Homo sapiens (human): 3551
Entry
3551 CDS
T01001
Gene name
IKBKB, IKK-beta, IKK2, IKKB, IMD15, IMD15A, IMD15B, NFKBIKB
Definition
(RefSeq) inhibitor of nuclear factor kappa B kinase subunit beta
KO
K07209
inhibitor of nuclear factor kappa-B kinase subunit beta [EC:
2.7.11.10
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa01523
Antifolate resistance
hsa04010
MAPK signaling pathway
hsa04014
Ras signaling pathway
hsa04062
Chemokine signaling pathway
hsa04064
NF-kappa B signaling pathway
hsa04068
FoxO signaling pathway
hsa04150
mTOR signaling pathway
hsa04151
PI3K-Akt signaling pathway
hsa04210
Apoptosis
hsa04380
Osteoclast differentiation
hsa04620
Toll-like receptor signaling pathway
hsa04621
NOD-like receptor signaling pathway
hsa04622
RIG-I-like receptor signaling pathway
hsa04623
Cytosolic DNA-sensing pathway
hsa04625
C-type lectin receptor signaling pathway
hsa04657
IL-17 signaling pathway
hsa04658
Th1 and Th2 cell differentiation
hsa04659
Th17 cell differentiation
hsa04660
T cell receptor signaling pathway
hsa04662
B cell receptor signaling pathway
hsa04668
TNF signaling pathway
hsa04722
Neurotrophin signaling pathway
hsa04910
Insulin signaling pathway
hsa04920
Adipocytokine signaling pathway
hsa04930
Type II diabetes mellitus
hsa04931
Insulin resistance
hsa04932
Non-alcoholic fatty liver disease (NAFLD)
hsa05120
Epithelial cell signaling in Helicobacter pylori infection
hsa05131
Shigellosis
hsa05135
Yersinia infection
hsa05142
Chagas disease (American trypanosomiasis)
hsa05145
Toxoplasmosis
hsa05160
Hepatitis C
hsa05161
Hepatitis B
hsa05162
Measles
hsa05163
Human cytomegalovirus infection
hsa05164
Influenza A
hsa05165
Human papillomavirus infection
hsa05166
Human T-cell leukemia virus 1 infection
hsa05167
Kaposi sarcoma-associated herpesvirus infection
hsa05168
Herpes simplex virus 1 infection
hsa05169
Epstein-Barr virus infection
hsa05170
Human immunodeficiency virus 1 infection
hsa05200
Pathways in cancer
hsa05206
MicroRNAs in cancer
hsa05212
Pancreatic cancer
hsa05215
Prostate cancer
hsa05220
Chronic myeloid leukemia
hsa05221
Acute myeloid leukemia
hsa05222
Small cell lung cancer
hsa05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
hsa05418
Fluid shear stress and atherosclerosis
Network
nt06114
PI3K signaling (virus)
nt06121
TLR signaling (virus)
nt06123
TNF signaling (virus)
nt06124
Chemokine signaling (virus)
nt06133
RIG-I signaling (virus)
nt06160
Human T-cell leukemia virus 1 (HTLV-1)
nt06161
Human immunodeficiency virus type 1 (HIV-1)
nt06162
Hepatitis B virus (HBV)
nt06163
Hepatitis C virus (HCV)
nt06164
Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165
Epstein-Barr virus (EBV)
nt06167
Human cytomegalovirus (HCMV)
nt06168
Herpes simplex virus 1 (HSV-1)
nt06169
Measles virus (MV)
nt06170
Influenza A virus (IAV)
nt06214
PI3K signaling
nt06223
TNF-NFKB signaling
nt06263
Hepatocellular carcinoma
Element
N00151
TNF-NFKB signaling pathway
N00171
KSHV vFLIP to NFKB signaling pathway
N00173
KSHV K15 to TNF-NFKB signaling pathway
N00174
KSHV vFLIP to TNF-NFKB signaling pathway
N00179
KSHV K1 to PI3K-NFKB signaling pathway
N00182
IGF-IGFR-PI3K-NFKB signaling pathway
N00390
EGF-EGFR-PI3K-NFKB signaling pathway
N00391
HCMV gB to EGFR-PI3K-NFKB signaling pathway
N00397
HCMV UL26 to NFKB signaling pathway
N00399
CCR2-GNB/G-PI3K-NFKB signaling pathway
N00400
HCMV US28 to GNB/G-PI3K-NFKB signaling pathway
N00435
TLR2/4-NFKB signaling pathway
N00441
HIV gp120 to TNF-NFKB signaling pathway
N00442
HIV Nef to TNF-NFKB signaling pathway
N00466
EBV BPLF1 to TLR2/4-NFKB signaling pathway
N00467
EBV BPLF1 to TLR2/4-NFKB signaling pathway
N00501
HTLV-1 Tax to EGFR-PI3K-NFKB signaling pathway
N00504
HTLV-1 Tax to NFKB signaling pathway
N00525
HCV NS5A to TNF-NFKB signaling pathway
N00549
HBV HBeAg to TLR2/4-NFKB signaling pathway
N00556
HBV HBe to TLR2/4-NFKB signaling pathway
N00557
HBV HBe to TLR2/4-NFKB signaling pathway
N00559
LIGHT-HVEM-NFKB signaling pathway
N00560
HSV gD to HVEM-NFKB signaling pathway
N00561
HSV ICP0 to TLR2/4-NFKB signaling pathway
N00562
HSV US3 to TLR2/4-NFKB signaling pathway
N00563
TLR3-NFKB signaling pathway
N00564
HSV US3 to TLR3-NFKB signaling pathway
N00688
RIG-I-NFKB signaling pathway
N00692
MV P to TLR2/4-NFKB signaling pathway
Disease
H00093
Combined immunodeficiency
Drug target
Ertiprotafib:
D04050
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04014 Ras signaling pathway
3551 (IKBKB)
04010 MAPK signaling pathway
3551 (IKBKB)
04064 NF-kappa B signaling pathway
3551 (IKBKB)
04668 TNF signaling pathway
3551 (IKBKB)
04068 FoxO signaling pathway
3551 (IKBKB)
04151 PI3K-Akt signaling pathway
3551 (IKBKB)
04150 mTOR signaling pathway
3551 (IKBKB)
09140 Cellular Processes
09143 Cell growth and death
04210 Apoptosis
3551 (IKBKB)
09150 Organismal Systems
09151 Immune system
04620 Toll-like receptor signaling pathway
3551 (IKBKB)
04621 NOD-like receptor signaling pathway
3551 (IKBKB)
04622 RIG-I-like receptor signaling pathway
3551 (IKBKB)
04623 Cytosolic DNA-sensing pathway
3551 (IKBKB)
04625 C-type lectin receptor signaling pathway
3551 (IKBKB)
04660 T cell receptor signaling pathway
3551 (IKBKB)
04658 Th1 and Th2 cell differentiation
3551 (IKBKB)
04659 Th17 cell differentiation
3551 (IKBKB)
04657 IL-17 signaling pathway
3551 (IKBKB)
04662 B cell receptor signaling pathway
3551 (IKBKB)
04062 Chemokine signaling pathway
3551 (IKBKB)
09152 Endocrine system
04910 Insulin signaling pathway
3551 (IKBKB)
04920 Adipocytokine signaling pathway
3551 (IKBKB)
09156 Nervous system
04722 Neurotrophin signaling pathway
3551 (IKBKB)
09158 Development
04380 Osteoclast differentiation
3551 (IKBKB)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
3551 (IKBKB)
05206 MicroRNAs in cancer
3551 (IKBKB)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
3551 (IKBKB)
09162 Cancer: specific types
05212 Pancreatic cancer
3551 (IKBKB)
05221 Acute myeloid leukemia
3551 (IKBKB)
05220 Chronic myeloid leukemia
3551 (IKBKB)
05215 Prostate cancer
3551 (IKBKB)
05222 Small cell lung cancer
3551 (IKBKB)
09166 Cardiovascular disease
05418 Fluid shear stress and atherosclerosis
3551 (IKBKB)
09167 Endocrine and metabolic disease
04930 Type II diabetes mellitus
3551 (IKBKB)
04932 Non-alcoholic fatty liver disease (NAFLD)
3551 (IKBKB)
04931 Insulin resistance
3551 (IKBKB)
09171 Infectious disease: bacterial
05120 Epithelial cell signaling in Helicobacter pylori infection
3551 (IKBKB)
05131 Shigellosis
3551 (IKBKB)
05135 Yersinia infection
3551 (IKBKB)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
3551 (IKBKB)
05170 Human immunodeficiency virus 1 infection
3551 (IKBKB)
05162 Measles
3551 (IKBKB)
05164 Influenza A
3551 (IKBKB)
05161 Hepatitis B
3551 (IKBKB)
05160 Hepatitis C
3551 (IKBKB)
05168 Herpes simplex virus 1 infection
3551 (IKBKB)
05163 Human cytomegalovirus infection
3551 (IKBKB)
05167 Kaposi sarcoma-associated herpesvirus infection
3551 (IKBKB)
05169 Epstein-Barr virus infection
3551 (IKBKB)
05165 Human papillomavirus infection
3551 (IKBKB)
09174 Infectious disease: parasitic
05145 Toxoplasmosis
3551 (IKBKB)
05142 Chagas disease (American trypanosomiasis)
3551 (IKBKB)
09176 Drug resistance: antineoplastic
01523 Antifolate resistance
3551 (IKBKB)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
hsa01001
]
3551 (IKBKB)
Enzymes [BR:
hsa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.10 IkappaB kinase
3551 (IKBKB)
Protein kinases [BR:
hsa01001
]
Serine/threonine kinases: Other
IKK family [OT]
3551 (IKBKB)
SSDB
Motif
Pfam:
IKBKB_SDD
Pkinase
Pkinase_Tyr
IKKbetaNEMObind
Pkinase_fungal
Kdo
ubiquitin
APH
YrbL-PhoP_reg
Med20
Glyco_hydro_65m
Other DBs
NCBI-GeneID:
3551
NCBI-ProteinID:
NP_001547
OMIM:
603258
HGNC:
5960
Ensembl:
ENSG00000104365
Vega:
OTTHUMG00000164092
Pharos:
O14920
(Tchem)
UniProt:
O14920
LinkDB
Structure
PDB:
4KIK
4E3C
Position
8p11.21
AA seq
756 aa
MSWSPSLTTQTCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCL
EIQIMRRLTHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREG
AILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCT
SFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSE
VDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPTYGPNGCF
KALDDILNLKLVHILNMVTGTIHTYPVTEDESLQSLKARIQQDTGIPEEDQELLQEAGLA
LIPDKPATQCISDGKLNEGHTLDMDLVFLFDNSKITYETQISPRPQPESVSCILQEPKRN
LAFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMMNLLRNNSCLSKMKNSMASMSQQLK
AKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAVELCGRENEVKLLVERMMAL
QTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLREKPRDQRTEGDSQEMVRLLLQAIQS
FEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLMNEDEKTVVRLQEKRQKELWNLLKI
ACSKVRGPVSGSPDSMNASRLSQPGQLMSQPSTASNSLPEPAKKSEELVAEAHNLCTLLE
NAIQDTVREQDQSFTALDWSWLQTEEEEHSCLEQAS
NT seq
2271 nt
+upstream
nt +downstream
nt
atgagctggtcaccttccctgacaacgcagacatgtggggcctgggaaatgaaagagcgc
cttgggacagggggatttggaaatgtcatccgatggcacaatcaggaaacaggtgagcag
attgccatcaagcagtgccggcaggagctcagcccccggaaccgagagcggtggtgcctg
gagatccagatcatgagaaggctgacccaccccaatgtggtggctgcccgagatgtccct
gaggggatgcagaacttggcgcccaatgacctgcccctgctggccatggagtactgccaa
ggaggagatctccggaagtacctgaaccagtttgagaactgctgtggtctgcgggaaggt
gccatcctcaccttgctgagtgacattgcctctgcgcttagataccttcatgaaaacaga
atcatccatcgggatctaaagccagaaaacatcgtcctgcagcaaggagaacagaggtta
atacacaaaattattgacctaggatatgccaaggagctggatcagggcagtctttgcaca
tcattcgtggggaccctgcagtacctggccccagagctactggagcagcagaagtacaca
gtgaccgtcgactactggagcttcggcaccctggcctttgagtgcatcacgggcttccgg
cccttcctccccaactggcagcccgtgcagtggcattcaaaagtgcggcagaagagtgag
gtggacattgttgttagcgaagacttgaatggaacggtgaagttttcaagctctttaccc
taccccaataatcttaacagtgtcctggctgagcgactggagaagtggctgcaactgatg
ctgatgtggcacccccgacagaggggcacggatcccacgtatgggcccaatggctgcttc
aaggccctggatgacatcttaaacttaaagctggttcatatcttgaacatggtcacgggc
accatccacacctaccctgtgacagaggatgagagtctgcagagcttgaaggccagaatc
caacaggacacgggcatcccagaggaggaccaggagctgctgcaggaagcgggcctggcg
ttgatccccgataagcctgccactcagtgtatttcagacggcaagttaaatgagggccac
acattggacatggatcttgtttttctctttgacaacagtaaaatcacctatgagactcag
atctccccacggccccaacctgaaagtgtcagctgtatccttcaagagcccaagaggaat
ctcgccttcttccagctgaggaaggtgtggggccaggtctggcacagcatccagaccctg
aaggaagattgcaaccggctgcagcagggacagcgagccgccatgatgaatctcctccga
aacaacagctgcctctccaaaatgaagaattccatggcttccatgtctcagcagctcaag
gccaagttggatttcttcaaaaccagcatccagattgacctggagaagtacagcgagcaa
accgagtttgggatcacatcagataaactgctgctggcctggagggaaatggagcaggct
gtggagctctgtgggcgggagaacgaagtgaaactcctggtagaacggatgatggctctg
cagaccgacattgtggacttacagaggagccccatgggccggaagcaggggggaacgctg
gacgacctagaggagcaagcaagggagctgtacaggagactaagggaaaaacctcgagac
cagcgaactgagggtgacagtcaggaaatggtacggctgctgcttcaggcaattcagagc
ttcgagaagaaagtgcgagtgatctatacgcagctcagtaaaactgtggtttgcaagcag
aaggcgctggaactgttgcccaaggtggaagaggtggtgagcttaatgaatgaggatgag
aagactgttgtccggctgcaggagaagcggcagaaggagctctggaatctcctgaagatt
gcttgtagcaaggtccgtggtcctgtcagtggaagcccggatagcatgaatgcctctcga
cttagccagcctgggcagctgatgtctcagccctccacggcctccaacagcttacctgag
ccagccaagaagagtgaagaactggtggctgaagcacataacctctgcaccctgctagaa
aatgccatacaggacactgtgagggaacaagaccagagtttcacggccctagactggagc
tggttacagacggaagaagaagagcacagctgcctggagcaggcctcatga
DBGET
integrated database retrieval system
