Entry |
|
Gene name |
HLA-DRA, HLA-DRA1
|
Definition |
(RefSeq) major histocompatibility complex, class II, DR alpha
|
KO |
|
Organism |
|
Pathway |
hsa04612 | Antigen processing and presentation |
hsa04658 | Th1 and Th2 cell differentiation |
hsa04672 | Intestinal immune network for IgA production |
hsa05150 | Staphylococcus aureus infection |
hsa05166 | Human T-cell leukemia virus 1 infection |
hsa05168 | Herpes simplex virus 1 infection |
|
Network |
nt06129 MHC presentation (viruses) nt06140 Transcription (viruses) nt06160 Human T-cell leukemia virus 1 (HTLV-1) nt06168 Herpes simplex virus 1 (HSV-1) |
Element |
N00508 | HTLV-1 Tax to NFY-mediated transcription |
N00590 | Antigen processing and presentation by MHC class II molecules |
|
Drug target |
Glatiramer acetate: | D04318<JP/US> |
|
Brite |
KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
09133 Signaling molecules and interaction
04514 Cell adhesion molecules
3122 (HLA-DRA)
09140 Cellular Processes
09141 Transport and catabolism
04145 Phagosome
3122 (HLA-DRA)
09150 Organismal Systems
09151 Immune system
04640 Hematopoietic cell lineage
3122 (HLA-DRA)
04612 Antigen processing and presentation
3122 (HLA-DRA)
04658 Th1 and Th2 cell differentiation
3122 (HLA-DRA)
04659 Th17 cell differentiation
3122 (HLA-DRA)
04672 Intestinal immune network for IgA production
3122 (HLA-DRA)
09160 Human Diseases
09163 Immune disease
05310 Asthma
3122 (HLA-DRA)
05322 Systemic lupus erythematosus
3122 (HLA-DRA)
05323 Rheumatoid arthritis
3122 (HLA-DRA)
05320 Autoimmune thyroid disease
3122 (HLA-DRA)
05321 Inflammatory bowel disease
3122 (HLA-DRA)
05330 Allograft rejection
3122 (HLA-DRA)
05332 Graft-versus-host disease
3122 (HLA-DRA)
09166 Cardiovascular disease
05416 Viral myocarditis
3122 (HLA-DRA)
09167 Endocrine and metabolic disease
04940 Type I diabetes mellitus
3122 (HLA-DRA)
09171 Infectious disease: bacterial
05150 Staphylococcus aureus infection
3122 (HLA-DRA)
05152 Tuberculosis
3122 (HLA-DRA)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
3122 (HLA-DRA)
05164 Influenza A
3122 (HLA-DRA)
05168 Herpes simplex virus 1 infection
3122 (HLA-DRA)
05169 Epstein-Barr virus infection
3122 (HLA-DRA)
09174 Infectious disease: parasitic
05145 Toxoplasmosis
3122 (HLA-DRA)
05140 Leishmaniasis
3122 (HLA-DRA)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:hsa04147]
3122 (HLA-DRA)
Exosome [BR:hsa04147]
Exosomal proteins
Exosomal proteins of haemopoietic cells (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
3122 (HLA-DRA)
Exosomal proteins of epithelial cells
3122 (HLA-DRA)
Exosomal proteins of breast milk
3122 (HLA-DRA)
|
SSDB |
|
Motif |
|
Other DBs |
|
LinkDB |
|
Structure |
PDB: |
Position |
6p21.32
|
AA seq |
254 aa
MAISGVPVLGFFIIAVLMSAQESWAIKEEHVIIQAEFYLNPDQSGEFMFDFDGDEIFHVD
MAKKETVWRLEEFGRFASFEAQGALANIAVDKANLEIMTKRSNYTPITNVPPEVTVLTNS
PVELREPNVLICFIDKFTPPVVNVTWLRNGKPVTTGVSETVFLPREDHLFRKFHYLPFLP
STEDVYDCRVEHWGLDEPLLKHWEFDAPSPLPETTENVVCALGLTVGLVGIIIGTIFIIK
GLRKSNAAERRGPL |
NT seq |
765 nt +upstreamnt +downstreamnt
atggccataagtggagtccctgtgctaggatttttcatcatagctgtgctgatgagcgct
caggaatcatgggctatcaaagaagaacatgtgatcatccaggccgagttctatctgaat
cctgaccaatcaggcgagtttatgtttgactttgatggtgatgagattttccatgtggat
atggcaaagaaggagacggtctggcggcttgaagaatttggacgatttgccagctttgag
gctcaaggtgcattggccaacatagctgtggacaaagccaacctggaaatcatgacaaag
cgctccaactatactccgatcaccaatgtacctccagaggtaactgtgctcacaaacagc
cctgtggaactgagagagcccaacgtcctcatctgtttcatagacaagttcaccccacca
gtggtcaatgtcacgtggcttcgaaatggaaaacctgtcaccacaggagtgtcagagaca
gtcttcctgcccagggaagaccaccttttccgcaagttccactatctccccttcctgccc
tcaactgaggacgtttacgactgcagggtggagcactggggcttggatgagcctcttctc
aagcactgggagtttgatgctccaagccctctcccagagactacagagaacgtggtgtgt
gccctgggcctgactgtgggtctggtgggcatcattattgggaccatcttcatcatcaag
ggattgcgcaaaagcaatgcagcagaacgcagggggcctctgtaa |