KEGG   Homo sapiens (human): 2645Help
Entry
2645              CDS       T01001                                 

Gene name
GCK, FGQTL3, GK, GLK, HHF3, HK4, HKIV, HXKP, LGLK, MODY2
Definition
(RefSeq) glucokinase
  KO
K12407  glucokinase [EC:2.7.1.2]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00010  Glycolysis / Gluconeogenesis
hsa00052  Galactose metabolism
hsa00500  Starch and sucrose metabolism
hsa00520  Amino sugar and nucleotide sugar metabolism
hsa00524  Neomycin, kanamycin and gentamicin biosynthesis
hsa01100  Metabolic pathways
hsa01200  Carbon metabolism
hsa04910  Insulin signaling pathway
hsa04911  Insulin secretion
hsa04917  Prolactin signaling pathway
hsa04922  Glucagon signaling pathway
hsa04930  Type II diabetes mellitus
hsa04950  Maturity onset diabetes of the young
hsa05230  Central carbon metabolism in cancer
Module
hsa_M00001  Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate
hsa_M00549  Nucleotide sugar biosynthesis, glucose => UDP-glucose
Disease
H00410  Maturity onset diabetes of the young (MODY)
H00512  Permanent neonatal diabetes mellitus (PNDM)
H01267  Familial hyperinsulinemic hypoglycemia (HHF)
Drug target
Piragliatin: D08970
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Metabolism
  Carbohydrate metabolism
   00010 Glycolysis / Gluconeogenesis
    2645 (GCK)
   00052 Galactose metabolism
    2645 (GCK)
   00500 Starch and sucrose metabolism
    2645 (GCK)
   00520 Amino sugar and nucleotide sugar metabolism
    2645 (GCK)
  Biosynthesis of other secondary metabolites
   00524 Neomycin, kanamycin and gentamicin biosynthesis
    2645 (GCK)
 Organismal Systems
  Endocrine system
   04911 Insulin secretion
    2645 (GCK)
   04910 Insulin signaling pathway
    2645 (GCK)
   04922 Glucagon signaling pathway
    2645 (GCK)
   04917 Prolactin signaling pathway
    2645 (GCK)
 Human Diseases
  Cancers
   05230 Central carbon metabolism in cancer
    2645 (GCK)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    2645 (GCK)
   04950 Maturity onset diabetes of the young
    2645 (GCK)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.2  glucokinase
     2645 (GCK)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Hexokinase_2 Hexokinase_1 VIT1 DUF4795
Motif
Other DBs
NCBI-GeneID: 2645
NCBI-ProteinID: NP_000153
OMIM: 138079
HGNC: 4195
Ensembl: ENSG00000106633
Vega: OTTHUMG00000022903
Pharos: P35557(Tchem)
UniProt: P35557 Q53Y25
LinkDB All DBs
Structure
PDB: 

Position
7p13
AA seq 465 aa AA seqDB search
MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPT
YVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAE
MLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNN
VVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQN
VELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGE
LVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPS
TTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFK
ERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
NT seq 1398 nt NT seq  +upstreamnt  +downstreamnt
atgctggacgacagagccaggatggaggccgccaagaaggagaaggtagagcagatcctg
gcagagttccagctgcaggaggaggacctgaagaaggtgatgagacggatgcagaaggag
atggaccgcggcctgaggctggagacccatgaagaggccagtgtgaagatgctgcccacc
tacgtgcgctccaccccagaaggctcagaagtcggggacttcctctccctggacctgggt
ggcactaacttcagggtgatgctggtgaaggtgggagaaggtgaggaggggcagtggagc
gtgaagaccaaacaccagatgtactccatccccgaggacgccatgaccggcactgctgag
atgctcttcgactacatctctgagtgcatctccgacttcctggacaagcatcagatgaaa
cacaagaagctgcccctgggcttcaccttctcctttcctgtgaggcacgaagacatcgat
aagggcatccttctcaactggaccaagggcttcaaggcctcaggagcagaagggaacaat
gtcgtggggcttctgcgagacgctatcaaacggagaggggactttgaaatggatgtggtg
gcaatggtgaatgacacggtggccacgatgatctcctgctactacgaagaccatcagtgc
gaggtcggcatgatcgtgggcacgggctgcaatgcctgctacatggaggagatgcagaat
gtggagctggtggagggggacgagggccgcatgtgcgtcaataccgagtggggcgccttc
ggggactccggcgagctggacgagttcctgctggagtatgaccgcctggtggacgagagc
tctgcaaaccccggtcagcagctgtatgagaagctcataggtggcaagtacatgggcgag
ctggtgcggcttgtgctgctcaggctcgtggacgaaaacctgctcttccacggggaggcc
tccgagcagctgcgcacacgcggagccttcgagacgcgcttcgtgtcgcaggtggagagc
gacacgggcgaccgcaagcagatctacaacatcctgagcacgctggggctgcgaccctcg
accaccgactgcgacatcgtgcgccgcgcctgcgagagcgtgtctacgcgcgctgcgcac
atgtgctcggcggggctggcgggcgtcatcaaccgcatgcgcgagagccgcagcgaggac
gtaatgcgcatcactgtgggcgtggatggctccgtgtacaagctgcaccccagcttcaag
gagcggttccatgccagcgtgcgcaggctgacgcccagctgcgagatcaccttcatcgag
tcggaggagggcagtggccggggcgcggccctggtctcggcggtggcctgtaagaaggcc
tgtatgctgggccagtga

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