| Entry |
|
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| Gene name |
EPOR, EPO-R
|
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| Definition |
(RefSeq) erythropoietin receptor
|
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| KO |
| K05079 | erythropoietin receptor |
|
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| Organism |
|
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| Pathway |
| hsa04060 | Cytokine-cytokine receptor interaction |
|
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| Network |
nt06119 JAK-STAT signaling (viruses) nt06160 Human T-cell leukemia virus 1 (HTLV-1) nt06162 Hepatitis B virus (HBV) nt06164 Kaposi sarcoma-associated herpesvirus (KSHV) nt06165 Epstein-Barr virus (EBV) nt06219 JAK-STAT signaling nt06263 Hepatocellular carcinoma nt06266 Non-small cell lung cancer nt06276 Chronic myeloid leukemia |
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| Element |
| N00053 | Cytokine-Jak-STAT signaling pathway |
|
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| Disease |
| H00236 | Congenital polycythemia |
|
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| Drug target |
| Darbepoetin alfa: | D03651<JP/US> |
| Methoxy polyethylene glycol-epoetin beta: | D09998<JP/US> |
|
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| Brite |
KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
09132 Signal transduction
04630 JAK-STAT signaling pathway
2057 (EPOR)
04151 PI3K-Akt signaling pathway
2057 (EPOR)
09133 Signaling molecules and interaction
04060 Cytokine-cytokine receptor interaction
2057 (EPOR)
09150 Organismal Systems
09151 Immune system
04640 Hematopoietic cell lineage
2057 (EPOR)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
2057 (EPOR)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04050 Cytokine receptors [BR:hsa04050]
2057 (EPOR)
Cytokine receptors [BR:hsa04050]
Interleukin receptor families
Prolactin receptor family
2057 (EPOR)
|
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| SSDB |
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| Motif |
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| Other DBs |
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| LinkDB |
|
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| Structure |
PDB: |
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| Position |
19p13.2
|
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| AA seq |
508 aa
MDHLGASLWPQVGSLCLLLAGAAWAPPPNLPDPKFESKAALLAARGPEELLCFTERLEDL
VCFWEEAASAGVGPGNYSFSYQLEDEPWKLCRLHQAPTARGAVRFWCSLPTADTSSFVPL
ELRVTAASGAPRYHRVIHINEVVLLDAPVGLVARLADESGHVVLRWLPPPETPMTSHIRY
EVDVSAGNGAGSVQRVEILEGRTECVLSNLRGRTRYTFAVRARMAEPSFGGFWSAWSEPV
SLLTPSDLDPLILTLSLILVVILVLLTVLALLSHRRALKQKIWPGIPSPESEFEGLFTTH
KGNFQLWLYQNDGCLWWSPCTPFTEDPPASLEVLSERCWGTMQAVEPGTDDEGPLLEPVG
SEHAQDTYLVLDKWLLPRNPPSEDLPGPGGSVDIVAMDEGSEASSCSSALASKPSPEGAS
AASFEYTILDPSSQLLRPWTLCPELPPTPPHLKYLYLVVSDSGISTDYSSGDSQGAQGGL
SDGPYSNPYENSLIPAAEPLPPSYVACS |
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| NT seq |
1527 nt +upstreamnt +downstreamnt
atggaccacctcggggcgtccctctggccccaggtcggctccctttgtctcctgctcgct
ggggccgcctgggcgcccccgcctaacctcccggaccccaagttcgagagcaaagcggcc
ttgctggcggcccgggggcccgaagagcttctgtgcttcaccgagcggttggaggacttg
gtgtgtttctgggaggaagcggcgagcgctggggtgggcccgggcaactacagcttctcc
taccagctcgaggatgagccatggaagctgtgtcgcctgcaccaggctcccacggctcgt
ggtgcggtgcgcttctggtgttcgctgcctacagccgacacgtcgagcttcgtgccccta
gagttgcgcgtcacagcagcctccggcgctccgcgatatcaccgtgtcatccacatcaat
gaagtagtgctcctagacgcccccgtggggctggtggcgcggttggctgacgagagcggc
cacgtagtgttgcgctggctcccgccgcctgagacacccatgacgtctcacatccgctac
gaggtggacgtctcggccggcaacggcgcagggagcgtacagagggtggagatcctggag
ggccgcaccgagtgtgtgctgagcaacctgcggggccggacgcgctacaccttcgccgtc
cgcgcgcgtatggctgagccgagcttcggcggcttctggagcgcctggtcggagcctgtg
tcgctgctgacgcctagcgacctggaccccctcatcctgacgctctccctcatcctcgtg
gtcatcctggtgctgctgaccgtgctcgcgctgctctcccaccgccgggctctgaagcag
aagatctggcctggcatcccgagcccagagagcgagtttgaaggcctcttcaccacccac
aagggtaacttccagctgtggctgtaccagaatgatggctgcctgtggtggagcccctgc
acccccttcacggaggacccacctgcttccctggaagtcctctcagagcgctgctggggg
acgatgcaggcagtggagccggggacagatgatgagggccccctgctggagccagtgggc
agtgagcatgcccaggatacctatctggtgctggacaaatggttgctgccccggaacccg
cccagtgaggacctcccagggcctggtggcagtgtggacatagtggccatggatgaaggc
tcagaagcatcctcctgctcatctgctttggcctcgaagcccagcccagagggagcctct
gctgccagctttgagtacactatcctggaccccagctcccagctcttgcgtccatggaca
ctgtgccctgagctgccccctaccccaccccacctaaagtacctgtaccttgtggtatct
gactctggcatctcaactgactacagctcaggggactcccagggagcccaagggggctta
tccgatggcccctactccaacccttatgagaacagccttatcccagccgctgagcctctg
ccccccagctatgtggcttgctcttag |
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