KEGG T01001: 1565

Homo sapiens (human): 1565

Entry

1565 CDS T01001

Gene name

CYP2D6, CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, P450-DB1, P450C2D, P450DB1

Definition

(RefSeq) cytochrome P450 family 2 subfamily D member 6

K17712

cytochrome P450 family 2 subfamily D polypeptide 6 [EC:1.14.14.1]

Organism

hsa Homo sapiens (human)

Pathway

hsa00980

Metabolism of xenobiotics by cytochrome P450

hsa00982

Drug metabolism - cytochrome P450

hsa01522

Endocrine resistance

hsa04726

Serotonergic synapse

Disease

H01171

Poor drug metabolism

Brite

KEGG Orthology (KO) [BR:hsa00001]
09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    1565 (CYP2D6)
   00982 Drug metabolism - cytochrome P450
    1565 (CYP2D6)
09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    1565 (CYP2D6)
09160 Human Diseases
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    1565 (CYP2D6)
09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450 [BR:hsa00199]
    1565 (CYP2D6)
Enzymes [BR:hsa01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     1565 (CYP2D6)
Cytochrome P450 [BR:hsa00199]
Cytochrome P450, animal type
  CYP2 family
   1565 (CYP2D6)

SSDB

Motif

Pfam:

p450

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

Vega:

Pharos:

P10635(Tclin)

UniProt:

P10635 C1ID52 Q5Y7H2

LinkDB

Structure

PDB:

3TBG 4WNU 4WNV 6CSB 6CSD 4XRZ 4XRY 4WNT 3TDA 5TFT 5TFU 3QM4 2F9Q 4WNW

Position

22q13.2

AA seq 497 aa
MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ
LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF
LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK
AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV
LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA
DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI
HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF
LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV
FAFLVSPSPYELCAVPR

NT seq 1494 nt +upstreamnt +downstreamnt
atggggctagaagcactggtgcccctggccgtgatagtggccatcttcctgctcctggtg
gacctgatgcaccggcgccaacgctgggctgcacgctacccaccaggccccctgccactg
cccgggctgggcaacctgctgcatgtggacttccagaacacaccatactgcttcgaccag
ttgcggcgccgcttcggggacgtgttcagcctgcagctggcctggacgccggtggtcgtg
ctcaatgggctggcggccgtgcgcgaggcgctggtgacccacggcgaggacaccgccgac
cgcccgcctgtgcccatcacccagatcctgggtttcgggccgcgttcccaaggggtgttc
ctggcgcgctatgggcccgcgtggcgcgagcagaggcgcttctccgtgtccaccttgcgc
aacttgggcctgggcaagaagtcgctggagcagtgggtgaccgaggaggccgcctgcctt
tgtgccgccttcgccaaccactccggacgcccctttcgccccaacggtctcttggacaaa
gccgtgagcaacgtgatcgcctccctcacctgcgggcgccgcttcgagtacgacgaccct
cgcttcctcaggctgctggacctagctcaggagggactgaaggaggagtcgggctttctg
cgcgaggtgctgaatgctgtccccgtcctcctgcatatcccagcgctggctggcaaggtc
ctacgcttccaaaaggctttcctgacccagctggatgagctgctaactgagcacaggatg
acctgggacccagcccagcccccccgagacctgactgaggccttcctggcagagatggag
aaggccaaggggaaccctgagagcagcttcaatgatgagaacctgcgcatagtggtggct
gacctgttctctgccgggatggtgaccacctcgaccacgctggcctggggcctcctgctc
atgatcctacatccggatgtgcagcgccgtgtccaacaggagatcgacgacgtgataggg
caggtgcggcgaccagagatgggtgaccaggctcacatgccctacaccactgccgtgatt
catgaggtgcagcgctttggggacatcgtccccctgggtgtgacccatatgacatcccgt
gacatcgaagtacagggcttccgcatccctaagggaacgacactcatcaccaacctgtca
tcggtgctgaaggatgaggccgtctgggagaagcccttccgcttccaccccgaacacttc
ctggatgcccagggccactttgtgaagccggaggccttcctgcctttctcagcaggccgc
cgtgcatgcctcggggagcccctggcccgcatggagctcttcctcttcttcacctccctg
ctgcagcacttcagcttctcggtgcccactggacagccccggcccagccaccatggtgtc
tttgctttcctggtgagcccatccccctatgagctttgtgctgtgccccgctag

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