Homo sapiens (human): 3423
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Entry
3423 CDS
T01001
Gene name
IDS, ID2S, MPS2, SIDS
Definition
(RefSeq) iduronate 2-sulfatase
KO
K01136
iduronate 2-sulfatase [EC:
3.1.6.13
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00531
Glycosaminoglycan degradation
hsa01100
Metabolic pathways
hsa04142
Lysosome
Module
hsa_M00076
Dermatan sulfate degradation
hsa_M00078
Heparan sulfate degradation
Network
nt06012
Glycosaminoglycan degradation
Element
N00610
Dermatan sulfate degradation
N00611
HYAL1 deficiency in dermatan sulfate degradation
N00612
ARSB deficiency in dermatan sulfate degradation
N00613
IDUA deficiency in dermatan sulfate degradation
N00614
IDS deficiency in dermatan sulfate degradation
N00615
Heparan sulfate degradation
N00616
GNS deficiency in heparan sulfate degradation
N00617
GUSB deficiency in heparan sulfate degradation
N00618
NAGLU deficiency in heparan sulfate degradation
N00619
HGSNAT deficiency in heparan sulfate degradation
N00620
SGSH deficiency in heparan sulfate degradation
N00621
IDUA deficiency in heparan sulfate degradation
N00622
IDS deficiency in heparan sulfate degradation
N10013
Replacement of deficient IDS
Disease
H00129
Mucopolysaccharidosis type II
H00421
Mucopolysaccharidosis
Drug target
Idursulfase:
D04499
<JP/US>
Idursulfase beta:
D11025
<JP>
Pabinafusp alfa:
D11812
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09107 Glycan biosynthesis and metabolism
00531 Glycosaminoglycan degradation
3423 (IDS)
09140 Cellular Processes
09141 Transport and catabolism
04142 Lysosome
3423 (IDS)
Enzymes [BR:
hsa01000
]
3. Hydrolases
3.1 Acting on ester bonds
3.1.6 Sulfuric-ester hydrolases
3.1.6.13 iduronate-2-sulfatase
3423 (IDS)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
Sulfatase
Phosphodiest
DUF229
Motif
Other DBs
NCBI-GeneID:
3423
NCBI-ProteinID:
NP_000193
OMIM:
300823
HGNC:
5389
Ensembl:
ENSG00000010404
Vega:
OTTHUMG00000022615
Pharos:
P22304
(Tbio)
UniProt:
P22304
LinkDB
All DBs
Structure
PDB:
5FQL
6IOZ
Thumbnails
Position
Xq28
AA seq
550 aa
AA seq
DB search
MPPPRTGRGLLWLGLVLSSVCVALGSETQANSTTDALNVLLIIVDDLRPSLGCYGDKLVR
SPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGRRPDTTRLYDFNSYWRVHAGNFSTIP
QYFKENGYVTMSVGKVFHPGISSNHTDDSPYSWSFPPYHPSSEKYENTKTCRGPDGELHA
NLLCPVDVLDVPEGTLPDKQSTEQAIQLLEKMKTSASPFFLAVGYHKPHIPFRYPKEFQK
LYPLENITLAPDPEVPDGLPPVAYNPWMDIRQREDVQALNISVPYGPIPVDFQRKIRQSY
FASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWALGEHGEWAKYSNFDVATHVPLI
FYVPGRTASLPEAGEKLFPYLDPFDSASQLMEPGRQSMDLVELVSLFPTLAGLAGLQVPP
RCPVPSFHVELCREGKNLLKHFRFRDLEEDPYLPGNPRELIAYSQYPRPSDIPQWNSDKP
SLKDIKIMGYSIRTIDYRYTVWVGFNPDEFLANFSDIHAGELYFVDSDPLQDHNMYNDSQ
GGDLFQLLMP
NT seq
1653 nt
NT seq
+upstream
nt +downstream
nt
atgccgccaccccggaccggccgaggccttctctggctgggtctggttctgagctccgtc
tgcgtcgccctcggatccgaaacgcaggccaactcgaccacagatgctctgaacgttctt
ctcatcatcgtggatgacctgcgcccctccctgggctgttatggggataagctggtgagg
tccccaaatattgaccaactggcatcccacagcctcctcttccagaatgcctttgcgcag
caagcagtgtgcgccccgagccgcgtttctttcctcactggcaggagacctgacaccacc
cgcctgtacgacttcaactcctactggagggtgcacgctggaaacttctccaccatcccc
cagtacttcaaggagaatggctatgtgaccatgtcggtgggaaaagtctttcaccctggg
atatcttctaaccataccgatgattctccgtatagctggtcttttccaccttatcatcct
tcctctgagaagtatgaaaacactaagacatgtcgagggccagatggagaactccatgcc
aacctgctttgccctgtggatgtgctggatgttcccgagggcaccttgcctgacaaacag
agcactgagcaagccatacagttgttggaaaagatgaaaacgtcagccagtcctttcttc
ctggccgttgggtatcataagccacacatccccttcagataccccaaggaatttcagaag
ttgtatcccttggagaacatcaccctggcccccgatcccgaggtccctgatggcctaccc
cctgtggcctacaacccctggatggacatcaggcaacgggaagacgtccaagccttaaac
atcagtgtgccgtatggtccaattcctgtggactttcagcggaaaatccgccagagctac
tttgcctctgtgtcatatttggatacacaggtcggccgcctcttgagtgctttggacgat
cttcagctggccaacagcaccatcattgcatttacctcggatcatgggtgggctctaggt
gaacatggagaatgggccaaatacagcaattttgatgttgctacccatgttcccctgata
ttctatgttcctggaaggacggcttcacttccggaggcaggcgagaagcttttcccttac
ctcgacccttttgattccgcctcacagttgatggagccaggcaggcaatccatggacctt
gtggaacttgtgtctctttttcccacgctggctggacttgcaggactgcaggttccacct
cgctgccccgttccttcatttcacgttgagctgtgcagagaaggcaagaaccttctgaag
cattttcgattccgtgacttggaagaggatccgtacctccctggtaatccccgtgaactg
attgcctatagccagtatccccggccttcagacatccctcagtggaattctgacaagccg
agtttaaaagatataaagatcatgggctattccatacgcaccatagactataggtatact
gtgtgggttggcttcaatcctgatgaatttctagctaacttttctgacatccatgcaggg
gaactgtattttgtggattctgacccattgcaggatcacaatatgtataatgattcccaa
ggtggagatcttttccagttgttgatgccttga
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integrated database retrieval system