Homo sapiens (human): 207
Help
Entry
207 CDS
T01001
Gene name
AKT1, AKT, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA
Definition
(RefSeq) AKT serine/threonine kinase 1
KO
K04456
RAC serine/threonine-protein kinase [EC:
2.7.11.1
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa01521
EGFR tyrosine kinase inhibitor resistance
hsa01522
Endocrine resistance
hsa01524
Platinum drug resistance
hsa04010
MAPK signaling pathway
hsa04012
ErbB signaling pathway
hsa04014
Ras signaling pathway
hsa04015
Rap1 signaling pathway
hsa04022
cGMP-PKG signaling pathway
hsa04024
cAMP signaling pathway
hsa04062
Chemokine signaling pathway
hsa04066
HIF-1 signaling pathway
hsa04068
FoxO signaling pathway
hsa04071
Sphingolipid signaling pathway
hsa04072
Phospholipase D signaling pathway
hsa04140
Autophagy - animal
hsa04150
mTOR signaling pathway
hsa04151
PI3K-Akt signaling pathway
hsa04152
AMPK signaling pathway
hsa04210
Apoptosis
hsa04211
Longevity regulating pathway
hsa04213
Longevity regulating pathway - multiple species
hsa04218
Cellular senescence
hsa04261
Adrenergic signaling in cardiomyocytes
hsa04370
VEGF signaling pathway
hsa04371
Apelin signaling pathway
hsa04380
Osteoclast differentiation
hsa04510
Focal adhesion
hsa04550
Signaling pathways regulating pluripotency of stem cells
hsa04611
Platelet activation
hsa04613
Neutrophil extracellular trap formation
hsa04620
Toll-like receptor signaling pathway
hsa04625
C-type lectin receptor signaling pathway
hsa04630
JAK-STAT signaling pathway
hsa04660
T cell receptor signaling pathway
hsa04662
B cell receptor signaling pathway
hsa04664
Fc epsilon RI signaling pathway
hsa04666
Fc gamma R-mediated phagocytosis
hsa04668
TNF signaling pathway
hsa04722
Neurotrophin signaling pathway
hsa04725
Cholinergic synapse
hsa04728
Dopaminergic synapse
hsa04910
Insulin signaling pathway
hsa04914
Progesterone-mediated oocyte maturation
hsa04915
Estrogen signaling pathway
hsa04917
Prolactin signaling pathway
hsa04919
Thyroid hormone signaling pathway
hsa04920
Adipocytokine signaling pathway
hsa04922
Glucagon signaling pathway
hsa04923
Regulation of lipolysis in adipocytes
hsa04926
Relaxin signaling pathway
hsa04929
GnRH secretion
hsa04931
Insulin resistance
hsa04932
Non-alcoholic fatty liver disease
hsa04933
AGE-RAGE signaling pathway in diabetic complications
hsa04935
Growth hormone synthesis, secretion and action
hsa04973
Carbohydrate digestion and absorption
hsa05010
Alzheimer disease
hsa05017
Spinocerebellar ataxia
hsa05131
Shigellosis
hsa05132
Salmonella infection
hsa05135
Yersinia infection
hsa05142
Chagas disease
hsa05145
Toxoplasmosis
hsa05152
Tuberculosis
hsa05160
Hepatitis C
hsa05161
Hepatitis B
hsa05162
Measles
hsa05163
Human cytomegalovirus infection
hsa05164
Influenza A
hsa05165
Human papillomavirus infection
hsa05166
Human T-cell leukemia virus 1 infection
hsa05167
Kaposi sarcoma-associated herpesvirus infection
hsa05168
Herpes simplex virus 1 infection
hsa05169
Epstein-Barr virus infection
hsa05170
Human immunodeficiency virus 1 infection
hsa05200
Pathways in cancer
hsa05205
Proteoglycans in cancer
hsa05210
Colorectal cancer
hsa05211
Renal cell carcinoma
hsa05212
Pancreatic cancer
hsa05213
Endometrial cancer
hsa05214
Glioma
hsa05215
Prostate cancer
hsa05218
Melanoma
hsa05220
Chronic myeloid leukemia
hsa05221
Acute myeloid leukemia
hsa05222
Small cell lung cancer
hsa05223
Non-small cell lung cancer
hsa05224
Breast cancer
hsa05225
Hepatocellular carcinoma
hsa05226
Gastric cancer
hsa05230
Central carbon metabolism in cancer
hsa05231
Choline metabolism in cancer
hsa05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
hsa05415
Diabetic cardiomyopathy
hsa05417
Lipid and atherosclerosis
hsa05418
Fluid shear stress and atherosclerosis
Network
nt06114
PI3K signaling (viruses)
nt06124
Chemokine signaling (viruses)
nt06135
Cytoskeletal regulation (viruses and bacteria)
nt06150
Cytokine-cytokine receptor interaction (viruses)
nt06160
Human T-cell leukemia virus 1 (HTLV-1)
nt06161
Human immunodeficiency virus type 1 (HIV-1)
nt06162
Hepatitis B virus (HBV)
nt06163
Hepatitis C virus (HCV)
nt06164
Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165
Epstein-Barr virus (EBV)
nt06166
Human papillomavirus (HPV)
nt06167
Human cytomegalovirus (HCMV)
nt06168
Herpes simplex virus 1 (HSV-1)
nt06169
Measles virus (MV)
nt06170
Influenza A virus (IAV)
nt06214
PI3K signaling
nt06224
CXCR signaling
nt06260
Colorectal cancer
nt06261
Gastric cancer
nt06262
Pancreatic cancer
nt06263
Hepatocellular carcinoma
nt06264
Renal cell carcinoma
nt06266
Non-small cell lung cancer
nt06267
Small cell lung cancer
nt06268
Melanoma
nt06270
Breast cancer
nt06271
Endometrial cancer
nt06272
Prostate cancer
nt06273
Glioma
nt06275
Acute myeloid leukemia
nt06276
Chronic myeloid leukemia
nt06415
PI3K signaling
nt06462
Spinocerebellar ataxia
nt06464
Amyotrophic lateral sclerosis
Element
N00030
EGF-EGFR-RAS-PI3K signaling pathway
N00031
Duplication or mutation-activated FLT3 to RAS-PI3K signaling pathway
N00032
Mutation-activated KRAS/NRAS to PI3K signaling pathway
N00033
EGF-EGFR-PI3K signaling pathway
N00034
ERBB2-overexpression to PI3K signaling pathway
N00035
Amplified EGFR to PI3K signaling pathway
N00036
Mutation-activated EGFR to PI3K signaling pathway
N00037
FGF-FGFR-PI3K signaling pathway
N00038
Amplified FGFR to PI3K signaling pathway
N00039
PDGF-PDGFR-PI3K signaling pathway
N00040
Amplified PDGFR to PI3K signaling pathway
N00042
EGFR-overexpression to PI3K signaling pathway
N00043
HGF-MET-PI3K signaling pathway
N00044
Mutation-activated MET to PI3K signaling pathway
N00045
KITLG-KIT-PI3K signaling pathway
N00046
Mutation-activated KIT to PI3K signaling pathway
N00047
EML4-ALK fusion kinase to PI3K signaling pathway
N00048
BCR-ABL fusion kinase to PI3K signaling pathway
N00049
Mutation-activated PI3K to PI3K signaling pathway
N00050
Amplified PI3K to PI3K signaling pathway
N00051
Deleted PTEN to PI3K signaling pathway
N00052
Mutation-inactivated PTEN to PI3K signaling pathway
N00082
Loss of NKX3-1 to PI3K signaling pathway
N00154
CXCR-GNB/G-PI3K-AKT signaling pathway
N00158
KSHV vGPCR to GNB/G-PI3K-AKT signaling pathway
N00159
KSHV K1 to PI3K signaling pathway
N00179
KSHV K1 to PI3K-NFKB signaling pathway
N00182
IGF-IGFR-PI3K-NFKB signaling pathway
N00218
FLT3LG-FLT3-RAS-PI3K signaling pathway
N00220
PTEN-PIP3-AKT signaling pathway
N00231
TGFA-EGFR-PI3K signaling pathway
N00232
TGFA-overexpression to PI3K signaling pathway
N00234
IGF2-IGF1R-PI3K signaling pathway
N00236
IGF2-overexpression to PI3K signaling pathway
N00238
IGF1R-overexpression to PI3K signaling pathway
N00247
HGF-overexpression to PI3K signaling pathway
N00249
MET-overexpression to PI3K signaling pathway
N00253
Amplified ERBB2 to PI3K signaling pathway
N00260
Amplified MET to PI3K signaling pathway
N00266
EBV LMP2A to PI3K signaling pathway
N00267
HBV HBx to PI3K signaling pathway
N00272
HCV NS5A to PI3K signaling pathway
N00281
EGF-overexpression to PI3K signaling pathway
N00282
EREG-EGFR-PI3K signaling pathway
N00283
EREG-overexpression to PI3K signaling pathway
N00284
AREG-EGFR-PI3K signaling pathway
N00285
AREG-overexpression to PI3K signaling pathway
N00342
MAGI-PTEN signaling pathway
N00355
PP2A-AKT signaling pathway
N00366
HPV E5 to EGFR-PI3K signaling pathway
N00368
HPV E5 to PDGFR-PI3K signaling pathway
N00385
HCMV gB to PDGFR-PI3K signaling pathway
N00387
HCMV IE1-72/IE2-86 to PI3K signaling pathway
N00390
EGF-EGFR-PI3K-NFKB signaling pathway
N00391
HCMV gB to EGFR-PI3K-NFKB signaling pathway
N00399
CCR2-GNB/G-PI3K-NFKB signaling pathway
N00400
HCMV US28 to GNB/G-PI3K-NFKB signaling pathway
N00430
CXCR4-GNAI-PI3K-BAD signaling pathway
N00431
HIV gp120 to CXCR4-GNAI-PI3K-BAD signaling pathway
N00485
EBV LMP1 to PI3K signaling pathway
N00501
HTLV-1 Tax to EGFR-PI3K-NFKB signaling pathway
N00514
Mutation-activated EGFR to PI3K signaling pathway
N00582
IGF-IGF1R-PI3K signaling pathway
N00583
HSV VP11/12 to PI3K signaling pathway
N00683
CD80/CD86-CD28-PI3K signaling pathway
N00684
MV F/H to CD28-PI3K signaling pathway
N00736
IAV NS1 to PI3K signaling pathway
N00963
RELN-VLDLR-PI3K signaling pathway
N00964
DAB1-overexpression to RELN-VLDLR-PI3K signaling pathway
N01063
Mutation-activated MET to PI3K signaling pathway
N01065
Mutation-activated RET to PI3K signaling pathway
N01163
NRG-ERBB4-PI3K signaling pathway
Disease
H01222
Cowden syndrome
H01556
Meningioma
H01649
Schizophrenia
H02119
Proteus syndrome
Drug target
Afuresertib (
DG01408
):
D10381
D10382
Capivasertib:
D11371
Ipatasertib (
DG02851
):
D10641
D11074
Miransertib (
DG03026
):
D11409
D11508
Triciribine phosphate:
D06221
Uprosertib:
D10674
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
207 (AKT1)
04012 ErbB signaling pathway
207 (AKT1)
04014 Ras signaling pathway
207 (AKT1)
04015 Rap1 signaling pathway
207 (AKT1)
04370 VEGF signaling pathway
207 (AKT1)
04371 Apelin signaling pathway
207 (AKT1)
04630 JAK-STAT signaling pathway
207 (AKT1)
04668 TNF signaling pathway
207 (AKT1)
04066 HIF-1 signaling pathway
207 (AKT1)
04068 FoxO signaling pathway
207 (AKT1)
04072 Phospholipase D signaling pathway
207 (AKT1)
04071 Sphingolipid signaling pathway
207 (AKT1)
04024 cAMP signaling pathway
207 (AKT1)
04022 cGMP-PKG signaling pathway
207 (AKT1)
04151 PI3K-Akt signaling pathway
207 (AKT1)
04152 AMPK signaling pathway
207 (AKT1)
04150 mTOR signaling pathway
207 (AKT1)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
207 (AKT1)
09143 Cell growth and death
04210 Apoptosis
207 (AKT1)
04218 Cellular senescence
207 (AKT1)
09144 Cellular community - eukaryotes
04510 Focal adhesion
207 (AKT1)
04550 Signaling pathways regulating pluripotency of stem cells
207 (AKT1)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
207 (AKT1)
04613 Neutrophil extracellular trap formation
207 (AKT1)
04620 Toll-like receptor signaling pathway
207 (AKT1)
04625 C-type lectin receptor signaling pathway
207 (AKT1)
04660 T cell receptor signaling pathway
207 (AKT1)
04662 B cell receptor signaling pathway
207 (AKT1)
04664 Fc epsilon RI signaling pathway
207 (AKT1)
04666 Fc gamma R-mediated phagocytosis
207 (AKT1)
04062 Chemokine signaling pathway
207 (AKT1)
09152 Endocrine system
04910 Insulin signaling pathway
207 (AKT1)
04922 Glucagon signaling pathway
207 (AKT1)
04923 Regulation of lipolysis in adipocytes
207 (AKT1)
04920 Adipocytokine signaling pathway
207 (AKT1)
04929 GnRH secretion
207 (AKT1)
04915 Estrogen signaling pathway
207 (AKT1)
04914 Progesterone-mediated oocyte maturation
207 (AKT1)
04917 Prolactin signaling pathway
207 (AKT1)
04926 Relaxin signaling pathway
207 (AKT1)
04935 Growth hormone synthesis, secretion and action
207 (AKT1)
04919 Thyroid hormone signaling pathway
207 (AKT1)
09153 Circulatory system
04261 Adrenergic signaling in cardiomyocytes
207 (AKT1)
09154 Digestive system
04973 Carbohydrate digestion and absorption
207 (AKT1)
09156 Nervous system
04725 Cholinergic synapse
207 (AKT1)
04728 Dopaminergic synapse
207 (AKT1)
04722 Neurotrophin signaling pathway
207 (AKT1)
09158 Development and regeneration
04380 Osteoclast differentiation
207 (AKT1)
09149 Aging
04211 Longevity regulating pathway
207 (AKT1)
04213 Longevity regulating pathway - multiple species
207 (AKT1)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
207 (AKT1)
05205 Proteoglycans in cancer
207 (AKT1)
05230 Central carbon metabolism in cancer
207 (AKT1)
05231 Choline metabolism in cancer
207 (AKT1)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
207 (AKT1)
09162 Cancer: specific types
05210 Colorectal cancer
207 (AKT1)
05212 Pancreatic cancer
207 (AKT1)
05225 Hepatocellular carcinoma
207 (AKT1)
05226 Gastric cancer
207 (AKT1)
05214 Glioma
207 (AKT1)
05221 Acute myeloid leukemia
207 (AKT1)
05220 Chronic myeloid leukemia
207 (AKT1)
05218 Melanoma
207 (AKT1)
05211 Renal cell carcinoma
207 (AKT1)
05215 Prostate cancer
207 (AKT1)
05213 Endometrial cancer
207 (AKT1)
05224 Breast cancer
207 (AKT1)
05222 Small cell lung cancer
207 (AKT1)
05223 Non-small cell lung cancer
207 (AKT1)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
207 (AKT1)
05170 Human immunodeficiency virus 1 infection
207 (AKT1)
05161 Hepatitis B
207 (AKT1)
05160 Hepatitis C
207 (AKT1)
05164 Influenza A
207 (AKT1)
05162 Measles
207 (AKT1)
05168 Herpes simplex virus 1 infection
207 (AKT1)
05163 Human cytomegalovirus infection
207 (AKT1)
05167 Kaposi sarcoma-associated herpesvirus infection
207 (AKT1)
05169 Epstein-Barr virus infection
207 (AKT1)
05165 Human papillomavirus infection
207 (AKT1)
09171 Infectious disease: bacterial
05132 Salmonella infection
207 (AKT1)
05131 Shigellosis
207 (AKT1)
05135 Yersinia infection
207 (AKT1)
05152 Tuberculosis
207 (AKT1)
09174 Infectious disease: parasitic
05145 Toxoplasmosis
207 (AKT1)
05142 Chagas disease
207 (AKT1)
09164 Neurodegenerative disease
05010 Alzheimer disease
207 (AKT1)
05017 Spinocerebellar ataxia
207 (AKT1)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
207 (AKT1)
05418 Fluid shear stress and atherosclerosis
207 (AKT1)
05415 Diabetic cardiomyopathy
207 (AKT1)
09167 Endocrine and metabolic disease
04932 Non-alcoholic fatty liver disease
207 (AKT1)
04931 Insulin resistance
207 (AKT1)
04933 AGE-RAGE signaling pathway in diabetic complications
207 (AKT1)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
207 (AKT1)
01524 Platinum drug resistance
207 (AKT1)
01522 Endocrine resistance
207 (AKT1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
hsa01001
]
207 (AKT1)
Enzymes [BR:
hsa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
207 (AKT1)
Protein kinases [BR:
hsa01001
]
Serine/threonine kinases: AGC group
AKT/PKB family
207 (AKT1)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
Pkinase
PK_Tyr_Ser-Thr
PH
Pkinase_C
Kinase-like
PH_11
Seadorna_VP7
Pkinase_fungal
ABC1
APH
Motif
Other DBs
NCBI-GeneID:
207
NCBI-ProteinID:
NP_001014431
OMIM:
164730
HGNC:
391
Ensembl:
ENSG00000142208
Vega:
OTTHUMG00000170795
Pharos:
P31749
(Tchem)
UniProt:
P31749
B0LPE5
LinkDB
All DBs
Structure
PDB:
1UNQ
1UNR
1H10
4GV1
1UNP
3QKL
2UZR
2UVM
4EKL
3CQW
3MVH
6NPZ
6CCY
4EJN
3QKM
3CQU
6S9W
6HHG
6HHJ
3QKK
6BUU
2UZS
3MV5
6S9X
3OW4
6HHH
6HHI
5KCV
3OCB
3O96
4EKK
6HHF
Thumbnails
Position
14q32.33
AA seq
480 aa
AA seq
DB search
MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQC
QLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDF
RSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKI
LKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS
RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGI
KDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFEL
ILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKK
LSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA
NT seq
1443 nt
NT seq
+upstream
nt +downstream
nt
atgagcgacgtggctattgtgaaggagggttggctgcacaaacgaggggagtacatcaag
acctggcggccacgctacttcctcctcaagaatgatggcaccttcattggctacaaggag
cggccgcaggatgtggaccaacgtgaggctcccctcaacaacttctctgtggcgcagtgc
cagctgatgaagacggagcggccccggcccaacaccttcatcatccgctgcctgcagtgg
accactgtcatcgaacgcaccttccatgtggagactcctgaggagcgggaggagtggaca
accgccatccagactgtggctgacggcctcaagaagcaggaggaggaggagatggacttc
cggtcgggctcacccagtgacaactcaggggctgaagagatggaggtgtccctggccaag
cccaagcaccgcgtgaccatgaacgagtttgagtacctgaagctgctgggcaagggcact
ttcggcaaggtgatcctggtgaaggagaaggccacaggccgctactacgccatgaagatc
ctcaagaaggaagtcatcgtggccaaggacgaggtggcccacacactcaccgagaaccgc
gtcctgcagaactccaggcaccccttcctcacagccctgaagtactctttccagacccac
gaccgcctctgctttgtcatggagtacgccaacgggggcgagctgttcttccacctgtcc
cgggagcgtgtgttctccgaggaccgggcccgcttctatggcgctgagattgtgtcagcc
ctggactacctgcactcggagaagaacgtggtgtaccgggacctcaagctggagaacctc
atgctggacaaggacgggcacattaagatcacagacttcgggctgtgcaaggaggggatc
aaggacggtgccaccatgaagaccttttgcggcacacctgagtacctggcccccgaggtg
ctggaggacaatgactacggccgtgcagtggactggtgggggctgggcgtggtcatgtac
gagatgatgtgcggtcgcctgcccttctacaaccaggaccatgagaagctttttgagctc
atcctcatggaggagatccgcttcccgcgcacgcttggtcccgaggccaagtccttgctt
tcagggctgctcaagaaggaccccaagcagaggcttggcgggggctccgaggacgccaag
gagatcatgcagcatcgcttctttgccggtatcgtgtggcagcacgtgtacgagaagaag
ctcagcccacccttcaagccccaggtcacgtcggagactgacaccaggtattttgatgag
gagttcacggcccagatgatcaccatcacaccacctgaccaagatgacagcatggagtgt
gtggacagcgagcgcaggccccacttcccccagttctcctactcggccagcggcacggcc
tga
Homo sapiens (human): 208
Help
Entry
208 CDS
T01001
Gene name
AKT2, HIHGHH, PKBB, PKBBETA, PRKBB, RAC-BETA
Definition
(RefSeq) AKT serine/threonine kinase 2
KO
K04456
RAC serine/threonine-protein kinase [EC:
2.7.11.1
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa01521
EGFR tyrosine kinase inhibitor resistance
hsa01522
Endocrine resistance
hsa01524
Platinum drug resistance
hsa04010
MAPK signaling pathway
hsa04012
ErbB signaling pathway
hsa04014
Ras signaling pathway
hsa04015
Rap1 signaling pathway
hsa04022
cGMP-PKG signaling pathway
hsa04024
cAMP signaling pathway
hsa04062
Chemokine signaling pathway
hsa04066
HIF-1 signaling pathway
hsa04068
FoxO signaling pathway
hsa04071
Sphingolipid signaling pathway
hsa04072
Phospholipase D signaling pathway
hsa04140
Autophagy - animal
hsa04150
mTOR signaling pathway
hsa04151
PI3K-Akt signaling pathway
hsa04152
AMPK signaling pathway
hsa04210
Apoptosis
hsa04211
Longevity regulating pathway
hsa04213
Longevity regulating pathway - multiple species
hsa04218
Cellular senescence
hsa04261
Adrenergic signaling in cardiomyocytes
hsa04370
VEGF signaling pathway
hsa04371
Apelin signaling pathway
hsa04380
Osteoclast differentiation
hsa04510
Focal adhesion
hsa04550
Signaling pathways regulating pluripotency of stem cells
hsa04611
Platelet activation
hsa04613
Neutrophil extracellular trap formation
hsa04620
Toll-like receptor signaling pathway
hsa04625
C-type lectin receptor signaling pathway
hsa04630
JAK-STAT signaling pathway
hsa04660
T cell receptor signaling pathway
hsa04662
B cell receptor signaling pathway
hsa04664
Fc epsilon RI signaling pathway
hsa04666
Fc gamma R-mediated phagocytosis
hsa04668
TNF signaling pathway
hsa04722
Neurotrophin signaling pathway
hsa04725
Cholinergic synapse
hsa04728
Dopaminergic synapse
hsa04910
Insulin signaling pathway
hsa04914
Progesterone-mediated oocyte maturation
hsa04915
Estrogen signaling pathway
hsa04917
Prolactin signaling pathway
hsa04919
Thyroid hormone signaling pathway
hsa04920
Adipocytokine signaling pathway
hsa04922
Glucagon signaling pathway
hsa04923
Regulation of lipolysis in adipocytes
hsa04926
Relaxin signaling pathway
hsa04929
GnRH secretion
hsa04931
Insulin resistance
hsa04932
Non-alcoholic fatty liver disease
hsa04933
AGE-RAGE signaling pathway in diabetic complications
hsa04935
Growth hormone synthesis, secretion and action
hsa04973
Carbohydrate digestion and absorption
hsa05010
Alzheimer disease
hsa05017
Spinocerebellar ataxia
hsa05131
Shigellosis
hsa05132
Salmonella infection
hsa05135
Yersinia infection
hsa05142
Chagas disease
hsa05145
Toxoplasmosis
hsa05152
Tuberculosis
hsa05160
Hepatitis C
hsa05161
Hepatitis B
hsa05162
Measles
hsa05163
Human cytomegalovirus infection
hsa05164
Influenza A
hsa05165
Human papillomavirus infection
hsa05166
Human T-cell leukemia virus 1 infection
hsa05167
Kaposi sarcoma-associated herpesvirus infection
hsa05168
Herpes simplex virus 1 infection
hsa05169
Epstein-Barr virus infection
hsa05170
Human immunodeficiency virus 1 infection
hsa05200
Pathways in cancer
hsa05205
Proteoglycans in cancer
hsa05210
Colorectal cancer
hsa05211
Renal cell carcinoma
hsa05212
Pancreatic cancer
hsa05213
Endometrial cancer
hsa05214
Glioma
hsa05215
Prostate cancer
hsa05218
Melanoma
hsa05220
Chronic myeloid leukemia
hsa05221
Acute myeloid leukemia
hsa05222
Small cell lung cancer
hsa05223
Non-small cell lung cancer
hsa05224
Breast cancer
hsa05225
Hepatocellular carcinoma
hsa05226
Gastric cancer
hsa05230
Central carbon metabolism in cancer
hsa05231
Choline metabolism in cancer
hsa05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
hsa05415
Diabetic cardiomyopathy
hsa05417
Lipid and atherosclerosis
hsa05418
Fluid shear stress and atherosclerosis
Network
nt06114
PI3K signaling (viruses)
nt06124
Chemokine signaling (viruses)
nt06135
Cytoskeletal regulation (viruses and bacteria)
nt06150
Cytokine-cytokine receptor interaction (viruses)
nt06160
Human T-cell leukemia virus 1 (HTLV-1)
nt06161
Human immunodeficiency virus type 1 (HIV-1)
nt06162
Hepatitis B virus (HBV)
nt06163
Hepatitis C virus (HCV)
nt06164
Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165
Epstein-Barr virus (EBV)
nt06166
Human papillomavirus (HPV)
nt06167
Human cytomegalovirus (HCMV)
nt06168
Herpes simplex virus 1 (HSV-1)
nt06169
Measles virus (MV)
nt06170
Influenza A virus (IAV)
nt06214
PI3K signaling
nt06224
CXCR signaling
nt06260
Colorectal cancer
nt06261
Gastric cancer
nt06262
Pancreatic cancer
nt06263
Hepatocellular carcinoma
nt06264
Renal cell carcinoma
nt06266
Non-small cell lung cancer
nt06267
Small cell lung cancer
nt06268
Melanoma
nt06270
Breast cancer
nt06271
Endometrial cancer
nt06272
Prostate cancer
nt06273
Glioma
nt06275
Acute myeloid leukemia
nt06276
Chronic myeloid leukemia
nt06415
PI3K signaling
nt06462
Spinocerebellar ataxia
nt06464
Amyotrophic lateral sclerosis
Element
N00030
EGF-EGFR-RAS-PI3K signaling pathway
N00031
Duplication or mutation-activated FLT3 to RAS-PI3K signaling pathway
N00032
Mutation-activated KRAS/NRAS to PI3K signaling pathway
N00033
EGF-EGFR-PI3K signaling pathway
N00034
ERBB2-overexpression to PI3K signaling pathway
N00035
Amplified EGFR to PI3K signaling pathway
N00036
Mutation-activated EGFR to PI3K signaling pathway
N00037
FGF-FGFR-PI3K signaling pathway
N00038
Amplified FGFR to PI3K signaling pathway
N00039
PDGF-PDGFR-PI3K signaling pathway
N00040
Amplified PDGFR to PI3K signaling pathway
N00042
EGFR-overexpression to PI3K signaling pathway
N00043
HGF-MET-PI3K signaling pathway
N00044
Mutation-activated MET to PI3K signaling pathway
N00045
KITLG-KIT-PI3K signaling pathway
N00046
Mutation-activated KIT to PI3K signaling pathway
N00047
EML4-ALK fusion kinase to PI3K signaling pathway
N00048
BCR-ABL fusion kinase to PI3K signaling pathway
N00049
Mutation-activated PI3K to PI3K signaling pathway
N00050
Amplified PI3K to PI3K signaling pathway
N00051
Deleted PTEN to PI3K signaling pathway
N00052
Mutation-inactivated PTEN to PI3K signaling pathway
N00082
Loss of NKX3-1 to PI3K signaling pathway
N00154
CXCR-GNB/G-PI3K-AKT signaling pathway
N00158
KSHV vGPCR to GNB/G-PI3K-AKT signaling pathway
N00159
KSHV K1 to PI3K signaling pathway
N00179
KSHV K1 to PI3K-NFKB signaling pathway
N00182
IGF-IGFR-PI3K-NFKB signaling pathway
N00218
FLT3LG-FLT3-RAS-PI3K signaling pathway
N00220
PTEN-PIP3-AKT signaling pathway
N00231
TGFA-EGFR-PI3K signaling pathway
N00232
TGFA-overexpression to PI3K signaling pathway
N00234
IGF2-IGF1R-PI3K signaling pathway
N00236
IGF2-overexpression to PI3K signaling pathway
N00238
IGF1R-overexpression to PI3K signaling pathway
N00247
HGF-overexpression to PI3K signaling pathway
N00249
MET-overexpression to PI3K signaling pathway
N00253
Amplified ERBB2 to PI3K signaling pathway
N00260
Amplified MET to PI3K signaling pathway
N00266
EBV LMP2A to PI3K signaling pathway
N00267
HBV HBx to PI3K signaling pathway
N00272
HCV NS5A to PI3K signaling pathway
N00281
EGF-overexpression to PI3K signaling pathway
N00282
EREG-EGFR-PI3K signaling pathway
N00283
EREG-overexpression to PI3K signaling pathway
N00284
AREG-EGFR-PI3K signaling pathway
N00285
AREG-overexpression to PI3K signaling pathway
N00342
MAGI-PTEN signaling pathway
N00355
PP2A-AKT signaling pathway
N00366
HPV E5 to EGFR-PI3K signaling pathway
N00368
HPV E5 to PDGFR-PI3K signaling pathway
N00385
HCMV gB to PDGFR-PI3K signaling pathway
N00387
HCMV IE1-72/IE2-86 to PI3K signaling pathway
N00390
EGF-EGFR-PI3K-NFKB signaling pathway
N00391
HCMV gB to EGFR-PI3K-NFKB signaling pathway
N00399
CCR2-GNB/G-PI3K-NFKB signaling pathway
N00400
HCMV US28 to GNB/G-PI3K-NFKB signaling pathway
N00430
CXCR4-GNAI-PI3K-BAD signaling pathway
N00431
HIV gp120 to CXCR4-GNAI-PI3K-BAD signaling pathway
N00485
EBV LMP1 to PI3K signaling pathway
N00501
HTLV-1 Tax to EGFR-PI3K-NFKB signaling pathway
N00514
Mutation-activated EGFR to PI3K signaling pathway
N00582
IGF-IGF1R-PI3K signaling pathway
N00583
HSV VP11/12 to PI3K signaling pathway
N00683
CD80/CD86-CD28-PI3K signaling pathway
N00684
MV F/H to CD28-PI3K signaling pathway
N00736
IAV NS1 to PI3K signaling pathway
N00963
RELN-VLDLR-PI3K signaling pathway
N00964
DAB1-overexpression to RELN-VLDLR-PI3K signaling pathway
N01063
Mutation-activated MET to PI3K signaling pathway
N01065
Mutation-activated RET to PI3K signaling pathway
N01163
NRG-ERBB4-PI3K signaling pathway
Disease
H00027
Ovarian cancer
H00420
Familial partial lipodystrophy
H01909
Hypoinsulinemic hypoglycemia with hemihypertrophy
Drug target
Afuresertib (
DG01408
):
D10381
D10382
Capivasertib:
D11371
Ipatasertib (
DG02851
):
D10641
D11074
Miransertib (
DG03026
):
D11409
D11508
Triciribine phosphate:
D06221
Uprosertib:
D10674
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
208 (AKT2)
04012 ErbB signaling pathway
208 (AKT2)
04014 Ras signaling pathway
208 (AKT2)
04015 Rap1 signaling pathway
208 (AKT2)
04370 VEGF signaling pathway
208 (AKT2)
04371 Apelin signaling pathway
208 (AKT2)
04630 JAK-STAT signaling pathway
208 (AKT2)
04668 TNF signaling pathway
208 (AKT2)
04066 HIF-1 signaling pathway
208 (AKT2)
04068 FoxO signaling pathway
208 (AKT2)
04072 Phospholipase D signaling pathway
208 (AKT2)
04071 Sphingolipid signaling pathway
208 (AKT2)
04024 cAMP signaling pathway
208 (AKT2)
04022 cGMP-PKG signaling pathway
208 (AKT2)
04151 PI3K-Akt signaling pathway
208 (AKT2)
04152 AMPK signaling pathway
208 (AKT2)
04150 mTOR signaling pathway
208 (AKT2)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
208 (AKT2)
09143 Cell growth and death
04210 Apoptosis
208 (AKT2)
04218 Cellular senescence
208 (AKT2)
09144 Cellular community - eukaryotes
04510 Focal adhesion
208 (AKT2)
04550 Signaling pathways regulating pluripotency of stem cells
208 (AKT2)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
208 (AKT2)
04613 Neutrophil extracellular trap formation
208 (AKT2)
04620 Toll-like receptor signaling pathway
208 (AKT2)
04625 C-type lectin receptor signaling pathway
208 (AKT2)
04660 T cell receptor signaling pathway
208 (AKT2)
04662 B cell receptor signaling pathway
208 (AKT2)
04664 Fc epsilon RI signaling pathway
208 (AKT2)
04666 Fc gamma R-mediated phagocytosis
208 (AKT2)
04062 Chemokine signaling pathway
208 (AKT2)
09152 Endocrine system
04910 Insulin signaling pathway
208 (AKT2)
04922 Glucagon signaling pathway
208 (AKT2)
04923 Regulation of lipolysis in adipocytes
208 (AKT2)
04920 Adipocytokine signaling pathway
208 (AKT2)
04929 GnRH secretion
208 (AKT2)
04915 Estrogen signaling pathway
208 (AKT2)
04914 Progesterone-mediated oocyte maturation
208 (AKT2)
04917 Prolactin signaling pathway
208 (AKT2)
04926 Relaxin signaling pathway
208 (AKT2)
04935 Growth hormone synthesis, secretion and action
208 (AKT2)
04919 Thyroid hormone signaling pathway
208 (AKT2)
09153 Circulatory system
04261 Adrenergic signaling in cardiomyocytes
208 (AKT2)
09154 Digestive system
04973 Carbohydrate digestion and absorption
208 (AKT2)
09156 Nervous system
04725 Cholinergic synapse
208 (AKT2)
04728 Dopaminergic synapse
208 (AKT2)
04722 Neurotrophin signaling pathway
208 (AKT2)
09158 Development and regeneration
04380 Osteoclast differentiation
208 (AKT2)
09149 Aging
04211 Longevity regulating pathway
208 (AKT2)
04213 Longevity regulating pathway - multiple species
208 (AKT2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
208 (AKT2)
05205 Proteoglycans in cancer
208 (AKT2)
05230 Central carbon metabolism in cancer
208 (AKT2)
05231 Choline metabolism in cancer
208 (AKT2)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
208 (AKT2)
09162 Cancer: specific types
05210 Colorectal cancer
208 (AKT2)
05212 Pancreatic cancer
208 (AKT2)
05225 Hepatocellular carcinoma
208 (AKT2)
05226 Gastric cancer
208 (AKT2)
05214 Glioma
208 (AKT2)
05221 Acute myeloid leukemia
208 (AKT2)
05220 Chronic myeloid leukemia
208 (AKT2)
05218 Melanoma
208 (AKT2)
05211 Renal cell carcinoma
208 (AKT2)
05215 Prostate cancer
208 (AKT2)
05213 Endometrial cancer
208 (AKT2)
05224 Breast cancer
208 (AKT2)
05222 Small cell lung cancer
208 (AKT2)
05223 Non-small cell lung cancer
208 (AKT2)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
208 (AKT2)
05170 Human immunodeficiency virus 1 infection
208 (AKT2)
05161 Hepatitis B
208 (AKT2)
05160 Hepatitis C
208 (AKT2)
05164 Influenza A
208 (AKT2)
05162 Measles
208 (AKT2)
05168 Herpes simplex virus 1 infection
208 (AKT2)
05163 Human cytomegalovirus infection
208 (AKT2)
05167 Kaposi sarcoma-associated herpesvirus infection
208 (AKT2)
05169 Epstein-Barr virus infection
208 (AKT2)
05165 Human papillomavirus infection
208 (AKT2)
09171 Infectious disease: bacterial
05132 Salmonella infection
208 (AKT2)
05131 Shigellosis
208 (AKT2)
05135 Yersinia infection
208 (AKT2)
05152 Tuberculosis
208 (AKT2)
09174 Infectious disease: parasitic
05145 Toxoplasmosis
208 (AKT2)
05142 Chagas disease
208 (AKT2)
09164 Neurodegenerative disease
05010 Alzheimer disease
208 (AKT2)
05017 Spinocerebellar ataxia
208 (AKT2)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
208 (AKT2)
05418 Fluid shear stress and atherosclerosis
208 (AKT2)
05415 Diabetic cardiomyopathy
208 (AKT2)
09167 Endocrine and metabolic disease
04932 Non-alcoholic fatty liver disease
208 (AKT2)
04931 Insulin resistance
208 (AKT2)
04933 AGE-RAGE signaling pathway in diabetic complications
208 (AKT2)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
208 (AKT2)
01524 Platinum drug resistance
208 (AKT2)
01522 Endocrine resistance
208 (AKT2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
hsa01001
]
208 (AKT2)
Enzymes [BR:
hsa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
208 (AKT2)
Protein kinases [BR:
hsa01001
]
Serine/threonine kinases: AGC group
AKT/PKB family
208 (AKT2)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
Pkinase
PK_Tyr_Ser-Thr
PH
Kinase-like
Pkinase_C
ABC1
Motif
Other DBs
NCBI-GeneID:
208
NCBI-ProteinID:
NP_001617
OMIM:
164731
HGNC:
392
Ensembl:
ENSG00000105221
Vega:
OTTHUMG00000137375
Pharos:
P31751
(Tchem)
UniProt:
P31751
LinkDB
All DBs
Structure
PDB:
2X39
3D0E
3E87
3E88
3E8D
2XH5
1GZO
1MRV
1MRY
2UW9
2JDR
2JDO
1P6S
1O6K
1O6L
1GZN
1GZK
Thumbnails
Position
19q13.2
AA seq
481 aa
AA seq
DB search
MNEVSVIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPEAPDQTLPPLNNFSVAEC
QLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQMVANSLKQRAPGEDPM
DYKCGSPSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAM
KILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFH
LSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEG
ISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFE
LILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQK
KLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLGLLELDQRTHFPQFSYSASIR
E
NT seq
1446 nt
NT seq
+upstream
nt +downstream
nt
atgaatgaggtgtctgtcatcaaagaaggctggctccacaagcgtggtgaatacatcaag
acctggaggccacggtacttcctgctgaagagcgacggctccttcattgggtacaaggag
aggcccgaggcccctgatcagactctaccccccttaaacaacttctccgtagcagaatgc
cagctgatgaagaccgagaggccgcgacccaacacctttgtcatacgctgcctgcagtgg
accacagtcatcgagaggaccttccacgtggattctccagacgagagggaggagtggatg
cgggccatccagatggtcgccaacagcctcaagcagcgggccccaggcgaggaccccatg
gactacaagtgtggctcccccagtgactcctccacgactgaggagatggaagtggcggtc
agcaaggcacgggctaaagtgaccatgaatgacttcgactatctcaaactccttggcaag
ggaacctttggcaaagtcatcctggtgcgggagaaggccactggccgctactacgccatg
aagatcctgcggaaggaagtcatcattgccaaggatgaagtcgctcacacagtcaccgag
agccgggtcctccagaacaccaggcacccgttcctcactgcgctgaagtatgccttccag
acccacgaccgcctgtgctttgtgatggagtatgccaacgggggtgagctgttcttccac
ctgtcccgggagcgtgtcttcacagaggagcgggcccggttttatggtgcagagattgtc
tcggctcttgagtacttgcactcgcgggacgtggtataccgcgacatcaagctggaaaac
ctcatgctggacaaagatggccacatcaagatcactgactttggcctctgcaaagagggc
atcagtgacggggccaccatgaaaaccttctgtgggaccccggagtacctggcgcctgag
gtgctggaggacaatgactatggccgggccgtggactggtgggggctgggtgtggtcatg
tacgagatgatgtgcggccgcctgcccttctacaaccaggaccacgagcgcctcttcgag
ctcatcctcatggaagagatccgcttcccgcgcacgctcagccccgaggccaagtccctg
cttgctgggctgcttaagaaggaccccaagcagaggcttggtggggggcccagcgatgcc
aaggaggtcatggagcacaggttcttcctcagcatcaactggcaggacgtggtccagaag
aagctcctgccacccttcaaacctcaggtcacgtccgaggtcgacacaaggtacttcgat
gatgaatttaccgcccagtccatcacaatcacaccccctgaccgctatgacagcctgggc
ttactggagctggaccagcggacccacttcccccagttctcctactcggccagcatccgc
gagtga
Homo sapiens (human): 10000
Help
Entry
10000 CDS
T01001
Gene name
AKT3, MPPH, MPPH2, PKB-GAMMA, PKBG, PRKBG, RAC-PK-gamma, RAC-gamma, STK-2
Definition
(RefSeq) AKT serine/threonine kinase 3
KO
K04456
RAC serine/threonine-protein kinase [EC:
2.7.11.1
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa01521
EGFR tyrosine kinase inhibitor resistance
hsa01522
Endocrine resistance
hsa01524
Platinum drug resistance
hsa04010
MAPK signaling pathway
hsa04012
ErbB signaling pathway
hsa04014
Ras signaling pathway
hsa04015
Rap1 signaling pathway
hsa04022
cGMP-PKG signaling pathway
hsa04024
cAMP signaling pathway
hsa04062
Chemokine signaling pathway
hsa04066
HIF-1 signaling pathway
hsa04068
FoxO signaling pathway
hsa04071
Sphingolipid signaling pathway
hsa04072
Phospholipase D signaling pathway
hsa04140
Autophagy - animal
hsa04150
mTOR signaling pathway
hsa04151
PI3K-Akt signaling pathway
hsa04152
AMPK signaling pathway
hsa04210
Apoptosis
hsa04211
Longevity regulating pathway
hsa04213
Longevity regulating pathway - multiple species
hsa04218
Cellular senescence
hsa04261
Adrenergic signaling in cardiomyocytes
hsa04370
VEGF signaling pathway
hsa04371
Apelin signaling pathway
hsa04380
Osteoclast differentiation
hsa04510
Focal adhesion
hsa04550
Signaling pathways regulating pluripotency of stem cells
hsa04611
Platelet activation
hsa04613
Neutrophil extracellular trap formation
hsa04620
Toll-like receptor signaling pathway
hsa04625
C-type lectin receptor signaling pathway
hsa04630
JAK-STAT signaling pathway
hsa04660
T cell receptor signaling pathway
hsa04662
B cell receptor signaling pathway
hsa04664
Fc epsilon RI signaling pathway
hsa04666
Fc gamma R-mediated phagocytosis
hsa04668
TNF signaling pathway
hsa04722
Neurotrophin signaling pathway
hsa04725
Cholinergic synapse
hsa04728
Dopaminergic synapse
hsa04910
Insulin signaling pathway
hsa04914
Progesterone-mediated oocyte maturation
hsa04915
Estrogen signaling pathway
hsa04917
Prolactin signaling pathway
hsa04919
Thyroid hormone signaling pathway
hsa04920
Adipocytokine signaling pathway
hsa04922
Glucagon signaling pathway
hsa04923
Regulation of lipolysis in adipocytes
hsa04926
Relaxin signaling pathway
hsa04929
GnRH secretion
hsa04931
Insulin resistance
hsa04932
Non-alcoholic fatty liver disease
hsa04933
AGE-RAGE signaling pathway in diabetic complications
hsa04935
Growth hormone synthesis, secretion and action
hsa04973
Carbohydrate digestion and absorption
hsa05010
Alzheimer disease
hsa05017
Spinocerebellar ataxia
hsa05131
Shigellosis
hsa05132
Salmonella infection
hsa05135
Yersinia infection
hsa05142
Chagas disease
hsa05145
Toxoplasmosis
hsa05152
Tuberculosis
hsa05160
Hepatitis C
hsa05161
Hepatitis B
hsa05162
Measles
hsa05163
Human cytomegalovirus infection
hsa05164
Influenza A
hsa05165
Human papillomavirus infection
hsa05166
Human T-cell leukemia virus 1 infection
hsa05167
Kaposi sarcoma-associated herpesvirus infection
hsa05168
Herpes simplex virus 1 infection
hsa05169
Epstein-Barr virus infection
hsa05170
Human immunodeficiency virus 1 infection
hsa05200
Pathways in cancer
hsa05205
Proteoglycans in cancer
hsa05210
Colorectal cancer
hsa05211
Renal cell carcinoma
hsa05212
Pancreatic cancer
hsa05213
Endometrial cancer
hsa05214
Glioma
hsa05215
Prostate cancer
hsa05218
Melanoma
hsa05220
Chronic myeloid leukemia
hsa05221
Acute myeloid leukemia
hsa05222
Small cell lung cancer
hsa05223
Non-small cell lung cancer
hsa05224
Breast cancer
hsa05225
Hepatocellular carcinoma
hsa05226
Gastric cancer
hsa05230
Central carbon metabolism in cancer
hsa05231
Choline metabolism in cancer
hsa05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
hsa05415
Diabetic cardiomyopathy
hsa05417
Lipid and atherosclerosis
hsa05418
Fluid shear stress and atherosclerosis
Network
nt06114
PI3K signaling (viruses)
nt06124
Chemokine signaling (viruses)
nt06135
Cytoskeletal regulation (viruses and bacteria)
nt06150
Cytokine-cytokine receptor interaction (viruses)
nt06160
Human T-cell leukemia virus 1 (HTLV-1)
nt06161
Human immunodeficiency virus type 1 (HIV-1)
nt06162
Hepatitis B virus (HBV)
nt06163
Hepatitis C virus (HCV)
nt06164
Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165
Epstein-Barr virus (EBV)
nt06166
Human papillomavirus (HPV)
nt06167
Human cytomegalovirus (HCMV)
nt06168
Herpes simplex virus 1 (HSV-1)
nt06169
Measles virus (MV)
nt06170
Influenza A virus (IAV)
nt06214
PI3K signaling
nt06224
CXCR signaling
nt06260
Colorectal cancer
nt06261
Gastric cancer
nt06262
Pancreatic cancer
nt06263
Hepatocellular carcinoma
nt06264
Renal cell carcinoma
nt06266
Non-small cell lung cancer
nt06267
Small cell lung cancer
nt06268
Melanoma
nt06270
Breast cancer
nt06271
Endometrial cancer
nt06272
Prostate cancer
nt06273
Glioma
nt06275
Acute myeloid leukemia
nt06276
Chronic myeloid leukemia
nt06415
PI3K signaling
nt06462
Spinocerebellar ataxia
nt06464
Amyotrophic lateral sclerosis
Element
N00030
EGF-EGFR-RAS-PI3K signaling pathway
N00031
Duplication or mutation-activated FLT3 to RAS-PI3K signaling pathway
N00032
Mutation-activated KRAS/NRAS to PI3K signaling pathway
N00033
EGF-EGFR-PI3K signaling pathway
N00034
ERBB2-overexpression to PI3K signaling pathway
N00035
Amplified EGFR to PI3K signaling pathway
N00036
Mutation-activated EGFR to PI3K signaling pathway
N00037
FGF-FGFR-PI3K signaling pathway
N00038
Amplified FGFR to PI3K signaling pathway
N00039
PDGF-PDGFR-PI3K signaling pathway
N00040
Amplified PDGFR to PI3K signaling pathway
N00042
EGFR-overexpression to PI3K signaling pathway
N00043
HGF-MET-PI3K signaling pathway
N00044
Mutation-activated MET to PI3K signaling pathway
N00045
KITLG-KIT-PI3K signaling pathway
N00046
Mutation-activated KIT to PI3K signaling pathway
N00047
EML4-ALK fusion kinase to PI3K signaling pathway
N00048
BCR-ABL fusion kinase to PI3K signaling pathway
N00049
Mutation-activated PI3K to PI3K signaling pathway
N00050
Amplified PI3K to PI3K signaling pathway
N00051
Deleted PTEN to PI3K signaling pathway
N00052
Mutation-inactivated PTEN to PI3K signaling pathway
N00082
Loss of NKX3-1 to PI3K signaling pathway
N00154
CXCR-GNB/G-PI3K-AKT signaling pathway
N00158
KSHV vGPCR to GNB/G-PI3K-AKT signaling pathway
N00159
KSHV K1 to PI3K signaling pathway
N00179
KSHV K1 to PI3K-NFKB signaling pathway
N00182
IGF-IGFR-PI3K-NFKB signaling pathway
N00218
FLT3LG-FLT3-RAS-PI3K signaling pathway
N00220
PTEN-PIP3-AKT signaling pathway
N00231
TGFA-EGFR-PI3K signaling pathway
N00232
TGFA-overexpression to PI3K signaling pathway
N00234
IGF2-IGF1R-PI3K signaling pathway
N00236
IGF2-overexpression to PI3K signaling pathway
N00238
IGF1R-overexpression to PI3K signaling pathway
N00247
HGF-overexpression to PI3K signaling pathway
N00249
MET-overexpression to PI3K signaling pathway
N00253
Amplified ERBB2 to PI3K signaling pathway
N00260
Amplified MET to PI3K signaling pathway
N00266
EBV LMP2A to PI3K signaling pathway
N00267
HBV HBx to PI3K signaling pathway
N00272
HCV NS5A to PI3K signaling pathway
N00281
EGF-overexpression to PI3K signaling pathway
N00282
EREG-EGFR-PI3K signaling pathway
N00283
EREG-overexpression to PI3K signaling pathway
N00284
AREG-EGFR-PI3K signaling pathway
N00285
AREG-overexpression to PI3K signaling pathway
N00342
MAGI-PTEN signaling pathway
N00355
PP2A-AKT signaling pathway
N00366
HPV E5 to EGFR-PI3K signaling pathway
N00368
HPV E5 to PDGFR-PI3K signaling pathway
N00385
HCMV gB to PDGFR-PI3K signaling pathway
N00387
HCMV IE1-72/IE2-86 to PI3K signaling pathway
N00390
EGF-EGFR-PI3K-NFKB signaling pathway
N00391
HCMV gB to EGFR-PI3K-NFKB signaling pathway
N00399
CCR2-GNB/G-PI3K-NFKB signaling pathway
N00400
HCMV US28 to GNB/G-PI3K-NFKB signaling pathway
N00430
CXCR4-GNAI-PI3K-BAD signaling pathway
N00431
HIV gp120 to CXCR4-GNAI-PI3K-BAD signaling pathway
N00485
EBV LMP1 to PI3K signaling pathway
N00501
HTLV-1 Tax to EGFR-PI3K-NFKB signaling pathway
N00514
Mutation-activated EGFR to PI3K signaling pathway
N00582
IGF-IGF1R-PI3K signaling pathway
N00583
HSV VP11/12 to PI3K signaling pathway
N00683
CD80/CD86-CD28-PI3K signaling pathway
N00684
MV F/H to CD28-PI3K signaling pathway
N00736
IAV NS1 to PI3K signaling pathway
N00963
RELN-VLDLR-PI3K signaling pathway
N00964
DAB1-overexpression to RELN-VLDLR-PI3K signaling pathway
N01063
Mutation-activated MET to PI3K signaling pathway
N01065
Mutation-activated RET to PI3K signaling pathway
N01163
NRG-ERBB4-PI3K signaling pathway
Disease
H01885
Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome
Drug target
Afuresertib (
DG01408
):
D10381
D10382
Capivasertib:
D11371
Ipatasertib (
DG02851
):
D10641
D11074
Miransertib (
DG03026
):
D11409
D11508
Triciribine phosphate:
D06221
Uprosertib:
D10674
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
10000 (AKT3)
04012 ErbB signaling pathway
10000 (AKT3)
04014 Ras signaling pathway
10000 (AKT3)
04015 Rap1 signaling pathway
10000 (AKT3)
04370 VEGF signaling pathway
10000 (AKT3)
04371 Apelin signaling pathway
10000 (AKT3)
04630 JAK-STAT signaling pathway
10000 (AKT3)
04668 TNF signaling pathway
10000 (AKT3)
04066 HIF-1 signaling pathway
10000 (AKT3)
04068 FoxO signaling pathway
10000 (AKT3)
04072 Phospholipase D signaling pathway
10000 (AKT3)
04071 Sphingolipid signaling pathway
10000 (AKT3)
04024 cAMP signaling pathway
10000 (AKT3)
04022 cGMP-PKG signaling pathway
10000 (AKT3)
04151 PI3K-Akt signaling pathway
10000 (AKT3)
04152 AMPK signaling pathway
10000 (AKT3)
04150 mTOR signaling pathway
10000 (AKT3)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
10000 (AKT3)
09143 Cell growth and death
04210 Apoptosis
10000 (AKT3)
04218 Cellular senescence
10000 (AKT3)
09144 Cellular community - eukaryotes
04510 Focal adhesion
10000 (AKT3)
04550 Signaling pathways regulating pluripotency of stem cells
10000 (AKT3)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
10000 (AKT3)
04613 Neutrophil extracellular trap formation
10000 (AKT3)
04620 Toll-like receptor signaling pathway
10000 (AKT3)
04625 C-type lectin receptor signaling pathway
10000 (AKT3)
04660 T cell receptor signaling pathway
10000 (AKT3)
04662 B cell receptor signaling pathway
10000 (AKT3)
04664 Fc epsilon RI signaling pathway
10000 (AKT3)
04666 Fc gamma R-mediated phagocytosis
10000 (AKT3)
04062 Chemokine signaling pathway
10000 (AKT3)
09152 Endocrine system
04910 Insulin signaling pathway
10000 (AKT3)
04922 Glucagon signaling pathway
10000 (AKT3)
04923 Regulation of lipolysis in adipocytes
10000 (AKT3)
04920 Adipocytokine signaling pathway
10000 (AKT3)
04929 GnRH secretion
10000 (AKT3)
04915 Estrogen signaling pathway
10000 (AKT3)
04914 Progesterone-mediated oocyte maturation
10000 (AKT3)
04917 Prolactin signaling pathway
10000 (AKT3)
04926 Relaxin signaling pathway
10000 (AKT3)
04935 Growth hormone synthesis, secretion and action
10000 (AKT3)
04919 Thyroid hormone signaling pathway
10000 (AKT3)
09153 Circulatory system
04261 Adrenergic signaling in cardiomyocytes
10000 (AKT3)
09154 Digestive system
04973 Carbohydrate digestion and absorption
10000 (AKT3)
09156 Nervous system
04725 Cholinergic synapse
10000 (AKT3)
04728 Dopaminergic synapse
10000 (AKT3)
04722 Neurotrophin signaling pathway
10000 (AKT3)
09158 Development and regeneration
04380 Osteoclast differentiation
10000 (AKT3)
09149 Aging
04211 Longevity regulating pathway
10000 (AKT3)
04213 Longevity regulating pathway - multiple species
10000 (AKT3)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
10000 (AKT3)
05205 Proteoglycans in cancer
10000 (AKT3)
05230 Central carbon metabolism in cancer
10000 (AKT3)
05231 Choline metabolism in cancer
10000 (AKT3)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
10000 (AKT3)
09162 Cancer: specific types
05210 Colorectal cancer
10000 (AKT3)
05212 Pancreatic cancer
10000 (AKT3)
05225 Hepatocellular carcinoma
10000 (AKT3)
05226 Gastric cancer
10000 (AKT3)
05214 Glioma
10000 (AKT3)
05221 Acute myeloid leukemia
10000 (AKT3)
05220 Chronic myeloid leukemia
10000 (AKT3)
05218 Melanoma
10000 (AKT3)
05211 Renal cell carcinoma
10000 (AKT3)
05215 Prostate cancer
10000 (AKT3)
05213 Endometrial cancer
10000 (AKT3)
05224 Breast cancer
10000 (AKT3)
05222 Small cell lung cancer
10000 (AKT3)
05223 Non-small cell lung cancer
10000 (AKT3)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
10000 (AKT3)
05170 Human immunodeficiency virus 1 infection
10000 (AKT3)
05161 Hepatitis B
10000 (AKT3)
05160 Hepatitis C
10000 (AKT3)
05164 Influenza A
10000 (AKT3)
05162 Measles
10000 (AKT3)
05168 Herpes simplex virus 1 infection
10000 (AKT3)
05163 Human cytomegalovirus infection
10000 (AKT3)
05167 Kaposi sarcoma-associated herpesvirus infection
10000 (AKT3)
05169 Epstein-Barr virus infection
10000 (AKT3)
05165 Human papillomavirus infection
10000 (AKT3)
09171 Infectious disease: bacterial
05132 Salmonella infection
10000 (AKT3)
05131 Shigellosis
10000 (AKT3)
05135 Yersinia infection
10000 (AKT3)
05152 Tuberculosis
10000 (AKT3)
09174 Infectious disease: parasitic
05145 Toxoplasmosis
10000 (AKT3)
05142 Chagas disease
10000 (AKT3)
09164 Neurodegenerative disease
05010 Alzheimer disease
10000 (AKT3)
05017 Spinocerebellar ataxia
10000 (AKT3)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
10000 (AKT3)
05418 Fluid shear stress and atherosclerosis
10000 (AKT3)
05415 Diabetic cardiomyopathy
10000 (AKT3)
09167 Endocrine and metabolic disease
04932 Non-alcoholic fatty liver disease
10000 (AKT3)
04931 Insulin resistance
10000 (AKT3)
04933 AGE-RAGE signaling pathway in diabetic complications
10000 (AKT3)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
10000 (AKT3)
01524 Platinum drug resistance
10000 (AKT3)
01522 Endocrine resistance
10000 (AKT3)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
hsa01001
]
10000 (AKT3)
Enzymes [BR:
hsa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
10000 (AKT3)
Protein kinases [BR:
hsa01001
]
Serine/threonine kinases: AGC group
AKT/PKB family
10000 (AKT3)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
Pkinase
PK_Tyr_Ser-Thr
PH
Kinase-like
Pkinase_C
ABC1
PH_11
Motif
Other DBs
NCBI-GeneID:
10000
NCBI-ProteinID:
NP_005456
OMIM:
611223
HGNC:
393
Ensembl:
ENSG00000117020
Vega:
OTTHUMG00000039994
Pharos:
Q9Y243
(Tchem)
UniProt:
Q9Y243
LinkDB
All DBs
Structure
PDB:
2X18
Thumbnails
Position
1q43-q44
AA seq
479 aa
AA seq
DB search
MSDVTIVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDLPYPLNNFSVAKCQ
LMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCS
PTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILK
KEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRE
RVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDA
ATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILM
EDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVP
PFKPQVTSETDTRYFDEEFTAQTITITPPEKYDEDGMDCMDNERRPHFPQFSYSASGRE
NT seq
1440 nt
NT seq
+upstream
nt +downstream
nt
atgagcgatgttaccattgtgaaagaaggttgggttcagaagaggggagaatatataaaa
aactggaggccaagatacttccttttgaagacagatggctcattcataggatataaagag
aaacctcaagatgtggatttaccttatcccctcaacaacttttcagtggcaaaatgccag
ttaatgaaaacagaacgaccaaagccaaacacatttataatcagatgtctccagtggact
actgttatagagagaacatttcatgtagatactccagaggaaagggaagaatggacagaa
gctatccaggctgtagcagacagactgcagaggcaagaagaggagagaatgaattgtagt
ccaacttcacaaattgataatataggagaggaagagatggatgcctctacaacccatcat
aaaagaaagacaatgaatgattttgactatttgaaactactaggtaaaggcacttttggg
aaagttattttggttcgagagaaggcaagtggaaaatactatgctatgaagattctgaag
aaagaagtcattattgcaaaggatgaagtggcacacactctaactgaaagcagagtatta
aagaacactagacatccctttttaacatccttgaaatattccttccagacaaaagaccgt
ttgtgttttgtgatggaatatgttaatgggggcgagctgtttttccatttgtcgagagag
cgggtgttctctgaggaccgcacacgtttctatggtgcagaaattgtctctgccttggac
tatctacattccggaaagattgtgtaccgtgatctcaagttggagaatctaatgctggac
aaagatggccacataaaaattacagattttggactttgcaaagaagggatcacagatgca
gccaccatgaagacattctgtggcactccagaatatctggcaccagaggtgttagaagat
aatgactatggccgagcagtagactggtggggcctaggggttgtcatgtatgaaatgatg
tgtgggaggttacctttctacaaccaggaccatgagaaactttttgaattaatattaatg
gaagacattaaatttcctcgaacactctcttcagatgcaaaatcattgctttcagggctc
ttgataaaggatccaaataaacgccttggtggaggaccagatgatgcaaaagaaattatg
agacacagtttcttctctggagtaaactggcaagatgtatatgataaaaagcttgtacct
ccttttaaacctcaagtaacatctgagacagatactagatattttgatgaagaatttaca
gctcagactattacaataacaccacctgaaaaatatgatgaggatggtatggactgcatg
gacaatgagaggcggccgcatttccctcaattttcctactctgcaagtggacgagaataa
DBGET
integrated database retrieval system