Homo sapiens (human): 1965
Entry
1965 CDS
T01001
Gene name
EIF2S1, EIF-2, EIF-2A, EIF-2alpha, EIF2, EIF2A
Definition
(RefSeq) eukaryotic translation initiation factor 2 subunit alpha
KO
K03237
translation initiation factor 2 subunit 1
Organism
hsa
Homo sapiens (human)
Pathway
hsa03013
RNA transport
hsa04140
Autophagy - animal
hsa04141
Protein processing in endoplasmic reticulum
hsa04210
Apoptosis
hsa04932
Non-alcoholic fatty liver disease (NAFLD)
hsa05010
Alzheimer disease
hsa05012
Parkinson disease
hsa05160
Hepatitis C
hsa05162
Measles
hsa05164
Influenza A
hsa05168
Herpes simplex virus 1 infection
Network
nt06138
PKR-eIF2alpha signaling (viruses)
nt06168
Herpes simplex virus 1 (HSV-1)
nt06169
Measles virus (MV)
nt06170
Influenza A virus (IAV)
nt06412
Unfolded protein response (UPR) signaling
nt06460
Alzheimer disease
nt06463
Parkinson disease
Element
N00571
PKR-eIF2alpha signaling pathway
N00572
HSV ICP34.5 to PKR-eIF2alpha signaling pathway
N00573
HSV US11 to PKR-eIF2alpha signaling pathway
N00696
MV C to PKR-eIF2alpha signaling pathway
N00725
IAV NS1 to PKR-eIF2alpha signaling pathway
N00726
IAV NP to PKR-eIF2alpha signaling pathway
N01009
PERK-ATF4 signaling pathway
N01010
Mutation-caused aberrant PSEN1 to PERK-ATF4 signaling pathway
N01035
Mutation-caused aberrant SNCA to PERK-ATF4 signaling pathway
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09120 Genetic Information Processing
09122 Translation
03013 RNA transport
1965 (EIF2S1)
09123 Folding, sorting and degradation
04141 Protein processing in endoplasmic reticulum
1965 (EIF2S1)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
1965 (EIF2S1)
09143 Cell growth and death
04210 Apoptosis
1965 (EIF2S1)
09160 Human Diseases
09164 Neurodegenerative disease
05010 Alzheimer disease
1965 (EIF2S1)
05012 Parkinson disease
1965 (EIF2S1)
09167 Endocrine and metabolic disease
04932 Non-alcoholic fatty liver disease (NAFLD)
1965 (EIF2S1)
09172 Infectious disease: viral
05162 Measles
1965 (EIF2S1)
05164 Influenza A
1965 (EIF2S1)
05160 Hepatitis C
1965 (EIF2S1)
05168 Herpes simplex virus 1 infection
1965 (EIF2S1)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03012 Translation factors [BR:
hsa03012
]
1965 (EIF2S1)
Translation factors [BR:
hsa03012
]
Eukaryotic type
Initiation factors
eIF-2
1965 (EIF2S1)
SSDB
Motif
Pfam:
EIF_2_alpha
S1
DUF4453
Other DBs
NCBI-GeneID:
1965
NCBI-ProteinID:
NP_004085
OMIM:
603907
HGNC:
3265
Ensembl:
ENSG00000134001
Vega:
OTTHUMG00000029800
Pharos:
P05198
(Tbio)
UniProt:
P05198
Q53XC0
LinkDB
Structure
PDB:
1KL9
6O9Z
6O85
6O81
6K71
6K72
1Q8K
Position
14q23.3
AA seq
315 aa
MPGLSCRFYQHKFPEVEDVVMVNVRSIAEMGAYVSLLEYNNIEGMILLSELSRRRIRSIN
KLIRIGRNECVVVIRVDKEKGYIDLSKRRVSPEEAIKCEDKFTKSKTVYSILRHVAEVLE
YTKDEQLESLFQRTAWVFDDKYKRPGYGAYDAFKHAVSDPSILDSLDLNEDEREVLINNI
NRRLTPQAVKIRADIEVACYGYEGIDAVKEALRAGLNCSTENMPIKINLIAPPRYVMTTT
TLERTEGLSVLSQAMAVIKEKIEEKRGVFNVQMEPKVVTDTDETELARQMERLERENAEV
DGDDDAEEMEAKAED
NT seq
948 nt
+upstream
nt +downstream
nt
atgccgggtctaagttgtagattttatcaacacaaatttcctgaggtggaagatgtagtg
atggtgaatgtcagatccattgctgaaatgggggcttatgtcagcttgctggaatacaac
aacattgaaggcatgattcttcttagtgaattatccagaaggcgtatccgttctatcaac
aaactcatccgaattggcaggaatgagtgtgtggttgtcattagggtggacaaagaaaaa
ggatatattgatttgtcaaaaagaagagtttctccagaggaagcaatcaaatgtgaagac
aaattcacaaaatccaaaactgtttatagcattcttcgtcatgttgctgaggtgttagaa
tacaccaaggatgagcagctggaaagcctattccagaggactgcctgggtctttgatgac
aagtacaagagacctggatatggtgcctatgatgcatttaagcatgcagtctcagaccca
tctattttggatagtttagatttgaatgaagatgaacgggaagtactcattaataatatt
aataggcgcttgaccccacaggctgtcaaaattcgagcagatattgaagtggcttgttat
ggttatgaaggcattgatgctgtaaaagaagccctaagagcaggtttgaattgttctaca
gaaaacatgcccattaagattaatctaatagctcctcctcggtatgtaatgactacgaca
accctggagagaacagaaggcctttctgtcctcagtcaagctatggctgttatcaaagag
aagattgaggaaaagaggggtgtgttcaatgttcaaatggagcccaaagtggtcacagat
acagatgagactgaacttgcgaggcagatggagaggcttgaaagagaaaatgccgaagtg
gatggagatgatgatgcagaagaaatggaagccaaagctgaagattaa
DBGET
integrated database retrieval system
