Homo sapiens (human): 3082
Entry
3082 CDS
T01001
Gene name
HGF, DFNB39, F-TCF, HGFB, HPTA, SF
Definition
(RefSeq) hepatocyte growth factor
KO
K05460
hepatocyte growth factor
Organism
hsa
Homo sapiens (human)
Pathway
hsa01521
EGFR tyrosine kinase inhibitor resistance
hsa04010
MAPK signaling pathway
hsa04014
Ras signaling pathway
hsa04015
Rap1 signaling pathway
hsa04151
PI3K-Akt signaling pathway
hsa04510
Focal adhesion
hsa05144
Malaria
hsa05200
Pathways in cancer
hsa05205
Proteoglycans in cancer
hsa05211
Renal cell carcinoma
hsa05218
Melanoma
hsa05225
Hepatocellular carcinoma
hsa05226
Gastric cancer
Network
nt06110
MAPK signaling (virus)
nt06162
Hepatitis B virus (HBV)
nt06163
Hepatitis C virus (HCV)
nt06164
Kaposi sarcoma-associated herpesvirus (KSHV)
nt06170
Influenza A virus (IAV)
nt06210
ERK signaling
nt06214
PI3K signaling
nt06261
Gastric cancer
nt06262
Pancreatic cancer
nt06263
Hepatocellular carcinoma
nt06264
Renal cell carcinoma
Element
N00043
HGF-MET-PI3K signaling pathway
N00216
HGF-MET-RAS-ERK signaling pathway
N00246
HGF-overexpression to RAS-ERK signaling pathway
N00247
HGF-overexpression to PI3K signaling pathway
Disease
H00048
Hepatocellular carcinoma
H00605
Deafness, autosomal recessive
Drug target
Ficlatuzumab:
D10123
Rilotumumab:
D09659
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04014 Ras signaling pathway
3082 (HGF)
04015 Rap1 signaling pathway
3082 (HGF)
04010 MAPK signaling pathway
3082 (HGF)
04151 PI3K-Akt signaling pathway
3082 (HGF)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04510 Focal adhesion
3082 (HGF)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
3082 (HGF)
05205 Proteoglycans in cancer
3082 (HGF)
09162 Cancer: specific types
05225 Hepatocellular carcinoma
3082 (HGF)
05226 Gastric cancer
3082 (HGF)
05218 Melanoma
3082 (HGF)
05211 Renal cell carcinoma
3082 (HGF)
09174 Infectious disease: parasitic
05144 Malaria
3082 (HGF)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
3082 (HGF)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04052 Cytokines and growth factors [BR:
hsa04052
]
3082 (HGF)
00536 Glycosaminoglycan binding proteins [BR:
hsa00536
]
3082 (HGF)
Cytokines and growth factors [BR:
hsa04052
]
Growth factors
Growth factors (RTK binding)
3082 (HGF)
Glycosaminoglycan binding proteins [BR:
hsa00536
]
Heparan sulfate/Haparin
Growth factors/receptors
3082 (HGF)
SSDB
Motif
Pfam:
Kringle
Trypsin
PAN_1
DUF1986
Other DBs
NCBI-GeneID:
3082
NCBI-ProteinID:
NP_000592
OMIM:
142409
HGNC:
4893
Ensembl:
ENSG00000019991
Vega:
OTTHUMG00000023804
Pharos:
P14210
(Tchem)
UniProt:
P14210
LinkDB
Structure
PDB:
3HMS
2QJ2
3SP8
5CS5
5CP9
5CSQ
5CS1
5CS9
5CT1
5CT2
5CT3
3HMT
1BHT
5COE
1GMN
5CS3
1GP9
1NK1
1SI5
3HN4
4D3C
4K3J
3MKP
4O3T
1GMO
4O3U
1SHY
2HGF
Position
7q21.11
AA seq
728 aa
MWVTKLLPALLLQHVLLHLLLLPIAIPYAEGQRKRRNTIHEFKKSAKTTLIKIDPALKIK
TKKVNTADQCANRCTRNKGLPFTCKAFVFDKARKQCLWFPFNSMSSGVKKEFGHEFDLYE
NKDYIRNCIIGKGRSYKGTVSITKSGIKCQPWSSMIPHEHSFLPSSYRGKDLQENYCRNP
RGEEGGPWCFTSNPEVRYEVCDIPQCSEVECMTCNGESYRGLMDHTESGKICQRWDHQTP
HRHKFLPERYPDKGFDDNYCRNPDGQPRPWCYTLDPHTRWEYCAIKTCADNTMNDTDVPL
ETTECIQGQGEGYRGTVNTIWNGIPCQRWDSQYPHEHDMTPENFKCKDLRENYCRNPDGS
ESPWCFTTDPNIRVGYCSQIPNCDMSHGQDCYRGNGKNYMGNLSQTRSGLTCSMWDKNME
DLHRHIFWEPDASKLNENYCRNPDDDAHGPWCYTGNPLIPWDYCPISRCEGDTTPTIVNL
DHPVISCAKTKQLRVVNGIPTRTNIGWMVSLRYRNKHICGGSLIKESWVLTARQCFPSRD
LKDYEAWLGIHDVHGRGDEKCKQVLNVSQLVYGPEGSDLVLMKLARPAVLDDFVSTIDLP
NYGCTIPEKTSCSVYGWGYTGLINYDGLLRVAHLYIMGNEKCSQHHRGKVTLNESEICAG
AEKIGSGPCEGDYGGPLVCEQHKMRMVLGVIVPGRGCAIPNRPGIFVRVAYYAKWIHKII
LTYKVPQS
NT seq
2187 nt
+upstream
nt +downstream
nt
atgtgggtgaccaaactcctgccagccctgctgctgcagcatgtcctcctgcatctcctc
ctgctccccatcgccatcccctatgcagagggacaaaggaaaagaagaaatacaattcat
gaattcaaaaaatcagcaaagactaccctaatcaaaatagatccagcactgaagataaaa
accaaaaaagtgaatactgcagaccaatgtgctaatagatgtactaggaataaaggactt
ccattcacttgcaaggcttttgtttttgataaagcaagaaaacaatgcctctggttcccc
ttcaatagcatgtcaagtggagtgaaaaaagaatttggccatgaatttgacctctatgaa
aacaaagactacattagaaactgcatcattggtaaaggacgcagctacaagggaacagta
tctatcactaagagtggcatcaaatgtcagccctggagttccatgataccacacgaacac
agctttttgccttcgagctatcggggtaaagacctacaggaaaactactgtcgaaatcct
cgaggggaagaagggggaccctggtgtttcacaagcaatccagaggtacgctacgaagtc
tgtgacattcctcagtgttcagaagttgaatgcatgacctgcaatggggagagttatcga
ggtctcatggatcatacagaatcaggcaagatttgtcagcgctgggatcatcagacacca
caccggcacaaattcttgcctgaaagatatcccgacaagggctttgatgataattattgc
cgcaatcccgatggccagccgaggccatggtgctatactcttgaccctcacacccgctgg
gagtactgtgcaattaaaacatgcgctgacaatactatgaatgacactgatgttcctttg
gaaacaactgaatgcatccaaggtcaaggagaaggctacaggggcactgtcaataccatt
tggaatggaattccatgtcagcgttgggattctcagtatcctcacgagcatgacatgact
cctgaaaatttcaagtgcaaggacctacgagaaaattactgccgaaatccagatgggtct
gaatcaccctggtgttttaccactgatccaaacatccgagttggctactgctcccaaatt
ccaaactgtgatatgtcacatggacaagattgttatcgtgggaatggcaaaaattatatg
ggcaacttatcccaaacaagatctggactaacatgttcaatgtgggacaagaacatggaa
gacttacatcgtcatatcttctgggaaccagatgcaagtaagctgaatgagaattactgc
cgaaatccagatgatgatgctcatggaccctggtgctacacgggaaatccactcattcct
tgggattattgccctatttctcgttgtgaaggtgataccacacctacaatagtcaattta
gaccatcccgtaatatcttgtgccaaaacgaaacaattgcgagttgtaaatgggattcca
acacgaacaaacataggatggatggttagtttgagatacagaaataaacatatctgcgga
ggatcattgataaaggagagttgggttcttactgcacgacagtgtttcccttctcgagac
ttgaaagattatgaagcttggcttggaattcatgatgtccacggaagaggagatgagaaa
tgcaaacaggttctcaatgtttcccagctggtatatggccctgaaggatcagatctggtt
ttaatgaagcttgccaggcctgctgtcctggatgattttgttagtacgattgatttacct
aattatggatgcacaattcctgaaaagaccagttgcagtgtttatggctggggctacact
ggattgatcaactatgatggcctattacgagtggcacatctctatataatgggaaatgag
aaatgcagccagcatcatcgagggaaggtgactctgaatgagtctgaaatatgtgctggg
gctgaaaagattggatcaggaccatgtgagggggattatggtggcccacttgtttgtgag
caacataaaatgagaatggttcttggtgtcattgttcctggtcgtggatgtgccattcca
aatcgtcctggtatttttgtccgagtagcatattatgcaaaatggatacacaaaattatt
ttaacatataaggtaccacagtcatag
DBGET
integrated database retrieval system
