Homo sapiens (human): 2224
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Entry
2224 CDS
T01001
Symbol
FDPS, FPPS, FPS, POROK9
Name
(RefSeq) farnesyl diphosphate synthase
KO
K00787
farnesyl diphosphate synthase [EC:
2.5.1.1
2.5.1.10
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00900
Terpenoid backbone biosynthesis
hsa01100
Metabolic pathways
hsa05164
Influenza A
hsa05166
Human T-cell leukemia virus 1 infection
Module
hsa_M00367
C10-C20 isoprenoid biosynthesis, non-plant eukaryotes
Network
nt06034
Cholesterol biosynthesis
Element
N01635
Mevalonate pathway
Disease
H01933
Porokeratosis
Drug target
Alendronic acid (
DG00783
):
D00939
<JP/US>
D07119
Ibandronic acid (
DG00785
):
D04486
<JP/US>
D08056
Incadronic acid (
DG01266
):
D07123
D08073
Minodronic acid hydrate:
D09198
<JP>
Pamidronic acid (
DG00782
):
D00941
<JP/US>
D07281
Risedronic acid (
DG00786
):
D00942
<US>
D03234
<JP/US>
D08484
D11570
<US>
Zoledronic acid (
DG00787
):
D01968
<JP/US>
D06378
D06379
D08689
D10515
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09109 Metabolism of terpenoids and polyketides
00900 Terpenoid backbone biosynthesis
2224 (FDPS)
09160 Human Diseases
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
2224 (FDPS)
05164 Influenza A
2224 (FDPS)
09180 Brite Hierarchies
09181 Protein families: metabolism
01006 Prenyltransferases [BR:
hsa01006
]
2224 (FDPS)
Enzymes [BR:
hsa01000
]
2. Transferases
2.5 Transferring alkyl or aryl groups, other than methyl groups
2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
2.5.1.1 dimethylallyltranstransferase
2224 (FDPS)
2.5.1.10 (2E,6E)-farnesyl diphosphate synthase
2224 (FDPS)
Prenyltransferases [BR:
hsa01006
]
Terpene biosynthesis
Prenyl diphosphate synthase
2224 (FDPS)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
polyprenyl_synt
Motif
Other DBs
NCBI-GeneID:
2224
NCBI-ProteinID:
NP_001129293
OMIM:
134629
HGNC:
3631
Ensembl:
ENSG00000160752
UniProt:
P14324
Structure
PDB
LinkDB
All DBs
Position
1:155308866..155320665
Genome browser
AA seq
419 aa
AA seq
DB search
MPLSRWLRSVGVFLLPAPYWAPRERWLGSLRRPSLVHGYPVLAWHSARCWCQAWTEEPRA
LCSSLRMNGDQNSDVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAI
GGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRG
QICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLD
LLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLE
MGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKE
AEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK
NT seq
1260 nt
NT seq
+upstream
nt +downstream
nt
atgcccctgtcccgctggttgagatctgtgggggtcttcctgctgccagccccctactgg
gcaccccgggagaggtggctgggttccctacggcggccctccctggtgcacgggtaccca
gtcctggcctggcacagtgcccgctgctggtgccaagcgtggacagaggaacctcgagcc
ctttgctcctccctcagaatgaacggagaccagaattcagatgtttatgcccaagaaaag
caggatttcgttcagcacttctcccagatcgttagggtgctgactgaggatgagatgggg
cacccagagataggagatgctattgcccggctcaaggaggtcctggagtacaatgccatt
ggaggcaagtataaccggggtttgacggtggtagtagcattccgggagctggtggagcca
aggaaacaggatgctgatagtctccagcgggcctggactgtgggctggtgtgtggaactg
ctgcaagctttcttcctggtggcagatgacatcatggattcatcccttacccgccgggga
cagatctgctggtatcagaagccgggcgtgggtttggatgccatcaatgatgctaacctc
ctggaagcatgtatctaccgcctgctgaagctctattgccgggagcagccctattacctg
aacctgatcgagctcttcctgcagagttcctatcagactgagattgggcagaccctggac
ctcctcacagccccccagggcaatgtggatcttgtcagattcactgaaaagaggtacaaa
tctattgtcaagtacaagacagctttctactccttctaccttcctatagctgcagccatg
tacatggcaggaattgatggcgagaaggagcacgccaatgccaagaagatcctgctggag
atgggggagttctttcagattcaggatgattaccttgacctctttggggaccccagtgtg
accggcaaaattggcactgacatccaggacaacaaatgcagctggctggtggttcagtgt
ctgcaacgggccactccagaacagtaccagatcctgaaggaaaattacgggcagaaggag
gctgagaaagtggcccgggtgaaggcgctatatgaggagctggatctgccagcagtgttc
ttgcaatatgaggaagacagttacagccacattatggctctcattgaacagtacgcagca
cccctgcccccagccgtctttctggggcttgcgcgcaaaatctacaagcggagaaagtga
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