KEGG   Homo sapiens (human): 158835
Entry
158835            CDS       T01001                                 

Gene name
AWAT2, ARAT, DC4, DGAT2L4, MFAT, WS
Definition
(RefSeq) acyl-CoA wax alcohol acyltransferase 2
  KO
K11156  diacylglycerol O-acyltransferase 2-like protein 4 [EC:2.3.1.75 2.3.1.76]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00830  Retinol metabolism
hsa04977  Vitamin digestion and absorption
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    158835 (AWAT2)
 09150 Organismal Systems
  09154 Digestive system
   04977 Vitamin digestion and absorption
    158835 (AWAT2)
Enzymes [BR:hsa01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.75  long-chain-alcohol O-fatty-acyltransferase
     158835 (AWAT2)
    2.3.1.76  retinol O-fatty-acyltransferase
     158835 (AWAT2)
SSDB
Motif
Pfam: DAGAT Acyltransferase
Other DBs
NCBI-GeneID: 158835
NCBI-ProteinID: NP_001002254
OMIM: 300925
HGNC: 23251
Ensembl: ENSG00000147160
Vega: OTTHUMG00000021763
Pharos: Q6E213(Tbio)
UniProt: Q6E213
LinkDB
Position
Xq13.1
AA seq 333 aa
MLLPSKKDLKTALDVFAVFQWSFSALLITTTVIAVNLYLVVFTPYWPVTVLILTWLAFDW
KTPQRGGRRFTCVRHWRLWKHYSDYFPLKLLKTHDICPSRNYILVCHPHGLFAHGWFGHF
ATEASGFSKIFPGITPYILTLGAFFWMPFLREYVMSTGACSVSRSSIDFLLTHKGTGNMV
IVVIGGLAECRYSLPGSSTLVLKNRSGFVRMALQHGVPLIPAYAFGETDLYDQHIFTPGG
FVNRFQKWFQSMVHIYPCAFYGRGFTKNSWGLLPYSRPVTTIVGEPLPMPKIENPSQEIV
AKYHTLYIDALRKLFDQHKTKFGISETQELEII
NT seq 1002 nt   +upstreamnt  +downstreamnt
atgctcttgccctctaagaaggacctcaagactgccctggatgtctttgctgttttccag
tggtccttcagtgccttgcttatcacaaccactgtgattgctgtcaacctctacctggtg
gtgttcacaccatactggcctgtcactgtgcttattcttacctggctggcttttgactgg
aagacccctcagcgaggcggccgccggtttacctgtgtgaggcactggcgcctgtggaaa
cactacagcgattatttccctctcaagcttctgaagactcatgacatctgccccagccgc
aactacatcctcgtctgccaccctcatgggctctttgcccatggatggtttggccacttt
gccacagaggcctcaggcttctccaagatatttcctggcatcaccccttacatactcaca
ctgggagcctttttctggatgcctttcctcagagaatatgtaatgtctacaggggcctgc
tctgtgagtcgatcctccattgactttctgctgactcataaaggcacaggcaacatggtc
attgtggtgattggtggactggctgagtgcagatacagcctgccaggttcttctaccctg
gtgttgaagaaccggtctggctttgtgcgcatggcccttcagcatggggtgcctctaata
cctgcctatgcctttggggagacggacctctatgatcagcacattttcactcctggtggc
tttgtcaaccgcttccagaagtggttccagagcatggtacacatctacccttgtgctttc
tatggacgtggcttcaccaagaactcctggggccttctgccctatagtcggcctgtaacc
accatcgtcggggagcctctaccaatgcccaagattgagaatccaagccaggagatcgtg
gctaaatatcacacactctatattgatgccctacgtaaactgtttgaccagcataagacc
aagtttggtatctcagagacccaggagctggagataatttga

KEGG   Homo sapiens (human): 8694
Entry
8694              CDS       T01001                                 

Gene name
DGAT1, ARAT, ARGP1, DGAT, DIAR7
Definition
(RefSeq) diacylglycerol O-acyltransferase 1
  KO
K11155  diacylglycerol O-acyltransferase 1 [EC:2.3.1.20 2.3.1.75 2.3.1.76]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00561  Glycerolipid metabolism
hsa00830  Retinol metabolism
hsa01100  Metabolic pathways
hsa04975  Fat digestion and absorption
Module
hsa_M00089  Triacylglycerol biosynthesis
Disease
H01174  Congenital diarrhea
Drug target
Pradigastat (DG01846): D10657 D10664
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00561 Glycerolipid metabolism
    8694 (DGAT1)
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    8694 (DGAT1)
 09150 Organismal Systems
  09154 Digestive system
   04975 Fat digestion and absorption
    8694 (DGAT1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.20  diacylglycerol O-acyltransferase
     8694 (DGAT1)
    2.3.1.75  long-chain-alcohol O-fatty-acyltransferase
     8694 (DGAT1)
    2.3.1.76  retinol O-fatty-acyltransferase
     8694 (DGAT1)
SSDB
Motif
Pfam: MBOAT MBOAT_2
Other DBs
NCBI-GeneID: 8694
NCBI-ProteinID: NP_036211
OMIM: 604900
HGNC: 2843
Ensembl: ENSG00000185000
Vega: OTTHUMG00000174606
Pharos: O75907(Tclin)
UniProt: O75907
LinkDB
Position
8q24.3
AA seq 488 aa
MGDRGSSRRRRTGSRPSSHGGGGPAAAEEEVRDAAAGPDVGAAGDAPAPAPNKDGDAGVG
SGHWELRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQV
VSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGLLLHVANLATILCFPA
AVVLLVESITPVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKASSAAAPHT
VSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQVGLIQQWM
VPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREF
YRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKWMARTGVFLASAFFHEYLVS
VPLRMFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVLN
YEAPAAEA
NT seq 1467 nt   +upstreamnt  +downstreamnt
atgggcgaccgcggcagctcccggcgccggaggacagggtcgcggccctcgagccacggc
ggcggcgggcctgcggcggcggaagaggaggtgcgggacgccgctgcgggccccgacgtg
ggagccgcgggggacgcgccagccccggcccccaacaaggacggagacgccggcgtgggc
agcggccactgggagctgaggtgccatcgcctgcaggattctttattcagctctgacagt
ggcttcagcaactaccgtggcatcctgaactggtgtgtggtgatgctgatcttgagcaat
gcccggttatttctggagaacctcatcaagtatggcatcctggtggaccccatccaggtg
gtttctctgttcctgaaggatccctatagctggcccgccccatgcctggttattgcggcc
aatgtctttgctgtggctgcattccaggttgagaagcgcctggcggtgggtgccctgacg
gagcaggcgggactgctgctgcacgtggccaacctggccaccattctgtgtttcccagcg
gctgtggtcttactggttgagtctatcactccagtgggctccctgctggcgctgatggcg
cacaccatcctcttcctcaagctcttctcctaccgcgacgtcaactcatggtgccgcagg
gccagggccaaggctgcctctgcagggaagaaggccagcagtgctgctgccccgcacacc
gtgagctacccggacaatctgacctaccgcgatctctactacttcctcttcgcccccacc
ttgtgctacgagctcaactttccccgctctccccgcatccggaagcgctttctgctgcga
cggatccttgagatgctgttcttcacccagctccaggtggggctgatccagcagtggatg
gtccccaccatccagaactccatgaagcccttcaaggacatggactactcacgcatcatc
gagcgcctcctgaagctggcggtccccaatcacctcatctggctcatcttcttctactgg
ctcttccactcctgcctgaatgccgtggctgagctcatgcagtttggagaccgggagttc
taccgggactggtggaactccgagtctgtcacctacttctggcagaactggaacatccct
gtgcacaagtggtgcatcagacacttctacaagcccatgcttcgacggggcagcagcaag
tggatggccaggacaggggtgttcctggcctcggccttcttccacgagtacctggtgagc
gtccctctgcgaatgttccgcctctgggcgttcacgggcatgatggctcagatcccactg
gcctggttcgtgggccgctttttccagggcaactatggcaacgcagctgtgtggctgtcg
ctcatcatcggacagccaatagccgtcctcatgtacgtccacgactactacgtgctcaac
tatgaggccccagcggcagaggcctga

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