Homo sapiens (human): 2100
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Entry
2100 CDS
T01001
Symbol
ESR2, ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2, ODG8
Name
(RefSeq) estrogen receptor 2
KO
K08551
estrogen receptor beta
Organism
hsa
Homo sapiens (human)
Pathway
hsa01522
Endocrine resistance
hsa04915
Estrogen signaling pathway
hsa04917
Prolactin signaling pathway
hsa04929
GnRH secretion
hsa05200
Pathways in cancer
hsa05207
Chemical carcinogenesis - receptor activation
hsa05224
Breast cancer
Network
nt06210
ERK signaling
nt06214
PI3K signaling
nt06227
Nuclear receptor signaling
nt06270
Breast cancer
nt06323
KISS1-GnRH-LH/FSH-E2 signaling
Element
N00286
Nuclear-initiated estrogen signaling pathway
N01350
NNK/NNN to PI3K signaling pathway
N01351
E2-ER-RAS-ERK signaling pathway
N01352
BPA to RAS-ERK signaling pathway
N01353
E2 to RAS-ERK signaling pathway
N01364
E2 to nuclear-initiated estrogen signaling pathway
Disease
H00599
Ovarian dysgenesis
Drug target
Acolbifene hydrochloride:
D02758
Afimoxifene:
D06551
Alfatradiol:
D07121
Arzoxifene hydrochloride:
D02993
Bazedoxifene:
D03062
<JP>
Brilanestrant:
D11264
Chlorotrianisene:
D00269
Clometherone:
D03551
Clomifene (
DG00474
):
D00962
<JP/US>
D07726
Delmadinone (
DG02935
):
D07783
Dienestrol:
D00898
Diethylstilbestrol (
DG00466
):
D00577
D00946
D07826
Droloxifene (
DG01265
):
D03911
D03912
Enclomiphene (
DG01992
):
D08910
D10876
Epitiostanol:
D01265
Equilin:
D04041
Erteberel:
D09899
Estetrol (
DG03027
):
D11513
D11514
Estradiol (
DG00462
):
D00105
<JP/US>
D01413
<JP/US>
D01617
D01953
D04061
<US>
D04063
<US>
D04064
D04065
D07918
<US>
D07919
Estriol (
DG00463
):
D00185
<JP>
D01986
D01989
D07920
D07921
Estrogens, esterified:
D04071
<US>
Estrone (
DG00464
):
D00067
D00312
D00948
Fispemifene:
D10008
Fluoroestradiol (18F):
D11829
<US>
Fulvestrant:
D01161
<JP/US>
Hexestrol (
DG02847
):
D01641
D02018
Idoxifene:
D04496
Lasofoxifene:
D04672
Levormeloxifene fumarate:
D09834
Mepitiostane:
D01602
<JP>
Mestranol:
D00575
Miproxifene phosphate:
D01853
Nafoxidine hydrochloride:
D05106
Nitromifene citrate:
D05192
Ormeloxifen:
D08301
Prasterone (
DG00141
):
D01616
D08409
<US>
Prinaberel:
D06631
Promestriene:
D07221
Raloxifene (
DG00476
):
D02217
<JP/US>
D08465
D10606
<JP>
Tamoxifen (
DG00734
):
D00966
<JP/US>
D08559
Toremifene (
DG00735
):
D00967
<JP/US>
D08620
Trioxifene mesylate:
D06245
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09150 Organismal Systems
09152 Endocrine system
04929 GnRH secretion
2100 (ESR2)
04915 Estrogen signaling pathway
2100 (ESR2)
04917 Prolactin signaling pathway
2100 (ESR2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
2100 (ESR2)
05207 Chemical carcinogenesis - receptor activation
2100 (ESR2)
09162 Cancer: specific types
05224 Breast cancer
2100 (ESR2)
09176 Drug resistance: antineoplastic
01522 Endocrine resistance
2100 (ESR2)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03000 Transcription factors [BR:
hsa03000
]
2100 (ESR2)
09183 Protein families: signaling and cellular processes
03310 Nuclear receptors [BR:
hsa03310
]
2100 (ESR2)
Transcription factors [BR:
hsa03000
]
Eukaryotic type
Zinc finger
Cys4 estrogen receptor-like
2100 (ESR2)
Nuclear receptors [BR:
hsa03310
]
3. Estrogen like
3A. Estrogen receptor
2100 (ESR2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
ERbeta_N
Hormone_recep
zf-C4
Motif
Other DBs
NCBI-GeneID:
2100
NCBI-ProteinID:
NP_001428
OMIM:
601663
HGNC:
3468
Ensembl:
ENSG00000140009
Pharos:
Q92731
(Tclin)
UniProt:
Q92731
Q7LCB3
Structure
PDB
LinkDB
All DBs
Position
14:complement(64226707..64338613)
Genome browser
AA seq
530 aa
AA seq
DB search
MDIKNSPSSLNSPSSYNCSQSILPLEHGSIYIPSSYVDSHHEYPAMTFYSPAVMNYSIPS
NVTNLEGGPGRQTTSPNVLWPTPGHLSPLVVHRQLSHLYAEPQKSPWCEARSLEHTLPVN
RETLKRKVSGNRCASPVTGPGSKRDAHFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGH
NDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRLVRRQRSADEQLH
CAGKAKRSGGHAPRVRELLLDALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTK
LADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDL
VLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLVTATQDA
DSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMK
CKNVVPVYDLLLEMLNAHVLRGCKSSITGSECSPAEDSKSKEGSQNPQSQ
NT seq
1593 nt
NT seq
+upstream
nt +downstream
nt
atggatataaaaaactcaccatctagccttaattctccttcctcctacaactgcagtcaa
tccatcttacccctggagcacggctccatatacataccttcctcctatgtagacagccac
catgaatatccagccatgacattctatagccctgctgtgatgaattacagcattcccagc
aatgtcactaacttggaaggtgggcctggtcggcagaccacaagcccaaatgtgttgtgg
ccaacacctgggcacctttctcctttagtggtccatcgccagttatcacatctgtatgcg
gaacctcaaaagagtccctggtgtgaagcaagatcgctagaacacaccttacctgtaaac
agagagacactgaaaaggaaggttagtgggaaccgttgcgccagccctgttactggtcca
ggttcaaagagggatgctcacttctgcgctgtctgcagcgattacgcatcgggatatcac
tatggagtctggtcgtgtgaaggatgtaaggccttttttaaaagaagcattcaaggacat
aatgattatatttgtccagctacaaatcagtgtacaatcgataaaaaccggcgcaagagc
tgccaggcctgccgacttcggaagtgttacgaagtgggaatggtgaagtgtggctcccgg
agagagagatgtgggtaccgccttgtgcggagacagagaagtgccgacgagcagctgcac
tgtgccggcaaggccaagagaagtggcggccacgcgccccgagtgcgggagctgctgctg
gacgccctgagccccgagcagctagtgctcaccctcctggaggctgagccgccccatgtg
ctgatcagccgccccagtgcgcccttcaccgaggcctccatgatgatgtccctgaccaag
ttggccgacaaggagttggtacacatgatcagctgggccaagaagattcccggctttgtg
gagctcagcctgttcgaccaagtgcggctcttggagagctgttggatggaggtgttaatg
atggggctgatgtggcgctcaattgaccaccccggcaagctcatctttgctccagatctt
gttctggacagggatgaggggaaatgcgtagaaggaattctggaaatctttgacatgctc
ctggcaactacttcaaggtttcgagagttaaaactccaacacaaagaatatctctgtgtc
aaggccatgatcctgctcaattccagtatgtaccctctggtcacagcgacccaggatgct
gacagcagccggaagctggctcacttgctgaacgccgtgaccgatgctttggtttgggtg
attgccaagagcggcatctcctcccagcagcaatccatgcgcctggctaacctcctgatg
ctcctgtcccacgtcaggcatgcgagtaacaagggcatggaacatctgctcaacatgaag
tgcaaaaatgtggtcccagtgtatgacctgctgctggagatgctgaatgcccacgtgctt
cgcgggtgcaagtcctccatcacggggtccgagtgcagcccggcagaggacagtaaaagc
aaagagggctcccagaacccacagtctcagtga
DBGET
integrated database retrieval system
