Homo sapiens (human): 1558
Entry
1558 CDS
T01001
Gene name
CYP2C8, CPC8, CYP2C8DM, CYPIIC8, MP-12/MP-20
Definition
(RefSeq) cytochrome P450 family 2 subfamily C member 8
KO
K17718
cytochrome P450 family 2 subfamily C polypeptide 8 [EC:
1.14.14.1
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00590
Arachidonic acid metabolism
hsa00591
Linoleic acid metabolism
hsa00830
Retinol metabolism
hsa00982
Drug metabolism - cytochrome P450
hsa01100
Metabolic pathways
hsa04726
Serotonergic synapse
hsa05204
Chemical carcinogenesis
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09103 Lipid metabolism
00590 Arachidonic acid metabolism
1558 (CYP2C8)
00591 Linoleic acid metabolism
1558 (CYP2C8)
09108 Metabolism of cofactors and vitamins
00830 Retinol metabolism
1558 (CYP2C8)
09111 Xenobiotics biodegradation and metabolism
00982 Drug metabolism - cytochrome P450
1558 (CYP2C8)
09150 Organismal Systems
09156 Nervous system
04726 Serotonergic synapse
1558 (CYP2C8)
09160 Human Diseases
09161 Cancer: overview
05204 Chemical carcinogenesis
1558 (CYP2C8)
09180 Brite Hierarchies
09181 Protein families: metabolism
00199 Cytochrome P450 [BR:
hsa00199
]
1558 (CYP2C8)
Enzymes [BR:
hsa01000
]
1. Oxidoreductases
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
1.14.14.1 unspecific monooxygenase
1558 (CYP2C8)
Cytochrome P450 [BR:
hsa00199
]
Cytochrome P450, animal type
CYP2 family
1558 (CYP2C8)
SSDB
Motif
Pfam:
p450
Other DBs
NCBI-GeneID:
1558
NCBI-ProteinID:
NP_000761
OMIM:
601129
HGNC:
2622
Ensembl:
ENSG00000138115
Vega:
OTTHUMG00000018804
Pharos:
P10632
(Tbio)
UniProt:
P10632
LinkDB
Structure
PDB:
2NNJ
2NNH
2VN0
1PQ2
2NNI
Position
10q23.33
AA seq
490 aa
MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKV
YGPVFTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRW
KEIRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICS
VVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALT
RSYIREKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTE
TTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSD
LVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFK
KSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLP
PSYQICFIPV
NT seq
1473 nt
+upstream
nt +downstream
nt
atggaaccttttgtggtcctggtgctgtgtctctcttttatgcttctcttttcactctgg
agacagagctgtaggagaaggaagctccctcctggccccactcctcttcctattattgga
aatatgctacagatagatgttaaggacatctgcaaatctttcaccaatttctcaaaagtc
tatggtcctgtgttcaccgtgtattttggcatgaatcccatagtggtgtttcatggatat
gaggcagtgaaggaagccctgattgataatggagaggagttttctggaagaggcaattcc
ccaatatctcaaagaattactaaaggacttggaatcatttccagcaatggaaagagatgg
aaggagatccggcgtttctccctcacaaccttgcggaattttgggatggggaagaggagc
attgaggaccgtgttcaagaggaagctcactgccttgtggaggagttgagaaaaaccaag
gcttcaccctgtgatcccactttcatcctgggctgtgctccctgcaatgtgatctgctcc
gttgttttccagaaacgatttgattataaagatcagaattttctcaccctgatgaaaaga
ttcaatgaaaacttcaggattctgaactccccatggatccaggtctgcaataatttccct
ctactcattgattgtttcccaggaactcacaacaaagtgcttaaaaatgttgctcttaca
cgaagttacattagggagaaagtaaaagaacaccaagcatcactggatgttaacaatcct
cgggactttatcgattgcttcctgatcaaaatggagcaggaaaaggacaaccaaaagtca
gaattcaatattgaaaacttggttggcactgtagctgatctatttgttgctggaacagag
acaacaagcaccactctgagatatggactcctgctcctgctgaagcacccagaggtcaca
gctaaagtccaggaagagattgatcatgtaattggcagacacaggagcccctgcatgcag
gataggagccacatgccttacactgatgctgtagtgcacgagatccagagatacagtgac
cttgtccccaccggtgtgccccatgcagtgaccactgatactaagttcagaaactacctc
atccccaagggcacaaccataatggcattactgacttccgtgctacatgatgacaaagaa
tttcctaatccaaatatctttgaccctggccactttctagataagaatggcaactttaag
aaaagtgactacttcatgcctttctcagcaggaaaacgaatttgtgcaggagaaggactt
gcccgcatggagctatttttatttctaaccacaattttacagaactttaacctgaaatct
gttgatgatttaaagaacctcaatactactgcagttaccaaagggattgtttctctgcca
ccctcataccagatctgcttcatccctgtctga
DBGET
integrated database retrieval system
