KEGG   Homo sapiens (human): 2159
Entry
2159              CDS       T01001                                 

Gene name
F10, FX, FXA
Definition
(RefSeq) coagulation factor X
  KO
K01314  coagulation factor X [EC:3.4.21.6]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04610  Complement and coagulation cascades
Disease
H02257  Factor X deficiency
Drug target
Andexanet alfa: D11029<US>
Antithrombin alfa: D08858
Apixaban: D03213<JP/US>
Betrixaban: D08873
Darexaban maleate: D09817
Edoxaban (DG01398): D09546<JP/US> D09710 D11568
Emicizumab: D10821<JP/US>
Eribaxaban: D08913
Fidexaban: D04183
Fondaparinux: D01844<JP/US>
Idraparinux sodium: D10471
Letaxaban: D09923
Razaxaban hydrochloride: D04029
Rivaroxaban: D07086<JP/US>
Tifacogin: D06142
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09151 Immune system
   04610 Complement and coagulation cascades
    2159 (F10)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    2159 (F10)
  09183 Protein families: signaling and cellular processes
   00536 Glycosaminoglycan binding proteins [BR:hsa00536]
    2159 (F10)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.21  Serine endopeptidases
    3.4.21.6  coagulation factor Xa
     2159 (F10)
Peptidases and inhibitors [BR:hsa01002]
 Serine peptidases
  Family S1: chymotrypsin family
   2159 (F10)
Glycosaminoglycan binding proteins [BR:hsa00536]
 Heparan sulfate / Heparin
  Coagulation and fibrinolysis
   2159 (F10)
SSDB
Motif
Pfam: Trypsin Gla FXa_inhibition EGF hEGF Trypsin_2 cEGF EGF_3 DUF1986 EGF_2 Fusion_gly
Other DBs
NCBI-GeneID: 2159
NCBI-ProteinID: NP_000495
OMIM: 613872
HGNC: 3528
Ensembl: ENSG00000126218
Vega: OTTHUMG00000017374
Pharos: P00742(Tclin)
UniProt: P00742 Q5JVE7
LinkDB
Structure
PDB: 

Position
13q34
AA seq 488 aa
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
NT seq 1467 nt   +upstreamnt  +downstreamnt
atggggcgcccactgcacctcgtcctgctcagtgcctccctggctggcctcctgctgctc
ggggaaagtctgttcatccgcagggagcaggccaacaacatcctggcgagggtcacgagg
gccaattcctttcttgaagagatgaagaaaggacacctcgaaagagagtgcatggaagag
acctgctcatacgaagaggcccgcgaggtctttgaggacagcgacaagacgaatgaattc
tggaataaatacaaagatggcgaccagtgtgagaccagtccttgccagaaccagggcaaa
tgtaaagacggcctcggggaatacacctgcacctgtttagaaggattcgaaggcaaaaac
tgtgaattattcacacggaagctctgcagcctggacaacggggactgtgaccagttctgc
cacgaggaacagaactctgtggtgtgctcctgcgcccgcgggtacaccctggctgacaac
ggcaaggcctgcattcccacagggccctacccctgtgggaaacagaccctggaacgcagg
aagaggtcagtggcccaggccaccagcagcagcggggaggcccctgacagcatcacatgg
aagccatatgatgcagccgacctggaccccaccgagaaccccttcgacctgcttgacttc
aaccagacgcagcctgagaggggcgacaacaacctcaccaggatcgtgggaggccaggaa
tgcaaggacggggagtgtccctggcaggccctgctcatcaatgaggaaaacgagggtttc
tgtggtggaaccattctgagcgagttctacatcctaacggcagcccactgtctctaccaa
gccaagagattcaaggtgagggtaggggaccggaacacggagcaggaggagggcggtgag
gcggtgcacgaggtggaggtggtcatcaagcacaaccggttcacaaaggagacctatgac
ttcgacatcgccgtgctccggctcaagacccccatcaccttccgcatgaacgtggcgcct
gcctgcctccccgagcgtgactgggccgagtccacgctgatgacgcagaagacggggatt
gtgagcggcttcgggcgcacccacgagaagggccggcagtccaccaggctcaagatgctg
gaggtgccctacgtggaccgcaacagctgcaagctgtccagcagcttcatcatcacccag
aacatgttctgtgccggctacgacaccaagcaggaggatgcctgccagggggacagcggg
ggcccgcacgtcacccgcttcaaggacacctacttcgtgacaggcatcgtcagctgggga
gagggctgtgcccgtaaggggaagtacgggatctacaccaaggtcaccgccttcctcaag
tggatcgacaggtccatgaaaaccaggggcttgcccaaggccaagagccatgccccggag
gtcataacgtcctctccattaaagtga

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