KEGG   Homo sapiens (human): 332Help
Entry
332               CDS       T01001                                 

Gene name
BIRC5, API4, EPR-1
Definition
(RefSeq) baculoviral IAP repeat containing 5
  KO
K08731  baculoviral IAP repeat-containing protein 5
Organism
hsa  Homo sapiens (human)
Pathway
hsa01524  Platinum drug resistance
hsa04210  Apoptosis
hsa04215  Apoptosis - multiple species
hsa04390  Hippo signaling pathway
hsa05161  Hepatitis B
hsa05200  Pathways in cancer
hsa05210  Colorectal cancer
Network
nt06131  Apoptosis (virus)
nt06162  Hepatitis B virus (HBV)
nt06215  WNT signaling
nt06260  Colorectal cancer
nt06261  Gastric cancer
nt06263  Hepatocellular carcinoma
nt06271  Endometrial cancer
  Element
N00057  Mutation-inactivated APC to Wnt signaling pathway
N00058  Mutation-activated CTNNB1 to Wnt signaling pathway
N00533  HBV HBx to Crosstalk between extrinsic and intrinsic apoptotic pathways
Drug target
Gataparsen (DG01431): D09909 D09910
Sepantronium bromide: D10164
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04390 Hippo signaling pathway
    332 (BIRC5)
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    332 (BIRC5)
   04215 Apoptosis - multiple species
    332 (BIRC5)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    332 (BIRC5)
  09162 Cancer: specific types
   05210 Colorectal cancer
    332 (BIRC5)
  09172 Infectious disease: viral
   05161 Hepatitis B
    332 (BIRC5)
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    332 (BIRC5)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    332 (BIRC5)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic Type
  Centromeric chromatin formation proteins
   Kinetochore proteins
    CPC (chromosomal passenger complex)
     332 (BIRC5)
  Centrosome formation and ciliogenesis proteins
   Other centriole associated proteins
    332 (BIRC5)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: BIR
Motif
Other DBs
NCBI-GeneID: 332
NCBI-ProteinID: NP_001159
OMIM: 603352
HGNC: 593
Ensembl: ENSG00000089685
Vega: OTTHUMG00000177505
Pharos: O15392(Tchem)
UniProt: O15392 A0A0B4J1S3
LinkDB All DBs
Structure
PDB: 

Position
17q25.3
AA seq 142 aa AA seqDB search
MGAPTLPPAWQPFLKDHRISTFKNWPFLEGCACTPERMAEAGFIHCPTENEPDLAQCFFC
FKELEGWEPDDDPIEEHKKHSSGCAFLSVKKQFEELTLGEFLKLDRERAKNKIAKETNNK
KKEFEETAEKVRRAIEQLAAMD
NT seq 429 nt NT seq  +upstreamnt  +downstreamnt
atgggtgccccgacgttgccccctgcctggcagccctttctcaaggaccaccgcatctct
acattcaagaactggcccttcttggagggctgcgcctgcaccccggagcggatggccgag
gctggcttcatccactgccccactgagaacgagccagacttggcccagtgtttcttctgc
ttcaaggagctggaaggctgggagccagatgacgaccccatagaggaacataaaaagcat
tcgtccggttgcgctttcctttctgtcaagaagcagtttgaagaattaacccttggtgaa
tttttgaaactggacagagaaagagccaagaacaaaattgcaaaggaaaccaacaataag
aagaaagaatttgaggaaactgcggagaaagtgcgccgtgccatcgagcagctggctgcc
atggattga

KEGG   Homo sapiens (human): 57448Help
Entry
57448             CDS       T01001                                 

Gene name
BIRC6, APOLLON, BRUCE
Definition
(RefSeq) baculoviral IAP repeat containing 6
  KO
K10586  baculoviral IAP repeat-containing protein 6 (apollon) [EC:2.3.2.23]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04120  Ubiquitin mediated proteolysis
hsa04215  Apoptosis - multiple species
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    57448 (BIRC6)
 09140 Cellular Processes
  09143 Cell growth and death
   04215 Apoptosis - multiple species
    57448 (BIRC6)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system [BR:hsa04121]
    57448 (BIRC6)
Enzymes [BR:hsa01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.23  E2 ubiquitin-conjugating enzyme
     57448 (BIRC6)
Ubiquitin system [BR:hsa04121]
 Ubiquitin-conjugating enzymes (E2)
  Ubiquitin-conjugating enzymes
   57448 (BIRC6)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: BIRC6 UQ_con BIR UEV
Motif
Other DBs
NCBI-GeneID: 57448
NCBI-ProteinID: NP_057336
OMIM: 605638
HGNC: 13516
Ensembl: ENSG00000115760
Vega: OTTHUMG00000150528
Pharos: Q9NR09(Tbio)
UniProt: Q9NR09
LinkDB All DBs
Structure
PDB: 

Position
2p22.3
AA seq 4857 aa AA seqDB search
MVTGGGAAPPGTVTEPLPSVIVLSAGRKMAAAAAAASGPGCSSAAGAGAAGVSEWLVLRD
GCMHCDADGLHSLSYHPALNAILAVTSRGTIKVIDGTSGATLQASALSAKPGGQVKCQYI
SAVDKVIFVDDYAVGCRKDLNGILLLDTALQTPVSKQDDVVQLELPVTEAQQLLSACLEK
VDISSTEGYDLFITQLKDGLKNTSHETAANHKVAKWATVTFHLPHHVLKSIASAIVNELK
KINQNVAALPVASSVMDRLSYLLPSARPELGVGPGRSVDRSLMYSEANRRETFTSWPHVG
YRWAQPDPMAQAGFYHQPASSGDDRAMCFTCSVCLVCWEPTDEPWSEHERHSPNCPFVKG
EHTQNVPLSVTLATSPAQFPCTDGTDRISCFGSGSCPHFLAAATKRGKICIWDVSKLMKV
HLKFEINAYDPAIVQQLILSGDPSSGVDSRRPTLAWLEDSSSCSDIPKLEGDSDDLLEDS
DSEEHSRSDSVTGHTSQKEAMEVSLDITALSILQQPEKLQWEIVANVLEDTVKDLEELGA
NPCLTNSKSEKTKEKHQEQHNIPFPCLLAGGLLTYKSPATSPISSNSHRSLDGLSRTQGE
SISEQGSTDNESCTNSELNSPLVRRTLPVLLLYSIKESDEKAGKIFSQMNNIMSKSLHDD
GFTVPQIIEMELDSQEQLLLQDPPVTYIQQFADAAANLTSPDSEKWNSVFPKPGTLVQCL
RLPKFAEEENLCIDSITPCADGIHLLVGLRTCPVESLSAINQVEALNNLNKLNSALCNRR
KGELESNLAVVNGANISVIQHESPADVQTPLIIQPEQRNVSGGYLVLYKMNYATRIVTLE
EEPIKIQHIKDPQDTITSLILLPPDILDNREDDCEEPIEDMQLTSKNGFEREKTSDISTL
GHLVITTQGGYVKILDLSNFEILAKVEPPKKEGTEEQDTFVSVIYCSGTDRLCACTKGGE
LHFLQIGGTCDDIDEADILVDGSLSKGIEPSSEGSKPLSNPSSPGISGVDLLVDQPFTLE
ILTSLVELTRFETLTPRFSATVPPCWVEVQQEQQQRRHPQHLHQQHHGDAAQHTRTWKLQ
TDSNSWDEHVFELVLPKACMVGHVDFKFVLNSNITNIPQIQVTLLKNKAPGLGKVNALNI
EVEQNGKPSLVDLNEEMQHMDVEESQCLRLCPFLEDHKEDILCGPVWLASGLDLSGHAGM
LTLTSPKLVKGMAGGKYRSFLIHVKAVNERGTEEICNGGMRPVVRLPSLKHQSNKGYSLA
SLLAKVAAGKEKSSNVKNENTSGTRKSENLRGCDLLQEVSVTIRRFKKTSISKERVQRCA
MLQFSEFHEKLLNTLCRKTDDGQITEHAQSLVLDTLCWLAGVHSNGPGSSKEGNENLLSK
TRKFLSDIVRVCFFEAGRSIAHKCARFLALCISNGKCDPCQPAFGPVLLKALLDNMSFLP
AATTGGSVYWYFVLLNYVKDEDLAGCSTACASLLTAVSRQLQDRLTPMEALLQTRYGLYS
SPFDPVLFDLEMSGSSCKNVYNSSIGVQSDEIDLSDVLSGNGKVSSCTAAEGSFTSLTGL
LEVEPLHFTCVSTSDGTRIERDDAMSSFGVTPAVGGLSSGTVGEASTALSSAAQVALQSL
SHAMASAEQQLQVLQEKQQQLLKLQQQKAKLEAKLHQTTAAAAAAASAVGPVHNSVPSNP
VAAPGFFIHPSDVIPPTPKTTPLFMTPPLTPPNEAVSVVINAELAQLFPGSVIDPPAVNL
AAHNKNSNKSRMNPLGSGLALAISHASHFLQPPPHQSIIIERMHSGARRFVTLDFGRPIL
LTDVLIPTCGDLASLSIDIWTLGEEVDGRRLVVATDISTHSLILHDLIPPPVCRFMKITV
IGRYGSTNARAKIPLGFYYGHTYILPWESELKLMHDPLKGEGESANQPEIDQHLAMMVAL
QEDIQCRYNLACHRLETLLQSIDLPPLNSANNAQYFLRKPDKAVEEDSRVFSAYQDCIQL
QLQLNLAHNAVQRLKVALGASRKMLSETSNPEDLIQTSSTEQLRTIIRYLLDTLLSLLHA
SNGHSVPAVLQSTFHAQACEELFKHLCISGTPKIRLHTGLLLVQLCGGERWWGQFLSNVL
QELYNSEQLLIFPQDRVFMLLSCIGQRSLSNSGVLESLLNLLDNLLSPLQPQLPMHRRTE
GVLDIPMISWVVMLVSRLLDYVATVEDEAAAAKKPLNGNQWSFINNNLHTQSLNRSSKGS
SSLDRLYSRKIRKQLVHHKQQLNLLKAKQKALVEQMEKEKIQSNKGSSYKLLVEQAKLKQ
ATSKHFKDLIRLRRTAEWSRSNLDTEVTTAKESPEIEPLPFTLAHERCISVVQKLVLFLL
SMDFTCHADLLLFVCKVLARIANATRPTIHLCEIVNEPQLERLLLLLVGTDFNRGDISWG
GAWAQYSLTCMLQDILAGELLAPVAAEAMEEGTVGDDVGATAGDSDDSLQQSSVQLLETI
DEPLTHDITGAPPLSSLEKDKEIDLELLQDLMEVDIDPLDIDLEKDPLAAKVFKPISSTW
YDYWGADYGTYNYNPYIGGLGIPVAKPPANTEKNGSQTVSVSVSQALDARLEVGLEQQAE
LMLKMMSTLEADSILQALTNTSPTLSQSPTGTDDSLLGGLQAANQTSQLIIQLSSVPMLN
VCFNKLFSMLQVHHVQLESLLQLWLTLSLNSSSTGNKENGADIFLYNANRIPVISLNQAS
ITSFLTVLAWYPNTLLRTWCLVLHSLTLMTNMQLNSGSSSAIGTQESTAHLLVSDPNLIH
VLVKFLSGTSPHGTNQHSPQVGPTATQAMQEFLTRLQVHLSSTCPQIFSEFLLKLIHILS
TERGAFQTGQGPLDAQVKLLEFTLEQNFEVVSVSTISAVIESVTFLVHHYITCSDKVMSR
SGSDSSVGARACFGGLFANLIRPGDAKAVCGEMTRDQLMFDLLKLVNILVQLPLSGNREY
SARVSVTTNTTDSVSDEEKVSGGKDGNGSSTSVQGSPAYVADLVLANQQIMSQILSALGL
CNSSAMAMIIGASGLHLTKHENFHGGLDAISVGDGLFTILTTLSKKASTVHMMLQPILTY
MACGYMGRQGSLATCQLSEPLLWFILRVLDTSDALKAFHDMGGVQLICNNMVTSTRAIVN
TARSMVSTIMKFLDSGPNKAVDSTLKTRILASEPDNAEGIHNFAPLGTITSSSPTAQPAE
VLLQATPPHRRARSAAWSYIFLPEEAWCDLTIHLPAAVLLKEIHIQPHLASLATCPSSVS
VEVSADGVNMLPLSTPVVTSGLTYIKIQLVKAEVASAVCLRLHRPRDASTLGLSQIKLLG
LTAFGTTSSATVNNPFLPSEDQVSKTSIGWLRLLHHCLTHISDLEGMMASAAAPTANLLQ
TCAALLMSPYCGMHSPNIEVVLVKIGLQSTRIGLKLIDILLRNCAASGSDPTDLNSPLLF
GRLNGLSSDSTIDILYQLGTTQDPGTKDRIQALLKWVSDSARVAAMKRSGRMNYMCPNSS
TVEYGLLMPSPSHLHCVAAILWHSYELLVEYDLPALLDQELFELLFNWSMSLPCNMVLKK
AVDSLLCSMCHVHPNYFSLLMGWMGITPPPVQCHHRLSMTDDSKKQDLSSSLTDDSKNAQ
APLALTESHLATLASSSQSPEAIKQLLDSGLPSLLVRSLASFCFSHISSSESIAQSIDIS
QDKLRRHHVPQQCNKMPITADLVAPILRFLTEVGNSHIMKDWLGGSEVNPLWTALLFLLC
HSGSTSGSHNLGAQQTSARSASLSSAATTGLTTQQRTAIENATVAFFLQCISCHPNNQKL
MAQVLCELFQTSPQRGNLPTSGNISGFIRRLFLQLMLEDEKVTMFLQSPCPLYKGRINAT
SHVIQHPMYGAGHKFRTLHLPVSTTLSDVLDRVSDTPSITAKLISEQKDDKEKKNHEEKE
KVKAENGFQDNYSVVVASGLKSQSKRAVSATPPRPPSRRGRTIPDKIGSTSGAEAANKII
TVPVFHLFHKLLAGQPLPAEMTLAQLLTLLYDRKLPQGYRSIDLTVKLGSRVITDPSLSK
TDSYKRLHPEKDHGDLLASCPEDEALTPGDECMDGILDESLLETCPIQSPLQVFAGMGGL
ALIAERLPMLYPEVIQQVSAPVVTSTTQEKPKDSDQFEWVTIEQSGELVYEAPETVAAEP
PPIKSAVQTMSPIPAHSLAAFGLFLRLPGYAEVLLKERKHAQCLLRLVLGVTDDGEGSHI
LQSPSANVLPTLPFHVLRSLFSTTPLTTDDGVLLRRMALEIGALHLILVCLSALSHHSPR
VPNSSVNQTEPQVSSSHNPTSTEEQQLYWAKGTGFGTGSTASGWDVEQALTKQRLEEEHV
TCLLQVLASYINPVSSAVNGEAQSSHETRGQNSNALPSVLLELLSQSCLIPAMSSYLRND
SVLDMARHVPLYRALLELLRAIASCAAMVPLLLPLSTENGEEEEEQSECQTSVGTLLAKM
KTCVDTYTNRLRSKRENVKTGVKPDASDQEPEGLTLLVPDIQKTAEIVYAATTSLRQANQ
EKKLGEYSKKAAMKPKPLSVLKSLEEKYVAVMKKLQFDTFEMVSEDEDGKLGFKVNYHYM
SQVKNANDANSAARARRLAQEAVTLSTSLPLSSSSSVFVRCDEERLDIMKVLITGPADTP
YANGCFEFDVYFPQDYPSSPPLVNLETTGGHSVRFNPNLYNDGKVCLSILNTWHGRPEEK
WNPQTSSFLQVLVSVQSLILVAEPYFNEPGYERSRGTPSGTQSSREYDGNIRQATVKWAM
LEQIRNPSPCFKEVIHKHFYLKRVEIMAQCEEWIADIQQYSSDKRVGRTMSHHAAALKRH
TAQLREELLKLPCPEGLDPDTDDAPEVCRATTGAEETLMHDQVKPSSSKELPSDFQL
NT seq 14574 nt NT seq  +upstreamnt  +downstreamnt
atggtgactggtggtggtgctgcacctcccgggactgtcactgagccgcttcccagtgtg
attgtgctgagcgcaggccggaagatggcggctgcggctgcggcggcctcgggccccggc
tgctcctcggcggcgggggcgggggcggccggggtctcagagtggctggtgctgcgggac
ggctgcatgcactgcgacgccgacgggctgcacagcctgtcctaccaccctgcgctcaac
gccatcctggccgtcactagccgcgggaccatcaaagtcatcgacggcacctcgggggcc
acactgcaggcctccgcgctcagtgctaaaccaggtggacaggtgaaatgtcagtatatc
tctgctgtggataaagttatatttgtggatgattatgcagtagggtgtaggaaggacctt
aatggaatcttgttgttagacactgctctgcaaactccagtttcaaagcaggatgatgtg
gttcagcttgaattacccgttacagaggcacagcagctcttatcagcatgtttagaaaag
gtagatatttctagtacagagggttatgatttgttcatcacacagctcaaagatggttta
aaaaatacatctcatgagactgcagcaaaccacaaagttgctaagtgggccacagttaca
tttcatcttcctcatcatgtgttgaagtccattgccagtgccattgtaaatgaactcaag
aaaataaatcaaaatgttgctgccttacctgtggcgtcctcagtgatggacagattgtct
tacctcttacctagtgcacgtccagaactcggagtggggccaggccgttctgtagacaga
tcactgatgtatagtgaagctaacagacgggagacatttacctcatggcctcatgtaggc
tataggtgggcacaaccagatcccatggctcaagctggattttatcatcagcctgcctca
tctggagatgatagagccatgtgttttacttgtagtgtatgcctcgtttgttgggaacct
actgatgaaccttggtctgaacacgaaagacattccccaaactgcccatttgtgaaaggt
gagcacacacagaatgtgccattgtcagtcactcttgcaacaagtcctgcacagtttcct
tgtacggatggaactgacagaatatcttgctttgggtcggggagctgccctcattttcta
gctgctgcaactaaacgaggaaagatctgcatatgggatgtttccaaacttatgaaggtg
cacttaaagtttgaaattaatgcctatgatccagcaattgtacaacagcttattctatca
ggagacccaagctcaggagttgattcaaggagaccaactttggcgtggctggaggactcc
tctagttgctcagatataccaaaattggaaggagatagtgatgatttactggaggattca
gacagtgaagagcattccagatcagattctgtgacagggcatacatcacagaaggaagcc
atggaagtaagccttgatataacagcactcagcattctccaacagccagaaaaacttcag
tgggagattgttgcaaatgtgcttgaagatactgttaaggatcttgaagaacttggggca
aatccttgtttaacaaactctaagagtgaaaagacaaaggaaaagcaccaggagcaacac
aacattccttttccatgtttattagctggaggtttattaacatataaatctcctgctacc
tcacccattagtagtaattctcacaggtcactggatggtttaagcagaactcagggtgaa
agtatatcagaacaagggtcaactgacaatgaatcctgcactaattcagaactaaattct
cctctggtaaggaggactttaccggttttgcttctttatagcatcaaggaatctgatgag
aaagcaggaaagatcttttcacagatgaacaatattatgagtaaaagtttgcatgatgat
ggttttactgttccacagattattgaaatggagctggatagtcaggagcagttgttattg
caggatcctcctgtgacttacattcagcaatttgcagatgcagcagccaaccttacctct
ccggattctgagaagtggaactctgtgtttcccaagcctgggactttggttcagtgcttg
aggctgccaaagtttgcagaggaggagaatctttgtatagactcaataactccttgtgct
gacggaattcatttgttggtaggactgcggacatgccctgttgaatccttgagtgcaata
aatcaagtagaggccttgaataatttaaataaattaaactctgcactatgtaatagacgg
aaaggtgagctggaatcaaatcttgctgtagtgaatggtgcaaatattagtgtaatccaa
catgaatcaccagcagatgtacagactcctttaataattcagcctgagcagaggaatgtt
agtggtggatatttagtgctttataaaatgaattatgccactcggatagtgactttagaa
gaggagccaataaaaatacaacatatcaaagatccccaggacacaattacctcgctcatt
ttgcttccacccgatatattggataatcgagaggatgactgtgaggaacctattgaggac
atgcagttaacctcaaagaatggttttgagagagaaaaaacgtctgacatttctactctt
ggacacctggtaataaccactcagggaggatatgtaaaaatactagatctttcaaacttt
gaaattttggccaaagtggagcctcccaaaaaggagggcactgaggaacaggacacattt
gtttctgtgatttactgttctggcacagacaggctgtgtgcatgcaccaaaggtggtgag
cttcattttctccaaattggaggaacctgtgatgatattgatgaagctgatatactagtg
gatggatctctttctaaaggaatagaaccatcttcagaaggttccaaacctttatcaaat
ccttcaagtcctggcatttcaggagttgatttattggtggaccagccattcacccttgaa
atcttgacatccctagtggagctaacccgctttgagactttgactccaaggttttcagcg
actgttcctccatgctgggtagaagttcaacaagaacagcagcaaaggaggcatcctcaa
catttgcatcagcaacaccatggtgatgctgctcagcatactcgaacttggaaactacag
accgacagcaacagctgggatgaacatgtatttgaattagtactacctaaagcttgtatg
gttggacatgtggacttcaaattcgttttgaactcaaacatcaccaatattccacagata
caagtgacactgctgaaaaataaagctccaggattagggaaagtcaatgctcttaacatt
gaagtggaacaaaatgggaaaccgtccctggttgatttgaatgaagaaatgcagcacatg
gatgtagaggaatcacagtgtcttagattatgtccatttttggaggatcataaagaagac
attctatgtgggccagtatggcttgctagtggccttgatctatcagggcatgctggaatg
ttgacgttaacaagccccaaacttgttaaaggtatggcaggaggaaaatatcgttcgttt
ttaatccatgtcaaggcagtgaatgaaagaggaacagaagagatttgtaatggtggtatg
cgtcctgtagtaaggcttccatccctaaaacaccagagtaacaagggttattcacttgct
tcacttttggctaaagttgcagcaggcaaggaaaaatcatctaatgttaagaatgaaaat
acaagtggcacccgtaaatctgaaaacctccggggctgtgatttacttcaagaggtctca
gtcaccattcgaagatttaagaaaacctcaatttctaaggaaagagtgcaacgatgtgcc
atgttacagttttcagaatttcatgagaagcttcttaatactctttgcagaaaaacagat
gatggccagatcacagaacatgcccagagccttgtgttggatactctctgttggttagct
ggagttcattcaaatggacccggaagctcaaaggaaggaaatgagaacctactttcaaaa
acacgaaaatttctgtcagacatcgtacgtgtttgcttctttgaggcaggacgaagtata
gcccataagtgtgcccgatttctagccttgtgcattagtaatggcaaatgtgacccatgt
caaccagcatttggacctgttctgttgaaggctttacttgataatatgtcatttttacct
gcagcaacaactggtggttctgtctattggtattttgtcttactgaattatgtgaaagat
gaagatctggctggatgcagtacagcttgtgcatctttgcttactgcagtgtccagacag
ttacaggacaggctaacaccaatggaggctttacttcagacaagatatggattatatagc
tcaccatttgatccagtcctctttgatttggagatgagtggctcttcttgtaaaaatgtt
tataacagcagcattggtgtccagtcagatgaaattgatttatcagatgtcctttcagga
aatggaaaggtcagtagttgcacagctgctgagggtagtttcacatctctcactggactt
ttggaagttgaacctctgcactttacttgtgtgtcaactagtgatggaaccagaatagaa
agggatgatgcaatgagttccttcggggttactcctgcagtaggtggactatcatctggg
acagttggggaagcctcgacagccctgagttcagcagcccaggtagctttgcagtctctc
tctcatgcaatggcttcagccgagcaacagctacaggtgctgcaagagaaacagcagcag
cttttgaagcttcagcaacagaaagcaaagctggaagccaagttacatcagacaacagct
gcagcagctgcagcagcatcagcagtaggtcctgttcacaactctgtgccttccaaccca
gtggctgcccctggattcttcattcatccatctgatgttattccacccactccaaaaaca
acacctctttttatgactccaccactcactccacccaatgaagcagtttccgttgtgatt
aatgccgaacttgcacagcttttcccaggctcagtcattgatcccccagcagtcaatctt
gctgcacataacaaaaattccaacaagtccagaatgaatccacttggttctggtctagcc
cttgcaatttctcatgcttcacattttcttcaacctccgcctcaccagtccattattata
gagcgaatgcattcaggagcaagaagatttgtgaccttggattttgggaggcctatattg
ttgactgatgtattgattcccacttgtggagacttggcctctttgtcaattgacatttgg
acattaggagaagaggtggatggaaggcggttggtagtggcaactgatataagcactcat
tcactaattcttcatgacttaataccacctcccgtgtgcagattcatgaagatcactgtt
attggacgttacgggagtacaaatgccagagccaaaatcccattaggattttactatggt
catacctacatcttgccttgggaaagtgaactgaagttaatgcatgatcctctaaaggga
gagggagaatctgcaaaccagccagaaattgaccagcatttagcaatgatggttgctttg
caggaggatatacagtgcaggtataacttggcttgtcatcgtctggaaacccttttgcaa
agtattgatcttcctcctctaaacagtgctaacaatgcacagtactttttacgaaaacca
gataaggcagttgaggaagacagtagggttttttctgcttatcaagattgtattcagcta
cagcttcaactaaatttggctcataatgcagtgcagaggctcaaagtggcgctaggtgca
agccggaagatgttgagtgaaacatcaaatccagaagatttaattcagacatcttccaca
gagcagttacgtactatcatcagatatttactggacactttgctcagcctgcttcatgct
tctaatggacactctgttcctgcagttttgcagagcacatttcatgcccaggcctgtgaa
gagctctttaaacacttgtgcatcagtggaaccccaaagatacggttacatactggtctt
cttcttgttcaactgtgtggtggtgaaaggtggtggggtcaatttctttctaatgtcctt
caggaattgtacaattcggaacagcttctcatctttccacaggatagggtcttcatgtta
ctttcctgcattggtcaaagatcacttagtaatagtggagtattagaaagcttacttaat
ctcttggataatttattgtcacctcttcagccacagttacccatgcataggaggacagaa
ggagtactagatattcccatgatcagttgggttgttatgctggtgtccaggttgctggat
tatgtggcaactgttgaagatgaagcagcagctgcaaagaaacctttgaatggtaatcag
tggagttttattaacaataatctacacactcagagcttaaatagatcttctaaaggcagc
agtagccttgatagattatattccagaaaaatcagaaagcagcttgttcatcataaacag
caacttaacctactaaaagcaaagcagaaggcattggtagaacagatggaaaaagaaaaa
atacaaagtaacaaaggatcatcatataaactcctggtagaacaagcaaaactaaagcag
gccacttcaaagcactttaaggatttaattcgtttacgtcggacagcagaatggtcccgt
tctaatttagacacagaagttacaacagcaaaagaaagtcctgagatagaaccacttcca
tttactctggcccatgagcgttgtatctcagtagtccagaaacttgttctgtttcttctc
tccatggactttacatgtcatgcagatctcttattgtttgtttgtaaggttcttgcacgc
attgcaaatgccacgaggccaactattcatctgtgtgagattgtgaacgaaccccagctg
gaaagactgctgttacttttggttggaactgacttcaatagaggagatatatcttggggt
ggtgcttgggctcagtattccttaacttgcatgctacaagatattttagcaggagaatta
ctggctccagtagccgcagaagccatggaggaaggaacagtgggtgatgatgtaggtgcg
acagctggtgactctgatgactcccttcaacagtcctcagttcagttgctggaaactata
gatgaacctttgacacatgacataacaggtgcacctcctctgtcctctttggaaaaagat
aaagaaattgaccttgagttacttcaggatctaatggaagttgacattgatcctttagat
attgatttggaaaaggaccctcttgcagccaaggtttttaagccaataagcagtacatgg
tatgattattggggtgctgattatgggacctacaattacaacccttacattggaggtctg
ggaattcctgtagcaaagccaccagcaaacacggagaagaacggatcacagacagttagc
gtttcagtctctcaggccctggatgctcgcctagaagttggacttgaacagcaagcagaa
ctgatgttgaaaatgatgtctactctggaggcagattccattttacaggcattaacaaat
acatctcctacattatcacagtctcccactggaacagatgattcacttctagggggttta
caagcagcaaaccaaaccagccagcttattatacagttatcatctgtcccaatgttaaat
gtttgtttcaacaaacttttttccatgcttcaagtccatcatgttcagttggagtcactt
ctccaattgtggctcacactgagcctgaattctagttcaactggaaacaaagaaaatgga
gcagacatatttttatataatgctaataggatacctgttatttcattaaatcaagcatca
ataactagctttctcacagtgttagcttggtatcccaatactttgctccggacatggtgc
cttgtgcttcatagcctaacactcatgacaaacatgcagcttaattctggttccagcagt
gccattggaactcaggagagtactgctcatttgttggtttcagatccaaacctaattcat
gtattagtgaaatttctttctggcaccagtccacatggaacaaatcaacacagtccacag
gttggtcctacagctacacaagctatgcaagaatttcttactcgattacaagtgcatctt
tcttcaacatgtcctcagatattcagtgaatttttgctcaagctaattcatatactttca
actgaaaggggtgctttccagacaggccaaggacctctcgatgcccaagtgaagctctta
gaattcactctggagcagaattttgaagtcgtttcagttagtactatttctgccgtgata
gaatcggttacatttttagtgcaccactatatcacttgctcagacaaagtaatgtcaaga
agtggatcagatagctccgtgggtgctcgagcatgctttgggggactctttgccaatctt
attcgtccgggtgatgcaaaagcagtttgtggcgaaatgacaagagatcaactcatgttt
gatttgttaaaacttgttaacattttagtgcagctgcctctttcaggcaatagggaatac
agtgcaagagtgtctgtgaccacaaatacaacagatagtgtttcagatgaagaaaaagtc
tcaggaggcaaagatggcaatggaagcagtaccagtgttcaaggatcgcctgcatatgtt
gctgacttagtcttagccaaccaacaaattatgagccagattttgtctgctctgggcctg
tgtaatagcagtgccatggcaatgataattggagcaagtggattacatctcactaaacat
gaaaactttcatggtgggttggatgccatatcagttggggatggattatttaccatactg
acaacccttagtaaaaaagcttctacagtccacatgatgctgcagccaattttaacatac
atggcctgtggatatatgggcagacaaggctctcttgctacttgccagttatctgagcca
ttattgtggttcattttgagagtattggatactagtgatgccttgaaagcatttcatgat
atgggtggtgttcagctcatatgcaataatatggttactagtacaagggctattgtgaac
actgcaagaagtatggtatcaactattatgaaatttcttgactctggtccaaataaagct
gttgacagcacattgaaaacaagaatactagcttctgagcctgacaatgctgaagggatt
cataactttgcacccctcggtacaatcacatctagcagtcctactgcccaaccagctgaa
gtgctattgcaggccacacctcctcacagaagagctcgctctgctgcttggtcctacatc
tttcttccagaggaggcttggtgtgaccttaccattcaccttcctgcagcagtgctgctt
aaggagatacatatccagcctcatcttgcatctcttgcaacctgcccttcctcagtgtct
gttgaagtaagtgcagatggggtaaatatgctacctttgtccactcctgttgtcacaagt
ggcctcacctacataaaaattcagcttgtaaaagccgaagtagcttctgctgtctgcctt
agactacatcgtccacgggatgccagcacattaggcctttcacaaattaaattattgggg
ctcactgcttttggtaccacctcttctgcaacagttaataatccattccttccatctgaa
gatcaggtatccaaaacaagtattggatggttacggttattacatcattgccttactcac
ataagtgatctagaaggaatgatggcaagtgcagctgcacctactgctaatctgctgcag
acttgtgcggccttattgatgtcaccttactgtggaatgcattcacccaacatcgaggtt
gtgcttgtaaagataggactgcagtctactagaattggcctgaagctcatagacattctc
ctgagaaattgtgcagcatcaggcagtgatcctacagatttgaatagtcctttacttttt
ggaagactaaatggactctcttctgactctacgatagatattctttaccagcttggaaca
actcaggatcctggtacaaaagacagaattcaggccttgttaaaatgggttagtgattct
gcaagagtggctgctatgaagagaagtggcaggatgaactacatgtgtcctaactcctca
acagtagagtatggtcttctgatgccatctccttctcatttgcactgtgtagcagccatt
ctgtggcatagttatgagctgcttgtagaatatgacttaccagcactcctggaccaagag
ctctttgagttactttttaattggtccatgtctcttccctgcaatatggttttgaagaaa
gctgttgacagtctactttgctcaatgtgtcacgtacacccaaactatttttctttgctc
atgggctggatgggaattacccctcctccagtgcaatgtcatcatagactgtccatgaca
gatgatagcaaaaagcaggatcttagttcatctttaacagatgactctaaaaatgcacaa
gcacctctcgcattaactgaatcacatttggctacccttgcttcctcttctcaatctcct
gaagctattaaacaattactagactcaggtttgccttctcttcttgtgaggagtctggct
agtttctgctttagccacatttctagctcagaaagcattgcccagtcaatagatatttcc
caggacaaactcaggcgccatcatgtcccacaacaatgtaataagatgcctatcacagcc
gacctagttgctcctattcttaggtttttgacagaagttggcaatagccatattatgaaa
gattggcttggtggttctgaagtcaatccactatggacagcacttctgtttttattgtgt
cactctgggtccacttctggaagccataatttaggtgcacaacagaccagtgcaagatca
gcttctctttcttcagctgctacaacaggactgactactcaacagcgcacagcaattgag
aatgcaactgttgcgttctttctacagtgcatttcatgccatcctaataatcaaaagctg
atggcacaggttctttgtgaactatttcagacatctcctcaaagagggaaccttccaaca
tctgggaacatttcagggtttatacgaagattatttttacagttgatgctggaagatgag
aaagtgacaatgtttcttcagtctccatgtccactgtacaaaggtagaattaatgctact
agccacgtcatccagcatccaatgtatggagcaggccacaaattccgtactcttcatttg
ccagtctcaacaacattatcagatgttcttgacagagtgtcagatactccaagtatcaca
gctaaattaattagtgaacaaaaagatgacaaagaaaagaaaaaccatgaagagaaagaa
aaagttaaagcggaaaatggatttcaagacaattacagtgttgttgttgcctctgggctg
aagtctcaatctaaacgtgctgtgtcagctacaccacctcgcccaccatccaggaggggg
aggacaatacctgataaaataggaagtacttcaggagcagaggctgccaacaaaataatt
actgtcccagtgtttcacctgtttcacaaactcttggcaggccagccattgccagctgaa
atgacacttgcccagcttttaactctcctatatgaccgaaaacttcctcagggttaccgc
tcaatagatctgactgttaaattgggatcaagagttataacagaccccagtctatcaaaa
acagattcttataaaagactacaccctgaaaaagatcatggagacttacttgctagctgt
ccagaagatgaggctctcactccaggtgatgaatgcatggatgggatactggatgaatct
ttgcttgaaacctgtccaattcagtcaccattacaagtttttgcaggaatgggtggactg
gctcttattgctgaaagactacccatgctatatccagaagtaattcaacaggtgagtgct
ccagttgtaacatctaccactcaggaaaagccgaaggatagcgatcagtttgaatgggtg
accattgaacagtcaggggagttagtttatgaagcaccagaaactgttgcggctgaacct
ccacctatcaagtcagcagtacagaccatgtctcccatacctgcccattctttggctgct
tttggattatttcttcgtcttccgggctatgcggaagtgctactgaaagagagaaaacat
gcccagtgccttcttcgattggtattgggagtgacagatgatggagaaggaagtcatatt
cttcaatctccatcagccaatgtgcttccaacccttcctttccacgtccttcgtagcttg
tttagcactacacctttgacaactgatgatggtgtacttctaaggcggatggcattggaa
attggagccttacacctcattcttgtctgtctctctgctttgagccaccattccccacga
gttccaaactctagcgtgaatcaaactgagccacaggtgtcaagctctcataaccctaca
tcaacagaagaacaacagttatattgggccaaagggactggctttggaacaggctctaca
gcttctgggtgggatgtggaacaagccttaactaagcaaaggctggaagaggaacatgtt
acctgccttctgcaggttcttgccagttacataaatcccgtcagtagtgcggtaaatgga
gaagctcagtcatctcatgagactagagggcagaacagtaatgcccttccttctgtactt
ctcgagcttctcagtcagtcctgcctcatcccagccatgtcatcttatctacgaaatgat
tcagttctggacatggcaagacatgtgccactctatcgggcactgctggaattgcttcgg
gccattgcttcttgtgctgccatggtgcccctattgttgcccctttctacagagaacggt
gaagaggaagaagaacagtcagaatgtcaaacttctgttggtacattgttagccaaaatg
aagacctgtgttgatacctataccaaccgtttaagatctaaaagggaaaatgttaaaaca
ggagtaaaaccagatgcgtctgatcaagaaccagaaggacttactcttttggtaccagac
atccaaaagactgctgagatagtttatgcagccaccaccagtttgcggcaagcaaatcag
gaaaaaaaactgggtgaatactccaagaaggcggctatgaaacccaaacctttgtcagta
ttaaagtcacttgaagaaaaatatgtggctgttatgaagaaattacagtttgatacgttt
gaaatggtttctgaagatgaagatgggaaattgggatttaaagtaaattaccactacatg
tctcaggtgaaaaatgctaatgatgcgaacagtgctgccagagctcgccgccttgcccag
gaagctgtgacgctttcaacctcactgcctctgtcttcatcctctagtgtgtttgtacgc
tgtgatgaggagcgacttgatatcatgaaggttctaataactggtccagcggacacccct
tatgcaaatggctgctttgagtttgatgtgtattttcctcaagattatcccagttcaccc
cctcttgtgaatctagagacaactggtggtcatagcgtgcgattcaatccaaacctttat
aatgatggcaaggtttgtttaagcatcttaaacacgtggcatggaagaccagaagagaag
tggaatcctcagacctcaagctttttgcaagtgttggtgtctgtccagtcccttatatta
gtagctgagccttattttaatgaaccgggatatgaacggtctagaggcactcccagtggc
acacagagttctcgagaatatgatggaaacattcgacaagcaacagttaagtgggcaatg
ctagaacaaatcagaaacccttcaccatgttttaaagaggtaatacacaaacatttttac
ttgaaaagagttgagataatggcccaatgtgaggagtggattgcggatatccagcagtac
agcagtgataagcgggtaggcaggactatgtctcaccatgcagcagctctcaagcgtcac
actgctcagctccgcgaagagttgctgaaacttccctgccctgaaggcttggatcctgac
actgacgatgccccagaggtgtgcagagccacaacaggtgctgaggagactctaatgcat
gatcaggttaaacccagcagcagcaaagaactccccagtgacttccagttatga

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