| Entry |
|
|---|
| Gene name |
CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1
|
|---|
| Definition |
(RefSeq) cytochrome P450 family 3 subfamily A member 4
|
|---|
| KO |
|
|---|
| Organism |
|
|---|
| Pathway |
| hsa00980 | Metabolism of xenobiotics by cytochrome P450 |
| hsa00982 | Drug metabolism - cytochrome P450 |
| hsa00983 | Drug metabolism - other enzymes |
|
|---|
| Drug target |
|
|---|
| Brite |
KEGG Orthology (KO) [BR:hsa00001]
09100 Metabolism
09103 Lipid metabolism
00140 Steroid hormone biosynthesis
1576 (CYP3A4)
00591 Linoleic acid metabolism
1576 (CYP3A4)
09108 Metabolism of cofactors and vitamins
00830 Retinol metabolism
1576 (CYP3A4)
09111 Xenobiotics biodegradation and metabolism
00980 Metabolism of xenobiotics by cytochrome P450
1576 (CYP3A4)
00982 Drug metabolism - cytochrome P450
1576 (CYP3A4)
00983 Drug metabolism - other enzymes
1576 (CYP3A4)
09150 Organismal Systems
09154 Digestive system
04976 Bile secretion
1576 (CYP3A4)
09160 Human Diseases
09161 Cancer: overview
05204 Chemical carcinogenesis
1576 (CYP3A4)
09180 Brite Hierarchies
09181 Protein families: metabolism
00199 Cytochrome P450 [BR:hsa00199]
1576 (CYP3A4)
Enzymes [BR:hsa01000]
1. Oxidoreductases
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
1.14.13.32 albendazole monooxygenase
1576 (CYP3A4)
1.14.13.-
1576 (CYP3A4)
1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
1.14.14.55 quinine 3-monooxygenase
1576 (CYP3A4)
1.14.14.56 1,8-cineole 2-exo-monooxygenase
1576 (CYP3A4)
1.14.14.57 taurochenodeoxycholate 6alpha-hydroxylase
1576 (CYP3A4)
1.14.14.73 albendazole monooxygenase (sulfoxide-forming)
1576 (CYP3A4)
Cytochrome P450 [BR:hsa00199]
Cytochrome P450, animal type
CYP3 family
1576 (CYP3A4)
 |
|---|
| SSDB |
   |
|---|
| Motif |
 |
|---|
| Other DBs |
|
|---|
| LinkDB |
 |
|---|
| Structure |
PDB: |
|---|
| Position |
7q22.1
|
|---|
| AA seq |
503 aa  
MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMF
DMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISI
AEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYS
MDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICV
FPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSI
IFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVV
NETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFS
KKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLG
GLLQPEKPVVLKVESRDGTVSGA |
|---|
| NT seq |
1512 nt  +upstreamnt +downstreamnt
atggctctcatcccagacttggccatggaaacctggcttctcctggctgtcagcctggtg
ctcctctatctatatggaacccattcacatggactttttaagaagcttggaattccaggg
cccacacctctgccttttttgggaaatattttgtcctaccataagggcttttgtatgttt
gacatggaatgtcataaaaagtatggaaaagtgtggggcttttatgatggtcaacagcct
gtgctggctatcacagatcctgacatgatcaaaacagtgctagtgaaagaatgttattct
gtcttcacaaaccggaggccttttggtccagtgggatttatgaaaagtgccatctctata
gctgaggatgaagaatggaagagattacgatcattgctgtctccaaccttcaccagtgga
aaactcaaggagatggtccctatcattgcccagtatggagatgtgttggtgagaaatctg
aggcgggaagcagagacaggcaagcctgtcaccttgaaagacgtctttggggcctacagc
atggatgtgatcactagcacatcatttggagtgaacatcgactctctcaacaatccacaa
gacccctttgtggaaaacaccaagaagcttttaagatttgattttttggatccattcttt
ctctcaataacagtctttccattcctcatcccaattcttgaagtattaaatatctgtgtg
tttccaagagaagttacaaattttttaagaaaatctgtaaaaaggatgaaagaaagtcgc
ctcgaagatacacaaaagcaccgagtggatttccttcagctgatgattgactctcagaat
tcaaaagaaactgagtcccacaaagctctgtccgatctggagctcgtggcccaatcaatt
atctttatttttgctggctatgaaaccacgagcagtgttctctccttcattatgtatgaa
ctggccactcaccctgatgtccagcagaaactgcaggaggaaattgatgcagttttaccc
aataaggcaccacccacctatgatactgtgctacagatggagtatcttgacatggtggtg
aatgaaacgctcagattattcccaattgctatgagacttgagagggtctgcaaaaaagat
gttgagatcaatgggatgttcattcccaaaggggtggtggtgatgattccaagctatgct
cttcaccgtgacccaaagtactggacagagcctgagaagttcctccctgaaagattcagc
aagaagaacaaggacaacatagatccttacatatacacaccctttggaagtggacccaga
aactgcattggcatgaggtttgctctcatgaacatgaaacttgctctaatcagagtcctt
cagaacttctccttcaaaccttgtaaagaaacacagatccccctgaaattaagcttagga
ggacttcttcaaccagaaaaacccgttgttctaaaggttgagtcaagggatggcaccgta
agtggagcctga |
|---|
