQK
NT seq 2874 nt   +upstreamnt  +downstreamnt
atggcggatccagccgaatgcagcatcaaagtgatgtgccggttccggcccctcaacgaa
gcggagatcctccgcggggacaaattcatccccaaatttaaaggcgatgagaccgtggtg
atcgggcaagggaagccatatgtcttcgacagagtgctacctcccaacacgacccaagag
caggtttacaatgcatgtgcgaagcaaattgtcaaagatgtccttgaaggttataacggg
acgatttttgcgtatgggcagacttcatcaggaaaaacccacaccatggaggggaagctg
catgacccccagctcatggggatcatcccacgaattgcccatgatatctttgaccatatc
tactccatggatgagaacctggagtttcacataaaggtttcctattttgagatctacttg
gacaaaataagggacttacttgatgtatccaagaccaacttggctgttcatgaagataaa
aacagagtcccgtatgtaaaggggtgcactgagcggtttgtgtcgagccctgaggaagtc
atggatgtaatagatgaaggcaaagcaaaccgacacgtggctgtgacaaacatgaatgaa
cacagctctagaagtcacagtatcttcctgataaatattaaacaagagaatgtagagact
gaaaaaaaactcagtgggaaactttatttggttgatttggctgggagcgaaaaggtcagc
aaaactggtgccgagggagctgttcttgacgaagctaaaaatatcaataagtctttgtct
gctcttggaaatgtgatctctgctttggcagaagggacaaaaacacatgtgccataccgg
gacagcaagatgactcggattcttcaggactctttgggtgggaactgcagaaccaccatc
gtcatttgctgttctccttctgtcttcaatgaggctgagaccaagtccacactgatgttc
ggacagagagctaagaccatcaagaatacagtctctgtgaacctagaactgacagcagaa
gaatggaagaagaaatatgaaaaagagaaagagaaaaacaagactttgaagaatgttatc
cagcatctggagatggagctaaacaggtggaggaatggagaagctgtgcctgaggatgaa
cagatcagtgccaaggaccagaagaacctggagccttgtgataacacccccatcatagac
aatattgctcctgttgttgctggcatctctacagaggagaaagagaagtacgatgaggag
atctccagtctctacagacaactggatgacaaggatgatgaaattaaccagcagagccag
ctggctgaaaagctgaagcaacagatgttggatcaggatgagcttttagcttccacaaga
agagactatgagaagatacaggaggagctgacacgtctccagattgaaaatgaggcagcc
aaggatgaggtgaaagaagttctccaggccctggaggagctggctgtcaattatgaccag
aaatcacaggaagtggaggataagacccgggccaatgagcagctgacagacgagctggcc
cagaaaacgactacattgacaaccacacagagagagctgagccagctacaagagcttagc
aaccaccagaagaaaagggcaactgagatcctgaatttgctgttgaaagatctgggggag
ataggtggaattattggcaccaatgatgtgaaaactttggcagatgtgaatggagtcatt
gaggaggagtttaccatggcccgcctgtacatcagcaagatgaagtcagaggtcaagtcc
ctggtgaaccgcagcaaacagctcgagagcgcccagatggactccaacaggaagatgaat
gccagcgagcgggagctggcagcctgccagctgctcatctcccagcacgaagccaagatc
aagtctctgacagactacatgcagaacatggaacagaagaggaggcagctagaagagtcc
caggactcgctcagcgaagagctggcaaagctccgagcccaggaaaaaatgcacgaagtc
agcttccaggataaggagaaggaacatctgacgcggttgcaggatgctgaagaaatgaag
aaggcgctggagcagcagatggagagccaccgggaagctcaccagaagcagctgtccaga
ctccgagacgaaattgaggagaagcagaaaatcattgatgagattcgggatttgaatcag
aaactgcaactggaacaggagaagcttagttctgattataacaagctgaaaatagaggac
caagagagagaaatgaagctggaaaagctcttattgctcaacgataaaagggaacaagcc
agagaagacctcaaagggctggaggagacagtgtctagagaattgcagacactgcacaac
cttcggaaactctttgtccaggatctgaccacccgagttaaaaaaagtgtggagttggac
aacgatgatggagggggcagtgctgcccagaagcagaaaatttccttcttggagaataac
ctggagcagctcaccaaagttcacaagcagctggtccgggacaacgcagacctgcgctgt
gaactgcccaagctggagaagcggctgcgtgccacggcggagcgcgtcaaggctctggag
agcgcgctgaaggaggccaaggagaacgccatgcgggaccgtaagcgctaccagcaggag
gtggatcgtatcaaggaggccgtgcgggccaagaacatggccagaagggcccattcagcc
cagatcgccaagcccatccgccccggacactacccggcctcatctccaacggccgtccat
gccattcgagggggaggaggcagctcttcaaattccactcactaccagaaataa

KEGG   Homo sapiens (human): 3831
Entry
3831              CDS       T01001                                 

Gene name
KLC1, KLC, KNS2, KNS2A
Definition
(RefSeq) kinesin light chain 1
  KO
K10407  kinesin light chain
Organism
hsa  Homo sapiens (human)
Pathway
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05132  Salmonella infection
Network
nt06419  Microtubule-based transport
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06465  Prion disease
  Element
N00978  Anterograde axonal transport
N00979  Mutation-caused aberrant Htt to anterograde axonal transport
N01017  Mutation-caused aberrant PSEN1 to anterograde axonal transport
N01055  Mutation-caused aberrant SNCA to anterograde axonal transport
N01202  Oligomeric conformation PrPc to anterograde axonal transport
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    3831 (KLC1)
   05012 Parkinson disease
    3831 (KLC1)
   05014 Amyotrophic lateral sclerosis
    3831 (KLC1)
   05016 Huntington disease
    3831 (KLC1)
   05020 Prion disease
    3831 (KLC1)
   05022 Pathways of neurodegeneration - multiple diseases
    3831 (KLC1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    3831 (KLC1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis [BR:hsa03019]
    3831 (KLC1)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    3831 (KLC1)
Messenger RNA biogenesis [BR:hsa03019]
 Eukaryotic type
  mRNA surveillance and transport factors
   mRNA cycle factors
    P-body specific factors
     3831 (KLC1)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulin-binding proteins
    Kinesins
     3831 (KLC1)
SSDB
Motif
Pfam: TPR_12 TPR_10 TPR_7 TPR_1 TPR_2 TPR_16 TPR_8 TPR_MalT TPR_19 TPR_17 ANAPC3 PPR RNPP_C JIP_LZII GHL5 DUF4919 COG2 TPR_11
Other DBs
NCBI-GeneID: 3831
NCBI-ProteinID: NP_891553
OMIM: 600025
HGNC: 6387
Ensembl: ENSG00000126214
Vega: OTTHUMG00000169227
Pharos: Q07866(Tbio)
UniProt: Q07866
LinkDB
Structure
PDB: 
5OJ8 3NF1

Position
14q32.33
AA seq 573 aa
MYDNMSTMVYIKEDKLEKLTQDEIISKTKQVIQGLEALKNEHNSILQSLLETLKCLKKDD
ESNLVEEKSNMIRKSLEMLELGLSEAQVMMALSNHLNAVESEKQKLRAQVRRLCQENQWL
RDELANTQQKLQKSEQSVAQLEEEKKHLEFMNQLKKYDDDISPSEDKDTDSTKEPLDDLF
PNDEDDPGQGIQQQHSSAAAAAQQGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQAL
EDLEKTSGHDHPDVATMLNILALVYRDQNKYKDAANLLNDALAIREKTLGKDHPAVAATL
NNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKDHPDVAKQLNNLALLCQNQGKYEEVEY
YYQRALEIYQTKLGPDDPNVAKTKNNLASCYLKQGKFKQAETLYKEILTRAHEREFGSVD
DENKPIWMHAEEREECKGKQKDGTSFGEYGGWYKACKVDSPTVTTTLKNLGALYRRQGKF
EAAETLEEAAMRSRKQGLDNVHKQRVAEVLNDPENMEKRRSRESLNVDVVKYESGPDGGE
EVSMSVEWNGGVSGRASFCGKRQQQQWPGRRHR
NT seq 1722 nt   +upstreamnt  +downstreamnt
atgtatgacaacatgtccacaatggtgtacataaaggaagacaagttggagaagcttaca
caggatgaaattatttctaagacaaagcaagtaattcaggggctggaagctttgaagaat
gagcacaattccattttacaaagtttgctggagacactgaagtgtttgaagaaagatgat
gaaagtaatttggtggaggagaaatcaaacatgatccggaagtcactggagatgttggag
ctcggcctgagtgaggcacaggttatgatggctttgtcaaatcacctgaatgctgtggag
tccgagaagcagaaactgcgtgcgcaggttcgtcgtctgtgccaggagaatcagtggcta
cgggatgaactggccaacacgcagcagaaactgcagaagagtgagcagtctgtggctcaa
ctggaggaggagaagaagcatctggagtttatgaatcagctaaaaaaatatgatgacgac
atttccccatccgaggacaaagacactgattctaccaaagagcctctggatgaccttttc
cccaatgatgaagacgacccagggcaaggaatccagcagcagcacagcagtgcagccgcg
gctgcccagcagggcggctacgagatccccgcgcggctgcggacgctccacaacctggtg
atccagtacgcctcgcaggggcgctacgaggtagctgtgcccctctgcaagcaggccctg
gaggacctggagaagacttcaggacacgaccacccggacgtggccaccatgctcaacatc
ctggccttggtgtacagggatcagaataaatacaaagatgcagctaacctactgaatgat
gccttggctattcgtgagaaaactttgggcaaagatcatcctgcggtggcggcgactttg
aataaccttgcagtcctttatggtaaaagagggaagtacaaagaagcagagccgttgtgt
aaaagagctctggaaatccgagaaaaggttttggggaaggatcaccccgatgttgccaag
cagttaaataacttggccttactgtgccagaaccagggcaagtatgaagaagtagaatat
tattatcaaagagccctcgagatctaccagacaaaactgggacctgatgaccccaacgtg
gctaagacgaaaaataacctggcatcctgctatttgaaacaaggaaagttcaagcaagca
gaaacactgtacaaagagattctcactcgtgcacatgaaagggagtttggttctgtagat
gatgaaaataaacccatctggatgcatgctgaagaaagagaagaatgcaaaggaaagcaa
aaggatgggacatcttttggagagtatggcggctggtacaaagcctgcaaagttgatagt
ccaactgttacaaccactctaaaaaaccttggggcactttacagacgtcaaggcaaattt
gaagctgcagaaacgttagaagaagctgctatgaggtctcgtaaacagggtcttgacaat
gttcacaaacagagggtggcagaagtgctcaatgaccctgagaacatggagaagcgcagg
agccgtgagagcctcaacgtggacgtggtcaagtacgagagtggccctgacggaggggag
gaagtgagtatgagcgtagagtggaacgggggcgtctctggccgagcctctttttgtgga
aaacgacagcagcagcagtggcctggaagacgccaccgctaa

KEGG   Homo sapiens (human): 64837
Entry
64837             CDS       T01001                                 

Gene name
KLC2
Definition
(RefSeq) kinesin light chain 2
  KO
K10407  kinesin light chain
Organism
hsa  Homo sapiens (human)
Pathway
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05132  Salmonella infection
Network
nt06419  Microtubule-based transport
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06465  Prion disease
  Element
N00978  Anterograde axonal transport
N00979  Mutation-caused aberrant Htt to anterograde axonal transport
N01017  Mutation-caused aberrant PSEN1 to anterograde axonal transport
N01055  Mutation-caused aberrant SNCA to anterograde axonal transport
N01202  Oligomeric conformation PrPc to anterograde axonal transport
Disease
H02114  Spastic paraplegia, optic atrophy, and neuropathy
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    64837 (KLC2)
   05012 Parkinson disease
    64837 (KLC2)
   05014 Amyotrophic lateral sclerosis
    64837 (KLC2)
   05016 Huntington disease
    64837 (KLC2)
   05020 Prion disease
    64837 (KLC2)
   05022 Pathways of neurodegeneration - multiple diseases
    64837 (KLC2)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    64837 (KLC2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis [BR:hsa03019]
    64837 (KLC2)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    64837 (KLC2)
Messenger RNA biogenesis [BR:hsa03019]
 Eukaryotic type
  mRNA surveillance and transport factors
   mRNA cycle factors
    P-body specific factors
     64837 (KLC2)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulin-binding proteins
    Kinesins
     64837 (KLC2)
SSDB
Motif
Pfam: TPR_12 TPR_10 TPR_7 TPR_1 TPR_2 TPR_MalT TPR_8 TPR_16 TPR_19 TPR_17 SNAP ANAPC3 PPR JIP_LZII Crescentin DUF627 TMF_TATA_bd TMF_DNA_bd Csm1_N YabA KASH_CCD Uso1_p115_C COG2
Other DBs
NCBI-GeneID: 64837
NCBI-ProteinID: NP_001128247
OMIM: 611729
HGNC: 20716
Ensembl: ENSG00000174996
Vega: OTTHUMG00000133757
Pharos: Q9H0B6(Tdark)
UniProt: Q9H0B6
LinkDB
Structure
PDB: 
3EDT 3CEQ

Position
11q13.2
AA seq 622 aa
MAMMVFPREEKLSQDEIVLGTKAVIQGLETLRGEHRALLAPLVAPEAGEAEPGSQERCIL
LRRSLEAIELGLGEAQVILALSSHLGAVESEKQKLRAQVRRLVQENQWLREELAGTQQKL
QRSEQAVAQLEEEKQHLLFMSQIRKLDEDASPNEEKGDVPKDTLDDLFPNEDEQSPAPSP
GGGDVSGQHGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVA
TMLNILALVYRDQNKYKEAAHLLNDALAIREKTLGKDHPAVAATLNNLAVLYGKRGKYKE
AEPLCKRALEIREKVLGKFHPDVAKQLSNLALLCQNQGKAEEVEYYYRRALEIYATRLGP
DDPNVAKTKNNLASCYLKQGKYQDAETLYKEILTRAHEKEFGSVNGDNKPIWMHAEEREE
SKDKRRDSAPYGEYGSWYKACKVDSPTVNTTLRSLGALYRRQGKLEAAHTLEDCASRNRK
QGLDPASQTKVVELLKDGSGRRGDRRSSRDMAGGAGPRSESDLEDVGPTAEWNGDGSGSL
RRSGSFGKLRDALRRSSEMLVKKLQGGTPQEPPNPRMKRASSLNFLNKSVEEPTQPGGTG
LSDSRTLSSSSMDLSRRSSLVG
NT seq 1869 nt   +upstreamnt  +downstreamnt
atggccatgatggtgtttccgcgggaggagaagctgagccaggatgagatcgtgctgggc
accaaggctgtcatccagggactggagactctgcgtggggagcatcgtgccctgctggct
cctctggttgcacctgaggccggcgaagccgagcctggctcgcaggagcgctgcatcctc
ctgcgtcgctccctggaagccattgagcttgggctgggggaggcccaggtgatcttggca
ttgtcgagccacctgggggctgtagaatcagagaagcagaagctgcgggcgcaggtgcgg
cgtctggtgcaggagaaccagtggctgcgtgaggagctggcggggacacagcagaagctg
cagcgcagtgagcaggccgtggcccagctcgaggaggagaagcagcacttgctgttcatg
agccagatccgcaagttggatgaagacgcctcccctaacgaggagaagggggacgtcccc
aaagacacactggatgacctgttccccaatgaggatgagcagagcccagcccctagccca
ggaggaggggatgtgtctggtcagcatgggggctacgagatcccggcccggctccgcacc
ctgcacaacctggtgatccaatacgcctcacagggccgctacgaggtagctgtgccactc
tgcaagcaggcactcgaagacctggagaagacgtcaggccacgaccaccctgacgttgcc
accatgctgaacatcctggcactggtctatcgggatcagaacaagtacaaggaggctgcc
cacctgctcaatgatgctctggccatccgggagaaaacactgggcaaggaccacccagcc
gtggctgcgacactaaacaacctggcagtcctgtatggcaagaggggcaagtacaaggag
gctgagccattgtgcaagcgggcactggagatccgggagaaggtcctgggcaagtttcac
ccagatgtggccaagcagctcagcaacctggccctgctgtgccagaaccagggcaaagct
gaggaggtggaatattactatcggcgggcactggagatctatgctacacgcctcgggccc
gatgaccccaatgtggccaagaccaagaacaacctggcttcctgctacctgaagcagggc
aagtaccaggatgcggagaccttgtacaaggagatcctcacccgcgctcatgagaaagag
tttggctctgtcaatggggacaacaagcccatctggatgcacgcagaggagcgggaggaa
agcaaggataagcgccgggacagcgccccctatggggaatacggcagctggtacaaggcc
tgtaaagtagacagccccacagtcaacaccaccctgcgcagcttgggggccctataccgg
cgccagggcaagctggaagccgcgcacacactagaggactgtgccagccgtaaccgcaag
cagggtttggaccccgcaagccagaccaaggtggtagaactgctgaaagatggcagtggc
aggcggggagaccgccgcagcagccgagacatggctgggggtgccgggcctcggtctgag
tctgacctcgaggacgtgggacctacagctgagtggaatggggatggcagtggctccttg
aggcgcagcggttcctttgggaaactccgggatgccctgaggcgcagcagtgagatgctg
gtaaagaagctgcaggggggcaccccccaggagccccctaaccccaggatgaagcgggcc
agttccctcaacttcctcaacaagagcgtggaagagccgacccagcctggaggcacaggt
ctctctgacagccgcactctcagctccagctccatggacctctcccgacgaagctccctg
gtgggctaa

KEGG   Homo sapiens (human): 89953
Entry
89953             CDS       T01001                                 

Gene name
KLC4, KNSL8, bA387M24.3
Definition
(RefSeq) kinesin light chain 4
  KO
K10407  kinesin light chain
Organism
hsa  Homo sapiens (human)
Pathway
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05132  Salmonella infection
Network
nt06419  Microtubule-based transport
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06465  Prion disease
  Element
N00978  Anterograde axonal transport
N00979  Mutation-caused aberrant Htt to anterograde axonal transport
N01017  Mutation-caused aberrant PSEN1 to anterograde axonal transport
N01055  Mutation-caused aberrant SNCA to anterograde axonal transport
N01202  Oligomeric conformation PrPc to anterograde axonal transport
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    89953 (KLC4)
   05012 Parkinson disease
    89953 (KLC4)
   05014 Amyotrophic lateral sclerosis
    89953 (KLC4)
   05016 Huntington disease
    89953 (KLC4)
   05020 Prion disease
    89953 (KLC4)
   05022 Pathways of neurodegeneration - multiple diseases
    89953 (KLC4)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    89953 (KLC4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis [BR:hsa03019]
    89953 (KLC4)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    89953 (KLC4)
Messenger RNA biogenesis [BR:hsa03019]
 Eukaryotic type
  mRNA surveillance and transport factors
   mRNA cycle factors
    P-body specific factors
     89953 (KLC4)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulin-binding proteins
    Kinesins
     89953 (KLC4)
SSDB
Motif
Pfam: TPR_12 TPR_10 TPR_7 TPR_1 TPR_2 TPR_8 TPR_MalT TPR_16 TPR_19 TPR_14 TPR_17 ANAPC3 PPR JIP_LZII RPN7 Crescentin Uso1_p115_C TMF_TATA_bd LUD_dom TMF_DNA_bd Csm1_N
Other DBs
NCBI-GeneID: 89953
NCBI-ProteinID: NP_001275963
HGNC: 21624
Ensembl: ENSG00000137171
Vega: OTTHUMG00000014720
Pharos: Q9NSK0(Tdark)
UniProt: Q9NSK0 A0A024RCZ8
LinkDB
Position
6p21.1
AA seq 619 aa
MSGLVLGQRDEPAGHRLSQEEILGSTRLVSQGLEALRSEHQAVLQSLSQTIECLQQGGHE
EGLVHEKARQLRRSMENIELGLSEAQVMLALASHLSTVESEKQKLRAQVRRLCQENQWLR
DELAGTQQRLQRSEQAVAQLEEEKKHLEFLGQLRQYDEDGHTSEEKEGDATKDSLDDLFP
NEEEEDPSNGLSRGQGATAAQQGGYEIPARLRTLHNLVIQYAAQGRYEVAVPLCKQALED
LERTSGRGHPDVATMLNILALVYRDQNKYKEAAHLLNDALSIRESTLGPDHPAVAATLNN
LAVLYGKRGKYKEAEPLCQRALEIREKVLGTNHPDVAKQLNNLALLCQNQGKYEAVERYY
QRALAIYEGQLGPDNPNVARTKNNLASCYLKQGKYAEAETLYKEILTRAHVQEFGSVDDD
HKPIWMHAEEREEMSKSRHHEGGTPYAEYGGWYKACKVSSPTVNTTLRNLGALYRRQGKL
EAAETLEECALRSRRQGTDPISQTKVAELLGESDGRRTSQEGPGDSVKFEGGEDASVAVE
WSGDGSGTLQRSGSLGKIRDVLRRSSELLVRKLQGTEPRPSSSNMKRAASLNYLNQPSAA
PLQVSRGLSASTMDLSSSS
NT seq 1860 nt   +upstreamnt  +downstreamnt
atgtcaggcctggtgttggggcagcgggatgagcctgcaggccaccggctcagccaagag
gagatcctggggagcacacggctggtcagccaagggctagaggccctacgcagtgaacac
caggccgtgctgcaaagcctgtcccagaccattgagtgtctgcagcagggaggccatgag
gaagggctggtgcatgagaaggcccggcagcttcgccgttctatggaaaacattgagctc
gggctgagtgaggcccaggtgatgctggctctagccagccacctgagcacagtggagtcg
gagaaacagaagctgcgggctcaggtgcggcggctatgccaggagaaccagtggctgcgg
gatgagctggctggcacccagcagcggctacagcgcagtgaacaggctgtggctcagctg
gaggaggaaaagaagcacctggagttcctggggcagctgcggcagtatgatgaggatgga
catacctcggaggagaaagaaggcgatgccaccaaggattccctggatgacctctttcct
aatgaggaggaagaggaccccagcaatggcttgtcccgtggtcaaggtgctacagcagct
cagcagggtggatatgagatcccagcaaggttgcggacgttgcacaacctggtgatccag
tacgcagcccaaggtcgctatgaggtggccgtgccactctgtaagcaggcactagaggac
ctggagcgcacatcaggccgtggccaccctgatgtcgccaccatgctcaacatccttgct
ttggtgtatcgtgaccagaataagtataaggaagctgcccacctgctgaatgatgccctt
agcatccgggagagcaccttgggacctgaccatcctgctgtggctgccacactcaacaat
ttggctgtgctctatggcaaaaggggcaagtacaaggaggcagagcctctgtgccagcgg
gcactggagattcgagaaaaggtcctgggcacgaatcatccagatgtggcaaaacagctg
aacaacctggccctcttgtgccaaaaccagggcaagtatgaggccgtggaacgctactac
cagcgagcactggccatctacgaggggcagctggggccggacaaccctaatgtagcccgg
accaagaacaacctggcttcctgttacctgaaacagggcaaatatgctgaggctgagaca
ctatacaaagagatcctgacccgtgcccatgtacaggagtttgggtctgtggatgatgac
cacaagcccatctggatgcatgcagaggagcgggaggaaatgagcaaaagccggcaccat
gagggtgggacaccctatgctgagtatggaggctggtacaaggcctgcaaagtgagcagc
cccacagtgaacactactctgagaaacctgggagctctgtataggcgccagggaaagctg
gaggctgctgagaccctggaggaatgtgccctgcggtcccggagacagggcactgaccct
atcagccagacgaaggtggcagagctgcttggggagagtgatggtagaaggacctcccag
gagggccctggagacagtgtgaaattcgagggaggtgaagatgcttctgtggctgtggag
tggtccggggatggcagtgggaccctgcagaggagtggctctcttggcaagatccgggat
gtgctccgcagaagcagtgaactcttggtgaggaagctccaggggactgagcctcggccc
tccagcagcaacatgaagcgagcagcctccttgaactatctgaaccaacctagtgcagca
cccctccaggtctcccggggcctcagtgccagcaccatggacctctcttcaagcagctga

DBGET integrated database retrieval system