Homo sapiens (human): 2956 Help Entry 2956              CDS       T01001                                  Gene name MSH6, GTBP, GTMBP, HNPCC5, HSAP, p160 Definition (RefSeq) mutS homolog 6   KO K08737   DNA mismatch repair protein MSH6 Organism hsa  Homo sapiens (human) Pathway hsa01524   Platinum drug resistance hsa03430   Mismatch repair hsa05200   Pathways in cancer hsa05210   Colorectal cancer Disease H00020   Colorectal cancer H00876   Mismatch repair deficiency Brite KEGG Orthology (KO) [BR:hsa00001]  09120 Genetic Information Processing   09124 Replication and repair    03430 Mismatch repair     2956 (MSH6)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     2956 (MSH6)   09162 Cancer: specific types    05210 Colorectal cancer     2956 (MSH6)   09176 Drug resistance: antineoplastic    01524 Platinum drug resistance     2956 (MSH6)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03400 DNA repair and recombination proteins [BR:hsa03400]     2956 (MSH6) DNA repair and recombination proteins [BR:hsa03400]  Eukaryotic type   SSBR (single strand breaks repair)    MMR (mismatch excision repair)     Mismatch and loop recognition factors      2956 (MSH6) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  MutS_V MutS_III MutS_I PWWP MutS_IV MutS_II UPF0524 Motif Other DBs NCBI-GeneID:  2956 NCBI-ProteinID:  NP_000170 OMIM:  600678 HGNC:  7329 Ensembl:  ENSG00000116062 Vega:  OTTHUMG00000129129 Pharos:  P52701(Tbio) UniProt:  P52701 Q3SWU9 LinkDB All DBs Structure PDB:  6OQM 2O8B 2O8D 2O8F 2O8E 2O8C 2GFU Thumbnails Position 2p16.3 AA seq 1360 aa AA seqDB search MSRQSTLYSFFPKSPALSDANKASARASREGGRAAAAPGASPSPGGDAAWSEAGPGPRPL ARSASPPKAKNLNGGLRRSVAPAAPTSCDFSPGDLVWAKMEGYPWWPCLVYNHPFDGTFI REKGKSVRVHVQFFDDSPTRGWVSKRLLKPYTGSKSKEAQKGGHFYSAKPEILRAMQRAD EALNKDKIKRLELAVCDEPSEPEEEEEMEVGTTYVTDKSEEDNEIESEEEVQPKTQGSRR SSRQIKKRRVISDSESDIGGSDVEFKPDTKEEGSSDEISSGVGDSESEGLNSPVKVARKR KRMVTGNGSLKRKSSRKETPSATKQATSISSETKNTLRAFSAPQNSESQAHVSGGGDDSS RPTVWYHETLEWLKEEKRRDEHRRRPDHPDFDASTLYVPEDFLNSCTPGMRKWWQIKSQN FDLVICYKVGKFYELYHMDALIGVSELGLVFMKGNWAHSGFPEIAFGRYSDSLVQKGYKV ARVEQTETPEMMEARCRKMAHISKYDRVVRREICRIITKGTQTYSVLEGDPSENYSKYLL SLKEKEEDSSGHTRAYGVCFVDTSLGKFFIGQFSDDRHCSRFRTLVAHYPPVQVLFEKGN LSKETKTILKSSLSCSLQEGLIPGSQFWDASKTLRTLLEEEYFREKLSDGIGVMLPQVLK GMTSESDSIGLTPGEKSELALSALGGCVFYLKKCLIDQELLSMANFEEYIPLDSDTVSTT RSGAIFTKAYQRMVLDAVTLNNLEIFLNGTNGSTEGTLLERVDTCHTPFGKRLLKQWLCA PLCNHYAINDRLDAIEDLMVVPDKISEVVELLKKLPDLERLLSKIHNVGSPLKSQNHPDS RAIMYEETTYSKKKIIDFLSALEGFKVMCKIIGIMEEVADGFKSKILKQVISLQTKNPEG RFPDLTVELNRWDTAFDHEKARKTGLITPKAGFDSDYDQALADIRENEQSLLEYLEKQRN RIGCRTIVYWGIGRNRYQLEIPENFTTRNLPEEYELKSTKKGCKRYWTKTIEKKLANLIN AEERRDVSLKDCMRRLFYNFDKNYKDWQSAVECIAVLDVLLCLANYSRGGDGPMCRPVIL LPEDTPPFLELKGSRHPCITKTFFGDDFIPNDILIGCEEEEQENGKAYCVLVTGPNMGGK STLMRQAGLLAVMAQMGCYVPAEVCRLTPIDRVFTRLGASDRIMSGESTFFVELSETASI LMHATAHSLVLVDELGRGTATFDGTAIANAVVKELAETIKCRTLFSTHYHSLVEDYSQNV AVRLGHMACMVENECEDPSQETITFLYKFIKGACPKSYGFNAARLANLPEEVIQKGHRKA REFEKMNQSLRLFREVCLASERSTVDAEAVHKLLTLIKEL NT seq 4083 nt NT seq  +upstreamnt  +downstreamnt atgtcgcgacagagcaccctgtacagcttcttccccaagtctccggcgctgagtgatgcc aacaaggcctcggccagggcctcacgcgaaggcggccgtgccgccgctgcccccggggcc tctccttccccaggcggggatgcggcctggagcgaggctgggcctgggcccaggcccttg gcgcgctccgcgtcaccgcccaaggcgaagaacctcaacggagggctgcggagatcggta gcgcctgctgcccccaccagttgtgacttctcaccaggagatttggtttgggccaagatg gagggttacccctggtggccttgtctggtttacaaccacccctttgatggaacattcatc cgcgagaaagggaaatcagtccgtgttcatgtacagttttttgatgacagcccaacaagg ggctgggttagcaaaaggcttttaaagccatatacaggttcaaaatcaaaggaagcccag aagggaggtcatttttacagtgcaaagcctgaaatactgagagcaatgcaacgtgcagat gaagccttaaataaagacaagattaagaggcttgaattggcagtttgtgatgagccctca gagccagaagaggaagaagagatggaggtaggcacaacttacgtaacagataagagtgaa gaagataatgaaattgagagtgaagaggaagtacagcctaagacacaaggatctaggcga agtagccgccaaataaaaaaacgaagggtcatatcagattctgagagtgacattggtggc tctgatgtggaatttaagccagacactaaggaggaaggaagcagtgatgaaataagcagt ggagtgggggatagtgagagtgaaggcctgaacagccctgtcaaagttgctcgaaagcgg aagagaatggtgactggaaatggctctcttaaaaggaaaagctctaggaaggaaacgccc tcagccaccaaacaagcaactagcatttcatcagaaaccaagaatactttgagagctttc tctgcccctcaaaattctgaatcccaagcccacgttagtggaggtggtgatgacagtagt cgccctactgtttggtatcatgaaactttagaatggcttaaggaggaaaagagaagagat gagcacaggaggaggcctgatcaccccgattttgatgcatctacactctatgtgcctgag gatttcctcaattcttgtactcctgggatgaggaagtggtggcagattaagtctcagaac tttgatcttgtcatctgttacaaggtggggaaattttatgagctgtaccacatggatgct cttattggagtcagtgaactggggctggtattcatgaaaggcaactgggcccattctggc tttcctgaaattgcatttggccgttattcagattccctggtgcagaagggctataaagta gcacgagtggaacagactgagactccagaaatgatggaggcacgatgtagaaagatggca catatatccaagtatgatagagtggtgaggagggagatctgtaggatcattaccaagggt acacagacttacagtgtgctggaaggtgatccctctgagaactacagtaagtatcttctt agcctcaaagaaaaagaggaagattcttctggccatactcgtgcatatggtgtgtgcttt gttgatacttcactgggaaagtttttcataggtcagttttcagatgatcgccattgttcg agatttaggactctagtggcacactatcccccagtacaagttttatttgaaaaaggaaat ctctcaaaggaaactaaaacaattctaaagagttcattgtcctgttctcttcaggaaggt ctgatacccggctcccagttttgggatgcatccaaaactttgagaactctccttgaggaa gaatattttagggaaaagctaagtgatggcattggggtgatgttaccccaggtgcttaaa ggtatgacttcagagtctgattccattgggttgacaccaggagagaaaagtgaattggcc ctctctgctctaggtggttgtgtcttctacctcaaaaaatgccttattgatcaggagctt ttatcaatggctaattttgaagaatatattcccttggattctgacacagtcagcactaca agatctggtgctatcttcaccaaagcctatcaacgaatggtgctagatgcagtgacatta aacaacttggagatttttctgaatggaacaaatggttctactgaaggaaccctactagag agggttgatacttgccatactccttttggtaagcggctcctaaagcaatggctttgtgcc ccactctgtaaccattatgctattaatgatcgtctagatgccatagaagacctcatggtt gtgcctgacaaaatctccgaagttgtagagcttctaaagaagcttccagatcttgagagg ctactcagtaaaattcataatgttgggtctcccctgaagagtcagaaccacccagacagc agggctataatgtatgaagaaactacatacagcaagaagaagattattgattttctttct gctctggaaggattcaaagtaatgtgtaaaattatagggatcatggaagaagttgctgat ggttttaagtctaaaatccttaagcaggtcatctctctgcagacaaaaaatcctgaaggt cgttttcctgatttgactgtagaattgaaccgatgggatacagcctttgaccatgaaaag gctcgaaagactggacttattactcccaaagcaggctttgactctgattatgaccaagct cttgctgacataagagaaaatgaacagagcctcctggaatacctagagaaacagcgcaac agaattggctgtaggaccatagtctattgggggattggtaggaaccgttaccagctggaa attcctgagaatttcaccactcgcaatttgccagaagaatacgagttgaaatctaccaag aagggctgtaaacgatactggaccaaaactattgaaaagaagttggctaatctcataaat gctgaagaacggagggatgtatcattgaaggactgcatgcggcgactgttctataacttt gataaaaattacaaggactggcagtctgctgtagagtgtatcgcagtgttggatgtttta ctgtgcctggctaactatagtcgagggggtgatggtcctatgtgtcgcccagtaattctg ttgccggaagataccccccccttcttagagcttaaaggatcacgccatccttgcattacg aagactttttttggagatgattttattcctaatgacattctaataggctgtgaggaagag gagcaggaaaatggcaaagcctattgtgtgcttgttactggaccaaatatggggggcaag tctacgcttatgagacaggctggcttattagctgtaatggcccagatgggttgttacgtc cctgctgaagtgtgcaggctcacaccaattgatagagtgtttactagacttggtgcctca gacagaataatgtcaggtgaaagtacattttttgttgaattaagtgaaactgccagcata ctcatgcatgcaacagcacattctctggtgcttgtggatgaattaggaagaggtactgca acatttgatgggacggcaatagcaaatgcagttgttaaagaacttgctgagactataaaa tgtcgtacattattttcaactcactaccattcattagtagaagattattctcaaaatgtt gctgtgcgcctaggacatatggcatgcatggtagaaaatgaatgtgaagaccccagccag gagactattacgttcctctataaattcattaagggagcttgtcctaaaagctatggcttt aatgcagcaaggcttgctaatctcccagaggaagttattcaaaagggacatagaaaagca agagaatttgagaagatgaatcagtcactacgattatttcgggaagtttgcctggctagt gaaaggtcaactgtagatgctgaagctgtccataaattgctgactttgattaaggaatta tag

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