KEGG   Homo sapiens (human): 2741
Entry
2741              CDS       T01001                                 

Gene name
GLRA1, HKPX1, STHE
Definition
(RefSeq) glycine receptor alpha 1
  KO
K05193  glycine receptor alpha-1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
Disease
H00769  Hyperekplexia
Drug target
Strychnine nitrate: D10470
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2741 (GLRA1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    2741 (GLRA1)
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2741 (GLRA1)
Membrane trafficking [BR:hsa04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Acrosomal exocytosis proteins
    2741 (GLRA1)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  Glycine
   2741 (GLRA1)
SSDB
Motif
Pfam: Neur_chan_LBD Neur_chan_memb
Other DBs
NCBI-GeneID: 2741
NCBI-ProteinID: NP_001139512
OMIM: 138491
HGNC: 4326
Ensembl: ENSG00000145888
Vega: OTTHUMG00000130121
Pharos: P23415(Tclin)
UniProt: P23415
LinkDB
Structure
PDB: 
1VRY 1MOT

Position
5q33.1
AA seq 457 aa
MYSFNTLRLYLWETIVFFSLAASKEAEAARSAPKPMSPSDFLDKLMGRTSGYDARIRPNF
KGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYNEYPDDSLDLDPSMLDS
IWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRITLTLACPMDLKNFPMDVQTC
IMQLESFGYTMNDLIFEWQEQGAVQVADGLTLPQFILKEEKDLRYCTKHYNTGKFTCIEA
RFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPARVGLGITTVLTMTTQSSGSRA
SLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRRHHKSPMLNLF
QEDEAGEGRFNFSAYGMGPACLQAKDGISVKGANNSNTTNPPPAPSKSPEEMRKLFIQRA
KKIDKISRIGFPMAFLIFNMFYWIIYKIVRREDVHNQ
NT seq 1374 nt   +upstreamnt  +downstreamnt
atgtacagcttcaatactcttcgactctacctttgggagaccattgtattcttcagcctt
gctgcttctaaggaggctgaagctgctcgctccgcacccaagcctatgtcaccctcggat
ttcctggataagctaatggggagaacctccggatatgatgccaggatcaggcccaatttt
aaaggtcccccagtgaacgtgagctgcaacattttcatcaacagctttggttccattgct
gagacaaccatggactatagggtcaacatcttcctgcggcagcaatggaacgacccccgc
ctggcctataatgaataccctgacgactctctggacctggacccatccatgctggactcc
atctggaaacctgacctgttctttgccaacgagaagggggcccacttccatgagatcacc
acagacaacaaattgctaaggatctcccggaatgggaatgtcctctacagcatcagaatc
accctgacactggcctgccccatggacttgaagaatttccccatggatgtccagacatgt
atcatgcaactggaaagctttggatatacgatgaatgacctcatctttgagtggcaggaa
cagggagccgtgcaggtagcagatggactaactctgccccagtttatcttgaaggaagag
aaggacttgagatactgcaccaagcactacaacacaggtaaattcacctgcattgaggcc
cggttccacctggagcggcagatgggttactacctgattcagatgtatattcccagcctg
ctcattgtcatcctctcatggatctccttctggatcaacatggatgctgcacctgctcgt
gtgggcctaggcatcaccactgtgctcaccatgaccacccagagctccggctctcgagca
tctctgcccaaggtgtcctatgtgaaagccattgacatttggatggcagtttgcctgctc
tttgtgttctcagccctattagaatatgctgccgttaactttgtgtctcggcaacataag
gagctgctccgattcaggaggaagcggagacatcacaagagccccatgttgaatctattc
caggaggatgaagctggagaaggccgctttaacttctctgcctatgggatgggcccagcc
tgtctacaggccaaggatggcatctcagtcaagggcgccaacaacagtaacaccaccaac
ccccctcctgcaccatctaagtccccagaggagatgcgaaaactcttcatccagagggcc
aagaagatcgacaaaatatcccgcattggcttccccatggccttcctcattttcaacatg
ttctactggatcatctacaagattgtccgtagagaggacgtccacaaccagtga

KEGG   Homo sapiens (human): 2742
Entry
2742              CDS       T01001                                 

Gene name
GLRA2, GLR
Definition
(RefSeq) glycine receptor alpha 2
  KO
K05194  glycine receptor alpha-2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2742 (GLRA2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2742 (GLRA2)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  Glycine
   2742 (GLRA2)
SSDB
Motif
Pfam: Neur_chan_LBD Neur_chan_memb
Other DBs
NCBI-GeneID: 2742
NCBI-ProteinID: NP_001112357
OMIM: 305990
HGNC: 4327
Ensembl: ENSG00000101958
Vega: OTTHUMG00000021166
Pharos: P23416(Tchem)
UniProt: P23416
LinkDB
Position
Xp22.2
AA seq 452 aa
MNRQLVNILTALFAFFLETNHFRTAFCKDHDSRSGKQPSQTLSPSDFLDKLMGRTSGYDA
RIRPNFKGPPVNVTCNIFINSFGSVTETTMDYRVNIFLRQQWNDSRLAYSEYPDDSLDLD
PSMLDSIWKPDLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRLTLTLSCPMDLKNFP
MDVQTCTMQLESFGYTMNDLIFEWLSDGPVQVAEGLTLPQFILKEEKELGYCTKHYNTGK
FTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQ
SSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAVNFVSRQHKEFLRLRRRQKRQNK
EEDVTRESRFNFSGYGMGHCLQVKDGTAVKATPANPLPQPPKDGDAIKKKFVDRAKRIDT
ISRAAFPLAFLIFNIFYWITYKIIRHEDVHKK
NT seq 1359 nt   +upstreamnt  +downstreamnt
atgaaccggcagctagtgaacattttgacagccttgtttgcatttttcttagagacaaac
cacttcaggacggctttctgcaaagaccatgactccaggtctggaaaacaaccttcacag
accctatctccttcagatttcttggacaagttaatgggaaggacatcaggatatgatgca
agaatcaggccaaattttaaaggtcctccagtaaacgttacttgcaatatttttatcaac
agttttggatcagtcacagaaacgaccatggactaccgagtgaatatttttctgagacaa
cagtggaatgattcacggctggcgtacagtgagtacccagatgactccctggacttggac
ccatccatgctagactccatttggaaaccagatttgttctttgccaatgagaagggtgcc
aacttccacgatgtcaccactgacaacaaattgctacggatttcgaaaaatggcaaagtg
ctctacagtatcagactcaccttgaccttatcctgtcccatggacttgaagaactttccg
atggatgtccagacctgtacaatgcagctggagagttttgggtacacgatgaatgacctg
atatttgagtggttaagtgatggtccagtgcaagttgctgaaggattgaccctgccccag
tttattttgaaagaagagaaggaacttggctactgtacaaagcactacaacactggaaag
tttacctgcattgaggtcaagtttcatctggaacgccaaatgggatattatttgatccag
atgtacatcccaagcctgcttatagtaattttgtcctgggtttccttttggataaatatg
gatgcagcccctgccagggtcgcactgggcatcaccacagtcttaacgatgaccacccag
agttcaggctccagggcatctctgccaaaggtctcctatgtaaaagcgattgacatctgg
atggcggtgtgccttctgtttgtgtttgctgccttactggaatacgcagcggtgaacttc
gtctccaggcaacacaaggagttcctgcgcctccgaagaagacagaagaggcagaataag
gaagaagacgttactcgtgaaagtcgttttaattttagcggttatgggatgggtcactgc
ctccaagtgaaagatggaacagctgtcaaggccacacctgccaacccactcccacaaccg
ccaaaagatggagatgctatcaagaagaagtttgtggaccgggcaaaaaggattgacacg
atatctcgagctgccttcccattggccttcctcattttcaacatcttttactggatcaca
tacaagatcattcggcatgaagatgtccacaagaaatag

KEGG   Homo sapiens (human): 2743
Entry
2743              CDS       T01001                                 

Gene name
GLRB, HKPX2
Definition
(RefSeq) glycine receptor beta
  KO
K05196  glycine receptor beta
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
Disease
H00769  Hyperekplexia
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2743 (GLRB)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    2743 (GLRB)
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2743 (GLRB)
Membrane trafficking [BR:hsa04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Acrosomal exocytosis proteins
    2743 (GLRB)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  Glycine
   2743 (GLRB)
SSDB
Motif
Pfam: Neur_chan_LBD Neur_chan_memb DUF3267
Other DBs
NCBI-GeneID: 2743
NCBI-ProteinID: NP_000815
OMIM: 138492
HGNC: 4329
Ensembl: ENSG00000109738
Vega: OTTHUMG00000161954
Pharos: P48167(Tclin)
UniProt: P48167
LinkDB
Position
4q32.1
AA seq 497 aa
MKFLLTTAFLILISLWVEEAYSKEKSSKKGKGKKKQYLCPSQQSAEDLARVPANSTSNIL
NRLLVSYDPRIRPNFKGIPVDVVVNIFINSFGSIQETTMDYRVNIFLRQKWNDPRLKLPS
DFRGSDALTVDPTMYKCLWKPDLFFANEKSANFHDVTQENILLFIFRDGDVLVSMRLSIT
LSCPLDLTLFPMDTQRCKMQLESFGYTTDDLRFIWQSGDPVQLEKIALPQFDIKKEDIEY
GNCTKYYKGTGYYTCVEVIFTLRRQVGFYMMGVYAPTLLIVVLSWLSFWINPDASAARVP
LGIFSVLSLASECTTLAAELPKVSYVKALDVWLIACLLFGFASLVEYAVVQVMLNNPKRV
EAEKARIAKAEQADGKGGNVAKKNTVNGTGTPVHISTLQVGETRCKKVCTSKSDLRSNDF
SIVGSLPRDFELSNYDCYGKPIEVNNGLGKSQAKNNKKPPPAKPVIPTAAKRIDLYARAL
FPFCFLFFNVIYWSIYL
NT seq 1494 nt   +upstreamnt  +downstreamnt
atgaagtttttattgacaactgcctttttaattttaatttccttgtgggtggaagaagcc
tattctaaggaaaagtcttcaaagaaagggaaggggaaaaagaagcagtatctatgccca
tctcagcagtcagcagaggaccttgcccgagtacctgccaactccactagcaatatcttg
aacaggttattggtcagttatgatcccaggataagaccaaacttcaaaggcattcctgtt
gatgtagtagtcaacatttttattaacagttttggatccattcaagaaacaacaatggac
tatagagttaacatcttcctgagacaaaaatggaatgaccccaggctgaagctccccagt
gattttaggggttcagatgcactgacagtggatccaacaatgtacaagtgtttatggaaa
cctgatttattttttgcaaatgaaaaaagtgccaattttcatgatgtgacccaggaaaac
atcctcctctttatttttcgtgatggagatgtccttgtcagcatgaggttatctattact
ctttcatgccctttggacttgacattgtttcccatggatacacaacgttgcaagatgcaa
ctggagagctttggttacacaactgatgatttacgatttatctggcagtcaggagatcct
gtgcaattagaaaaaattgccttgcctcaatttgatatcaaaaaggaagatattgaatat
ggtaactgtacaaaatactataaaggcacgggctactacacatgcgtggaagtcatcttc
accctgaggaggcaggtcggcttttacatgatgggggtctacgccccaactctgctcatt
gttgttctctcctggctttccttctggatcaacccggacgcgagtgctgccagagtgccc
ctgggtatcttctcagtcctcagcttggcctctgagtgcacaacccttgccgctgagctt
cccaaagtttcctatgtgaaggctcttgatgtttggcttattgcttgccttctctttggg
tttgcttccctggtggagtatgcagttgtccaggtgatgctgaacaaccccaaaagggtt
gaagctgaaaaagccagaattgctaaggctgagcaagcagatggaaaaggtggaaatgtg
gctaaaaagaatactgtgaatggaacagggactcctgttcatattagcactttgcaggtt
ggtgagaccagatgcaaaaaagtttgtacttctaagtctgatctgagatctaatgacttc
agcattgttggaagcttaccaagagattttgaactatccaattatgactgctatggaaaa
cccattgaagttaacaacggacttgggaaatctcaggctaagaacaacaagaagcctccc
cctgcgaaacctgttattccaacagcagcaaagcgaattgatctttatgcaagagcattg
tttcctttctgcttcttgttcttcaatgttatatattggtctatatatttatga

KEGG   Homo sapiens (human): 8001
Entry
8001              CDS       T01001                                 

Gene name
GLRA3
Definition
(RefSeq) glycine receptor alpha 3
  KO
K05195  glycine receptor alpha-3
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    8001 (GLRA3)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    8001 (GLRA3)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  Glycine
   8001 (GLRA3)
SSDB
Motif
Pfam: Neur_chan_LBD Neur_chan_memb
Other DBs
NCBI-GeneID: 8001
NCBI-ProteinID: NP_006520
OMIM: 600421
HGNC: 4328
Ensembl: ENSG00000145451
Vega: OTTHUMG00000149816
Pharos: O75311(Tchem)
UniProt: O75311 Q9UPF3
LinkDB
Structure
PDB: 
5TIN 5VDH 5CFB 5VDI 5TIO

Position
4q34.1
AA seq 464 aa
MAHVRHFRTLVSGFYFWEAALLLSLVATKETDSARSRSAPMSPSDFLDKLMGRTSGYDAR
IRPNFKGPPVNVTCNIFINSFGSIAETTMDYRVNIFLRQKWNDPRLAYSEYPDDSLDLDP
SMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLTLSCPMDLKNFPM
DVQTCIMQLESFGYTMNDLIFEWQDEAPVQVAEGLTLPQFLLKEEKDLRYCTKHYNTGKF
TCIEVRFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQS
SGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRKNKTEA
FALEKFYRFSDMDDEVRESRFSFTAYGMGPCLQAKDGMTPKGPNHPVQVMPKSPDEMRKV
FIDRAKKIDTISRACFPLAFLIFNIFYWVIYKILRHEDIHQQQD
NT seq 1395 nt   +upstreamnt  +downstreamnt
atggcccacgtgagacactttcggacattagtttcgggattttacttctgggaagcagca
ctgttactcagtttggttgccacaaaggaaacagacagtgcaagatctcgaagtgctcca
atgtcaccttctgattttctggataaattaatgggcaggacatcaggatatgatgcaaga
atcagacccaattttaaaggccctccagttaatgtcacatgcaacatattcatcaacagc
tttggctctatcgcagagacgaccatggattacagagtgaatatctttcttcgtcagaaa
tggaatgatccccgcctcgcgtacagtgaatatcctgacgactctttagacctcgacccc
tccatgttggactccatttggaaacctgatttgttctttgccaatgaaaagggtgccaac
tttcatgaagtcactacagacaacaaattgctaagaattttcaaaaatggaaatgttctt
tattcaataagattaacattaacactttcctgtccaatggatctcaagaattttcccatg
gatgtacaaacatgtataatgcaactggaaagctttgggtacacaatgaatgatctcatt
tttgaatggcaagatgaggcacccgtacaagtggcagaaggactcactttgccccagttt
ctgttgaaagaagaaaaagatttacgatactgcactaaacattacaatacaggaaagttt
acgtgtatagaagtgcgattccatctggagcgacaaatgggatactatctgatccagatg
tacattcccagtctcctgattgttattctatcctgggtttcattctggatcaacatggat
gcagcaccggccagggtagctctggggataaccactgtgctaacgatgactacacagagt
tcaggatcacgagcttccttgccaaaagtttcatatgtcaaagctattgatatttggatg
gcagtatgcctcctttttgtgttttcagcacttctggagtatgcagctgtaaattttgta
tcaagacaacacaaagaacttctgagatttcgacgaaagagaaagaataagacagaagct
tttgcactggagaagttttaccgtttctcagatatggatgatgaggtaagggaaagccga
ttcagcttcacagcctatggaatgggaccatgtctacaagcaaaggatggcatgactcca
aagggccccaaccaccctgtccaggtaatgccaaaaagtcctgatgaaatgaggaaggtc
tttatcgaccgggccaagaagattgataccatctcccgagcctgcttcccattagctttt
ttgatttttaatattttctactgggttatctataaaattcttaggcatgaggatattcat
cagcagcaagattaa

DBGET integrated database retrieval system