KEGG T01001: 3066

Homo sapiens (human): 3066

Entry

3066              CDS       T01001

Symbol

HDAC2, HD2, KDAC2, RPD3, YAF1

Name

(RefSeq) histone deacetylase 2

K06067

histone deacetylase 1/2 [EC:3.5.1.98]

Organism

hsa Homo sapiens (human)

Pathway

hsa03082

ATP-dependent chromatin remodeling

hsa03083

Polycomb repressive complex

hsa04110

Cell cycle

hsa04213

Longevity regulating pathway - multiple species

hsa04330

Notch signaling pathway

hsa04350

TGF-beta signaling pathway

hsa04613

Neutrophil extracellular trap formation

hsa04919

Thyroid hormone signaling pathway

hsa05016

Huntington disease

hsa05031

Amphetamine addiction

hsa05034

Alcoholism

hsa05165

Human papillomavirus infection

hsa05169

Epstein-Barr virus infection

hsa05200

Pathways in cancer

hsa05202

Transcriptional misregulation in cancer

hsa05203

Viral carcinogenesis

hsa05206

MicroRNAs in cancer

hsa05220

Chronic myeloid leukemia

Network

nt06166  Human papillomavirus (HPV)
nt06240  Transcription (cancer)
nt06461  Huntington disease
nt06516  TNF signaling
nt06523  Epigenetic regulation by Polycomb complexes

Element

N00118

TEL-AML1 fusion to transcriptional repression

N00375

HPV E7 to TNF-IRF1 signaling pathway

N00980

Mutation-caused aberrant Htt to REST-mediated transcriptional repression

N01614

Activation of PRC2.2 by ubiquitination of H2AK119 in germline genes

Drug target

Abexinostat (DG01402):

D10060 D10084

Belinostat:

D08870<US>

Bocodepsin (DG03260):

D12551 D12552

Entinostat:

D09338

Fimepinostat:

D11319

Givinostat (DG03284):

D12742 D12743<US>

Mocetinostat (DG01404):

D09357 D09641

Nanatinostat:

D11442

Panobinostat (DG01403):

D10019 D10319

Quisinostat (DG01407):

D10321 D10322

Remetinostat:

D10977

Romidepsin:

D06637<JP/US>

Tinostamustine:

D11182

Tucidinostat:

D10993<JP>

Vorinostat:

D06320<JP/US>

Brite

KEGG Orthology (KO) [BR:hsa00001]
09120 Genetic Information Processing
  09126 Chromosome
   03082 ATP-dependent chromatin remodeling
    3066 (HDAC2)
   03083 Polycomb repressive complex
    3066 (HDAC2)
09130 Environmental Information Processing
  09132 Signal transduction
   04330 Notch signaling pathway
    3066 (HDAC2)
   04350 TGF-beta signaling pathway
    3066 (HDAC2)
09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    3066 (HDAC2)
09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    3066 (HDAC2)
  09152 Endocrine system
   04919 Thyroid hormone signaling pathway
    3066 (HDAC2)
  09149 Aging
   04213 Longevity regulating pathway - multiple species
    3066 (HDAC2)
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    3066 (HDAC2)
   05202 Transcriptional misregulation in cancer
    3066 (HDAC2)
   05206 MicroRNAs in cancer
    3066 (HDAC2)
   05203 Viral carcinogenesis
    3066 (HDAC2)
  09162 Cancer: specific types
   05220 Chronic myeloid leukemia
    3066 (HDAC2)
  09172 Infectious disease: viral
   05169 Epstein-Barr virus infection
    3066 (HDAC2)
   05165 Human papillomavirus infection
    3066 (HDAC2)
  09164 Neurodegenerative disease
   05016 Huntington disease
    3066 (HDAC2)
  09165 Substance dependence
   05031 Amphetamine addiction
    3066 (HDAC2)
   05034 Alcoholism
    3066 (HDAC2)
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    3066 (HDAC2)
Enzymes [BR:hsa01000]
3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.1  In linear amides
    3.5.1.98  histone deacetylase
     3066 (HDAC2)
Chromosome and associated proteins [BR:hsa03036]
Eukaryotic type
  Histone modification proteins
   HDACs (histone deacetylases)
    Class I HDACs
     3066 (HDAC2)
   HDAC complexes
    Sin3A-HDAC complex
     3066 (HDAC2)
    BRAF-HDAC complex
     3066 (HDAC2)
    REST complex
     3066 (HDAC2)
    SHIP complex
     3066 (HDAC2)
    MiDAC complex
     3066 (HDAC2)
   Polycomb repressive complex (PRC) and associated proteins
    Noncanonical PRC1 (PRC1.6)
     3066 (HDAC2)
  Heterochromatin formation proteins
   Other heterochromatin formation proteins
    3066 (HDAC2)
  Chromatin remodeling factors
   NuRD complex
    3066 (HDAC2)

SSDB

Motif

Pfam:

Hist_deacetyl

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

LinkDB

Position

6:complement(113933028..113971148)

AA seq 488 aa
MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKA
TAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA
GAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH
GDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQ
IFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLG
GGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYM
EKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEE
FSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGT
KSEQLSNP

NT seq 1467 nt +upstreamnt +downstreamnt
atggcgtacagtcaaggaggcggcaaaaaaaaagtctgctactactacgacggtgatatt
ggaaattattattatggacagggtcatcccatgaagcctcatagaatccgcatgacccat
aacttgctgttaaattatggcttatacagaaaaatggaaatatataggccccataaagcc
actgccgaagaaatgacaaaatatcacagtgatgagtatatcaaatttctacggtcaata
agaccagataacatgtctgagtatagtaagcagatgcagagatttaatgttggagaagat
tgtccagtgtttgatggactctttgagttttgtcagctctcaactggcggttcagttgct
ggagctgtgaagttaaaccgacaacagactgatatggctgttaattgggctggaggatta
catcatgctaagaaatcagaagcatcaggattctgttacgttaatgatattgtgcttgcc
atccttgaattactaaagtatcatcagagagtcttatatattgatatagatattcatcat
ggtgatggtgttgaagaagctttttatacaacagatcgtgtaatgacggtatcattccat
aaatatggggaatactttcctggcacaggagacttgagggatattggtgctggaaaaggc
aaatactatgctgtcaattttccaatgagagatggtatagatgatgagtcatatgggcag
atatttaagcctattatctcaaaggtgatggagatgtatcaacctagtgctgtggtatta
cagtgtggtgcagactcattatctggtgatagactgggttgtttcaatctaacagtcaaa
ggtcatgctaaatgtgtagaagttgtaaaaacttttaacttaccattactgatgcttgga
ggaggtggctacacaatccgtaatgttgctcgatgttggacatatgagactgcagttgcc
cttgattgtgagattcccaatgagttgccatataatgattactttgagtattttggacca
gacttcaaactgcatattagtccttcaaacatgacaaaccagaacactccagaatatatg
gaaaagataaaacagcgtttgtttgaaaatttgcgcatgttacctcatgcacctggtgtc
cagatgcaagctattccagaagatgctgttcatgaagacagtggagatgaagatggagaa
gatccagacaagagaatttctattcgagcatcagacaagcggatagcttgtgatgaagaa
ttctcagattctgaggatgaaggagaaggaggtcgaagaaatgtggctgatcataagaaa
ggagcaaagaaagctagaattgaagaagataagaaagaaacagaggacaaaaaaacagac
gttaaggaagaagataaatccaaggacaacagtggtgaaaaaacagataccaaaggaacc
aaatcagaacagctcagcaacccctga

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