KEGG   Homo sapiens (human): 3449
Entry
3449              CDS       T01001                                 
Symbol
IFNA16, IFN-alpha-16, IFN-alphaO
Name
(RefSeq) interferon alpha 16
  KO
K05414  interferon alpha
Organism
hsa  Homo sapiens (human)
Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04151  PI3K-Akt signaling pathway
hsa04217  Necroptosis
hsa04620  Toll-like receptor signaling pathway
hsa04621  NOD-like receptor signaling pathway
hsa04622  RIG-I-like receptor signaling pathway
hsa04623  Cytosolic DNA-sensing pathway
hsa04630  JAK-STAT signaling pathway
hsa04650  Natural killer cell mediated cytotoxicity
hsa04936  Alcoholic liver disease
hsa05152  Tuberculosis
hsa05160  Hepatitis C
hsa05161  Hepatitis B
hsa05162  Measles
hsa05163  Human cytomegalovirus infection
hsa05164  Influenza A
hsa05165  Human papillomavirus infection
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05168  Herpes simplex virus 1 infection
hsa05169  Epstein-Barr virus infection
hsa05170  Human immunodeficiency virus 1 infection
hsa05171  Coronavirus disease - COVID-19
hsa05200  Pathways in cancer
hsa05320  Autoimmune thyroid disease
hsa05417  Lipid and atherosclerosis
Network
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06162  Hepatitis B virus (HBV)
nt06163  Hepatitis C virus (HCV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165  Epstein-Barr virus (EBV)
nt06166  Human papillomavirus (HPV)
nt06167  Human cytomegalovirus (HCMV)
nt06168  Herpes simplex virus 1 (HSV-1)
nt06169  Measles virus (MV)
nt06170  Influenza A virus (IAV)
nt06171  SARS coronavirus 2 (SARS-CoV-2)
nt06182  Shigella
nt06222  IFN signaling (cancer)
nt06263  Hepatocellular carcinoma
nt06517  TLR signaling
nt06518  JAK-STAT signaling
nt06519  RLR signaling
nt06520  CGAS-STING signaling
nt06527  Necroptosis
  Element
N00148  TLR3-IRF7 signaling pathway
N00150  Type I IFN signaling pathway
N00395  cGAS-STING signaling pathway
N00436  HIV Tat to TLR2/4-NFKB signaling pathway
N00469  RIG-I-IRF7/3 signaling pathway
N00688  RIG-I-NFKB signaling pathway
N00690  TLR7/9-IRF7 signaling pathway
N01308  MDA5-IRF7/3 signaling pathway
N01543  TLR7/8/9-IRF5 signaling pathway
N01558  Type I interferon to Jak-STAT signaling pathway
N01559  Type II interferon to Jak-STAT signaling pathway
N01662  IFN-RIPK1/3 signaling pathway
Drug target
Rontalizumab: D09662
Sifalimumab: D09668
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    3449 (IFNA16)
   04151 PI3K-Akt signaling pathway
    3449 (IFNA16)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    3449 (IFNA16)
   04650 Natural killer cell mediated cytotoxicity
    3449 (IFNA16)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    3449 (IFNA16)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    3449 (IFNA16)
   05161 Hepatitis B
    3449 (IFNA16)
   05160 Hepatitis C
    3449 (IFNA16)
   05171 Coronavirus disease - COVID-19
    3449 (IFNA16)
   05164 Influenza A
    3449 (IFNA16)
   05162 Measles
    3449 (IFNA16)
   05163 Human cytomegalovirus infection
    3449 (IFNA16)
   05167 Kaposi sarcoma-associated herpesvirus infection
    3449 (IFNA16)
   05169 Epstein-Barr virus infection
    3449 (IFNA16)
   05165 Human papillomavirus infection
    3449 (IFNA16)
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    3449 (IFNA16)
  09163 Immune disease
   05320 Autoimmune thyroid disease
    3449 (IFNA16)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    3449 (IFNA16)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    3449 (IFNA16)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides [BR:hsa04052]
    3449 (IFNA16)
Cytokines and neuropeptides [BR:hsa04052]
 Cytokines
  Interferons
   3449 (IFNA16)
SSDB
Motif
Pfam: Interferon iSTAND
Other DBs
NCBI-GeneID: 3449
NCBI-ProteinID: NP_002164
OMIM: 147580
HGNC: 5421
Ensembl: ENSG00000147885
UniProt: P05015 A0A7R8C397
LinkDB
Position
9:complement(21216373..21217311)
AA seq 189 aa
MALSFSLLMAVLVLSYKSICSLGCDLPQTHSLGNRRALILLAQMGRISHFSCLKDRYDFG
FPQEVFDGNQFQKAQAISAFHEMIQQTFNLFSTKDSSAAWDETLLDKFYIELFQQLNDLE
ACVTQEVGVEEIALMNEDSILAVRKYFQRITLYLMGKKYSPCAWEVVRAEIMRSFSFSTN
LQKGLRRKD
NT seq 570 nt   +upstreamnt  +downstreamnt
atggccctgtccttttctttactgatggccgtgctggtgctcagctacaaatccatctgt
tctctgggctgtgatctgcctcagactcacagcctgggtaataggagggccttgatactc
ctggcacaaatgggaagaatctctcatttctcctgcctgaaggacagatatgatttcgga
ttcccccaggaggtgtttgatggcaaccagttccagaaggctcaagccatctctgccttc
catgagatgatccagcagaccttcaatctcttcagcacaaaggattcatctgctgcttgg
gatgagaccctcctagacaaattctacattgaacttttccagcaactgaatgacctagaa
gcctgtgtgacacaggaggttggggtggaagagattgccctgatgaatgaggactccatc
ctggctgtgaggaaatactttcaaagaatcactctttatctgatggggaagaaatacagc
ccttgtgcctgggaggttgtcagagcagaaatcatgagatccttctctttttcaacaaac
ttgcaaaaaggattaagaaggaaggattga

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