KEGG T01001: 1950

nt06110  MAPK signaling (viruses and bacteria)
nt06114  PI3K signaling (viruses)
nt06120  Calcium signaling (viruses and bacteria)
nt06135  Cytoskeletal regulation (viruses and bacteria)
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06162  Hepatitis B virus (HBV)
nt06163  Hepatitis C virus (HCV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165  Epstein-Barr virus (EBV)
nt06166  Human papillomavirus (HPV)
nt06167  Human cytomegalovirus (HCMV)
nt06170  Influenza A virus (IAV)
nt06210  ERK signaling
nt06213  Other RAS signaling
nt06214  PI3K signaling
nt06219  JAK-STAT signaling
nt06220  Calcium signaling
nt06260  Colorectal cancer
nt06261  Gastric cancer
nt06262  Pancreatic cancer
nt06263  Hepatocellular carcinoma
nt06265  Bladder cancer
nt06266  Non-small cell lung cancer
nt06268  Melanoma
nt06270  Breast cancer
nt06271  Endometrial cancer
nt06273  Glioma
nt06274  Thyroid cancer
nt06276  Chronic myeloid leukemia

Element

N00001

EGF-EGFR-RAS-ERK signaling pathway

N00021

EGF-ERBB2-RAS-ERK signaling pathway

N00022

ERBB2-overexpression to RAS-ERK signaling pathway

N00023

EGF-EGFR-PLCG-ERK signaling pathway

N00026

EGF-EGFR-PLCG-CAMK signaling pathway

N00030

EGF-EGFR-RAS-PI3K signaling pathway

N00033

EGF-EGFR-PI3K signaling pathway

N00034

ERBB2-overexpression to PI3K signaling pathway

N00094

EGF-Jak-STAT signaling pathway

N00095

ERBB2-overexpression to EGF-Jak-STAT signaling pathway

N00096

EGF-EGFR-RAS-RASSF1 signaling pathway

N00103

EGF-EGFR-RAS-RalGDS signaling pathway

N00147

EGF-EGFR-PLCG-calcineurin signaling pathway

N00252

Amplified ERBB2 to RAS-ERK signaling pathway

N00253

Amplified ERBB2 to PI3K signaling pathway

N00276

EGF-overexpression to RAS-ERK signaling pathway

N00281

EGF-overexpression to PI3K signaling pathway

N00390

EGF-EGFR-PI3K-NFKB signaling pathway

N00542

EGF-EGFR-RAS-JNK signaling pathway

N01078

EGF-EGFR-Actin signaling pathway

Disease

H00020

Colorectal cancer

H01210

Hypomagnesemia

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    1950 (EGF)
   04012 ErbB signaling pathway
    1950 (EGF)
   04014 Ras signaling pathway
    1950 (EGF)
   04015 Rap1 signaling pathway
    1950 (EGF)
   04630 JAK-STAT signaling pathway
    1950 (EGF)
   04066 HIF-1 signaling pathway
    1950 (EGF)
   04068 FoxO signaling pathway
    1950 (EGF)
   04020 Calcium signaling pathway
    1950 (EGF)
   04072 Phospholipase D signaling pathway
    1950 (EGF)
   04151 PI3K-Akt signaling pathway
    1950 (EGF)
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    1950 (EGF)
   04540 Gap junction
    1950 (EGF)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    1950 (EGF)
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    1950 (EGF)
   05231 Choline metabolism in cancer
    1950 (EGF)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    1950 (EGF)
  09162 Cancer: specific types
   05210 Colorectal cancer
    1950 (EGF)
   05212 Pancreatic cancer
    1950 (EGF)
   05226 Gastric cancer
    1950 (EGF)
   05214 Glioma
    1950 (EGF)
   05218 Melanoma
    1950 (EGF)
   05219 Bladder cancer
    1950 (EGF)
   05215 Prostate cancer
    1950 (EGF)
   05213 Endometrial cancer
    1950 (EGF)
   05224 Breast cancer
    1950 (EGF)
   05223 Non-small cell lung cancer
    1950 (EGF)
  09172 Infectious disease: viral
   05160 Hepatitis C
    1950 (EGF)
   05165 Human papillomavirus infection
    1950 (EGF)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    1950 (EGF)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and growth factors [BR:hsa04052]
    1950 (EGF)
Cytokines and growth factors [BR:hsa04052]
Growth factors
  Growth factors (RTK binding)
   1950 (EGF)

SSDB

Motif

Pfam:

Ldl_recept_b FXa_inhibition EGF EGF_CA cEGF DUF5050 EGF_3

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

Vega:

Pharos:

P01133(Tbio)

UniProt:

P01133

LinkDB

Structure

PDB:

1NQL 1JL9 3NJP 1IVO 2KV4 1P9J

Position

4q25

AA seq 1207 aa
MLLTLIILLPVVSKFSFVSLSAPQHWSCPEGTLAGNGNSTCVGPAPFLIFSHGNSIFRID
TEGTNYEQLVVDAGVSVIMDFHYNEKRIYWVDLERQLLQRVFLNGSRQERVCNIEKNVSG
MAINWINEEVIWSNQQEGIITVTDMKGNNSHILLSALKYPANVAVDPVERFIFWSSEVAG
SLYRADLDGVGVKALLETSEKITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHI
SKHPTQHNLFAMSLFGDRIFYSTWKMKTIWIANKHTGKDMVRINLHSSFVPLGELKVVHP
LAQPKAEDDTWEPEQKLCKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNEC
AFWNHGCTLGCKNTPGSYYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPL
CFCPEGSVLERDGKTCSGCSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSCAASG
PQPFLLFANSQDIRHMHFDGTDYGTLLSQQMGMVYALDHDPVENKIYFAHTALKWIERAN
MDGSQRERLIEEGVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQP
RGIAVHPMAKRLFWTDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCD
AKQSVIEMANLDGSKRRRLTQNDVGHPFAVAVFEDYVWFSDWAMPSVMRVNKRTGKDRVR
LQGSMLKPSSLVVVHPLAKPGADPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTC
LALDGHQLLAGGEVDLKNQVTPLDILSKTRVSEDNITESQHMLVAEIMVSDQDDCAPVGC
SMYARCISEGEDATCQCLKGFAGDGKLCSDIDECEMGVPVCPPASSKCINTEGGYVCRCS
EGYQGDGIHCLDIDECQLGEHSCGENASCTNTEGGYTCMCAGRLSEPGLICPDSTPPPHL
REDDHHYSVRNSDSECPLSHDGYCLHDGVCMYIEALDKYACNCVVGYIGERCQYRDLKWW
ELRHAGHGQQQKVIVVAVCVVVLVMLLLLSLWGAHYYRTQKLLSKNPKNPYEESSRDVRS
RRPADTEDGMSSCPQPWFVVIKEHQDLKNGGQPVAGEDGQAADGSMQPTSWRQEPQLCGM
GTEQGCWIPVSSDKGSCPQVMERSFHMPSYGTQTLEGGVEKPHSLLSANPLWQQRALDPP
HQMELTQ

NT seq 3624 nt +upstreamnt +downstreamnt
atgctgctcactcttatcattctgttgccagtagtttcaaaatttagttttgttagtctc
tcagcaccgcagcactggagctgtcctgaaggtactctcgcaggaaatgggaattctact
tgtgtgggtcctgcacccttcttaattttctcccatggaaatagtatctttaggattgac
acagaaggaaccaattatgagcaattggtggtggatgctggtgtctcagtgatcatggat
tttcattataatgagaaaagaatctattgggtggatttagaaagacaacttttgcaaaga
gtttttctgaatgggtcaaggcaagagagagtatgtaatatagagaaaaatgtttctgga
atggcaataaattggataaatgaagaagttatttggtcaaatcaacaggaaggaatcatt
acagtaacagatatgaaaggaaataattcccacattcttttaagtgctttaaaatatcct
gcaaatgtagcagttgatccagtagaaaggtttatattttggtcttcagaggtggctgga
agcctttatagagcagatctcgatggtgtgggagtgaaggctctgttggagacatcagag
aaaataacagctgtgtcattggatgtgcttgataagcggctgttttggattcagtacaac
agagaaggaagcaattctcttatttgctcctgtgattatgatggaggttctgtccacatt
agtaaacatccaacacagcataatttgtttgcaatgtccctttttggtgaccgtatcttc
tattcaacatggaaaatgaagacaatttggatagccaacaaacacactggaaaggacatg
gttagaattaacctccattcatcatttgtaccacttggtgaactgaaagtagtgcatcca
cttgcacaacccaaggcagaagatgacacttgggagcctgagcagaaactttgcaaattg
aggaaaggaaactgcagcagcactgtgtgtgggcaagacctccagtcacacttgtgcatg
tgtgcagagggatacgccctaagtcgagaccggaagtactgtgaagatgttaatgaatgt
gctttttggaatcatggctgtactcttgggtgtaaaaacacccctggatcctattactgc
acgtgccctgtaggatttgttctgcttcctgatgggaaacgatgtcatcaacttgtttcc
tgtccacgcaatgtgtctgaatgcagccatgactgtgttctgacatcagaaggtccctta
tgtttctgtcctgaaggctcagtgcttgagagagatgggaaaacatgtagcggttgttcc
tcacccgataatggtggatgtagccagctctgcgttcctcttagcccagtatcctgggaa
tgtgattgctttcctgggtatgacctacaactggatgaaaaaagctgtgcagcttcagga
ccacaaccatttttgctgtttgccaattctcaagatattcgacacatgcattttgatgga
acagactatggaactctgctcagccagcagatgggaatggtttatgccctagatcatgac
cctgtggaaaataagatatactttgcccatacagccctgaagtggatagagagagctaat
atggatggttcccagcgagaaaggcttattgaggaaggagtagatgtgccagaaggtctt
gctgtggactggattggccgtagattctattggacagacagagggaaatctctgattgga
aggagtgatttaaatgggaaacgttccaaaataatcactaaggagaacatctctcaacca
cgaggaattgctgttcatccaatggccaagagattattctggactgatacagggattaat
ccacgaattgaaagttcttccctccaaggccttggccgtctggttatagccagctctgat
ctaatctggcccagtggaataacgattgacttcttaactgacaagttgtactggtgcgat
gccaagcagtctgtgattgaaatggccaatctggatggttcaaaacgccgaagacttacc
cagaatgatgtaggtcacccatttgctgtagcagtgtttgaggattatgtgtggttctca
gattgggctatgccatcagtaatgagagtaaacaagaggactggcaaagatagagtacgt
ctccaaggcagcatgctgaagccctcatcactggttgtggttcatccattggcaaaacca
ggagcagatccctgcttatatcaaaacggaggctgtgaacatatttgcaaaaagaggctt
ggaactgcttggtgttcgtgtcgtgaaggttttatgaaagcctcagatgggaaaacgtgt
ctggctctggatggtcatcagctgttggcaggtggtgaagttgatctaaagaaccaagta
acaccattggacatcttgtccaagactagagtgtcagaagataacattacagaatctcaa
cacatgctagtggctgaaatcatggtgtcagatcaagatgactgtgctcctgtgggatgc
agcatgtatgctcggtgtatttcagagggagaggatgccacatgtcagtgtttgaaagga
tttgctggggatggaaaactatgttctgatatagatgaatgtgagatgggtgtcccagtg
tgcccccctgcctcctccaagtgcatcaacaccgaaggtggttatgtctgccggtgctca
gaaggctaccaaggagatgggattcactgtcttgatattgatgagtgccaactgggggag
cacagctgtggagagaatgccagctgcacaaatacagagggaggctatacctgcatgtgt
gctggacgcctgtctgaaccaggactgatttgccctgactctactccaccccctcacctc
agggaagatgaccaccactattccgtaagaaatagtgactctgaatgtcccctgtcccac
gatgggtactgcctccatgatggtgtgtgcatgtatattgaagcattggacaagtatgca
tgcaactgtgttgttggctacatcggggagcgatgtcagtaccgagacctgaagtggtgg
gaactgcgccacgctggccacgggcagcagcagaaggtcatcgtggtggctgtctgcgtg
gtggtgcttgtcatgctgctcctcctgagcctgtggggggcccactactacaggactcag
aagctgctatcgaaaaacccaaagaatccttatgaggagtcgagcagagatgtgaggagt
cgcaggcctgctgacactgaggatgggatgtcctcttgccctcaaccttggtttgtggtt
ataaaagaacaccaagacctcaagaatgggggtcaaccagtggctggtgaggatggccag
gcagcagatgggtcaatgcaaccaacttcatggaggcaggagccccagttatgtggaatg
ggcacagagcaaggctgctggattccagtatccagtgataagggctcctgtccccaggta
atggagcgaagctttcatatgccctcctatgggacacagacccttgaagggggtgtcgag
aagccccattctctcctatcagctaacccattatggcaacaaagggccctggacccacca
caccaaatggagctgactcagtga

Homo sapiens (human): 3479

Entry

3479 CDS T01001

Gene name

IGF1, IGF, IGF-I, IGFI, MGF

Definition

(RefSeq) insulin like growth factor 1

K05459

insulin-like growth factor 1

Organism

hsa Homo sapiens (human)

Pathway

hsa01521

EGFR tyrosine kinase inhibitor resistance

hsa01522

Endocrine resistance

hsa04010

MAPK signaling pathway

hsa04014

Ras signaling pathway

hsa04015

Rap1 signaling pathway

hsa04066

HIF-1 signaling pathway

hsa04068

FoxO signaling pathway

hsa04114

Oocyte meiosis

hsa04115

p53 signaling pathway

hsa04150

mTOR signaling pathway

hsa04151

PI3K-Akt signaling pathway

hsa04152

AMPK signaling pathway

hsa04211

Longevity regulating pathway

hsa04213

Longevity regulating pathway - multiple species

hsa04510

Focal adhesion

hsa04550

Signaling pathways regulating pluripotency of stem cells

hsa04730

Long-term depression

hsa04750

Inflammatory mediator regulation of TRP channels

hsa04913

Ovarian steroidogenesis

hsa04914

Progesterone-mediated oocyte maturation

hsa04935

Growth hormone synthesis, secretion and action

hsa04960

Aldosterone-regulated sodium reabsorption

hsa05200

Pathways in cancer

hsa05202

Transcriptional misregulation in cancer

hsa05205

Proteoglycans in cancer

hsa05214

Glioma

hsa05215

Prostate cancer

hsa05218

Melanoma

hsa05224

Breast cancer

hsa05410

Hypertrophic cardiomyopathy

hsa05414

Dilated cardiomyopathy

Network

nt06114  PI3K signaling (viruses)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06166  Human papillomavirus (HPV)
nt06167  Human cytomegalovirus (HCMV)
nt06168  Herpes simplex virus 1 (HSV-1)
nt06210  ERK signaling
nt06214  PI3K signaling
nt06240  Transcription
nt06263  Hepatocellular carcinoma
nt06324  GHRH-GH-IGF signaling

Element

N00133

EWSR1-FLI1 fusion to transcriptional activation

N00135

EWSR1-ERG fusion to transcriptional activation

N00182

IGF-IGFR-PI3K-NFKB signaling pathway

N00233

IGF-IGF1R-RAS-ERK signaling pathway

N00582

IGF-IGF1R-PI3K signaling pathway

N00907

GH-Jak-STAT signaling pathway

N00913

Mutation-inactivated IGF1 to RAS-ERK signaling pathway

N00914

Mutation-inactivated IGF1R to RAS-ERK signaling pathway

Disease

H00015

Malignant pleural mesothelioma

H02040

Insulin-like growth factor I deficiency

Drug target

Masoprocol:

D04862

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    3479 (IGF1)
   04014 Ras signaling pathway
    3479 (IGF1)
   04015 Rap1 signaling pathway
    3479 (IGF1)
   04066 HIF-1 signaling pathway
    3479 (IGF1)
   04068 FoxO signaling pathway
    3479 (IGF1)
   04151 PI3K-Akt signaling pathway
    3479 (IGF1)
   04152 AMPK signaling pathway
    3479 (IGF1)
   04150 mTOR signaling pathway
    3479 (IGF1)
09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    3479 (IGF1)
   04115 p53 signaling pathway
    3479 (IGF1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    3479 (IGF1)
   04550 Signaling pathways regulating pluripotency of stem cells
    3479 (IGF1)
09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    3479 (IGF1)
   04914 Progesterone-mediated oocyte maturation
    3479 (IGF1)
   04935 Growth hormone synthesis, secretion and action
    3479 (IGF1)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    3479 (IGF1)
  09156 Nervous system
   04730 Long-term depression
    3479 (IGF1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    3479 (IGF1)
  09149 Aging
   04211 Longevity regulating pathway
    3479 (IGF1)
   04213 Longevity regulating pathway - multiple species
    3479 (IGF1)
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    3479 (IGF1)
   05202 Transcriptional misregulation in cancer
    3479 (IGF1)
   05205 Proteoglycans in cancer
    3479 (IGF1)
  09162 Cancer: specific types
   05214 Glioma
    3479 (IGF1)
   05218 Melanoma
    3479 (IGF1)
   05215 Prostate cancer
    3479 (IGF1)
   05224 Breast cancer
    3479 (IGF1)
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    3479 (IGF1)
   05414 Dilated cardiomyopathy
    3479 (IGF1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    3479 (IGF1)
   01522 Endocrine resistance
    3479 (IGF1)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and growth factors [BR:hsa04052]
    3479 (IGF1)
Cytokines and growth factors [BR:hsa04052]
Growth factors
  Growth factors (RTK binding)
   3479 (IGF1)

SSDB

Motif

Pfam:

Insulin DUF2865

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

Vega:

Pharos:

P05019(Tbio)

CPD:

C16131

UniProt:

P05019

LinkDB

Structure

PDB:

1TGR 1WQJ 1IMX 1H02 1GZR 2DSR 1GZZ 2DSP 1GZY 6FF3 2DSQ 4XSS 5U8Q 6PYH 6RVA 1PMX 1H59 3LRI 1B9G 1BQT 3GF1 2GF1

Position

12q23.2

AA seq 195 aa
MGKISSLPTQLFKCCFCDFLKVKMHTMSSSHLFYLALCLLTFTSSATAGPETLCGAELVD
ALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSARS
VRAQRHTDMPKTQKYQPPSTNKNTKSQRRKGWPKTHPGGEQKEGTEASLQIRGKKKEQRR
EIGSRNAECRGKKGK

NT seq 588 nt +upstreamnt +downstreamnt
atgggaaaaatcagcagtcttccaacccaattatttaagtgctgcttttgtgatttcttg
aaggtgaagatgcacaccatgtcctcctcgcatctcttctacctggcgctgtgcctgctc
accttcaccagctctgccacggctggaccggagacgctctgcggggctgagctggtggat
gctcttcagttcgtgtgtggagacaggggcttttatttcaacaagcccacagggtatggc
tccagcagtcggagggcgcctcagacaggcatcgtggatgagtgctgcttccggagctgt
gatctaaggaggctggagatgtattgcgcacccctcaagcctgccaagtcagctcgctct
gtccgtgcccagcgccacaccgacatgcccaagacccagaagtatcagcccccatctacc
aacaagaacacgaagtctcagagaaggaaaggttggccaaagacacatccaggaggggaa
cagaaggaggggacagaagcaagtctgcagatcagaggaaagaagaaagagcagaggagg
gagattggaagtagaaatgctgaatgcagaggcaaaaaaggaaaatga

Homo sapiens (human): 3630

Entry

3630 CDS T01001

Gene name

INS, IDDM, IDDM1, IDDM2, ILPR, IRDN, MODY10, PNDM4

Definition

(RefSeq) insulin

K04526

insulin

Organism

hsa Homo sapiens (human)

Pathway

hsa04010

MAPK signaling pathway

hsa04014

Ras signaling pathway

hsa04015

Rap1 signaling pathway

hsa04022

cGMP-PKG signaling pathway

hsa04066

HIF-1 signaling pathway

hsa04068

FoxO signaling pathway

hsa04072

Phospholipase D signaling pathway

hsa04114

Oocyte meiosis

hsa04140

Autophagy - animal

hsa04150

mTOR signaling pathway

hsa04151

PI3K-Akt signaling pathway

hsa04152

AMPK signaling pathway

hsa04211

Longevity regulating pathway

hsa04213

Longevity regulating pathway - multiple species

hsa04810

Regulation of actin cytoskeleton

hsa04910

Insulin signaling pathway

hsa04911

Insulin secretion

hsa04913

Ovarian steroidogenesis

hsa04914

Progesterone-mediated oocyte maturation

hsa04917

Prolactin signaling pathway

hsa04923

Regulation of lipolysis in adipocytes

hsa04930

Type II diabetes mellitus

hsa04931

Insulin resistance

hsa04932

Non-alcoholic fatty liver disease

hsa04940

Type I diabetes mellitus

hsa04950

Maturity onset diabetes of the young

hsa04960

Aldosterone-regulated sodium reabsorption

hsa05010

Alzheimer disease

hsa05215

Prostate cancer

hsa05415

Diabetic cardiomyopathy

Disease

H00408

Type 1 diabetes mellitus

H00410

Maturity onset diabetes of the young (MODY)

H00512

Permanent neonatal diabetes mellitus

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    3630 (INS)
   04014 Ras signaling pathway
    3630 (INS)
   04015 Rap1 signaling pathway
    3630 (INS)
   04066 HIF-1 signaling pathway
    3630 (INS)
   04068 FoxO signaling pathway
    3630 (INS)
   04072 Phospholipase D signaling pathway
    3630 (INS)
   04022 cGMP-PKG signaling pathway
    3630 (INS)
   04151 PI3K-Akt signaling pathway
    3630 (INS)
   04152 AMPK signaling pathway
    3630 (INS)
   04150 mTOR signaling pathway
    3630 (INS)
09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    3630 (INS)
  09143 Cell growth and death
   04114 Oocyte meiosis
    3630 (INS)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    3630 (INS)
09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    3630 (INS)
   04910 Insulin signaling pathway
    3630 (INS)
   04923 Regulation of lipolysis in adipocytes
    3630 (INS)
   04913 Ovarian steroidogenesis
    3630 (INS)
   04914 Progesterone-mediated oocyte maturation
    3630 (INS)
   04917 Prolactin signaling pathway
    3630 (INS)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    3630 (INS)
  09149 Aging
   04211 Longevity regulating pathway
    3630 (INS)
   04213 Longevity regulating pathway - multiple species
    3630 (INS)
09160 Human Diseases
  09162 Cancer: specific types
   05215 Prostate cancer
    3630 (INS)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    3630 (INS)
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    3630 (INS)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    3630 (INS)
   04940 Type I diabetes mellitus
    3630 (INS)
   04950 Maturity onset diabetes of the young
    3630 (INS)
   04932 Non-alcoholic fatty liver disease
    3630 (INS)
   04931 Insulin resistance
    3630 (INS)

SSDB

Motif

Pfam:

Insulin Ins_beta

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

Vega:

Pharos:

P01308(Tbio)

CPD:	C00723 C16120

UniProt:

P01308 I3WAC9

LinkDB

Structure

PDB:

3W7Y 5E7W 5HQI 4FKA 3TT8 3W7Z 5USP 5UOZ 5URT 4AJX 5UU2 6GV0 5HRQ 5USV 5UQA 5HPR 6S34 5UDP 5ENA 3EXX 2OMH 4CY7 4NIB 3W80 4EY1 4EY9 4EYD 5EN9 4XC4 4CXL 4P65 2WS6 2WRX 1ZEH 2OMG 4EYN 5BQQ 5T7R 4EXX 2WRU 4UNE 4F1B 4EYP 4IUZ 3ZU1 2WS1 3I3Z 3E7Y 1ZEG 1GUJ 4F4T 4F4V 4F51 4F1D 4F1G 4IYD 4EX1 4F0O 4F8F 4F1F 4F0N 5VIZ 5CO2 5CNY 5BOQ 4CXN 3ZI3 4F1C 3E7Z 2OLY 2OLZ 4RXW 5BTS 4GBC 4EWZ 6P4Z 5CO6 4IYF 4F1A 4AJZ 2VJZ 2CEU 1XDA 4UNG 6H3M 3INC 3I40 4EX0 4GBN 5MT9 5BPO 3ZQR 3KQ6 2WS4 3ILG 1HTV 1TYL 1TYM 5CO9 2C8Q 1OS3 5UU4 3ZS2 2OM1 4EFX 3U4N 4FG3 3V19 3P2X 2W44 2R36 2QIU 1QIZ 1ZNJ 4AKJ 5MT3 3Q6E 2OM0 5USS 2R35 1W8P 2WS0 2WRV 6GNQ 5MAM 5HPU 4EWX 3V1G 3IR0 2VK0 2OMI 6CK2 5UU3 2R34 1OS4 4AK0 5EMS 4EWW 3ROV 3P33 1QIY 1LPH 4GBK 1QJ0 5URU 2WRW 4GBI 4GBL 1B9E 2WS7 2WBY 4UNH 5WDM 2WC0 6PXW 6PXV 6HN5 5CJO 4OGA 6BFC 6B70 6B3Q 3W11 5WOB 6CE9 3W12 3W13 6CEB 6CE7 5WBT 5MWQ 5MHD 2N2V 2N2W 2N2X 2MVC 2MVD 2MPI 2MPG 2MLI 2M2N 2M2O 2M2P 2M2M 2M1E 2LWZ 2LGB 2L1Y 2L1Z 2KXK 2KQQ 2KQP 2KJU 2KJJ 2K9R 2K91 2RN5 2JV1 2JMN 2HHO 2HH4 2H67 2C8R 1T0C 1UZ9 1SF1 1JCO 1IOG 1A7F 1SJT 1SJU 1AI0 1AIY 1VKT 1XGL 2HIU 1HUI 1HLS 1MHI 1MHJ 1HIQ 1HIS 1HIT

Position

11p15.5

AA seq 110 aa
MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAED
LQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN

NT seq 333 nt +upstreamnt +downstreamnt
atggccctgtggatgcgcctcctgcccctgctggcgctgctggccctctggggacctgac
ccagccgcagcctttgtgaaccaacacctgtgcggctcacacctggtggaagctctctac
ctagtgtgcggggaacgaggcttcttctacacacccaagacccgccgggaggcagaggac
ctgcaggtggggcaggtggagctgggcgggggccctggtgcaggcagcctgcagcccttg
gccctggaggggtccctgcagaagcgtggcattgtggaacaatgctgtaccagcatctgc
tccctctaccagctggagaactactgcaactag

Homo sapiens (human): 5154

Entry

5154 CDS T01001

Gene name

PDGFA, PDGF-A, PDGF1

Definition

(RefSeq) platelet derived growth factor subunit A

K04359

platelet-derived growth factor subunit A

Organism

hsa Homo sapiens (human)

Pathway

hsa01521

EGFR tyrosine kinase inhibitor resistance

hsa04010

MAPK signaling pathway

hsa04014

Ras signaling pathway

hsa04015

Rap1 signaling pathway

hsa04020

Calcium signaling pathway

hsa04072

Phospholipase D signaling pathway

hsa04151

PI3K-Akt signaling pathway

hsa04510

Focal adhesion

hsa04540

Gap junction

hsa04630

JAK-STAT signaling pathway

hsa04810

Regulation of actin cytoskeleton

hsa05200

Pathways in cancer

hsa05202

Transcriptional misregulation in cancer

hsa05206

MicroRNAs in cancer

hsa05214

Glioma

hsa05215

Prostate cancer

hsa05218

Melanoma

hsa05231

Choline metabolism in cancer

hsa05418

Fluid shear stress and atherosclerosis

Network

nt06110  MAPK signaling (viruses and bacteria)
nt06114  PI3K signaling (viruses)
nt06166  Human papillomavirus (HPV)
nt06167  Human cytomegalovirus (HCMV)
nt06210  ERK signaling
nt06214  PI3K signaling
nt06220  Calcium signaling
nt06240  Transcription
nt06273  Glioma

Element

N00015

PDGF-PDGFR-RAS-ERK signaling pathway

N00016

PDGF-overexpression to RAS-ERK signaling pathway

N00028

PDGF-PDGFR-PLCG-CAMK signaling pathway

N00039

PDGF-PDGFR-PI3K signaling pathway

N00137

EWSR1-WT1 fusion to transcriptional activation

Disease

H00015

Malignant pleural mesothelioma

H00042

Glioma

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    5154 (PDGFA)
   04014 Ras signaling pathway
    5154 (PDGFA)
   04015 Rap1 signaling pathway
    5154 (PDGFA)
   04630 JAK-STAT signaling pathway
    5154 (PDGFA)
   04020 Calcium signaling pathway
    5154 (PDGFA)
   04072 Phospholipase D signaling pathway
    5154 (PDGFA)
   04151 PI3K-Akt signaling pathway
    5154 (PDGFA)
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    5154 (PDGFA)
   04540 Gap junction
    5154 (PDGFA)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    5154 (PDGFA)
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    5154 (PDGFA)
   05202 Transcriptional misregulation in cancer
    5154 (PDGFA)
   05206 MicroRNAs in cancer
    5154 (PDGFA)
   05231 Choline metabolism in cancer
    5154 (PDGFA)
  09162 Cancer: specific types
   05214 Glioma
    5154 (PDGFA)
   05218 Melanoma
    5154 (PDGFA)
   05215 Prostate cancer
    5154 (PDGFA)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    5154 (PDGFA)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    5154 (PDGFA)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and growth factors [BR:hsa04052]
    5154 (PDGFA)
   00536 Glycosaminoglycan binding proteins [BR:hsa00536]
    5154 (PDGFA)
Cytokines and growth factors [BR:hsa04052]
Growth factors
  Growth factors (RTK binding)
   5154 (PDGFA)
Glycosaminoglycan binding proteins [BR:hsa00536]
Heparan sulfate / Heparin
  Growth factors/receptors
   5154 (PDGFA)

SSDB

Motif

Pfam:

PDGF_N PDGF

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

Vega:

Pharos:

P04085(Tchem)

UniProt:

P04085

LinkDB

Structure

PDB:

3MJK

Position

7p22.3

AA seq 211 aa
MRTLACLLLLGCGYLAHVLAEEAEIPREVIERLARSQIHSIRDLQRLLEIDSVGSEDSLD
TSLRAHGVHATKHVPEKRPLPIRRKRSIEEAVPAVCKTRTVIYEIPRSQVDPTSANFLIW
PPCVEVKRCTGCCNTSSVKCQPSRVHHRSVKVAKVEYVRKKPKLKEVQVRLEEHLECACA
TTSLNPDYREEDTGRPRESGKKRKRKRLKPT

NT seq 636 nt +upstreamnt +downstreamnt
atgaggaccttggcttgcctgctgctcctcggctgcggatacctcgcccatgttctggcc
gaggaagccgagatcccccgcgaggtgatcgagaggctggcccgcagtcagatccacagc
atccgggacctccagcgactcctggagatagactccgtagggagtgaggattctttggac
accagcctgagagctcacggggtccatgccactaagcatgtgcccgagaagcggcccctg
cccattcggaggaagagaagcatcgaggaagctgtccccgctgtctgcaagaccaggacg
gtcatttacgagattcctcggagtcaggtcgaccccacgtccgccaacttcctgatctgg
cccccgtgcgtggaggtgaaacgctgcaccggctgctgcaacacgagcagtgtcaagtgc
cagccctcccgcgtccaccaccgcagcgtcaaggtggccaaggtggaatacgtcaggaag
aagccaaaattaaaagaagtccaggtgaggttagaggagcatttggagtgcgcctgcgcg
accacaagcctgaatccggattatcgggaagaggacacgggaaggcctagggagtcaggt
aaaaaacggaaaagaaaaaggttaaaacccacctaa

Homo sapiens (human): 5155

Entry

5155 CDS T01001

Gene name

PDGFB, IBGC5, PDGF-2, PDGF2, SIS, SSV, c-sis

Definition

(RefSeq) platelet derived growth factor subunit B

K17386

platelet-derived growth factor subunit B

Organism

hsa Homo sapiens (human)

Pathway

hsa01521

EGFR tyrosine kinase inhibitor resistance

hsa04010

MAPK signaling pathway

hsa04014

Ras signaling pathway

hsa04015

Rap1 signaling pathway

hsa04020

Calcium signaling pathway

hsa04072

Phospholipase D signaling pathway

hsa04151

PI3K-Akt signaling pathway

hsa04510

Focal adhesion

hsa04540

Gap junction

hsa04630

JAK-STAT signaling pathway

hsa04810

Regulation of actin cytoskeleton

hsa05167

Kaposi sarcoma-associated herpesvirus infection

hsa05200

Pathways in cancer

hsa05206

MicroRNAs in cancer

hsa05211

Renal cell carcinoma

hsa05214

Glioma

hsa05215

Prostate cancer

hsa05218

Melanoma

hsa05231

Choline metabolism in cancer

hsa05418

Fluid shear stress and atherosclerosis

Network

nt06110  MAPK signaling (viruses and bacteria)
nt06114  PI3K signaling (viruses)
nt06124  Chemokine signaling (viruses)
nt06150  Cytokine-cytokine receptor interaction (viruses)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06166  Human papillomavirus (HPV)
nt06167  Human cytomegalovirus (HCMV)
nt06210  ERK signaling
nt06214  PI3K signaling
nt06220  Calcium signaling
nt06224  CXCR signaling
nt06225  HIF-1 signaling
nt06264  Renal cell carcinoma
nt06273  Glioma

Element

N00015

PDGF-PDGFR-RAS-ERK signaling pathway

N00016

PDGF-overexpression to RAS-ERK signaling pathway

N00028

PDGF-PDGFR-PLCG-CAMK signaling pathway

N00039

PDGF-PDGFR-PI3K signaling pathway

N00079

HIF-1 signaling pathway

N00080

Loss of VHL to HIF-1 signaling pathway

N00081

Mutation-inactivated VHL to HIF-1 signaling pathway

N00157

KSHV vGPCR to GNB/G-ERK signaling pathway

Disease

H00015

Malignant pleural mesothelioma

H00042

Glioma

H01574

Familial idiopathic basal ganglia calcification

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    5155 (PDGFB)
   04014 Ras signaling pathway
    5155 (PDGFB)
   04015 Rap1 signaling pathway
    5155 (PDGFB)
   04630 JAK-STAT signaling pathway
    5155 (PDGFB)
   04020 Calcium signaling pathway
    5155 (PDGFB)
   04072 Phospholipase D signaling pathway
    5155 (PDGFB)
   04151 PI3K-Akt signaling pathway
    5155 (PDGFB)
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    5155 (PDGFB)
   04540 Gap junction
    5155 (PDGFB)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    5155 (PDGFB)
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    5155 (PDGFB)
   05206 MicroRNAs in cancer
    5155 (PDGFB)
   05231 Choline metabolism in cancer
    5155 (PDGFB)
  09162 Cancer: specific types
   05214 Glioma
    5155 (PDGFB)
   05218 Melanoma
    5155 (PDGFB)
   05211 Renal cell carcinoma
    5155 (PDGFB)
   05215 Prostate cancer
    5155 (PDGFB)
  09172 Infectious disease: viral
   05167 Kaposi sarcoma-associated herpesvirus infection
    5155 (PDGFB)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    5155 (PDGFB)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    5155 (PDGFB)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and growth factors [BR:hsa04052]
    5155 (PDGFB)
   00536 Glycosaminoglycan binding proteins [BR:hsa00536]
    5155 (PDGFB)
Cytokines and growth factors [BR:hsa04052]
Growth factors
  Growth factors (RTK binding)
   5155 (PDGFB)
Glycosaminoglycan binding proteins [BR:hsa00536]
Heparan sulfate / Heparin
  Growth factors/receptors
   5155 (PDGFB)

SSDB

Motif

Pfam:

PDGF PDGF_N

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

Vega:

Pharos:

P01127(Tchem)

UniProt:

P01127 A0A384NYY3

LinkDB

Structure

PDB:

4HQU 4QCI 4HQX 3MJG 1PDG

Position

22q13.1

AA seq 241 aa
MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAEL
DLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLV
WPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKC
ETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLG
A

NT seq 726 nt +upstreamnt +downstreamnt
atgaatcgctgctgggcgctcttcctgtctctctgctgctacctgcgtctggtcagcgcc
gagggggaccccattcccgaggagctttatgagatgctgagtgaccactcgatccgctcc
tttgatgatctccaacgcctgctgcacggagaccccggagaggaagatggggccgagttg
gacctgaacatgacccgctcccactctggaggcgagctggagagcttggctcgtggaaga
aggagcctgggttccctgaccattgctgagccggccatgatcgccgagtgcaagacgcgc
accgaggtgttcgagatctcccggcgcctcatagaccgcaccaacgccaacttcctggtg
tggccgccctgtgtggaggtgcagcgctgctccggctgctgcaacaaccgcaacgtgcag
tgccgccccacccaggtgcagctgcgacctgtccaggtgagaaagatcgagattgtgcgg
aagaagccaatctttaagaaggccacggtgacgctggaagaccacctggcatgcaagtgt
gagacagtggcagctgcacggcctgtgacccgaagcccggggggttcccaggagcagcga
gccaaaacgccccaaactcgggtgaccattcggacggtgcgagtccgccggccccccaag
ggcaagcaccggaaattcaagcacacgcatgacaagacggcactgaaggagacccttgga
gcctag

Homo sapiens (human): 56034

Entry

56034 CDS T01001

Gene name

PDGFC, FALLOTEIN, SCDGF

Definition

(RefSeq) platelet derived growth factor C

K05450

platelet derived growth factor C/D

Organism

hsa Homo sapiens (human)

Pathway

hsa01521

EGFR tyrosine kinase inhibitor resistance

hsa04010

MAPK signaling pathway

hsa04014

Ras signaling pathway

hsa04015

Rap1 signaling pathway

hsa04020

Calcium signaling pathway

hsa04072

Phospholipase D signaling pathway

hsa04151

PI3K-Akt signaling pathway

hsa04510

Focal adhesion

hsa04540

Gap junction

hsa04810

Regulation of actin cytoskeleton

hsa05215

Prostate cancer

hsa05218

Melanoma

hsa05231

Choline metabolism in cancer

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    56034 (PDGFC)
   04014 Ras signaling pathway
    56034 (PDGFC)
   04015 Rap1 signaling pathway
    56034 (PDGFC)
   04020 Calcium signaling pathway
    56034 (PDGFC)
   04072 Phospholipase D signaling pathway
    56034 (PDGFC)
   04151 PI3K-Akt signaling pathway
    56034 (PDGFC)
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    56034 (PDGFC)
   04540 Gap junction
    56034 (PDGFC)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    56034 (PDGFC)
09160 Human Diseases
  09161 Cancer: overview
   05231 Choline metabolism in cancer
    56034 (PDGFC)
  09162 Cancer: specific types
   05218 Melanoma
    56034 (PDGFC)
   05215 Prostate cancer
    56034 (PDGFC)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    56034 (PDGFC)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and growth factors [BR:hsa04052]
    56034 (PDGFC)
Cytokines and growth factors [BR:hsa04052]
Growth factors
  Growth factors (RTK binding)
   56034 (PDGFC)

SSDB

Motif

Pfam:

CUB PDGF

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

Vega:

Pharos:

Q9NRA1(Tbio)

UniProt:

Q9NRA1

LinkDB

Position

4q32.1

AA seq 345 aa
MSLFGLLLLTSALAGQRQGTQAESNLSSKFQFSSNKEQNGVQDPQHERIITVSTNGSIHS
PRFPHTYPRNTVLVWRLVAVEENVWIQLTFDERFGLEDPEDDICKYDFVEVEEPSDGTIL
GRWCGSGTVPGKQISKGNQIRIRFVSDEYFPSEPGFCIHYNIVMPQFTEAVSPSVLPPSA
LPLDLLNNAITAFSTLEDLIRYLEPERWQLDLEDLYRPTWQLLGKAFVFGRKSRVVDLNL
LTEEVRLYSCTPRNFSVSIREELKRTDTIFWPGCLLVKRCGGNCACCLHNCNECQCVPSK
VTKKYHEVLQLRPKTGVRGLHKSLTDVALEHHEECDCVCRGSTGG

NT seq 1038 nt +upstreamnt +downstreamnt
atgagcctcttcgggcttctcctgctgacatctgccctggccggccagagacaggggact
caggcggaatccaacctgagtagtaaattccagttttccagcaacaaggaacagaacgga
gtacaagatcctcagcatgagagaattattactgtgtctactaatggaagtattcacagc
ccaaggtttcctcatacttatccaagaaatacggtcttggtatggagattagtagcagta
gaggaaaatgtatggatacaacttacgtttgatgaaagatttgggcttgaagacccagaa
gatgacatatgcaagtatgattttgtagaagttgaggaacccagtgatggaactatatta
gggcgctggtgtggttctggtactgtaccaggaaaacagatttctaaaggaaatcaaatt
aggataagatttgtatctgatgaatattttccttctgaaccagggttctgcatccactac
aacattgtcatgccacaattcacagaagctgtgagtccttcagtgctacccccttcagct
ttgccactggacctgcttaataatgctataactgcctttagtaccttggaagaccttatt
cgatatcttgaaccagagagatggcagttggacttagaagatctatataggccaacttgg
caacttcttggcaaggcttttgtttttggaagaaaatccagagtggtggatctgaacctt
ctaacagaggaggtaagattatacagctgcacacctcgtaacttctcagtgtccataagg
gaagaactaaagagaaccgataccattttctggccaggttgtctcctggttaaacgctgt
ggtgggaactgtgcctgttgtctccacaattgcaatgaatgtcaatgtgtcccaagcaaa
gttactaaaaaataccacgaggtccttcagttgagaccaaagaccggtgtcaggggattg
cacaaatcactcaccgacgtggccctggagcaccatgaggagtgtgactgtgtgtgcaga
gggagcacaggaggatag

Homo sapiens (human): 7039

Entry

7039 CDS T01001

Gene name

TGFA, TFGA

Definition

(RefSeq) transforming growth factor alpha

K08774

transforming growth factor, alpha

Organism

hsa Homo sapiens (human)

Pathway

hsa01521

EGFR tyrosine kinase inhibitor resistance

hsa04010

MAPK signaling pathway

hsa04012

ErbB signaling pathway

hsa04014

Ras signaling pathway

hsa04151

PI3K-Akt signaling pathway

hsa04915

Estrogen signaling pathway

hsa05200

Pathways in cancer

hsa05210

Colorectal cancer

hsa05211

Renal cell carcinoma

hsa05212

Pancreatic cancer

hsa05214

Glioma

hsa05215

Prostate cancer

hsa05223

Non-small cell lung cancer

hsa05225

Hepatocellular carcinoma

Network

nt06210  ERK signaling
nt06214  PI3K signaling
nt06220  Calcium signaling
nt06225  HIF-1 signaling
nt06260  Colorectal cancer
nt06263  Hepatocellular carcinoma
nt06264  Renal cell carcinoma

Element

N00079

HIF-1 signaling pathway

N00080

Loss of VHL to HIF-1 signaling pathway

N00081

Mutation-inactivated VHL to HIF-1 signaling pathway

N00227

TGFA-EGFR-PLCG-PKC signaling pathway

N00228

TGFA-overexpression to PLCG-PKC signaling pathway

N00229

TGFA-EGFR-RAS-ERK signaling pathway

N00230

TGFA-overexpression to RAS-ERK signaling pathway

N00231

TGFA-EGFR-PI3K signaling pathway

N00232

TGFA-overexpression to PI3K signaling pathway

Disease

H00020

Colorectal cancer

H00048

Hepatocellular carcinoma

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    7039 (TGFA)
   04012 ErbB signaling pathway
    7039 (TGFA)
   04014 Ras signaling pathway
    7039 (TGFA)
   04151 PI3K-Akt signaling pathway
    7039 (TGFA)
09150 Organismal Systems
  09152 Endocrine system
   04915 Estrogen signaling pathway
    7039 (TGFA)
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    7039 (TGFA)
  09162 Cancer: specific types
   05210 Colorectal cancer
    7039 (TGFA)
   05212 Pancreatic cancer
    7039 (TGFA)
   05225 Hepatocellular carcinoma
    7039 (TGFA)
   05214 Glioma
    7039 (TGFA)
   05211 Renal cell carcinoma
    7039 (TGFA)
   05215 Prostate cancer
    7039 (TGFA)
   05223 Non-small cell lung cancer
    7039 (TGFA)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    7039 (TGFA)

SSDB

Motif

Pfam:

EGF EGF_2 TMEM154

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

Vega:

Pharos:

P01135(Tbio)

UniProt:

P01135

LinkDB

Structure

PDB:

3E50 1MOX 5KN5 1YUF 1YUG 2TGF 3TGF 4TGF

Position

2p13.3

AA seq 160 aa
MVPSAGQLALFALGIVLAACQALENSTSPLSADPPVAAAVVSHFNDCPDSHTQFCFHGTC
RFLVQEDKPACVCHSGYVGARCEHADLLAVVAASQKKQAITALVVVSIVALAVLIITCVL
IHCCQVRKHCEWCRALICRHEKPSALLKGRTACCHSETVV

NT seq 483 nt +upstreamnt +downstreamnt
atggtcccctcggctggacagctcgccctgttcgctctgggtattgtgttggctgcgtgc
caggccttggagaacagcacgtccccgctgagtgcagacccgcccgtggctgcagcagtg
gtgtcccattttaatgactgcccagattcccacactcagttctgcttccatggaacctgc
aggtttttggtgcaggaggacaagccagcatgtgtctgccattctgggtacgttggtgca
cgctgtgagcatgcggacctcctggccgtggtggctgccagccagaagaagcaggccatc
accgccttggtggtggtctccatcgtggccctggctgtccttatcatcacatgtgtgctg
atacactgctgccaggtccgaaaacactgtgagtggtgccgggccctcatctgccggcac
gagaagcccagcgccctcctgaagggaagaaccgcttgctgccactcagaaacagtggtc
tga

Homo sapiens (human): 80310

Entry

80310 CDS T01001

Gene name

PDGFD, IEGF, MSTP036, SCDGF-B, SCDGFB

Definition

(RefSeq) platelet derived growth factor D

K05450

platelet derived growth factor C/D

Organism

hsa Homo sapiens (human)

Pathway

hsa01521

EGFR tyrosine kinase inhibitor resistance

hsa04010

MAPK signaling pathway

hsa04014

Ras signaling pathway

hsa04015

Rap1 signaling pathway

hsa04020

Calcium signaling pathway

hsa04072

Phospholipase D signaling pathway

hsa04151

PI3K-Akt signaling pathway

hsa04510

Focal adhesion

hsa04540

Gap junction

hsa04810

Regulation of actin cytoskeleton

hsa05215

Prostate cancer

hsa05218

Melanoma

hsa05231

Choline metabolism in cancer

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    80310 (PDGFD)
   04014 Ras signaling pathway
    80310 (PDGFD)
   04015 Rap1 signaling pathway
    80310 (PDGFD)
   04020 Calcium signaling pathway
    80310 (PDGFD)
   04072 Phospholipase D signaling pathway
    80310 (PDGFD)
   04151 PI3K-Akt signaling pathway
    80310 (PDGFD)
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    80310 (PDGFD)
   04540 Gap junction
    80310 (PDGFD)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    80310 (PDGFD)
09160 Human Diseases
  09161 Cancer: overview
   05231 Choline metabolism in cancer
    80310 (PDGFD)
  09162 Cancer: specific types
   05218 Melanoma
    80310 (PDGFD)
   05215 Prostate cancer
    80310 (PDGFD)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    80310 (PDGFD)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and growth factors [BR:hsa04052]
    80310 (PDGFD)
Cytokines and growth factors [BR:hsa04052]
Growth factors
  Growth factors (RTK binding)
   80310 (PDGFD)

SSDB

Motif

Pfam:

CUB PDGF

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

Vega:

Pharos:

Q9GZP0(Tbio)

UniProt:

Q9GZP0

LinkDB

Position

11q22.3

AA seq 370 aa
MHRLIFVYTLICANFCSCRDTSATPQSASIKALRNANLRRDESNHLTDLYRRDETIQVKG
NGYVQSPRFPNSYPRNLLLTWRLHSQENTRIQLVFDNQFGLEEAENDICRYDFVEVEDIS
ETSTIIRGRWCGHKEVPPRIKSRTNQIKITFKSDDYFVAKPGFKIYYSLLEDFQPAAASE
TNWESVTSSISGVSYNSPSVTDPTLIADALDKKIAEFDTVEDLLKYFNPESWQEDLENMY
LDTPRYRGRSYHDRKSKVDLDRLNDDAKRYSCTPRNYSVNIREELKLANVVFFPRCLLVQ
RCGGNCGCGTVNWRSCTCNSGKTVKKYHEVLQFEPGHIKRRGRAKTMALVDIQLDHHERC
DCICSSRPPR

NT seq 1113 nt +upstreamnt +downstreamnt
atgcaccggctcatctttgtctacactctaatctgcgcaaacttttgcagctgtcgggac
acttctgcaaccccgcagagcgcatccatcaaagctttgcgcaacgccaacctcaggcga
gatgagagcaatcacctcacagacttgtaccgaagagatgagaccatccaggtgaaagga
aacggctacgtgcagagtcctagattcccgaacagctaccccaggaacctgctcctgaca
tggcggcttcactctcaggagaatacacggatacagctagtgtttgacaatcagtttgga
ttagaggaagcagaaaatgatatctgtaggtatgattttgtggaagttgaagatatatcc
gaaaccagtaccattattagaggacgatggtgtggacacaaggaagttcctccaaggata
aaatcaagaacgaaccaaattaaaatcacattcaagtccgatgactactttgtggctaaa
cctggattcaagatttattattctttgctggaagatttccaacccgcagcagcttcagag
accaactgggaatctgtcacaagctctatttcaggggtatcctataactctccatcagta
acggatcccactctgattgcggatgctctggacaaaaaaattgcagaatttgatacagtg
gaagatctgctcaagtacttcaatccagagtcatggcaagaagatcttgagaatatgtat
ctggacacccctcggtatcgaggcaggtcataccatgaccggaagtcaaaagttgacctg
gataggctcaatgatgatgccaagcgttacagttgcactcccaggaattactcggtcaat
ataagagaagagctgaagttggccaatgtggtcttctttccacgttgcctcctcgtgcag
cgctgtggaggaaattgtggctgtggaactgtcaactggaggtcctgcacatgcaattca
gggaaaaccgtgaaaaagtatcatgaggtattacagtttgagcctggccacatcaagagg
aggggtagagctaagaccatggctctagttgacatccagttggatcaccatgaacgatgt
gattgtatctgcagctcaagaccacctcgataa

DBGET integrated database retrieval system