KEGG   Homo sapiens (human): 1977Help
Entry
1977              CDS       T01001                                 

Gene name
EIF4E, AUTS19, CBP, EIF4E1, EIF4EL1, EIF4F, eIF-4E
Definition
(RefSeq) eukaryotic translation initiation factor 4E
  KO
K03259  translation initiation factor 4E
Organism
hsa  Homo sapiens (human)
Pathway
hsa01521  EGFR tyrosine kinase inhibitor resistance
hsa03013  RNA transport
hsa04066  HIF-1 signaling pathway
hsa04150  mTOR signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04211  Longevity regulating pathway
hsa04910  Insulin signaling pathway
Disease
H02111  Autism
Drug target
Briciclib (DG01851): D10614 D10694
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09122 Translation
   03013 RNA transport
    1977 (EIF4E)
 09130 Environmental Information Processing
  09132 Signal transduction
   04066 HIF-1 signaling pathway
    1977 (EIF4E)
   04151 PI3K-Akt signaling pathway
    1977 (EIF4E)
   04150 mTOR signaling pathway
    1977 (EIF4E)
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    1977 (EIF4E)
  09149 Aging
   04211 Longevity regulating pathway
    1977 (EIF4E)
 09160 Human Diseases
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    1977 (EIF4E)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis [BR:hsa03019]
    1977 (EIF4E)
   03012 Translation factors [BR:hsa03012]
    1977 (EIF4E)
Messenger RNA biogenesis [BR:hsa03019]
 Eukaryotic type
  mRNA surveillance and transport factors
   Transport factors
    eIF4F and regulatory proteins
     1977 (EIF4E)
   mRNA cycle factors
    Common to processing body (P body) and stress granule
     1977 (EIF4E)
Translation factors [BR:hsa03012]
 Eukaryotic type
  Initiation factors
   eIF-4
    1977 (EIF4E)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: IF4E
Motif
Other DBs
NCBI-GeneID: 1977
NCBI-ProteinID: NP_001959
OMIM: 133440
HGNC: 3287
Ensembl: ENSG00000151247
Vega: OTTHUMG00000161090
Pharos: P06730(Tchem)
UniProt: P06730
LinkDB All DBs
Structure
PDB: 

Position
4q23
AA seq 217 aa AA seqDB search
MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANL
RLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQ
QRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIG
RVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV
NT seq 654 nt NT seq  +upstreamnt  +downstreamnt
atggcgactgtcgaaccggaaaccacccctactcctaatcccccgactacagaagaggag
aaaacggaatctaatcaggaggttgctaacccagaacactatattaaacatcccctacag
aacagatgggcactctggttttttaaaaatgataaaagcaaaacttggcaagcaaacctg
cggctgatctccaagtttgatactgttgaagacttttgggctctgtacaaccatatccag
ttgtctagtaatttaatgcctggctgtgactactcactttttaaggatggtattgagcct
atgtgggaagatgagaaaaacaaacggggaggacgatggctaattacattgaacaaacag
cagagacgaagtgacctcgatcgcttttggctagagacacttctgtgccttattggagaa
tcttttgatgactacagtgatgatgtatgtggcgctgttgttaatgttagagctaaaggt
gataagatagcaatatggactactgaatgtgaaaacagagaagctgttacacatataggg
agggtatacaaggaaaggttaggacttcctccaaagatagtgattggttatcagtcccac
gcagacacagctactaagagcggctccaccactaaaaataggtttgttgtttaa

KEGG   Homo sapiens (human): 253314Help
Entry
253314            CDS       T01001                                 

Gene name
EIF4E1B
Definition
(RefSeq) eukaryotic translation initiation factor 4E family member 1B
  KO
K03259  translation initiation factor 4E
Organism
hsa  Homo sapiens (human)
Pathway
hsa01521  EGFR tyrosine kinase inhibitor resistance
hsa03013  RNA transport
hsa04066  HIF-1 signaling pathway
hsa04150  mTOR signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04211  Longevity regulating pathway
hsa04910  Insulin signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09122 Translation
   03013 RNA transport
    253314 (EIF4E1B)
 09130 Environmental Information Processing
  09132 Signal transduction
   04066 HIF-1 signaling pathway
    253314 (EIF4E1B)
   04151 PI3K-Akt signaling pathway
    253314 (EIF4E1B)
   04150 mTOR signaling pathway
    253314 (EIF4E1B)
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    253314 (EIF4E1B)
  09149 Aging
   04211 Longevity regulating pathway
    253314 (EIF4E1B)
 09160 Human Diseases
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    253314 (EIF4E1B)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis [BR:hsa03019]
    253314 (EIF4E1B)
   03012 Translation factors [BR:hsa03012]
    253314 (EIF4E1B)
Messenger RNA biogenesis [BR:hsa03019]
 Eukaryotic type
  mRNA surveillance and transport factors
   Transport factors
    eIF4F and regulatory proteins
     253314 (EIF4E1B)
   mRNA cycle factors
    Common to processing body (P body) and stress granule
     253314 (EIF4E1B)
Translation factors [BR:hsa03012]
 Eukaryotic type
  Initiation factors
   eIF-4
    253314 (EIF4E1B)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: IF4E
Motif
Other DBs
NCBI-GeneID: 253314
NCBI-ProteinID: NP_001092878
HGNC: 33179
Ensembl: ENSG00000175766
Vega: OTTHUMG00000163227
Pharos: A6NMX2(Tdark)
UniProt: A6NMX2
LinkDB All DBs
Position
5q35.2
AA seq 242 aa AA seqDB search
MLAVEVSEAEGGIREWEEEEKEEEAAERTPTGEKSPNSPRTLLSLRGKARTGGPMEVKLE
LHPLQNRWALWFFKNDRSRAWQDNLHLVTKVDTVEDFWALYSHIQLASKLSSGCDYALFK
DGIQPMWEDSRNKRGGRWLVSLAKQQRHIELDRLWLETLLCLIGESFEEHSREVCGAVVN
IRTKGDKIAVWTREAENQAGVLHVGRVYKERLGLSPKTIIGYQAHADTATKSNSLAKNKF
VV
NT seq 729 nt NT seq  +upstreamnt  +downstreamnt
atgcttgctgttgaggtgagtgaagctgagggtggaatccgagagtgggaggaggaggag
aaggaggaggaggcagcagagaggacgcccacaggagaaaagtctccaaactctcccagg
actttgctgtctctgagagggaaggcccggacggggggccccatggaagtcaagctggag
ctgcaccccttgcagaacaggtgggctctgtggttcttcaagaatgaccgcagccgggcc
tggcaggacaacctgcacctggtcaccaaggtggacactgtggaggacttctgggcgcta
tacagtcacatccagctggccagcaagctctcctctggctgtgactacgccctcttcaag
gatggcatccagcccatgtgggaggacagcaggaataaacggggtggccgctggctggtc
agcctggccaagcagcagcgccacattgagctggaccggctgtggctggagacgctgctg
tgtctgatcggggagagctttgaggaacacagcagagaggtatgtggggccgtcgtcaac
atccgcaccaagggggacaagatcgctgtgtggacgagggaggcggaaaaccaggcgggc
gtgctgcacgttgggcgtgtatacaaagagcgcctgggcctctccccaaagaccatcatt
gggtaccaggcccatgcagacacagccaccaagagcaactccctagccaagaacaagttt
gtggtgtga

KEGG   Homo sapiens (human): 9470Help
Entry
9470              CDS       T01001                                 

Gene name
EIF4E2, 4E-LP, 4EHP, EIF4EL3, IF4e, h4EHP
Definition
(RefSeq) eukaryotic translation initiation factor 4E family member 2
  KO
K03259  translation initiation factor 4E
Organism
hsa  Homo sapiens (human)
Pathway
hsa01521  EGFR tyrosine kinase inhibitor resistance
hsa03013  RNA transport
hsa04066  HIF-1 signaling pathway
hsa04150  mTOR signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04211  Longevity regulating pathway
hsa04910  Insulin signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09122 Translation
   03013 RNA transport
    9470 (EIF4E2)
 09130 Environmental Information Processing
  09132 Signal transduction
   04066 HIF-1 signaling pathway
    9470 (EIF4E2)
   04151 PI3K-Akt signaling pathway
    9470 (EIF4E2)
   04150 mTOR signaling pathway
    9470 (EIF4E2)
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    9470 (EIF4E2)
  09149 Aging
   04211 Longevity regulating pathway
    9470 (EIF4E2)
 09160 Human Diseases
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    9470 (EIF4E2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis [BR:hsa03019]
    9470 (EIF4E2)
   03012 Translation factors [BR:hsa03012]
    9470 (EIF4E2)
Messenger RNA biogenesis [BR:hsa03019]
 Eukaryotic type
  mRNA surveillance and transport factors
   Transport factors
    eIF4F and regulatory proteins
     9470 (EIF4E2)
   mRNA cycle factors
    Common to processing body (P body) and stress granule
     9470 (EIF4E2)
Translation factors [BR:hsa03012]
 Eukaryotic type
  Initiation factors
   eIF-4
    9470 (EIF4E2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: IF4E
Motif
Other DBs
NCBI-GeneID: 9470
NCBI-ProteinID: NP_004837
OMIM: 605895
HGNC: 3293
Ensembl: ENSG00000135930
Vega: OTTHUMG00000133256
Pharos: O60573(Tbio)
UniProt: O60573 Q53RG0
LinkDB All DBs
Structure
PDB: 

Position
2q37.1
AA seq 245 aa AA seqDB search
MNNKFDALKDDDSGDHDQNEENSTQKDGEKEKTERDKNQSSSKRKAVVPGPAEHPLQYNY
TFWYSRRTPGRPTSSQSYEQNIKQIGTFASVEQFWRFYSHMVRPGDLTGHSDFHLFKEGI
KPMWEDDANKNGGKWIIRLRKGLASRCWENLILAMLGEQFMVGEEICGAVVSVRFQEDII
SIWNKTASDQATTARIRDTLRRVLNLPPNTIMEYKTHTDSIKMPGRLGPQRLLFQNLWKP
RLNVP
NT seq 738 nt NT seq  +upstreamnt  +downstreamnt
atgaacaacaagttcgacgctttgaaagatgatgacagtggggaccatgatcagaatgaa
gaaaacagcacacagaaagatggtgagaaggaaaaaacggaacgagacaagaatcagagc
agtagcaagagaaaggctgttgtccctggaccggcagagcatcccctgcagtacaactac
actttttggtactccaggagaacccccggccgtcccacgagctcacagagctatgaacag
aatatcaaacagattggcacctttgcctctgtggagcagttctggaggttttatagccac
atggtacgtcctggggacctgacaggccacagtgacttccatctcttcaaagaaggaatt
aaacccatgtgggaggatgatgcaaataaaaatggtggcaagtggattattcggctgcgg
aagggcttggcctcccgttgctgggagaatctcattttggccatgctgggggaacagttc
atggttggggaggagatctgtggggctgtggtgtctgtccgctttcaggaagacattatt
tcaatatggaataagactgccagtgaccaagcaaccacagcccgaatccgggacacactt
cggcgagtgcttaacctacctcccaacaccattatggaatacaaaactcacaccgacagc
atcaaaatgccaggcaggctgggcccccaaaggctcctttttcaaaacctctggaagccg
cggttgaatgtgccatga

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