Homo sapiens (human): 169355
Entry
169355 CDS
T01001
Gene name
IDO2, INDOL1
Definition
(RefSeq) indoleamine 2,3-dioxygenase 2
KO
K00463
indoleamine 2,3-dioxygenase [EC:
1.13.11.52
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00380
Tryptophan metabolism
hsa01100
Metabolic pathways
hsa05143
African trypanosomiasis
Module
hsa_M00038
Tryptophan metabolism, tryptophan => kynurenine => 2-aminomuconate
Drug target
Indoximod:
D10640
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09105 Amino acid metabolism
00380 Tryptophan metabolism
169355 (IDO2)
09160 Human Diseases
09174 Infectious disease: parasitic
05143 African trypanosomiasis
169355 (IDO2)
Enzymes [BR:
hsa01000
]
1. Oxidoreductases
1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
1.13.11 With incorporation of two atoms of oxygen
1.13.11.52 indoleamine 2,3-dioxygenase
169355 (IDO2)
SSDB
Motif
Pfam:
IDO
DUF1864
Other DBs
NCBI-GeneID:
169355
NCBI-ProteinID:
NP_919270
OMIM:
612129
HGNC:
27269
Ensembl:
ENSG00000188676
Vega:
OTTHUMG00000141271
Pharos:
Q6ZQW0
(Tbio)
UniProt:
Q6ZQW0
LinkDB
Position
8p11.21
AA seq
420 aa
MLHFHYYDTSNKIMEPHRPNVKTAVPLSLESYHISEEYGFLLPDSLKELPDHYRPWMEIA
NKLPQLIDAHQLQAHVDKMPLLSCQFLKGHREQRLAHLVLSFLTMGYVWQEGEAQPAEVL
PRNLALPFVEVSRNLGLPPILVHSDLVLTNWTKKDPDGFLEIGNLETIISFPGGESLHGF
ILVTALVEKEAVPGIKALVQATNAILQPNQEALLQALQRLRLSIQDITKTLGQMHDYVDP
DIFYAGIRIFLSGWKDNPAMPAGLMYEGVSQEPLKYSGGSAAQSTVLHAFDEFLGIRHSK
ESGDFLYRMRDYMPPSHKAFIEDIHSAPSLRDYILSSGQDHLLTAYNQCVQALAELRSYH
ITMVTKYLITAAAKAKHGKPNHLPGPPQALKDRGTGGTAVMSFLKSVRDKTLESILHPRG
NT seq
1263 nt
+upstream
nt +downstream
nt
atgttgcattttcattattatgatacttcaaacaaaataatggagccccacagaccgaat
gtgaagacagcagtgccattgtctttggaaagctatcacatatctgaagagtatggcttt
cttcttccagattctctgaaagaacttccagatcattataggccttggatggaaattgcc
aacaaacttcctcaattgattgatgctcaccagcttcaagctcatgtggacaagatgccc
ctgctgagctgccagttcctgaagggtcaccgggagcagcgcctggcccacctggtcctg
agcttcctcaccatgggttatgtctggcaggaaggagaggcgcagcctgcagaggtcctg
ccaaggaatcttgcccttccatttgtcgaagtctccaggaacttggggctccctcctatc
ctggtccactcagacttggtgctgacgaactggaccaaaaaagatccagacggattcctg
gaaattgggaacctggagaccatcatctcatttcctgggggagagagcctgcatggtttt
atactggtgactgctttggtagagaaagaagcagtgcctgggataaaggctcttgttcag
gccacgaatgctatcttgcagcccaaccaggaggccctgctccaagccctgcagcgactg
agactgtctattcaggacatcaccaaaaccttaggacagatgcatgattatgtagatcca
gacatattttatgcaggcatccggatctttctctctggatggaaagacaacccagcaatg
cctgcagggctgatgtatgaaggagtttcccaagagcccctgaaatactccggcgggagt
gcagctcagagcacagtgcttcatgcctttgatgagttcttaggcattcgtcatagcaag
gaaagtggtgactttctgtacagaatgagggattacatgcctccttcccataaggccttc
atagaagacatccactcagcaccttccctgagggactacatcctgtcatctggacaggac
cacttgctgacagcttataaccagtgtgtgcaggccctggcagagctgcggagctatcac
atcaccatggtcaccaaatacctcatcacagctgcagccaaggcaaagcatgggaagcca
aaccatctcccagggcctcctcaggctttaaaagacaggggcacaggtggaaccgcagtt
atgagctttcttaagagtgtcagggataagaccttggagtcaatccttcacccacgtggt
tag
Homo sapiens (human): 3620
Entry
3620 CDS
T01001
Gene name
IDO1, IDO, IDO-1, INDO
Definition
(RefSeq) indoleamine 2,3-dioxygenase 1
KO
K00463
indoleamine 2,3-dioxygenase [EC:
1.13.11.52
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00380
Tryptophan metabolism
hsa01100
Metabolic pathways
hsa05143
African trypanosomiasis
Module
hsa_M00038
Tryptophan metabolism, tryptophan => kynurenine => 2-aminomuconate
Drug target
Epacadostat:
D11049
Indoximod:
D10640
Linrodostat (
DG03010
):
D11412
D11413
Navoximod:
D11255
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09105 Amino acid metabolism
00380 Tryptophan metabolism
3620 (IDO1)
09160 Human Diseases
09174 Infectious disease: parasitic
05143 African trypanosomiasis
3620 (IDO1)
Enzymes [BR:
hsa01000
]
1. Oxidoreductases
1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
1.13.11 With incorporation of two atoms of oxygen
1.13.11.52 indoleamine 2,3-dioxygenase
3620 (IDO1)
SSDB
Motif
Pfam:
IDO
DUF1864
Meckelin
Other DBs
NCBI-GeneID:
3620
NCBI-ProteinID:
NP_002155
OMIM:
147435
HGNC:
6059
Ensembl:
ENSG00000131203
Vega:
OTTHUMG00000164057
Pharos:
P14902
(Tchem)
UniProt:
P14902
A0A348GSI3
LinkDB
Structure
PDB:
6E43
6E44
6E45
4U72
6E46
6E42
5EK3
6F0A
5WHR
6E41
2D0T
6E40
4U74
5WMU
6E35
6CXU
5WN8
6CXV
5WMV
5EK4
5EK2
6O3I
5WMX
5ETW
6AZV
6AZW
4PK5
6AZU
6R63
6DPQ
5WMW
6MQ6
6DPR
5XE1
2D0U
4PK6
Position
8p11.21
AA seq
403 aa
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVE
KLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLEL
PPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKV
IPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGN
PQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMP
PAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQ
QPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
NT seq
1212 nt
+upstream
nt +downstream
nt
atggcacacgctatggaaaactcctggacaatcagtaaagagtaccatattgatgaagaa
gtgggctttgctctgccaaatccacaggaaaatctacctgatttttataatgactggatg
ttcattgctaaacatctgcctgatctcatagagtctggccagcttcgagaaagagttgag
aagttaaacatgctcagcattgatcatctcacagaccacaagtcacagcgccttgcacgt
ctagttctgggatgcatcaccatggcatatgtgtggggcaaaggtcatggagatgtccgt
aaggtcttgccaagaaatattgctgttccttactgccaactctccaagaaactggaactg
cctcctattttggtttatgcagactgtgtcttggcaaactggaagaaaaaggatcctaat
aagcccctgacttatgagaacatggacgttttgttctcatttcgtgatggagactgcagt
aaaggattcttcctggtctctctattggtggaaatagcagctgcttctgcaatcaaagta
attcctactgtattcaaggcaatgcaaatgcaagaacgggacactttgctaaaggcgctg
ttggaaatagcttcttgcttggagaaagcccttcaagtgtttcaccaaatccacgatcat
gtgaacccaaaagcatttttcagtgttcttcgcatatatttgtctggctggaaaggcaac
ccccagctatcagacggtctggtgtatgaagggttctgggaagacccaaaggagtttgca
gggggcagtgcaggccaaagcagcgtctttcagtgctttgacgtcctgctgggcatccag
cagactgctggtggaggacatgctgctcagttcctccaggacatgagaagatatatgcca
ccagctcacaggaacttcctgtgctcattagagtcaaatccctcagtccgtgagtttgtc
ctttcaaaaggtgatgctggcctgcgggaagcttatgacgcctgtgtgaaagctctggtc
tccctgaggagctaccatctgcaaatcgtgactaagtacatcctgattcctgcaagccag
cagccaaaggagaataagacctctgaagacccttcaaaactggaagccaaaggaactgga
ggcactgatttaatgaatttcctgaagactgtaagaagtacaactgagaaatcccttttg
aaggaaggttaa
DBGET
integrated database retrieval system
