KEGG   Homo sapiens (human): 283455Help
Entry
283455            CDS       T01001                                 

Gene name
KSR2
Definition
(RefSeq) kinase suppressor of ras 2
  KO
K18529  kinase suppressor of Ras 2 [EC:2.7.11.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04014  Ras signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    283455 (KSR2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    283455 (KSR2)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     283455 (KSR2)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   283455 (KSR2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Pkinase_Tyr SAM_KSR1 Pkinase C1_1 Kinase-like Kdo RIO1 FTA2 APH C1_2 zf-RING-like
Motif
Other DBs
NCBI-GeneID: 283455
NCBI-ProteinID: NP_775869
OMIM: 610737
HGNC: 18610
Ensembl: ENSG00000171435
Vega: OTTHUMG00000169020
Pharos: Q6VAB6(Tbio)
UniProt: Q6VAB6 E9PB13
LinkDB All DBs
Structure
PDB: 

Position
12q24.22-q24.23
AA seq 950 aa AA seqDB search
MDEENMTKSEEQQPLSLQKALQQCELVQNMIDLSISNLEGLRTKCATSNDLTQKEIRTLE
SKLVKYFSRQLSCKKKVALQERNAELDGFPQLRHWFRIVDVRKEVLEEISPGQLSLEDLL
EMTDEQVCETVEKYGANREECARLNASLSCLRNVHMSGGNLSKQDWTIQWPTTETGKENN
PVCPPEPTPWIRTHLSQSPRVPSKCVQHYCHTSPTPGAPVYTHVDRLTVDAYPGLCPPPP
LESGHRSLPPSPRQRHAVRTPPRTPNIVTTVTPPGTPPMRKKNKLKPPGTPPPSSRKLIH
LIPGFTALHRSKSHEFQLGHRVDEAHTPKAKKKSKPLNLKIHSSVGSCENIPSQQRSPLL
SERSLRSFFVGHAPFLPSTPPVHTEANFSANTLSVPRWSPQIPRRDLGNSIKHRFSTKYW
MSQTCTVCGKGMLFGLKCKNCKLKCHNKCTKEAPPCHLLIIHRGDPARLVRTESVPCDIN
NPLRKPPRYSDLHISQTLPKTNKINKDHIPVPYQPDSSSNPSSTTSSTPSSPAPPLPPSA
TPPSPLHPSPQCTRQQKNFNLPASHYYKYKQQFIFPDVVPVPETPTRAPQVILHPVTSNP
ILEGNPLLQIEVEPTSENEEVHDEAEESEDDFEEMNLSLLSARSFPRKASQTSIFLQEWD
IPFEQLEIGELIGKGRFGQVYHGRWHGEVAIRLIDIERDNEDQLKAFKREVMAYRQTRHE
NVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLHAK
GILHKDLKSKNVFYDNGKVVITDFGLFSISGVLQAGRREDKLRIQNGWLCHLAPEIIRQL
SPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAIIWQMGTGMKPNLSQIGMG
KEISDILLFCWAFEQEERPTFTKLMDMLEKLPKRNRRLSHPGHFWKSAEL
NT seq 2853 nt NT seq  +upstreamnt  +downstreamnt
atggatgaggaaaacatgacgaaaagcgaggagcagcagcctctgagtttgcaaaaagcc
ttacagcagtgcgaactggtccaaaacatgatagacttgagcatctccaacctggaaggg
cttaggaccaaatgtgctacctccaacgacctcacacaaaaagaaatccggaccctggag
agcaagctggtgaagtacttcagccggcagctgtcctgcaaaaagaaggtagccttgcag
gagcgcaacgcggagctggacggcttcccccagctacggcactggttccgaatcgtcgat
gtgcgcaaggaggtcctggaggaaatctcccccggccagctgagcctggaggacctcttg
gagatgacggatgaacaggtgtgcgagactgtggagaaatacggagccaaccgggaggag
tgtgcccgcctcaacgcctccctctcctgcctcaggaatgtccacatgtcaggaggcaac
ctttccaaacaagactggaccatccagtggcccacgacagagacggggaaggagaacaat
cccgtgtgccccccggagcccaccccgtggatccgcacccatctctcccagagccccagg
gtcccgtccaagtgcgtccagcactattgtcacaccagccccactcccggggcccctgtg
tacacccacgtggacaggcttaccgtggacgcctacccgggcttgtgcccgcccccgcca
ctggagtcgggccaccgttccctgcccccatcgccccggcagcggcacgcggtccgcacc
ccgccgcgcacccccaacatcgtcaccaccgtgaccccgccgggcacgccgcccatgagg
aagaagaacaagctgaagcccccggggaccccaccgccctcctcccgaaaactgatacac
ttgatcccgggattcaccgcgctgcatcggagcaaatcccacgagttccagctggggcac
cgcgtggacgaggcccacacgcccaaagccaagaagaagagcaaacccttgaacctcaag
atccacagcagcgtaggcagctgcgagaacatcccctctcagcagcgctccccgctgctg
tccgagcgctccctccgctccttctttgtgggacacgcacctttcctgccttccacccct
cctgttcacactgaggccaacttctctgcaaacacactgtcagtgccacgctggtccccg
cagatccctcgcagagatctcggcaactccatcaagcacaggttttccaccaagtactgg
atgtctcagacgtgcacagtctgtgggaaagggatgctttttggcctcaagtgtaaaaac
tgcaagttaaagtgccacaacaaatgcaccaaagaagccccaccctgtcatcttctgatc
atccaccgaggagatccagcaaggttagtccggacagagtccgttccgtgtgacatcaac
aaccctctacggaagccacctcgctattcagacctgcacatcagtcagacgctccccaaa
accaacaaaatcaacaaggaccacatccctgtcccttaccagccagactccagcagcaac
ccctcctccacgacgtcctccacgccctcctcgccagcaccccccctccctcctagtgcc
acgccgccttctcccctacacccttccccacagtgcacacggcagcagaagaacttcaac
ctgccagcatcccactactacaaatacaagcagcagttcatcttcccagatgtggtgccg
gtgccggagacgccgacccgggcgccccaggtcatcctgcatccggtgacctcgaatcca
atcttggaaggaaatccattacttcaaattgaagtggagccaacgtcggagaatgaagag
gtccatgatgaggccgaagagtcagaggatgacttcgaggagatgaacctgtccctcctc
tcggcccggagcttcccacgcaaggccagccagaccagcatcttccttcaggagtgggac
atcccctttgagcagctggagatcggcgagctcattggaaagggccgctttgggcaagtg
taccacggccgctggcatggcgaggtggccatccggctgattgacattgagagggacaac
gaggaccagctcaaggccttcaagcgggaggtgatggcctacaggcagacacggcatgag
aacgtggtgcttttcatgggtgcctgcatgagcccgcctcacctggccatcatcaccagc
ctctgtaagggacggacgctctattccgttgtgagggatgccaaaatcgttttggatgtc
aacaaaaccaggcagattgctcaagaaattgtgaagggcatgggctacctccacgccaag
ggaatcctacacaaggacctcaagtcaaagaacgtcttctatgacaacggcaaagtggtc
atcacggactttggactcttcagcatttctggggtgctgcaggctggcaggcgggaggac
aaactgcgcatccagaatggctggctatgccacctggcaccagagatcatccgccagctg
tcccccgacacagaggaggataagctccccttctccaagcactctgacgtctttgccctt
ggcacaatctggtatgaactccacgccagggaatggcctttcaagacccaaccagcagag
gcaataatctggcaaatgggcacaggcatgaaacccaacctcagccagattggcatggga
aaagaaatctcggacattcttctcttctgctgggcctttgaacaagaagagagacctacc
ttcaccaagctcatggacatgctggagaaactgccaaagcgaaaccgtcgcctgtctcac
cctggacatttctggaagtctgcagagctgtga

KEGG   Homo sapiens (human): 8844Help
Entry
8844              CDS       T01001                                 

Gene name
KSR1, KSR, RSU2
Definition
(RefSeq) kinase suppressor of ras 1
  KO
K14958  kinase suppressor of Ras 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04014  Ras signaling pathway
hsa04625  C-type lectin receptor signaling pathway
hsa05152  Tuberculosis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    8844 (KSR1)
 09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    8844 (KSR1)
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    8844 (KSR1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    8844 (KSR1)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   8844 (KSR1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Pkinase_Tyr Pkinase Kinase-like RIO1 C1_1 Kdo APH FTA2 zf-RING-like
Motif
Other DBs
NCBI-GeneID: 8844
NCBI-ProteinID: NP_055053
OMIM: 601132
HGNC: 6465
Ensembl: ENSG00000141068
Vega: OTTHUMG00000132051
Pharos: Q8IVT5(Tbio)
UniProt: Q8IVT5
LinkDB All DBs
Structure
PDB: 

Position
17q11.2
AA seq 762 aa AA seqDB search
MNEAKVKETLRRCGASGDECGRLQYALTCLRKVTGLGGEHKEDSSWSSLDARRESGSGPS
TDTLSAASLPWPPGSSQLGRAGNSAQGPRSISVSALPASDSPTPSFSEGLSDTCIPLHAS
GRLTPRALHSFITPPTTPQLRRHTKLKPPRTPPPPSRKVFQLLPSFPTLTRSKSHESQLG
NRIDDVSSMRFDLSHGSPQMVRRDIGLSVTHRFSTKSWLSQVCHVCQKSMIFGVKCKHCR
LKCHNKCTKEAPACRISFLPLTRLRRTESVPSDINNPVDRAAEPHFGTLPKALTKKEHPP
AMNHLDSSSNPSSTTSSTPSSPAPFPTSSNPSSATTPPNPSPGQRDSRFNFPAAYFIHHR
QQFIFPVPSAGHCWKCLLIAESLKENAFNISAFAHAAPLPEAADGTRLDDQPKADVLEAH
EAEAEEPEAGKSEAEDDEDEVDDLPSSRRPWRGPISRKASQTSVYLQEWDIPFEQVELGE
PIGQGRWGRVHRGRWHGEVAIRLLEMDGHNQDHLKLFKKEVMNYRQTRHENVVLFMGACM
NPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKGMGYLHAKGIVHKDLKSK
NVFYDNGKVVITDFGLFGISGVVREGRRENQLKLSHDWLCYLAPEIVREMTPGKDEDQLP
FSKAADVYAFGTVWYELQARDWPLKNQAAEASIWQIGSGEGMKRVLTSVSLGKEVSEILS
ACWAFDLQERPSFSLLMDMLEKLPKLNRRLSHPGHFWKSAEL
NT seq 2289 nt NT seq  +upstreamnt  +downstreamnt
atgaatgaggccaaggtgaaggagacgctgcggcgctgtggggccagcggggatgagtgt
ggccgtctgcagtatgccctcacctgcctgcggaaggtgacaggcctgggaggggagcac
aaggaggactccagttggagttcattggatgcgcggcgggaaagtggctcagggccttcc
acggacaccctctcagcagccagcctgccctggcccccagggagctcccagctgggcaga
gcaggcaacagcgcccagggcccacgctccatctccgtgtcagctctgcccgcctcagac
tcccccacccccagcttcagtgagggcctctcagacacctgtattcccctgcacgccagc
ggccggctgaccccccgtgccctgcacagcttcatcaccccgcccaccacaccccagctg
cgacggcacaccaagctgaagccaccacggacgccccccccacccagccgcaaggtcttc
cagctgctgcccagcttccccacactcacccggagcaagtcccatgagtctcagctgggg
aaccgcattgatgacgtctcctcgatgaggtttgatctctcgcatggatccccacagatg
gtacggagggatatcgggctgtcggtgacgcacaggttctccaccaagtcctggctgtcg
caggtctgccacgtgtgccagaagagcatgatatttggagtgaagtgcaagcattgcagg
ttgaagtgtcacaacaaatgtaccaaagaagcccctgcctgtagaatatccttcctgcca
ctaactcggcttcggaggacagaatctgtcccctcggacatcaacaacccggtggacaga
gcagccgaaccccattttggaaccctccccaaagcactgacaaagaaggagcaccctccg
gccatgaatcacctggactccagcagcaacccttcctccaccacctcctccacaccctcc
tcaccggcgcccttcccgacatcatccaacccatccagcgccaccacgccccccaacccc
tcacctggccagcgggacagcaggttcaacttcccagctgcctacttcattcatcataga
cagcagtttatctttccagtgccatctgctggccattgctggaaatgcctccttattgca
gaaagtttaaaggaaaacgctttcaacatttcagcctttgcacacgcagccccgctccct
gaagctgccgacggtacccggctcgatgaccagccgaaagcagatgtgttggaagctcac
gaagcggaggctgaggagccagaggctggcaagtcagaggcagaagacgatgaggacgag
gtggacgacttgccgagctctcgccggccctggcggggccccatctctcgcaaggccagc
cagaccagcgtgtacctgcaggagtgggacatccccttcgagcaggtagagctgggcgag
cccatcgggcagggccgctggggccgggtgcaccgcggccgctggcatggcgaggtggcc
attcgcctgctggagatggacggccacaaccaggaccacctgaagctcttcaagaaagag
gtgatgaactaccggcagacgcggcatgagaacgtggtgctcttcatgggggcctgcatg
aacccgccccacctggccattatcaccagcttctgcaaggggcggacgttgcactcgttt
gtgagggaccccaagacgtctctggacatcaacaagacgaggcaaatcgctcaggagatc
atcaagggcatgggatatcttcatgccaagggcatcgtacacaaagatctcaaatctaag
aacgtcttctatgacaacggcaaggtggtcatcacagacttcgggctgtttgggatctca
ggcgtggtccgagagggacggcgtgagaaccagctaaagctgtcccacgactggctgtgc
tatctggcccctgagattgtacgcgagatgacccccgggaaggacgaggatcagctgcca
ttctccaaagctgctgatgtctatgcatttgggactgtttggtatgagctgcaagcaaga
gactggcccttgaagaaccaggctgcagaggcatccatctggcagattggaagcggggaa
ggaatgaagcgtgtcctgacttctgtcagcttggggaaggaagtcagtgagatcctgtcg
gcctgctgggctttcgacctgcaggagagacccagcttcagcctgctgatggacatgctg
gagaaacttcccaagctgaaccggcggctctcccaccctggacacttctggaagtcagct
gagttgtag

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