Homo sapiens (human): 3423 Help Entry 3423              CDS       T01001                                  Gene name IDS, ID2S, MPS2, SIDS Definition (RefSeq) iduronate 2-sulfatase   KO K01136   iduronate 2-sulfatase [EC:3.1.6.13] Organism hsa  Homo sapiens (human) Pathway hsa00531   Glycosaminoglycan degradation hsa01100   Metabolic pathways hsa04142   Lysosome Module hsa_M00076   Dermatan sulfate degradation hsa_M00078   Heparan sulfate degradation Network nt06012  Glycosaminoglycan degradation   Element N00610   Dermatan sulfate degradation N00611   HYAL1 deficiency in dermatan sulfate degradation N00612   ARSB deficiency in dermatan sulfate degradation N00613   IDUA deficiency in dermatan sulfate degradation N00614   IDS deficiency in dermatan sulfate degradation N00615   Heparan sulfate degradation N00616   GNS deficiency in heparan sulfate degradation N00617   GUSB deficiency in heparan sulfate degradation N00618   NAGLU deficiency in heparan sulfate degradation N00619   HGSNAT deficiency in heparan sulfate degradation N00620   SGSH deficiency in heparan sulfate degradation N00621   IDUA deficiency in heparan sulfate degradation N00622   IDS deficiency in heparan sulfate degradation N10013   Replacement of deficient IDS Disease H00129   Mucopolysaccharidosis type II H00421   Mucopolysaccharidosis Drug target Idursulfase:  D04499<JP/US> Idursulfase beta:  D11025<JP> Pabinafusp alfa:  D11812 Brite KEGG Orthology (KO) [BR:hsa00001]  09100 Metabolism   09107 Glycan biosynthesis and metabolism    00531 Glycosaminoglycan degradation     3423 (IDS)  09140 Cellular Processes   09141 Transport and catabolism    04142 Lysosome     3423 (IDS) Enzymes [BR:hsa01000]  3. Hydrolases   3.1  Acting on ester bonds    3.1.6  Sulfuric-ester hydrolases     3.1.6.13  iduronate-2-sulfatase      3423 (IDS) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Sulfatase Phosphodiest DUF229 Motif Other DBs NCBI-GeneID:  3423 NCBI-ProteinID:  NP_000193 OMIM:  300823 HGNC:  5389 Ensembl:  ENSG00000010404 Vega:  OTTHUMG00000022615 Pharos:  P22304(Tbio) UniProt:  P22304 LinkDB All DBs Structure PDB:  5FQL 6IOZ Thumbnails Position Xq28 AA seq 550 aa AA seqDB search MPPPRTGRGLLWLGLVLSSVCVALGSETQANSTTDALNVLLIIVDDLRPSLGCYGDKLVR SPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGRRPDTTRLYDFNSYWRVHAGNFSTIP QYFKENGYVTMSVGKVFHPGISSNHTDDSPYSWSFPPYHPSSEKYENTKTCRGPDGELHA NLLCPVDVLDVPEGTLPDKQSTEQAIQLLEKMKTSASPFFLAVGYHKPHIPFRYPKEFQK LYPLENITLAPDPEVPDGLPPVAYNPWMDIRQREDVQALNISVPYGPIPVDFQRKIRQSY FASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWALGEHGEWAKYSNFDVATHVPLI FYVPGRTASLPEAGEKLFPYLDPFDSASQLMEPGRQSMDLVELVSLFPTLAGLAGLQVPP RCPVPSFHVELCREGKNLLKHFRFRDLEEDPYLPGNPRELIAYSQYPRPSDIPQWNSDKP SLKDIKIMGYSIRTIDYRYTVWVGFNPDEFLANFSDIHAGELYFVDSDPLQDHNMYNDSQ GGDLFQLLMP NT seq 1653 nt NT seq  +upstreamnt  +downstreamnt atgccgccaccccggaccggccgaggccttctctggctgggtctggttctgagctccgtc tgcgtcgccctcggatccgaaacgcaggccaactcgaccacagatgctctgaacgttctt ctcatcatcgtggatgacctgcgcccctccctgggctgttatggggataagctggtgagg tccccaaatattgaccaactggcatcccacagcctcctcttccagaatgcctttgcgcag caagcagtgtgcgccccgagccgcgtttctttcctcactggcaggagacctgacaccacc cgcctgtacgacttcaactcctactggagggtgcacgctggaaacttctccaccatcccc cagtacttcaaggagaatggctatgtgaccatgtcggtgggaaaagtctttcaccctggg atatcttctaaccataccgatgattctccgtatagctggtcttttccaccttatcatcct tcctctgagaagtatgaaaacactaagacatgtcgagggccagatggagaactccatgcc aacctgctttgccctgtggatgtgctggatgttcccgagggcaccttgcctgacaaacag agcactgagcaagccatacagttgttggaaaagatgaaaacgtcagccagtcctttcttc ctggccgttgggtatcataagccacacatccccttcagataccccaaggaatttcagaag ttgtatcccttggagaacatcaccctggcccccgatcccgaggtccctgatggcctaccc cctgtggcctacaacccctggatggacatcaggcaacgggaagacgtccaagccttaaac atcagtgtgccgtatggtccaattcctgtggactttcagcggaaaatccgccagagctac tttgcctctgtgtcatatttggatacacaggtcggccgcctcttgagtgctttggacgat cttcagctggccaacagcaccatcattgcatttacctcggatcatgggtgggctctaggt gaacatggagaatgggccaaatacagcaattttgatgttgctacccatgttcccctgata ttctatgttcctggaaggacggcttcacttccggaggcaggcgagaagcttttcccttac ctcgacccttttgattccgcctcacagttgatggagccaggcaggcaatccatggacctt gtggaacttgtgtctctttttcccacgctggctggacttgcaggactgcaggttccacct cgctgccccgttccttcatttcacgttgagctgtgcagagaaggcaagaaccttctgaag cattttcgattccgtgacttggaagaggatccgtacctccctggtaatccccgtgaactg attgcctatagccagtatccccggccttcagacatccctcagtggaattctgacaagccg agtttaaaagatataaagatcatgggctattccatacgcaccatagactataggtatact gtgtgggttggcttcaatcctgatgaatttctagctaacttttctgacatccatgcaggg gaactgtattttgtggattctgacccattgcaggatcacaatatgtataatgattcccaa ggtggagatcttttccagttgttgatgccttga

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