| Entry |
|
|---|
| Symbol |
ALAS2, ALAS-E, ALASE, ANH1, ASB, SIDBA1, XLDPP, XLEPP, XLSA
|
|---|
| Name |
(RefSeq) 5'-aminolevulinate synthase 2
|
|---|
| KO |
|
|---|
| Organism |
|
|---|
| Pathway |
| hsa00260 | Glycine, serine and threonine metabolism |
|
|---|
| Module |
| hsa_M00868 | Heme biosynthesis, animals and fungi, glycine => heme |
|
|---|
| Network |
|
|---|
| Element |
|
|---|
| Disease |
| H00201 | Erythropoietic porphyria |
|
|---|
| Drug target |
|
|---|
| Brite |
KEGG Orthology (KO) [BR:hsa00001]
09100 Metabolism
09105 Amino acid metabolism
00260 Glycine, serine and threonine metabolism
212 (ALAS2)
09108 Metabolism of cofactors and vitamins
00860 Porphyrin metabolism
212 (ALAS2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01007 Amino acid related enzymes [BR:hsa01007]
212 (ALAS2)
Enzymes [BR:hsa01000]
2. Transferases
2.3 Acyltransferases
2.3.1 Transferring groups other than aminoacyl groups
2.3.1.37 5-aminolevulinate synthase
212 (ALAS2)
Amino acid related enzymes [BR:hsa01007]
Aminotransferase (transaminase)
Class II
212 (ALAS2)
|
|---|
| SSDB |
|
|---|
| Motif |
|
|---|
| Other DBs |
|
|---|
| Structure |
|
|---|
| LinkDB |
|
|---|
| Position |
X:complement(55009055..55030977)
|
|---|
| AA seq |
587 aa
MVTAAMLLQCCPVLARGPTSLLGKVVKTHQFLFGIGRCPILATQGPNCSQIHLKATKAGG
DSPSWAKGHCPFMLSELQDGKSKIVQKAAPEVQEDVKAFKTDLPSSLVSVSLRKPFSGPQ
EQEQISGKVTHLIQNNMPGNYVFSYDQFFRDKIMEKKQDHTYRVFKTVNRWADAYPFAQH
FSEASVASKDVSVWCSNDYLGMSRHPQVLQATQETLQRHGAGAGGTRNISGTSKFHVELE
QELAELHQKDSALLFSSCFVANDSTLFTLAKILPGCEIYSDAGNHASMIQGIRNSGAAKF
VFRHNDPDHLKKLLEKSNPKIPKIVAFETVHSMDGAICPLEELCDVSHQYGALTFVDEVH
AVGLYGSRGAGIGERDGIMHKIDIISGTLGKAFGCVGGYIASTRDLVDMVRSYAAGFIFT
TSLPPMVLSGALESVRLLKGEEGQALRRAHQRNVKHMRQLLMDRGLPVIPCPSHIIPIRV
GNAALNSKLCDLLLSKHGIYVQAINYPTVPRGEELLRLAPSPHHSPQMMEDFVEKLLLAW
TAVGLPLQDVSVAACNFCRRPVHFELMSEWERSYFGNMGPQYVTTYA |
|---|
| NT seq |
1764 nt +upstreamnt +downstreamnt
atggtgactgcagccatgctgctacagtgctgcccagtgcttgcccggggccccacaagc
ctcctaggcaaggtggttaagactcaccagttcctgtttggtattggacgctgtcccatc
ctggctacccaaggaccaaactgttctcaaatccaccttaaggcaacaaaggctggagga
gattctccatcttgggcgaagggccactgtcccttcatgctgtcggaactccaggatggg
aagagcaagattgtgcagaaggcagccccagaagtccaggaagatgtgaaggctttcaag
acagatctgcctagctccctggtctcagtcagcctaaggaagccattttccggtccccag
gagcaggagcagatctctgggaaggtcacacacctgattcagaacaatatgcctggaaac
tatgtcttcagttatgaccagtttttcagggacaagatcatggagaagaaacaggatcac
acctaccgtgtgttcaagactgtgaaccgctgggctgatgcatatccctttgcccaacat
ttctctgaggcatctgtggcctcaaaggatgtgtccgtctggtgtagtaatgattacctg
ggcatgagccgacaccctcaggtcttgcaagccacacaggagaccctgcagcgtcatggt
gctggagctggtggcacccgcaacatctcaggcaccagtaagtttcatgtggagcttgag
caggagctggctgagctgcaccagaaggactcagccctgctcttctcctcctgctttgtt
gccaatgactctactctcttcaccttggccaagatcctgccagggtgcgagatttactca
gacgcaggcaaccatgcttccatgatccaaggtatccgtaacagtggagcagccaagttt
gtcttcaggcacaatgaccctgaccacctaaagaaacttctagagaagtctaaccctaag
atacccaaaattgtggcctttgagactgtccactccatggatggtgccatctgtcccctc
gaggagttgtgtgatgtgtcccaccagtatggggccctgaccttcgtggatgaggtccat
gctgtaggactgtatgggtcccggggcgctgggattggggagcgtgatggaattatgcat
aagattgacatcatctctggaactcttggcaaggcctttggctgtgtgggcggctacatt
gccagcacccgtgacttggtggacatggtgcgctcctatgctgcaggcttcatctttacc
acttctctgccccccatggtgctctctggagctctagaatctgtgcggctgctcaaggga
gaggagggccaagccctgaggcgagcccaccagcgcaatgtcaagcacatgcgccagcta
ctcatggacaggggccttcctgtcatcccctgccccagccacatcatccccatccgggtg
ggcaatgcagcactcaacagcaagctctgtgatctcctgctctccaagcatggcatctat
gtgcaggccatcaactacccaactgtcccccggggtgaagagctcctgcgcttggcaccc
tccccccaccacagccctcagatgatggaagattttgtggagaagctgctgctggcttgg
actgcggtggggctgcccctccaggatgtgtctgtggctgcctgcaatttctgtcgccgt
cctgtacactttgagctcatgagtgagtgggaacgttcctacttcgggaacatggggccc
cagtatgtcaccacctatgcctga |
|---|
