KEGG   Homo sapiens (human): 3458
Entry
3458              CDS       T01001                                 

Gene name
IFNG, IFG, IFI, IMD69
Definition
(RefSeq) interferon gamma
  KO
K04687  interferon gamma
Organism
hsa  Homo sapiens (human)
Pathway
hsa03050  Proteasome
hsa04060  Cytokine-cytokine receptor interaction
hsa04066  HIF-1 signaling pathway
hsa04217  Necroptosis
hsa04350  TGF-beta signaling pathway
hsa04380  Osteoclast differentiation
hsa04612  Antigen processing and presentation
hsa04630  JAK-STAT signaling pathway
hsa04650  Natural killer cell mediated cytotoxicity
hsa04657  IL-17 signaling pathway
hsa04658  Th1 and Th2 cell differentiation
hsa04659  Th17 cell differentiation
hsa04660  T cell receptor signaling pathway
hsa04940  Type I diabetes mellitus
hsa05140  Leishmaniasis
hsa05142  Chagas disease
hsa05143  African trypanosomiasis
hsa05144  Malaria
hsa05145  Toxoplasmosis
hsa05146  Amoebiasis
hsa05152  Tuberculosis
hsa05160  Hepatitis C
hsa05164  Influenza A
hsa05168  Herpes simplex virus 1 infection
hsa05200  Pathways in cancer
hsa05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
hsa05321  Inflammatory bowel disease
hsa05322  Systemic lupus erythematosus
hsa05323  Rheumatoid arthritis
hsa05330  Allograft rejection
hsa05332  Graft-versus-host disease
hsa05418  Fluid shear stress and atherosclerosis
Network
nt06119  JAK-STAT signaling (viruses)
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06162  Hepatitis B virus (HBV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165  Epstein-Barr virus (EBV)
nt06219  JAK-STAT signaling
nt06263  Hepatocellular carcinoma
nt06266  Non-small cell lung cancer
nt06276  Chronic myeloid leukemia
  Element
N00053  Cytokine-Jak-STAT signaling pathway
Disease
H00083  Allograft rejection
H00084  Graft-versus-host disease
H01132  Aplastic anemia
Drug target
Darvadstrocel: D11397
Emapalumab: D11120<US>
Fontolizumab: D04242
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   03050 Proteasome
    3458 (IFNG)
 09130 Environmental Information Processing
  09132 Signal transduction
   04350 TGF-beta signaling pathway
    3458 (IFNG)
   04630 JAK-STAT signaling pathway
    3458 (IFNG)
   04066 HIF-1 signaling pathway
    3458 (IFNG)
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    3458 (IFNG)
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    3458 (IFNG)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    3458 (IFNG)
   04612 Antigen processing and presentation
    3458 (IFNG)
   04660 T cell receptor signaling pathway
    3458 (IFNG)
   04658 Th1 and Th2 cell differentiation
    3458 (IFNG)
   04659 Th17 cell differentiation
    3458 (IFNG)
   04657 IL-17 signaling pathway
    3458 (IFNG)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    3458 (IFNG)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    3458 (IFNG)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    3458 (IFNG)
  09172 Infectious disease: viral
   05160 Hepatitis C
    3458 (IFNG)
   05164 Influenza A
    3458 (IFNG)
   05168 Herpes simplex virus 1 infection
    3458 (IFNG)
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    3458 (IFNG)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    3458 (IFNG)
   05144 Malaria
    3458 (IFNG)
   05145 Toxoplasmosis
    3458 (IFNG)
   05140 Leishmaniasis
    3458 (IFNG)
   05142 Chagas disease
    3458 (IFNG)
   05143 African trypanosomiasis
    3458 (IFNG)
  09163 Immune disease
   05322 Systemic lupus erythematosus
    3458 (IFNG)
   05323 Rheumatoid arthritis
    3458 (IFNG)
   05321 Inflammatory bowel disease
    3458 (IFNG)
   05330 Allograft rejection
    3458 (IFNG)
   05332 Graft-versus-host disease
    3458 (IFNG)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    3458 (IFNG)
  09167 Endocrine and metabolic disease
   04940 Type I diabetes mellitus
    3458 (IFNG)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03051 Proteasome [BR:hsa03051]
    3458 (IFNG)
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and growth factors [BR:hsa04052]
    3458 (IFNG)
   00536 Glycosaminoglycan binding proteins [BR:hsa00536]
    3458 (IFNG)
Proteasome [BR:hsa03051]
 Eukaryotic proteasome
  Assembling factors
   Other assembling factors
    3458 (IFNG)
Cytokines and growth factors [BR:hsa04052]
 Cytokines
  Interferons
   3458 (IFNG)
Glycosaminoglycan binding proteins [BR:hsa00536]
 Heparan sulfate / Heparin
  Cytokines
   3458 (IFNG)
SSDB
Motif
Pfam: IFN-gamma API5 Tup_N
Other DBs
NCBI-GeneID: 3458
NCBI-ProteinID: NP_000610
OMIM: 147570
HGNC: 5438
Ensembl: ENSG00000111537
Vega: OTTHUMG00000169113
Pharos: P01579(Tbio)
UniProt: P01579
LinkDB
Structure
PDB: 

Position
12q15
AA seq 166 aa
MKYTSYILAFQLCIVLGSLGCYCQDPYVKEAENLKKYFNAGHSDVADNGTLFLGILKNWK
EESDRKIMQSQIVSFYFKLFKNFKDDQSIQKSVETIKEDMNVKFFNSNKKKRDDFEKLTN
YSVTDLNVQRKAIHELIQVMAELSPAAKTGKRKRSQMLFRGRRASQ
NT seq 501 nt   +upstreamnt  +downstreamnt
atgaaatatacaagttatatcttggcttttcagctctgcatcgttttgggttctcttggc
tgttactgccaggacccatatgtaaaagaagcagaaaaccttaagaaatattttaatgca
ggtcattcagatgtagcggataatggaactcttttcttaggcattttgaagaattggaaa
gaggagagtgacagaaaaataatgcagagccaaattgtctccttttacttcaaacttttt
aaaaactttaaagatgaccagagcatccaaaagagtgtggagaccatcaaggaagacatg
aatgtcaagtttttcaatagcaacaaaaagaaacgagatgacttcgaaaagctgactaat
tattcggtaactgacttgaatgtccaacgcaaagcaatacatgaactcatccaagtgatg
gctgaactgtcgccagcagctaaaacagggaagcgaaaaaggagtcagatgctgtttcga
ggtcgaagagcatcccagtaa

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