Homo sapiens (human): 169355 Help Entry 169355            CDS       T01001                                  Gene name IDO2, INDOL1 Definition (RefSeq) indoleamine 2,3-dioxygenase 2   KO K00463   indoleamine 2,3-dioxygenase [EC:1.13.11.52] Organism hsa  Homo sapiens (human) Pathway hsa00380   Tryptophan metabolism hsa01100   Metabolic pathways hsa01240   Biosynthesis of cofactors hsa05143   African trypanosomiasis Module hsa_M00038   Tryptophan metabolism, tryptophan => kynurenine => 2-aminomuconate hsa_M00912   NAD biosynthesis, tryptophan => quinolinate => NAD Drug target Indoximod:  D10640 Brite KEGG Orthology (KO) [BR:hsa00001]  09100 Metabolism   09105 Amino acid metabolism    00380 Tryptophan metabolism     169355 (IDO2)  09160 Human Diseases   09174 Infectious disease: parasitic    05143 African trypanosomiasis     169355 (IDO2) Enzymes [BR:hsa01000]  1. Oxidoreductases   1.13  Acting on single donors with incorporation of molecular oxygen (oxygenases)    1.13.11  With incorporation of two atoms of oxygen     1.13.11.52  indoleamine 2,3-dioxygenase      169355 (IDO2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  IDO DUF1864 Motif Other DBs NCBI-GeneID:  169355 NCBI-ProteinID:  NP_919270 OMIM:  612129 HGNC:  27269 Ensembl:  ENSG00000188676 Vega:  OTTHUMG00000141271 Pharos:  Q6ZQW0(Tbio) UniProt:  Q6ZQW0 LinkDB All DBs Position 8p11.21 AA seq 420 aa AA seqDB search MLHFHYYDTSNKIMEPHRPNVKTAVPLSLESYHISEEYGFLLPDSLKELPDHYRPWMEIA NKLPQLIDAHQLQAHVDKMPLLSCQFLKGHREQRLAHLVLSFLTMGYVWQEGEAQPAEVL PRNLALPFVEVSRNLGLPPILVHSDLVLTNWTKKDPDGFLEIGNLETIISFPGGESLHGF ILVTALVEKEAVPGIKALVQATNAILQPNQEALLQALQRLRLSIQDITKTLGQMHDYVDP DIFYAGIRIFLSGWKDNPAMPAGLMYEGVSQEPLKYSGGSAAQSTVLHAFDEFLGIRHSK ESGDFLYRMRDYMPPSHKAFIEDIHSAPSLRDYILSSGQDHLLTAYNQCVQALAELRSYH ITMVTKYLITAAAKAKHGKPNHLPGPPQALKDRGTGGTAVMSFLKSVRDKTLESILHPRG NT seq 1263 nt NT seq  +upstreamnt  +downstreamnt atgttgcattttcattattatgatacttcaaacaaaataatggagccccacagaccgaat gtgaagacagcagtgccattgtctttggaaagctatcacatatctgaagagtatggcttt cttcttccagattctctgaaagaacttccagatcattataggccttggatggaaattgcc aacaaacttcctcaattgattgatgctcaccagcttcaagctcatgtggacaagatgccc ctgctgagctgccagttcctgaagggtcaccgggagcagcgcctggcccacctggtcctg agcttcctcaccatgggttatgtctggcaggaaggagaggcgcagcctgcagaggtcctg ccaaggaatcttgcccttccatttgtcgaagtctccaggaacttggggctccctcctatc ctggtccactcagacttggtgctgacgaactggaccaaaaaagatccagacggattcctg gaaattgggaacctggagaccatcatctcatttcctgggggagagagcctgcatggtttt atactggtgactgctttggtagagaaagaagcagtgcctgggataaaggctcttgttcag gccacgaatgctatcttgcagcccaaccaggaggccctgctccaagccctgcagcgactg agactgtctattcaggacatcaccaaaaccttaggacagatgcatgattatgtagatcca gacatattttatgcaggcatccggatctttctctctggatggaaagacaacccagcaatg cctgcagggctgatgtatgaaggagtttcccaagagcccctgaaatactccggcgggagt gcagctcagagcacagtgcttcatgcctttgatgagttcttaggcattcgtcatagcaag gaaagtggtgactttctgtacagaatgagggattacatgcctccttcccataaggccttc atagaagacatccactcagcaccttccctgagggactacatcctgtcatctggacaggac cacttgctgacagcttataaccagtgtgtgcaggccctggcagagctgcggagctatcac atcaccatggtcaccaaatacctcatcacagctgcagccaaggcaaagcatgggaagcca aaccatctcccagggcctcctcaggctttaaaagacaggggcacaggtggaaccgcagtt atgagctttcttaagagtgtcagggataagaccttggagtcaatccttcacccacgtggt tag

Homo sapiens (human): 3620 Help Entry 3620              CDS       T01001                                  Gene name IDO1, IDO, IDO-1, INDO Definition (RefSeq) indoleamine 2,3-dioxygenase 1   KO K00463   indoleamine 2,3-dioxygenase [EC:1.13.11.52] Organism hsa  Homo sapiens (human) Pathway hsa00380   Tryptophan metabolism hsa01100   Metabolic pathways hsa01240   Biosynthesis of cofactors hsa05143   African trypanosomiasis Module hsa_M00038   Tryptophan metabolism, tryptophan => kynurenine => 2-aminomuconate hsa_M00912   NAD biosynthesis, tryptophan => quinolinate => NAD Drug target Epacadostat:  D11049 Indoximod:  D10640 Linrodostat (DG03010):  D11412 D11413 Navoximod:  D11255 Brite KEGG Orthology (KO) [BR:hsa00001]  09100 Metabolism   09105 Amino acid metabolism    00380 Tryptophan metabolism     3620 (IDO1)  09160 Human Diseases   09174 Infectious disease: parasitic    05143 African trypanosomiasis     3620 (IDO1) Enzymes [BR:hsa01000]  1. Oxidoreductases   1.13  Acting on single donors with incorporation of molecular oxygen (oxygenases)    1.13.11  With incorporation of two atoms of oxygen     1.13.11.52  indoleamine 2,3-dioxygenase      3620 (IDO1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  IDO DUF1864 Meckelin Motif Other DBs NCBI-GeneID:  3620 NCBI-ProteinID:  NP_002155 OMIM:  147435 HGNC:  6059 Ensembl:  ENSG00000131203 Vega:  OTTHUMG00000164057 Pharos:  P14902(Tchem) UniProt:  P14902 A0A348GSI3 LinkDB All DBs Structure PDB:  6E43 6E44 6E45 4U72 6E46 6E42 5EK3 6F0A 5WHR 6E41 2D0T 6E40 4U74 5WMU 6E35 6CXU 5WN8 6CXV 5WMV 5EK4 5EK2 6O3I 5WMX 5ETW 6AZV 6AZW 4PK5 6AZU 6R63 6DPQ 5WMW 6MQ6 6DPR 5XE1 2D0U 4PK6 Thumbnails Position 8p11.21 AA seq 403 aa AA seqDB search MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVE KLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLEL PPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKV IPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGN PQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMP PAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQ QPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG NT seq 1212 nt NT seq  +upstreamnt  +downstreamnt atggcacacgctatggaaaactcctggacaatcagtaaagagtaccatattgatgaagaa gtgggctttgctctgccaaatccacaggaaaatctacctgatttttataatgactggatg ttcattgctaaacatctgcctgatctcatagagtctggccagcttcgagaaagagttgag aagttaaacatgctcagcattgatcatctcacagaccacaagtcacagcgccttgcacgt ctagttctgggatgcatcaccatggcatatgtgtggggcaaaggtcatggagatgtccgt aaggtcttgccaagaaatattgctgttccttactgccaactctccaagaaactggaactg cctcctattttggtttatgcagactgtgtcttggcaaactggaagaaaaaggatcctaat aagcccctgacttatgagaacatggacgttttgttctcatttcgtgatggagactgcagt aaaggattcttcctggtctctctattggtggaaatagcagctgcttctgcaatcaaagta attcctactgtattcaaggcaatgcaaatgcaagaacgggacactttgctaaaggcgctg ttggaaatagcttcttgcttggagaaagcccttcaagtgtttcaccaaatccacgatcat gtgaacccaaaagcatttttcagtgttcttcgcatatatttgtctggctggaaaggcaac ccccagctatcagacggtctggtgtatgaagggttctgggaagacccaaaggagtttgca gggggcagtgcaggccaaagcagcgtctttcagtgctttgacgtcctgctgggcatccag cagactgctggtggaggacatgctgctcagttcctccaggacatgagaagatatatgcca ccagctcacaggaacttcctgtgctcattagagtcaaatccctcagtccgtgagtttgtc ctttcaaaaggtgatgctggcctgcgggaagcttatgacgcctgtgtgaaagctctggtc tccctgaggagctaccatctgcaaatcgtgactaagtacatcctgattcctgcaagccag cagccaaaggagaataagacctctgaagacccttcaaaactggaagccaaaggaactgga ggcactgatttaatgaatttcctgaagactgtaagaagtacaactgagaaatcccttttg aaggaaggttaa

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