KEGG   Homo sapiens (human): 332
Entry
332               CDS       T01001                                 

Gene name
BIRC5, API4, EPR-1
Definition
(RefSeq) baculoviral IAP repeat containing 5
  KO
K08731  baculoviral IAP repeat-containing protein 5
Organism
hsa  Homo sapiens (human)
Pathway
hsa01524  Platinum drug resistance
hsa04210  Apoptosis
hsa04215  Apoptosis - multiple species
hsa04390  Hippo signaling pathway
hsa05161  Hepatitis B
hsa05200  Pathways in cancer
hsa05210  Colorectal cancer
Network
nt06131  Apoptosis (viruses and bacteria)
nt06162  Hepatitis B virus (HBV)
nt06215  WNT signaling
nt06260  Colorectal cancer
nt06261  Gastric cancer
nt06263  Hepatocellular carcinoma
nt06271  Endometrial cancer
  Element
N00057  Mutation-inactivated APC to Wnt signaling pathway
N00058  Mutation-activated CTNNB1 to Wnt signaling pathway
N00533  HBV HBx to Crosstalk between extrinsic and intrinsic apoptotic pathways
Drug target
Gataparsen (DG01431): D09909 D09910
Sepantronium bromide: D10164
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04390 Hippo signaling pathway
    332 (BIRC5)
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    332 (BIRC5)
   04215 Apoptosis - multiple species
    332 (BIRC5)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    332 (BIRC5)
  09162 Cancer: specific types
   05210 Colorectal cancer
    332 (BIRC5)
  09172 Infectious disease: viral
   05161 Hepatitis B
    332 (BIRC5)
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    332 (BIRC5)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    332 (BIRC5)
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    332 (BIRC5)
Peptidases and inhibitors [BR:hsa01002]
 Peptidase inhibitors
  Family I32: IAP family
   332 (BIRC5)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centromeric chromatin formation proteins
   Kinetochore proteins
    CPC (chromosomal passenger complex)
     332 (BIRC5)
  Centrosome formation and ciliogenesis proteins
   Other centriole associated proteins
    332 (BIRC5)
SSDB
Motif
Pfam: BIR
Other DBs
NCBI-GeneID: 332
NCBI-ProteinID: NP_001159
OMIM: 603352
HGNC: 593
Ensembl: ENSG00000089685
Vega: OTTHUMG00000177505
Pharos: O15392(Tchem)
UniProt: O15392 A0A0B4J1S3
LinkDB
Structure
PDB: 

Position
17q25.3
AA seq 142 aa
MGAPTLPPAWQPFLKDHRISTFKNWPFLEGCACTPERMAEAGFIHCPTENEPDLAQCFFC
FKELEGWEPDDDPIEEHKKHSSGCAFLSVKKQFEELTLGEFLKLDRERAKNKIAKETNNK
KKEFEETAEKVRRAIEQLAAMD
NT seq 429 nt   +upstreamnt  +downstreamnt
atgggtgccccgacgttgccccctgcctggcagccctttctcaaggaccaccgcatctct
acattcaagaactggcccttcttggagggctgcgcctgcaccccggagcggatggccgag
gctggcttcatccactgccccactgagaacgagccagacttggcccagtgtttcttctgc
ttcaaggagctggaaggctgggagccagatgacgaccccatagaggaacataaaaagcat
tcgtccggttgcgctttcctttctgtcaagaagcagtttgaagaattaacccttggtgaa
tttttgaaactggacagagaaagagccaagaacaaaattgcaaaggaaaccaacaataag
aagaaagaatttgaggaaactgcggagaaagtgcgccgtgccatcgagcagctggctgcc
atggattga

KEGG   Homo sapiens (human): 57448
Entry
57448             CDS       T01001                                 

Gene name
BIRC6, APOLLON, BRUCE
Definition
(RefSeq) baculoviral IAP repeat containing 6
  KO
K10586  baculoviral IAP repeat-containing protein 6 (apollon) [EC:2.3.2.23]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04120  Ubiquitin mediated proteolysis
hsa04215  Apoptosis - multiple species
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    57448 (BIRC6)
 09140 Cellular Processes
  09143 Cell growth and death
   04215 Apoptosis - multiple species
    57448 (BIRC6)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    57448 (BIRC6)
  09182 Protein families: genetic information processing
   04121 Ubiquitin system [BR:hsa04121]
    57448 (BIRC6)
Enzymes [BR:hsa01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.23  E2 ubiquitin-conjugating enzyme
     57448 (BIRC6)
Peptidases and inhibitors [BR:hsa01002]
 Peptidase inhibitors
  Family I32: IAP family
   57448 (BIRC6)
Ubiquitin system [BR:hsa04121]
 Ubiquitin-conjugating enzymes (E2)
  Ubiquitin-conjugating enzymes
   57448 (BIRC6)
SSDB
Motif
Pfam: BIRC6 UQ_con BIR UEV
Other DBs
NCBI-GeneID: 57448
NCBI-ProteinID: NP_057336
OMIM: 605638
HGNC: 13516
Ensembl: ENSG00000115760
Vega: OTTHUMG00000150528
Pharos: Q9NR09(Tbio)
UniProt: Q9NR09
LinkDB
Structure
PDB: 
3CEG

Position
2p22.3
AA seq 4857 aa
MVTGGGAAPPGTVTEPLPSVIVLSAGRKMAAAAAAASGPGCSSAAGAGAAGVSEWLVLRD
GCMHCDADGLHSLSYHPALNAILAVTSRGTIKVIDGTSGATLQASALSAKPGGQVKCQYI
SAVDKVIFVDDYAVGCRKDLNGILLLDTALQTPVSKQDDVVQLELPVTEAQQLLSACLEK
VDISSTEGYDLFITQLKDGLKNTSHETAANHKVAKWATVTFHLPHHVLKSIASAIVNELK
KINQNVAALPVASSVMDRLSYLLPSARPELGVGPGRSVDRSLMYSEANRRETFTSWPHVG
YRWAQPDPMAQAGFYHQPASSGDDRAMCFTCSVCLVCWEPTDEPWSEHERHSPNCPFVKG
EHTQNVPLSVTLATSPAQFPCTDGTDRISCFGSGSCPHFLAAATKRGKICIWDVSKLMKV
HLKFEINAYDPAIVQQLILSGDPSSGVDSRRPTLAWLEDSSSCSDIPKLEGDSDDLLEDS
DSEEHSRSDSVTGHTSQKEAMEVSLDITALSILQQPEKLQWEIVANVLEDTVKDLEELGA
NPCLTNSKSEKTKEKHQEQHNIPFPCLLAGGLLTYKSPATSPISSNSHRSLDGLSRTQGE
SISEQGSTDNESCTNSELNSPLVRRTLPVLLLYSIKESDEKAGKIFSQMNNIMSKSLHDD
GFTVPQIIEMELDSQEQLLLQDPPVTYIQQFADAAANLTSPDSEKWNSVFPKPGTLVQCL
RLPKFAEEENLCIDSITPCADGIHLLVGLRTCPVESLSAINQVEALNNLNKLNSALCNRR
KGELESNLAVVNGANISVIQHESPADVQTPLIIQPEQRNVSGGYLVLYKMNYATRIVTLE
EEPIKIQHIKDPQDTITSLILLPPDILDNREDDCEEPIEDMQLTSKNGFEREKTSDISTL
GHLVITTQGGYVKILDLSNFEILAKVEPPKKEGTEEQDTFVSVIYCSGTDRLCACTKGGE
LHFLQIGGTCDDIDEADILVDGSLSKGIEPSSEGSKPLSNPSSPGISGVDLLVDQPFTLE
ILTSLVELTRFETLTPRFSATVPPCWVEVQQEQQQRRHPQHLHQQHHGDAAQHTRTWKLQ
TDSNSWDEHVFELVLPKACMVGHVDFKFVLNSNITNIPQIQVTLLKNKAPGLGKVNALNI
EVEQNGKPSLVDLNEEMQHMDVEESQCLRLCPFLEDHKEDILCGPVWLASGLDLSGHAGM
LTLTSPKLVKGMAGGKYRSFLIHVKAVNERGTEEICNGGMRPVVRLPSLKHQSNKGYSLA
SLLAKVAAGKEKSSNVKNENTSGTRKSENLRGCDLLQEVSVTIRRFKKTSISKERVQRCA
MLQFSEFHEKLLNTLCRKTDDGQITEHAQSLVLDTLCWLAGVHSNGPGSSKEGNENLLSK
TRKFLSDIVRVCFFEAGRSIAHKCARFLALCISNGKCDPCQPAFGPVLLKALLDNMSFLP
AATTGGSVYWYFVLLNYVKDEDLAGCSTACASLLTAVSRQLQDRLTPMEALLQTRYGLYS
SPFDPVLFDLEMSGSSCKNVYNSSIGVQSDEIDLSDVLSGNGKVSSCTAAEGSFTSLTGL
LEVEPLHFTCVSTSDGTRIERDDAMSSFGVTPAVGGLSSGTVGEASTALSSAAQVALQSL
SHAMASAEQQLQVLQEKQQQLLKLQQQKAKLEAKLHQTTAAAAAAASAVGPVHNSVPSNP
VAAPGFFIHPSDVIPPTPKTTPLFMTPPLTPPNEAVSVVINAELAQLFPGSVIDPPAVNL
AAHNKNSNKSRMNPLGSGLALAISHASHFLQPPPHQSIIIERMHSGARRFVTLDFGRPIL
LTDVLIPTCGDLASLSIDIWTLGEEVDGRRLVVATDISTHSLILHDLIPPPVCRFMKITV
IGRYGSTNARAKIPLGFYYGHTYILPWESELKLMHDPLKGEGESANQPEIDQHLAMMVAL
QEDIQCRYNLACHRLETLLQSIDLPPLNSANNAQYFLRKPDKAVEEDSRVFSAYQDCIQL
QLQLNLAHNAVQRLKVALGASRKMLSETSNPEDLIQTSSTEQLRTIIRYLLDTLLSLLHA
SNGHSVPAVLQSTFHAQACEELFKHLCISGTPKIRLHTGLLLVQLCGGERWWGQFLSNVL
QELYNSEQLLIFPQDRVFMLLSCIGQRSLSNSGVLESLLNLLDNLLSPLQPQLPMHRRTE
GVLDIPMISWVVMLVSRLLDYVATVEDEAAAAKKPLNGNQWSFINNNLHTQSLNRSSKGS
SSLDRLYSRKIRKQLVHHKQQLNLLKAKQKALVEQMEKEKIQSNKGSSYKLLVEQAKLKQ
ATSKHFKDLIRLRRTAEWSRSNLDTEVTTAKESPEIEPLPFTLAHERCISVVQKLVLFLL
SMDFTCHADLLLFVCKVLARIANATRPTIHLCEIVNEPQLERLLLLLVGTDFNRGDISWG
GAWAQYSLTCMLQDILAGELLAPVAAEAMEEGTVGDDVGATAGDSDDSLQQSSVQLLETI
DEPLTHDITGAPPLSSLEKDKEIDLELLQDLMEVDIDPLDIDLEKDPLAAKVFKPISSTW
YDYWGADYGTYNYNPYIGGLGIPVAKPPANTEKNGSQTVSVSVSQALDARLEVGLEQQAE
LMLKMMSTLEADSILQALTNTSPTLSQSPTGTDDSLLGGLQAANQTSQLIIQLSSVPMLN
VCFNKLFSMLQVHHVQLESLLQLWLTLSLNSSSTGNKENGADIFLYNANRIPVISLNQAS
ITSFLTVLAWYPNTLLRTWCLVLHSLTLMTNMQLNSGSSSAIGTQESTAHLLVSDPNLIH
VLVKFLSGTSPHGTNQHSPQVGPTATQAMQEFLTRLQVHLSSTCPQIFSEFLLKLIHILS
TERGAFQTGQGPLDAQVKLLEFTLEQNFEVVSVSTISAVIESVTFLVHHYITCSDKVMSR
SGSDSSVGARACFGGLFANLIRPGDAKAVCGEMTRDQLMFDLLKLVNILVQLPLSGNREY
SARVSVTTNTTDSVSDEEKVSGGKDGNGSSTSVQGSPAYVADLVLANQQIMSQILSALGL
CNSSAMAMIIGASGLHLTKHENFHGGLDAISVGDGLFTILTTLSKKASTVHMMLQPILTY
MACGYMGRQGSLATCQLSEPLLWFILRVLDTSDALKAFHDMGGVQLICNNMVTSTRAIVN
TARSMVSTIMKFLDSGPNKAVDSTLKTRILASEPDNAEGIHNFAPLGTITSSSPTAQPAE
VLLQATPPHRRARSAAWSYIFLPEEAWCDLTIHLPAAVLLKEIHIQPHLASLATCPSSVS
VEVSADGVNMLPLSTPVVTSGLTYIKIQLVKAEVASAVCLRLHRPRDASTLGLSQIKLLG
LTAFGTTSSATVNNPFLPSEDQVSKTSIGWLRLLHHCLTHISDLEGMMASAAAPTANLLQ
TCAALLMSPYCGMHSPNIEVVLVKIGLQSTRIGLKLIDILLRNCAASGSDPTDLNSPLLF
GRLNGLSSDSTIDILYQLGTTQDPGTKDRIQALLKWVSDSARVAAMKRSGRMNYMCPNSS
TVEYGLLMPSPSHLHCVAAILWHSYELLVEYDLPALLDQELFELLFNWSMSLPCNMVLKK
AVDSLLCSMCHVHPNYFSLLMGWMGITPPPVQCHHRLSMTDDSKKQDLSSSLTDDSKNAQ
APLALTESHLATLASSSQSPEAIKQLLDSGLPSLLVRSLASFCFSHISSSESIAQSIDIS
QDKLRRHHVPQQCNKMPITADLVAPILRFLTEVGNSHIMKDWLGGSEVNPLWTALLFLLC
HSGSTSGSHNLGAQQTSARSASLSSAATTGLTTQQRTAIENATVAFFLQCISCHPNNQKL
MAQVLCELFQTSPQRGNLPTSGNISGFIRRLFLQLMLEDEKVTMFLQSPCPLYKGRINAT
SHVIQHPMYGAGHKFRTLHLPVSTTLSDVLDRVSDTPSITAKLISEQKDDKEKKNHEEKE
KVKAENGFQDNYSVVVASGLKSQSKRAVSATPPRPPSRRGRTIPDKIGSTSGAEAANKII
TVPVFHLFHKLLAGQPLPAEMTLAQLLTLLYDRKLPQGYRSIDLTVKLGSRVITDPSLSK
TDSYKRLHPEKDHGDLLASCPEDEALTPGDECMDGILDESLLETCPIQSPLQVFAGMGGL
ALIAERLPMLYPEVIQQVSAPVVTSTTQEKPKDSDQFEWVTIEQSGELVYEAPETVAAEP
PPIKSAVQTMSPIPAHSLAAFGLFLRLPGYAEVLLKERKHAQCLLRLVLGVTDDGEGSHI
LQSPSANVLPTLPFHVLRSLFSTTPLTTDDGVLLRRMALEIGALHLILVCLSALSHHSPR
VPNSSVNQTEPQVSSSHNPTSTEEQQLYWAKGTGFGTGSTASGWDVEQALTKQRLEEEHV
TCLLQVLASYINPVSSAVNGEAQSSHETRGQNSNALPSVLLELLSQSCLIPAMSSYLRND
SVLDMARHVPLYRALLELLRAIASCAAMVPLLLPLSTENGEEEEEQSECQTSVGTLLAKM
KTCVDTYTNRLRSKRENVKTGVKPDASDQEPEGLTLLVPDIQKTAEIVYAATTSLRQANQ
EKKLGEYSKKAAMKPKPLSVLKSLEEKYVAVMKKLQFDTFEMVSEDEDGKLGFKVNYHYM
SQVKNANDANSAARARRLAQEAVTLSTSLPLSSSSSVFVRCDEERLDIMKVLITGPADTP
YANGCFEFDVYFPQDYPSSPPLVNLETTGGHSVRFNPNLYNDGKVCLSILNTWHGRPEEK
WNPQTSSFLQVLVSVQSLILVAEPYFNEPGYERSRGTPSGTQSSREYDGNIRQATVKWAM
LEQIRNPSPCFKEVIHKHFYLKRVEIMAQCEEWIADIQQYSSDKRVGRTMSHHAAALKRH
TAQLREELLKLPCPEGLDPDTDDAPEVCRATTGAEETLMHDQVKPSSSKELPSDFQL
NT seq 14574 nt   +upstreamnt  +downstreamnt
atggtgactggtggtggtgctgcacctcccgggactgtcactgagccgcttcccagtgtg
attgtgctgagcgcaggccggaagatggcggctgcggctgcggcggcctcgggccccggc
tgctcctcggcggcgggggcgggggcggccggggtctcagagtggctggtgctgcgggac
ggctgcatgcactgcgacgccgacgggctgcacagcctgtcctaccaccctgcgctcaac
gccatcctggccgtcactagccgcgggaccatcaaagtcatcgacggcacctcgggggcc
acactgcaggcctccgcgctcagtgctaaaccaggtggacaggtgaaatgtcagtatatc
tctgctgtggataaagttatatttgtggatgattatgcagtagggtgtaggaaggacctt
aatggaatcttgttgttagacactgctctgcaaactccagtttcaaagcaggatgatgtg
gttcagcttgaattacccgttacagaggcacagcagctcttatcagcatgtttagaaaag
gtagatatttctagtacagagggttatgatttgttcatcacacagctcaaagatggttta
aaaaatacatctcatgagactgcagcaaaccacaaagttgctaagtgggccacagttaca
tttcatcttcctcatcatgtgttgaagtccattgccagtgccattgtaaatgaactcaag
aaaataaatcaaaatgttgctgccttacctgtggcgtcctcagtgatggacagattgtct
tacctcttacctagtgcacgtccagaactcggagtggggccaggccgttctgtagacaga
tcactgatgtatagtgaagctaacagacgggagacatttacctcatggcctcatgtaggc
tataggtgggcacaaccagatcccatggctcaagctggattttatcatcagcctgcctca
tctggagatgatagagccatgtgttttacttgtagtgtatgcctcgtttgttgggaacct
actgatgaaccttggtctgaacacgaaagacattccccaaactgcccatttgtgaaaggt
gagcacacacagaatgtgccattgtcagtcactcttgcaacaagtcctgcacagtttcct
tgtacggatggaactgacagaatatcttgctttgggtcggggagctgccctcattttcta
gctgctgcaactaaacgaggaaagatctgcatatgggatgtttccaaacttatgaaggtg
cacttaaagtttgaaattaatgcctatgatccagcaattgtacaacagcttattctatca
ggagacccaagctcaggagttgattcaaggagaccaactttggcgtggctggaggactcc
tctagttgctcagatataccaaaattggaaggagatagtgatgatttactggaggattca
gacagtgaagagcattccagatcagattctgtgacagggcatacatcacagaaggaagcc
atggaagtaagccttgatataacagcactcagcattctccaacagccagaaaaacttcag
tgggagattgttgcaaatgtgcttgaagatactgttaaggatcttgaagaacttggggca
aatccttgtttaacaaactctaagagtgaaaagacaaaggaaaagcaccaggagcaacac
aacattccttttccatgtttattagctggaggtttattaacatataaatctcctgctacc
tcacccattagtagtaattctcacaggtcactggatggtttaagcagaactcagggtgaa
agtatatcagaacaagggtcaactgacaatgaatcctgcactaattcagaactaaattct
cctctggtaaggaggactttaccggttttgcttctttatagcatcaaggaatctgatgag
aaagcaggaaagatcttttcacagatgaacaatattatgagtaaaagtttgcatgatgat
ggttttactgttccacagattattgaaatggagctggatagtcaggagcagttgttattg
caggatcctcctgtgacttacattcagcaatttgcagatgcagcagccaaccttacctct
ccggattctgagaagtggaactctgtgtttcccaagcctgggactttggttcagtgcttg
aggctgccaaagtttgcagaggaggagaatctttgtatagactcaataactccttgtgct
gacggaattcatttgttggtaggactgcggacatgccctgttgaatccttgagtgcaata
aatcaagtagaggccttgaataatttaaataaattaaactctgcactatgtaatagacgg
aaaggtgagctggaatcaaatcttgctgtagtgaatggtgcaaatattagtgtaatccaa
catgaatcaccagcagatgtacagactcctttaataattcagcctgagcagaggaatgtt
agtggtggatatttagtgctttataaaatgaattatgccactcggatagtgactttagaa
gaggagccaataaaaatacaacatatcaaagatccccaggacacaattacctcgctcatt
ttgcttccacccgatatattggataatcgagaggatgactgtgaggaacctattgaggac
atgcagttaacctcaaagaatggttttgagagagaaaaaacgtctgacatttctactctt
ggacacctggtaataaccactcagggaggatatgtaaaaatactagatctttcaaacttt
gaaattttggccaaagtggagcctcccaaaaaggagggcactgaggaacaggacacattt
gtttctgtgatttactgttctggcacagacaggctgtgtgcatgcaccaaaggtggtgag
cttcattttctccaaattggaggaacctgtgatgatattgatgaagctgatatactagtg
gatggatctctttctaaaggaatagaaccatcttcagaaggttccaaacctttatcaaat
ccttcaagtcctggcatttcaggagttgatttattggtggaccagccattcacccttgaa
atcttgacatccctagtggagctaacccgctttgagactttgactccaaggttttcagcg
actgttcctccatgctgggtagaagttcaacaagaacagcagcaaaggaggcatcctcaa
catttgcatcagcaacaccatggtgatgctgctcagcatactcgaacttggaaactacag
accgacagcaacagctgggatgaacatgtatttgaattagtactacctaaagcttgtatg
gttggacatgtggacttcaaattcgttttgaactcaaacatcaccaatattccacagata
caagtgacactgctgaaaaataaagctccaggattagggaaagtcaatgctcttaacatt
gaagtggaacaaaatgggaaaccgtccctggttgatttgaatgaagaaatgcagcacatg
gatgtagaggaatcacagtgtcttagattatgtccatttttggaggatcataaagaagac
attctatgtgggccagtatggcttgctagtggccttgatctatcagggcatgctggaatg
ttgacgttaacaagccccaaacttgttaaaggtatggcaggaggaaaatatcgttcgttt
ttaatccatgtcaaggcagtgaatgaaagaggaacagaagagatttgtaatggtggtatg
cgtcctgtagtaaggcttccatccctaaaacaccagagtaacaagggttattcacttgct
tcacttttggctaaagttgcagcaggcaaggaaaaatcatctaatgttaagaatgaaaat
acaagtggcacccgtaaatctgaaaacctccggggctgtgatttacttcaagaggtctca
gtcaccattcgaagatttaagaaaacctcaatttctaaggaaagagtgcaacgatgtgcc
atgttacagttttcagaatttcatgagaagcttcttaatactctttgcagaaaaacagat
gatggccagatcacagaacatgcccagagccttgtgttggatactctctgttggttagct
ggagttcattcaaatggacccggaagctcaaaggaaggaaatgagaacctactttcaaaa
acacgaaaatttctgtcagacatcgtacgtgtttgcttctttgaggcaggacgaagtata
gcccataagtgtgcccgatttctagccttgtgcattagtaatggcaaatgtgacccatgt
caaccagcatttggacctgttctgttgaaggctttacttgataatatgtcatttttacct
gcagcaacaactggtggttctgtctattggtattttgtcttactgaattatgtgaaagat
gaagatctggctggatgcagtacagcttgtgcatctttgcttactgcagtgtccagacag
ttacaggacaggctaacaccaatggaggctttacttcagacaagatatggattatatagc
tcaccatttgatccagtcctctttgatttggagatgagtggctcttcttgtaaaaatgtt
tataacagcagcattggtgtccagtcagatgaaattgatttatcagatgtcctttcagga
aatggaaaggtcagtagttgcacagctgctgagggtagtttcacatctctcactggactt
ttggaagttgaacctctgcactttacttgtgtgtcaactagtgatggaaccagaatagaa
agggatgatgcaatgagttccttcggggttactcctgcagtaggtggactatcatctggg
acagttggggaagcctcgacagccctgagttcagcagcccaggtagctttgcagtctctc
tctcatgcaatggcttcagccgagcaacagctacaggtgctgcaagagaaacagcagcag
cttttgaagcttcagcaacagaaagcaaagctggaagccaagttacatcagacaacagct
gcagcagctgcagcagcatcagcagtaggtcctgttcacaactctgtgccttccaaccca
gtggctgcccctggattcttcattcatccatctgatgttattccacccactccaaaaaca
acacctctttttatgactccaccactcactccacccaatgaagcagtttccgttgtgatt
aatgccgaacttgcacagcttttcccaggctcagtcattgatcccccagcagtcaatctt
gctgcacataacaaaaattccaacaagtccagaatgaatccacttggttctggtctagcc
cttgcaatttctcatgcttcacattttcttcaacctccgcctcaccagtccattattata
gagcgaatgcattcaggagcaagaagatttgtgaccttggattttgggaggcctatattg
ttgactgatgtattgattcccacttgtggagacttggcctctttgtcaattgacatttgg
acattaggagaagaggtggatggaaggcggttggtagtggcaactgatataagcactcat
tcactaattcttcatgacttaataccacctcccgtgtgcagattcatgaagatcactgtt
attggacgttacgggagtacaaatgccagagccaaaatcccattaggattttactatggt
catacctacatcttgccttgggaaagtgaactgaagttaatgcatgatcctctaaaggga
gagggagaatctgcaaaccagccagaaattgaccagcatttagcaatgatggttgctttg
caggaggatatacagtgcaggtataacttggcttgtcatcgtctggaaacccttttgcaa
agtattgatcttcctcctctaaacagtgctaacaatgcacagtactttttacgaaaacca
gataaggcagttgaggaagacagtagggttttttctgcttatcaagattgtattcagcta
cagcttcaactaaatttggctcataatgcagtgcagaggctcaaagtggcgctaggtgca
agccggaagatgttgagtgaaacatcaaatccagaagatttaattcagacatcttccaca
gagcagttacgtactatcatcagatatttactggacactttgctcagcctgcttcatgct
tctaatggacactctgttcctgcagttttgcagagcacatttcatgcccaggcctgtgaa
gagctctttaaacacttgtgcatcagtggaaccccaaagatacggttacatactggtctt
cttcttgttcaactgtgtggtggtgaaaggtggtggggtcaatttctttctaatgtcctt
caggaattgtacaattcggaacagcttctcatctttccacaggatagggtcttcatgtta
ctttcctgcattggtcaaagatcacttagtaatagtggagtattagaaagcttacttaat
ctcttggataatttattgtcacctcttcagccacagttacccatgcataggaggacagaa
ggagtactagatattcccatgatcagttgggttgttatgctggtgtccaggttgctggat
tatgtggcaactgttgaagatgaagcagcagctgcaaagaaacctttgaatggtaatcag
tggagttttattaacaataatctacacactcagagcttaaatagatcttctaaaggcagc
agtagccttgatagattatattccagaaaaatcagaaagcagcttgttcatcataaacag
caacttaacctactaaaagcaaagcagaaggcattggtagaacagatggaaaaagaaaaa
atacaaagtaacaaaggatcatcatataaactcctggtagaacaagcaaaactaaagcag
gccacttcaaagcactttaaggatttaattcgtttacgtcggacagcagaatggtcccgt
tctaatttagacacagaagttacaacagcaaaagaaagtcctgagatagaaccacttcca
tttactctggcccatgagcgttgtatctcagtagtccagaaacttgttctgtttcttctc
tccatggactttacatgtcatgcagatctcttattgtttgtttgtaaggttcttgcacgc
attgcaaatgccacgaggccaactattcatctgtgtgagattgtgaacgaaccccagctg
gaaagactgctgttacttttggttggaactgacttcaatagaggagatatatcttggggt
ggtgcttgggctcagtattccttaacttgcatgctacaagatattttagcaggagaatta
ctggctccagtagccgcagaagccatggaggaaggaacagtgggtgatgatgtaggtgcg
acagctggtgactctgatgactcccttcaacagtcctcagttcagttgctggaaactata
gatgaacctttgacacatgacataacaggtgcacctcctctgtcctctttggaaaaagat
aaagaaattgaccttgagttacttcaggatctaatggaagttgacattgatcctttagat
attgatttggaaaaggaccctcttgcagccaaggtttttaagccaataagcagtacatgg
tatgattattggggtgctgattatgggacctacaattacaacccttacattggaggtctg
ggaattcctgtagcaaagccaccagcaaacacggagaagaacggatcacagacagttagc
gtttcagtctctcaggccctggatgctcgcctagaagttggacttgaacagcaagcagaa
ctgatgttgaaaatgatgtctactctggaggcagattccattttacaggcattaacaaat
acatctcctacattatcacagtctcccactggaacagatgattcacttctagggggttta
caagcagcaaaccaaaccagccagcttattatacagttatcatctgtcccaatgttaaat
gtttgtttcaacaaacttttttccatgcttcaagtccatcatgttcagttggagtcactt
ctccaattgtggctcacactgagcctgaattctagttcaactggaaacaaagaaaatgga
gcagacatatttttatataatgctaataggatacctgttatttcattaaatcaagcatca
ataactagctttctcacagtgttagcttggtatcccaatactttgctccggacatggtgc
cttgtgcttcatagcctaacactcatgacaaacatgcagcttaattctggttccagcagt
gccattggaactcaggagagtactgctcatttgttggtttcagatccaaacctaattcat
gtattagtgaaatttctttctggcaccagtccacatggaacaaatcaacacagtccacag
gttggtcctacagctacacaagctatgcaagaatttcttactcgattacaagtgcatctt
tcttcaacatgtcctcagatattcagtgaatttttgctcaagctaattcatatactttca
actgaaaggggtgctttccagacaggccaaggacctctcgatgcccaagtgaagctctta
gaattcactctggagcagaattttgaagtcgtttcagttagtactatttctgccgtgata
gaatcggttacatttttagtgcaccactatatcacttgctcagacaaagtaatgtcaaga
agtggatcagatagctccgtgggtgctcgagcatgctttgggggactctttgccaatctt
attcgtccgggtgatgcaaaagcagtttgtggcgaaatgacaagagatcaactcatgttt
gatttgttaaaacttgttaacattttagtgcagctgcctctttcaggcaatagggaatac
agtgcaagagtgtctgtgaccacaaatacaacagatagtgtttcagatgaagaaaaagtc
tcaggaggcaaagatggcaatggaagcagtaccagtgttcaaggatcgcctgcatatgtt
gctgacttagtcttagccaaccaacaaattatgagccagattttgtctgctctgggcctg
tgtaatagcagtgccatggcaatgataattggagcaagtggattacatctcactaaacat
gaaaactttcatggtgggttggatgccatatcagttggggatggattatttaccatactg
acaacccttagtaaaaaagcttctacagtccacatgatgctgcagccaattttaacatac
atggcctgtggatatatgggcagacaaggctctcttgctacttgccagttatctgagcca
ttattgtggttcattttgagagtattggatactagtgatgccttgaaagcatttcatgat
atgggtggtgttcagctcatatgcaataatatggttactagtacaagggctattgtgaac
actgcaagaagtatggtatcaactattatgaaatttcttgactctggtccaaataaagct
gttgacagcacattgaaaacaagaatactagcttctgagcctgacaatgctgaagggatt
cataactttgcacccctcggtacaatcacatctagcagtcctactgcccaaccagctgaa
gtgctattgcaggccacacctcctcacagaagagctcgctctgctgcttggtcctacatc
tttcttccagaggaggcttggtgtgaccttaccattcaccttcctgcagcagtgctgctt
aaggagatacatatccagcctcatcttgcatctcttgcaacctgcccttcctcagtgtct
gttgaagtaagtgcagatggggtaaatatgctacctttgtccactcctgttgtcacaagt
ggcctcacctacataaaaattcagcttgtaaaagccgaagtagcttctgctgtctgcctt
agactacatcgtccacgggatgccagcacattaggcctttcacaaattaaattattgggg
ctcactgcttttggtaccacctcttctgcaacagttaataatccattccttccatctgaa
gatcaggtatccaaaacaagtattggatggttacggttattacatcattgccttactcac
ataagtgatctagaaggaatgatggcaagtgcagctgcacctactgctaatctgctgcag
acttgtgcggccttattgatgtcaccttactgtggaatgcattcacccaacatcgaggtt
gtgcttgtaaagataggactgcagtctactagaattggcctgaagctcatagacattctc
ctgagaaattgtgcagcatcaggcagtgatcctacagatttgaatagtcctttacttttt
ggaagactaaatggactctcttctgactctacgatagatattctttaccagcttggaaca
actcaggatcctggtacaaaagacagaattcaggccttgttaaaatgggttagtgattct
gcaagagtggctgctatgaagagaagtggcaggatgaactacatgtgtcctaactcctca
acagtagagtatggtcttctgatgccatctccttctcatttgcactgtgtagcagccatt
ctgtggcatagttatgagctgcttgtagaatatgacttaccagcactcctggaccaagag
ctctttgagttactttttaattggtccatgtctcttccctgcaatatggttttgaagaaa
gctgttgacagtctactttgctcaatgtgtcacgtacacccaaactatttttctttgctc
atgggctggatgggaattacccctcctccagtgcaatgtcatcatagactgtccatgaca
gatgatagcaaaaagcaggatcttagttcatctttaacagatgactctaaaaatgcacaa
gcacctctcgcattaactgaatcacatttggctacccttgcttcctcttctcaatctcct
gaagctattaaacaattactagactcaggtttgccttctcttcttgtgaggagtctggct
agtttctgctttagccacatttctagctcagaaagcattgcccagtcaatagatatttcc
caggacaaactcaggcgccatcatgtcccacaacaatgtaataagatgcctatcacagcc
gacctagttgctcctattcttaggtttttgacagaagttggcaatagccatattatgaaa
gattggcttggtggttctgaagtcaatccactatggacagcacttctgtttttattgtgt
cactctgggtccacttctggaagccataatttaggtgcacaacagaccagtgcaagatca
gcttctctttcttcagctgctacaacaggactgactactcaacagcgcacagcaattgag
aatgcaactgttgcgttctttctacagtgcatttcatgccatcctaataatcaaaagctg
atggcacaggttctttgtgaactatttcagacatctcctcaaagagggaaccttccaaca
tctgggaacatttcagggtttatacgaagattatttttacagttgatgctggaagatgag
aaagtgacaatgtttcttcagtctccatgtccactgtacaaaggtagaattaatgctact
agccacgtcatccagcatccaatgtatggagcaggccacaaattccgtactcttcatttg
ccagtctcaacaacattatcagatgttcttgacagagtgtcagatactccaagtatcaca
gctaaattaattagtgaacaaaaagatgacaaagaaaagaaaaaccatgaagagaaagaa
aaagttaaagcggaaaatggatttcaagacaattacagtgttgttgttgcctctgggctg
aagtctcaatctaaacgtgctgtgtcagctacaccacctcgcccaccatccaggaggggg
aggacaatacctgataaaataggaagtacttcaggagcagaggctgccaacaaaataatt
actgtcccagtgtttcacctgtttcacaaactcttggcaggccagccattgccagctgaa
atgacacttgcccagcttttaactctcctatatgaccgaaaacttcctcagggttaccgc
tcaatagatctgactgttaaattgggatcaagagttataacagaccccagtctatcaaaa
acagattcttataaaagactacaccctgaaaaagatcatggagacttacttgctagctgt
ccagaagatgaggctctcactccaggtgatgaatgcatggatgggatactggatgaatct
ttgcttgaaacctgtccaattcagtcaccattacaagtttttgcaggaatgggtggactg
gctcttattgctgaaagactacccatgctatatccagaagtaattcaacaggtgagtgct
ccagttgtaacatctaccactcaggaaaagccgaaggatagcgatcagtttgaatgggtg
accattgaacagtcaggggagttagtttatgaagcaccagaaactgttgcggctgaacct
ccacctatcaagtcagcagtacagaccatgtctcccatacctgcccattctttggctgct
tttggattatttcttcgtcttccgggctatgcggaagtgctactgaaagagagaaaacat
gcccagtgccttcttcgattggtattgggagtgacagatgatggagaaggaagtcatatt
cttcaatctccatcagccaatgtgcttccaacccttcctttccacgtccttcgtagcttg
tttagcactacacctttgacaactgatgatggtgtacttctaaggcggatggcattggaa
attggagccttacacctcattcttgtctgtctctctgctttgagccaccattccccacga
gttccaaactctagcgtgaatcaaactgagccacaggtgtcaagctctcataaccctaca
tcaacagaagaacaacagttatattgggccaaagggactggctttggaacaggctctaca
gcttctgggtgggatgtggaacaagccttaactaagcaaaggctggaagaggaacatgtt
acctgccttctgcaggttcttgccagttacataaatcccgtcagtagtgcggtaaatgga
gaagctcagtcatctcatgagactagagggcagaacagtaatgcccttccttctgtactt
ctcgagcttctcagtcagtcctgcctcatcccagccatgtcatcttatctacgaaatgat
tcagttctggacatggcaagacatgtgccactctatcgggcactgctggaattgcttcgg
gccattgcttcttgtgctgccatggtgcccctattgttgcccctttctacagagaacggt
gaagaggaagaagaacagtcagaatgtcaaacttctgttggtacattgttagccaaaatg
aagacctgtgttgatacctataccaaccgtttaagatctaaaagggaaaatgttaaaaca
ggagtaaaaccagatgcgtctgatcaagaaccagaaggacttactcttttggtaccagac
atccaaaagactgctgagatagtttatgcagccaccaccagtttgcggcaagcaaatcag
gaaaaaaaactgggtgaatactccaagaaggcggctatgaaacccaaacctttgtcagta
ttaaagtcacttgaagaaaaatatgtggctgttatgaagaaattacagtttgatacgttt
gaaatggtttctgaagatgaagatgggaaattgggatttaaagtaaattaccactacatg
tctcaggtgaaaaatgctaatgatgcgaacagtgctgccagagctcgccgccttgcccag
gaagctgtgacgctttcaacctcactgcctctgtcttcatcctctagtgtgtttgtacgc
tgtgatgaggagcgacttgatatcatgaaggttctaataactggtccagcggacacccct
tatgcaaatggctgctttgagtttgatgtgtattttcctcaagattatcccagttcaccc
cctcttgtgaatctagagacaactggtggtcatagcgtgcgattcaatccaaacctttat
aatgatggcaaggtttgtttaagcatcttaaacacgtggcatggaagaccagaagagaag
tggaatcctcagacctcaagctttttgcaagtgttggtgtctgtccagtcccttatatta
gtagctgagccttattttaatgaaccgggatatgaacggtctagaggcactcccagtggc
acacagagttctcgagaatatgatggaaacattcgacaagcaacagttaagtgggcaatg
ctagaacaaatcagaaacccttcaccatgttttaaagaggtaatacacaaacatttttac
ttgaaaagagttgagataatggcccaatgtgaggagtggattgcggatatccagcagtac
agcagtgataagcgggtaggcaggactatgtctcaccatgcagcagctctcaagcgtcac
actgctcagctccgcgaagagttgctgaaacttccctgccctgaaggcttggatcctgac
actgacgatgccccagaggtgtgcagagccacaacaggtgctgaggagactctaatgcat
gatcaggttaaacccagcagcagcaaagaactccccagtgacttccagttatga

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