| Entry |
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| Gene name |
TBK1, FTDALS4, IIAE8, NAK, T2K
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| Definition |
(RefSeq) TANK binding kinase 1
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| KO |
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| Organism |
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| Pathway |
| hsa04620 | Toll-like receptor signaling pathway |
| hsa04621 | NOD-like receptor signaling pathway |
| hsa04622 | RIG-I-like receptor signaling pathway |
| hsa05022 | Pathways of neurodegeneration - multiple diseases |
| hsa05163 | Human cytomegalovirus infection |
| hsa05167 | Kaposi sarcoma-associated herpesvirus infection |
| hsa05168 | Herpes simplex virus 1 infection |
| hsa05170 | Human immunodeficiency virus 1 infection |
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| Network |
nt06121 TLR signaling (viruses and bacteria) nt06133 RLR signaling (viruses) nt06134 CGAS-STING signaling (viruses and bacteria) nt06161 Human immunodeficiency virus type 1 (HIV-1) nt06162 Hepatitis B virus (HBV) nt06163 Hepatitis C virus (HCV) nt06164 Kaposi sarcoma-associated herpesvirus (KSHV) nt06165 Epstein-Barr virus (EBV) nt06166 Human papillomavirus (HPV) nt06167 Human cytomegalovirus (HCMV) nt06168 Herpes simplex virus 1 (HSV-1) nt06169 Measles virus (MV) nt06170 Influenza A virus (IAV) nt06171 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nt06221 TLR signaling nt06263 Hepatocellular carcinoma nt06421 Mitophagy nt06464 Amyotrophic lateral sclerosis |
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| Element |
| N00148 | TLR3-IRF7 signaling pathway |
| N00149 | TLR3-IRF3 signaling pathway |
| N00395 | cGAS-STING signaling pathway |
| N00469 | RIG-I-IRF7/3 signaling pathway |
| N00552 | HBV pol to TLR3-IRF3 signaling pathway |
| N00553 | TLR4-IRF3/7 signaling pathway |
| N00567 | HSV ICP34.5 to TBK1 signaling pathway |
| N00734 | IAV PB1-F2/PB2 to RIG-I-like receptor signaling pathway |
| N00947 | Shigella Ipa4.5 to cGAS-STING signaling pathway |
| N01140 | TBK1-mediated autophagosome formation |
| N01141 | Mutation-inactivated TBK1 to TBK1-mediated autophagosome formation |
| N01308 | MDA5-IRF7/3 signaling pathway |
| N01310 | SARS-CoV-2 nsp13 to RIG-I-IRF7/3 signaling pathway |
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| Disease |
| H00058 | Amyotrophic lateral sclerosis (ALS) |
| H02342 | Frontotemporal dementia and amyotrophic lateral sclerosis |
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| Brite |
KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
09132 Signal transduction
04014 Ras signaling pathway
29110 (TBK1)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
29110 (TBK1)
04137 Mitophagy - animal
29110 (TBK1)
09150 Organismal Systems
09151 Immune system
04620 Toll-like receptor signaling pathway
29110 (TBK1)
04621 NOD-like receptor signaling pathway
29110 (TBK1)
04622 RIG-I-like receptor signaling pathway
29110 (TBK1)
04623 Cytosolic DNA-sensing pathway
29110 (TBK1)
04657 IL-17 signaling pathway
29110 (TBK1)
09160 Human Diseases
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
29110 (TBK1)
05161 Hepatitis B
29110 (TBK1)
05160 Hepatitis C
29110 (TBK1)
05171 Coronavirus disease - COVID-19
29110 (TBK1)
05164 Influenza A
29110 (TBK1)
05162 Measles
29110 (TBK1)
05168 Herpes simplex virus 1 infection
29110 (TBK1)
05163 Human cytomegalovirus infection
29110 (TBK1)
05167 Kaposi sarcoma-associated herpesvirus infection
29110 (TBK1)
05169 Epstein-Barr virus infection
29110 (TBK1)
05165 Human papillomavirus infection
29110 (TBK1)
09171 Infectious disease: bacterial
05131 Shigellosis
29110 (TBK1)
05135 Yersinia infection
29110 (TBK1)
09164 Neurodegenerative disease
05014 Amyotrophic lateral sclerosis
29110 (TBK1)
05022 Pathways of neurodegeneration - multiple diseases
29110 (TBK1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:hsa01001]
29110 (TBK1)
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:hsa04131]
29110 (TBK1)
Enzymes [BR:hsa01000]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.10 IkappaB kinase
29110 (TBK1)
Protein kinases [BR:hsa01001]
Serine/threonine kinases: Other
IKK family [OT]
29110 (TBK1)
Membrane trafficking [BR:hsa04131]
Autophagy
Xenophagy
Other xenophagy associated proteins
29110 (TBK1)
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| SSDB |
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| Motif |
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| Other DBs |
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| LinkDB |
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| Structure |
PDB: |
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| Position |
12q14.2
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| AA seq |
729 aa
MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLK
KLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVV
GGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYL
HPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITG
KPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFA
ETSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELIYEGRRLV
LEPGRLAQHFPKTTEENPIFVVSREPLNTIGLIYEKISLPKVHPRYDLDGDASMAKAITG
VVCYACRIASTLLLYQELMRKGIRWLIELIKDDYNETVHKKTEVVITLDFCIRNIEKTVK
VYEKLMKINLEAAELGEISDIHTKLLRLSSSQGTIETSLQDIDSRLSPGGSLADAWAHQE
GTHPKDRNVEKLQVLLNCMTEIYYQFKKDKAERRLAYNEEQIHKFDKQKLYYHATKAMTH
FTDECVKKYEAFLNKSEEWIRKMLHLRKQLLSLTNQCFDIEEEVSKYQEYTNELQETLPQ
KMFTASSGIKHTMTPIYPSSNTLVEMTLGMKKLKEEMEGVVKELAENNHILERFGSLTMD
GGLRNVDCL |
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| NT seq |
2190 nt +upstreamnt +downstreamnt
atgcagagcacttctaatcatctgtggcttttatctgatattttaggccaaggagctact
gcaaatgtctttcgtggaagacataagaaaactggtgatttatttgctatcaaagtattt
aataacataagcttccttcgtccagtggatgttcaaatgagagaatttgaagtgttgaaa
aaactcaatcacaaaaatattgtcaaattatttgctattgaagaggagacaacaacaaga
cataaagtacttattatggaattttgtccatgtgggagtttatacactgttttagaagaa
ccttctaatgcctatggactaccagaatctgaattcttaattgttttgcgagatgtggtg
ggtggaatgaatcatctacgagagaatggtatagtgcaccgtgatatcaagccaggaaat
atcatgcgtgttataggggaagatggacagtctgtgtacaaactcacagattttggtgca
gctagagaattagaagatgatgagcagtttgtttctctgtatggcacagaagaatatttg
caccctgatatgtatgagagagcagtgctaagaaaagatcatcagaagaaatatggagca
acagttgatctttggagcattggggtaacattttaccatgcagctactggatcactgcca
tttagaccctttgaagggcctcgtaggaataaagaagtgatgtataaaataattacagga
aagccttctggtgcaatatctggagtacagaaagcagaaaatggaccaattgactggagt
ggagacatgcctgtttcttgcagtctttctcggggtcttcaggttctacttacccctgtt
cttgcaaacatccttgaagcagatcaggaaaagtgttggggttttgaccagttttttgca
gaaactagtgatatacttcaccgaatggtaattcatgttttttcgctacaacaaatgaca
gctcataagatttatattcatagctataatactgctactatatttcatgaactggtatat
aaacaaaccaaaattatttcttcaaatcaagaacttatctacgaagggcgacgcttagtc
ttagaacctggaaggctggcacaacatttccctaaaactactgaggaaaaccctatattt
gtagtaagccgggaacctctgaataccataggattaatatatgaaaaaatttccctccct
aaagtacatccacgttatgatttagacggggatgctagcatggctaaggcaataacaggg
gttgtgtgttatgcctgcagaattgccagtaccttactgctttatcaggaattaatgcga
aaggggatacgatggctgattgaattaattaaagatgattacaatgaaactgttcacaaa
aagacagaagttgtgatcacattggatttctgtatcagaaacattgaaaaaactgtgaaa
gtatatgaaaagttgatgaagatcaacctggaagcggcagagttaggtgaaatttcagac
atacacaccaaattgttgagactttccagttctcagggaacaatagaaaccagtcttcag
gatatcgacagcagattatctccaggtggatcactggcagacgcatgggcacatcaagaa
ggcactcatccgaaagacagaaatgtagaaaaactacaagtcctgttaaattgcatgaca
gagatttactatcagttcaaaaaagacaaagcagaacgtagattagcttataatgaagaa
caaatccacaaatttgataagcaaaaactgtattaccatgccacaaaagctatgacgcac
tttacagatgaatgtgttaaaaagtatgaggcatttttgaataagtcagaagaatggata
agaaagatgcttcatcttaggaaacagttattatcgctgactaatcagtgttttgatatt
gaagaagaagtatcaaaatatcaagaatatactaatgagttacaagaaactctgcctcag
aaaatgtttacagcttccagtggaatcaaacataccatgaccccaatttatccaagttct
aacacattagtagaaatgactcttggtatgaagaaattaaaggaagagatggaaggggtg
gttaaagaacttgctgaaaataaccacattttagaaaggtttggctctttaaccatggat
ggtggccttcgcaacgttgactgtctttag |
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