Homo sapiens (human): 3454
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Entry
3454 CDS
T01001
Gene name
IFNAR1, AVP, IFN-alpha-REC, IFNAR, IFNBR, IFRC
Definition
(RefSeq) interferon alpha and beta receptor subunit 1
KO
K05130
interferon receptor 1
Organism
hsa
Homo sapiens (human)
Pathway
hsa04060
Cytokine-cytokine receptor interaction
hsa04151
PI3K-Akt signaling pathway
hsa04217
Necroptosis
hsa04380
Osteoclast differentiation
hsa04620
Toll-like receptor signaling pathway
hsa04621
NOD-like receptor signaling pathway
hsa04630
Jak-STAT signaling pathway
hsa04650
Natural killer cell mediated cytotoxicity
hsa05160
Hepatitis C
hsa05161
Hepatitis B
hsa05162
Measles
hsa05164
Influenza A
hsa05165
Human papillomavirus infection
hsa05167
Kaposi sarcoma-associated herpesvirus infection
hsa05168
Herpes simplex virus 1 infection
hsa05169
Epstein-Barr virus infection
hsa05200
Pathways in cancer
Network
nt06119
JAK-STAT signaling (viruses)
nt06122
IFN signaling (viruses)
nt06160
Human T-cell leukemia virus 1 (HTLV-1)
nt06162
Hepatitis B virus (HBV)
nt06163
Hepatitis C virus (HCV)
nt06164
Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165
Epstein-Barr virus (EBV)
nt06166
Human papillomavirus (HPV)
nt06168
Herpes simplex virus 1 (HSV-1)
nt06169
Measles virus (MV)
nt06170
Influenza A virus (IAV)
nt06219
JAK-STAT signaling
nt06222
IFN signaling
nt06263
Hepatocellular carcinoma
nt06266
Non-small cell lung cancer
nt06276
Chronic myeloid leukemia
Element
N00053
Cytokine-Jak-STAT signaling pathway
N00150
Type I IFN signaling pathway
N00471
EBV LMP2A/2B to IFN signaling pathway
Drug target
Albinterferon alfa-2b:
D08844
Anifrolumab:
D11082
Interferon alfa natural:
D03305
Interferon alfa-2a:
D00745
Interferon alfa-2b:
D02745
Interferon alfa-n1:
D04552
Interferon alfacon-1:
D02744
Interferon alpha (
DG01750
):
D04553
Interferon beta natural:
D03304
Interferon beta-1a:
D04554
Interferon beta-1b:
D00746
Peginterferon alfa-2a:
D02747
Peginterferon alfa-2b:
D02748
Peginterferon beta-1a:
D10483
Ropeginterferon alfa-2b:
D11027
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04630 Jak-STAT signaling pathway
3454 (IFNAR1)
04151 PI3K-Akt signaling pathway
3454 (IFNAR1)
09133 Signaling molecules and interaction
04060 Cytokine-cytokine receptor interaction
3454 (IFNAR1)
09140 Cellular Processes
09143 Cell growth and death
04217 Necroptosis
3454 (IFNAR1)
09150 Organismal Systems
09151 Immune system
04620 Toll-like receptor signaling pathway
3454 (IFNAR1)
04621 NOD-like receptor signaling pathway
3454 (IFNAR1)
04650 Natural killer cell mediated cytotoxicity
3454 (IFNAR1)
09158 Development and regeneration
04380 Osteoclast differentiation
3454 (IFNAR1)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
3454 (IFNAR1)
09172 Infectious disease: viral
05162 Measles
3454 (IFNAR1)
05164 Influenza A
3454 (IFNAR1)
05161 Hepatitis B
3454 (IFNAR1)
05160 Hepatitis C
3454 (IFNAR1)
05168 Herpes simplex virus 1 infection
3454 (IFNAR1)
05167 Kaposi sarcoma-associated herpesvirus infection
3454 (IFNAR1)
05169 Epstein-Barr virus infection
3454 (IFNAR1)
05165 Human papillomavirus infection
3454 (IFNAR1)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04050 Cytokine receptors [BR:
hsa04050
]
3454 (IFNAR1)
Cytokine receptors [BR:
hsa04050
]
Interleukin receptor families
IFN receptor family
3454 (IFNAR1)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
Interfer-bind
Tissue_fac
fn3
Motif
Other DBs
NCBI-GeneID:
3454
NCBI-ProteinID:
NP_000620
OMIM:
107450
HGNC:
5432
Ensembl:
ENSG00000142166
Vega:
OTTHUMG00000065126
Pharos:
P17181
(Tclin)
UniProt:
P17181
LinkDB
All DBs
Structure
PDB:
3S98
4PO6
3SE4
3SE3
Thumbnails
Position
21q22.11
AA seq
557 aa
AA seq
DB search
MMVVLLGATTLVLVAVAPWVLSAAAGGKNLKSPQKVEVDIIDDNFILRWNRSDESVGNVT
FSFDYQKTGMDNWIKLSGCQNITSTKCNFSSLKLNVYEEIKLRIRAEKENTSSWYEVDSF
TPFRKAQIGPPEVHLEAEDKAIVIHISPGTKDSVMWALDGLSFTYSLVIWKNSSGVEERI
ENIYSRHKIYKLSPETTYCLKVKAALLTSWKIGVYSPVHCIKTTVENELPPPENIEVSVQ
NQNYVLKWDYTYANMTFQVQWLHAFLKRNPGNHLYKWKQIPDCENVKTTQCVFPQNVFQK
GIYLLRVQASDGNNTSFWSEEIKFDTEIQAFLLPPVFNIRSLSDSFHIYIGAPKQSGNTP
VIQDYPLIYEIIFWENTSNAERKIIEKKTDVTVPNLKPLTVYCVKARAHTMDEKLNKSSV
FSDAVCEKTKPGNTSKIWLIVGICIALFALPFVIYAAKVFLRCINYVFFPSLKPSSSIDE
YFSEQPLKNLLLSTSEEQIEKCFIIENISTIATVEETNQTDEDHKKYSSQTSQDSGNYSN
EDESESKTSEELQQDFV
NT seq
1674 nt
NT seq
+upstream
nt +downstream
nt
atgatggtcgtcctcctgggcgcgacgaccctagtgctcgtcgccgtggcgccatgggtg
ttgtccgcagccgcaggtggaaaaaatctaaaatctcctcaaaaagtagaggtcgacatc
atagatgacaactttatcctgaggtggaacaggagcgatgagtctgtcgggaatgtgact
ttttcattcgattatcaaaaaactgggatggataattggataaaattgtctgggtgtcag
aatattactagtaccaaatgcaacttttcttcactcaagctgaatgtttatgaagaaatt
aaattgcgtataagagcagaaaaagaaaacacttcttcatggtatgaggttgactcattt
acaccatttcgcaaagctcagattggtcctccagaagtacatttagaagctgaagataag
gcaatagtgatacacatctctcctggaacaaaagatagtgttatgtgggctttggatggt
ttaagctttacatatagcttagttatctggaaaaactcttcaggtgtagaagaaaggatt
gaaaatatttattccagacataaaatttataaactctcaccagagactacttattgtcta
aaagttaaagcagcactacttacgtcatggaaaattggtgtctatagtccagtacattgt
ataaagaccacagttgaaaatgaactacctccaccagaaaatatagaagtcagtgtccaa
aatcagaactatgttcttaaatgggattatacatatgcaaacatgacctttcaagttcag
tggctccacgcctttttaaaaaggaatcctggaaaccatttgtataaatggaaacaaata
cctgactgtgaaaatgtcaaaactacccagtgtgtctttcctcaaaacgttttccaaaaa
ggaatttaccttctccgcgtacaagcatctgatggaaataacacatctttttggtctgaa
gagataaagtttgatactgaaatacaagctttcctacttcctccagtctttaacattaga
tcccttagtgattcattccatatctatatcggtgctccaaaacagtctggaaacacgcct
gtgatccaggattatccactgatttatgaaattattttttgggaaaacacttcaaatgct
gagagaaaaattatcgagaaaaaaactgatgttacagttcctaatttgaaaccactgact
gtatattgtgtgaaagccagagcacacaccatggatgaaaagctgaataaaagcagtgtt
tttagtgacgctgtatgtgagaaaacaaaaccaggaaatacctctaaaatttggcttata
gttggaatttgtattgcattatttgctctcccgtttgtcatttatgctgcgaaagtcttc
ttgagatgcatcaattatgtcttctttccatcacttaaaccttcttccagtatagatgag
tatttctctgaacagccattgaagaatcttctgctttcaacttctgaggaacaaatcgaa
aaatgtttcataattgaaaatataagcacaattgctacagtagaagaaactaatcaaact
gatgaagatcataaaaaatacagttcccaaactagccaagattcaggaaattattctaat
gaagatgaaagcgaaagtaaaacaagtgaagaactacagcaggactttgtatga
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