KEGG   Homo sapiens (human): 1734Help
Entry
1734              CDS       T01001                                 

Gene name
DIO2, 5DII, D2, DIOII, SelY, TXDI2
Definition
(RefSeq) iodothyronine deiodinase 2
  KO
K17904  type II thyroxine 5'-deiodinase [EC:1.21.99.4]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04919  Thyroid hormone signaling pathway
Drug target
Propylthiouracil: D00562
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09152 Endocrine system
   04919 Thyroid hormone signaling pathway
    1734 (DIO2)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.21  Catalysing the reaction X-H + Y-H = X-Y
   1.21.99  With unknown physiological acceptors
    1.21.99.4  thyroxine 5'-deiodinase
     1734 (DIO2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: T4_deiodinase AhpC-TSA Redoxin DUF2284
Motif
Other DBs
NCBI-GeneID: 1734
NCBI-ProteinID: NP_054644
OMIM: 601413
HGNC: 2884
Ensembl: ENSG00000211448
Vega: OTTHUMG00000171443
Pharos: Q92813(Tbio)
UniProt: Q92813
LinkDB All DBs
Position
14q31.1
AA seq 273 aa AA seqDB search
MGILSVDLLITLQILPVFFSNCLFLALYDSVILLKHVVLLLSRSKSTRGEWRRMLTSEGL
RCVWKSFLLDAYKQVKLGEDAPNSSVVHVSSTEGGDNSGNGTQEKIAEGATCHLLDFASP
ERPLVVNFGSATUPPFTSQLPAFRKLVEEFSSVADFLLVYIDEAHPSDGWAIPGDSSLSF
EVKKHQNQEDRCAAAQQLLERFSLPPQCRVVADRMDNNANIAYGVAFERVCIVQRQKIAY
LGGKGPFSYNLQEVRHWLEKNFSKRUKKTRLAG
NT seq 822 nt NT seq  +upstreamnt  +downstreamnt
atgggcatcctcagcgtagacttgctgatcacactgcaaattctgccagtttttttctcc
aactgcctcttcctggctctctatgactcggtcattctgctcaagcacgtggtgctgctg
ttgagccgctccaagtccactcgcggagagtggcggcgcatgctgacctcagagggactg
cgctgcgtctggaagagcttcctcctcgatgcctacaaacaggtgaaattgggtgaggat
gcccccaattccagtgtggtgcatgtctccagtacagaaggaggtgacaacagtggcaat
ggtacccaggagaagatagctgagggagccacatgccaccttcttgactttgccagccct
gagcgcccactagtggtcaactttggctcagccacttgacctcctttcacgagccagctg
ccagccttccgcaaactggtggaagagttctcctcagtggctgacttcctgctggtctac
attgatgaggctcatccatcagatggctgggcgataccgggggactcctctttgtctttt
gaggtgaagaagcaccagaaccaggaagatcgatgtgcagcagcccagcagcttctggag
cgtttctccttgccgccccagtgccgagttgtggctgaccgcatggacaataacgccaac
atagcttacggggtagcctttgaacgtgtgtgcattgtgcagagacagaaaattgcttat
ctgggaggaaagggccccttctcctacaaccttcaagaagtccggcattggctggagaag
aatttcagcaagagatgaaagaaaactagattagctggttaa

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