Homo sapiens (human): 2159
Help
Entry
2159 CDS
T01001
Symbol
F10, FX, FXA
Name
(RefSeq) coagulation factor X
KO
K01314
coagulation factor X [EC:
3.4.21.6
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04610
Complement and coagulation cascades
Disease
H02257
Factor X deficiency
Drug target
Andexanet alfa:
D11029
<US>
Antithrombin alfa:
D08858
<US>
Apixaban:
D03213
<JP/US>
Betrixaban:
D08873
Darexaban maleate:
D09817
Edoxaban (
DG01398
):
D09546
<JP/US>
D09710
D11568
Emicizumab:
D10821
<JP/US>
Eribaxaban:
D08913
Fidexaban:
D04183
Fondaparinux:
D01844
<JP/US>
Idraparinux sodium:
D10471
Letaxaban:
D09923
Razaxaban hydrochloride:
D04029
Rivaroxaban:
D07086
<JP/US>
Tifacogin:
D06142
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09150 Organismal Systems
09151 Immune system
04610 Complement and coagulation cascades
2159 (F10)
09180 Brite Hierarchies
09181 Protein families: metabolism
01002 Peptidases and inhibitors [BR:
hsa01002
]
2159 (F10)
09183 Protein families: signaling and cellular processes
00536 Glycosaminoglycan binding proteins [BR:
hsa00536
]
2159 (F10)
Enzymes [BR:
hsa01000
]
3. Hydrolases
3.4 Acting on peptide bonds (peptidases)
3.4.21 Serine endopeptidases
3.4.21.6 coagulation factor Xa
2159 (F10)
Peptidases and inhibitors [BR:
hsa01002
]
Serine peptidases
Family S1: chymotrypsin family
2159 (F10)
Glycosaminoglycan binding proteins [BR:
hsa00536
]
Heparan sulfate / Heparin
Coagulation and fibrinolysis
2159 (F10)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Trypsin
Gla
FXa_inhibition
EGF
hEGF
Trypsin_2
cEGF
EGF_3
DUF1986
EGF_2
Fusion_gly
Motif
Other DBs
NCBI-GeneID:
2159
NCBI-ProteinID:
NP_000495
OMIM:
613872
HGNC:
3528
Ensembl:
ENSG00000126218
Vega:
OTTHUMG00000017374
Pharos:
P00742
(Tclin)
UniProt:
P00742
Q5JVE7
Structure
PDB
LinkDB
All DBs
Position
13:113122799..113149529
Genome browser
AA seq
488 aa
AA seq
DB search
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
NT seq
1467 nt
NT seq
+upstream
nt +downstream
nt
atggggcgcccactgcacctcgtcctgctcagtgcctccctggctggcctcctgctgctc
ggggaaagtctgttcatccgcagggagcaggccaacaacatcctggcgagggtcacgagg
gccaattcctttcttgaagagatgaagaaaggacacctcgaaagagagtgcatggaagag
acctgctcatacgaagaggcccgcgaggtctttgaggacagcgacaagacgaatgaattc
tggaataaatacaaagatggcgaccagtgtgagaccagtccttgccagaaccagggcaaa
tgtaaagacggcctcggggaatacacctgcacctgtttagaaggattcgaaggcaaaaac
tgtgaattattcacacggaagctctgcagcctggacaacggggactgtgaccagttctgc
cacgaggaacagaactctgtggtgtgctcctgcgcccgcgggtacaccctggctgacaac
ggcaaggcctgcattcccacagggccctacccctgtgggaaacagaccctggaacgcagg
aagaggtcagtggcccaggccaccagcagcagcggggaggcccctgacagcatcacatgg
aagccatatgatgcagccgacctggaccccaccgagaaccccttcgacctgcttgacttc
aaccagacgcagcctgagaggggcgacaacaacctcaccaggatcgtgggaggccaggaa
tgcaaggacggggagtgtccctggcaggccctgctcatcaatgaggaaaacgagggtttc
tgtggtggaaccattctgagcgagttctacatcctaacggcagcccactgtctctaccaa
gccaagagattcaaggtgagggtaggggaccggaacacggagcaggaggagggcggtgag
gcggtgcacgaggtggaggtggtcatcaagcacaaccggttcacaaaggagacctatgac
ttcgacatcgccgtgctccggctcaagacccccatcaccttccgcatgaacgtggcgcct
gcctgcctccccgagcgtgactgggccgagtccacgctgatgacgcagaagacggggatt
gtgagcggcttcgggcgcacccacgagaagggccggcagtccaccaggctcaagatgctg
gaggtgccctacgtggaccgcaacagctgcaagctgtccagcagcttcatcatcacccag
aacatgttctgtgccggctacgacaccaagcaggaggatgcctgccagggggacagcggg
ggcccgcacgtcacccgcttcaaggacacctacttcgtgacaggcatcgtcagctgggga
gagggctgtgcccgtaaggggaagtacgggatctacaccaaggtcaccgccttcctcaag
tggatcgacaggtccatgaaaaccaggggcttgcccaaggccaagagccatgccccggag
gtcataacgtcctctccattaaagtga
DBGET
integrated database retrieval system
