Entry |
|
Gene name |
IKBKB, IKK-beta, IKK2, IKKB, IMD15, IMD15A, IMD15B, NFKBIKB
|
Definition |
(RefSeq) inhibitor of nuclear factor kappa B kinase subunit beta
|
KO |
K07209 | inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10] |
|
Organism |
|
Pathway |
hsa04620 | Toll-like receptor signaling pathway |
hsa04621 | NOD-like receptor signaling pathway |
hsa04622 | RIG-I-like receptor signaling pathway |
hsa04625 | C-type lectin receptor signaling pathway |
hsa04658 | Th1 and Th2 cell differentiation |
hsa04660 | T cell receptor signaling pathway |
hsa04662 | B cell receptor signaling pathway |
hsa04920 | Adipocytokine signaling pathway |
hsa04932 | Non-alcoholic fatty liver disease |
hsa05120 | Epithelial cell signaling in Helicobacter pylori infection |
hsa05130 | Pathogenic Escherichia coli infection |
hsa05163 | Human cytomegalovirus infection |
hsa05166 | Human T-cell leukemia virus 1 infection |
hsa05167 | Kaposi sarcoma-associated herpesvirus infection |
hsa05168 | Herpes simplex virus 1 infection |
hsa05170 | Human immunodeficiency virus 1 infection |
hsa05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer |
hsa05418 | Fluid shear stress and atherosclerosis |
|
Network |
nt06114 PI3K signaling (viruses) nt06121 TLR signaling (viruses and bacteria) nt06123 TNF signaling (viruses and bacteria) nt06124 Chemokine signaling (viruses) nt06133 RLR signaling (viruses) nt06139 NLR signaling (viruses and bacteria) nt06150 Cytokine-cytokine receptor interaction (viruses) nt06160 Human T-cell leukemia virus 1 (HTLV-1) nt06161 Human immunodeficiency virus type 1 (HIV-1) nt06162 Hepatitis B virus (HBV) nt06163 Hepatitis C virus (HCV) nt06164 Kaposi sarcoma-associated herpesvirus (KSHV) nt06165 Epstein-Barr virus (EBV) nt06167 Human cytomegalovirus (HCMV) nt06168 Herpes simplex virus 1 (HSV-1) nt06169 Measles virus (MV) nt06170 Influenza A virus (IAV) nt06214 PI3K signaling nt06223 TNF signaling nt06263 Hepatocellular carcinoma |
Element |
N00151 | TNF-NFKB signaling pathway |
N00171 | KSHV vFLIP to NFKB signaling pathway |
N00173 | KSHV K15 to TNF-NFKB signaling pathway |
N00174 | KSHV vFLIP to TNF-NFKB signaling pathway |
N00179 | KSHV K1 to PI3K-NFKB signaling pathway |
N00182 | IGF-IGFR-PI3K-NFKB signaling pathway |
N00265 | EBV LMP1 to NFKB signaling pathway |
N00390 | EGF-EGFR-PI3K-NFKB signaling pathway |
N00391 | HCMV gB to EGFR-PI3K-NFKB signaling pathway |
N00397 | HCMV UL26 to NFKB signaling pathway |
N00399 | CCR2-GNB/G-PI3K-NFKB signaling pathway |
N00400 | HCMV US28 to GNB/G-PI3K-NFKB signaling pathway |
N00435 | TLR2/4-NFKB signaling pathway |
N00441 | HIV gp120 to TNF-NFKB signaling pathway |
N00442 | HIV Nef to TNF-NFKB signaling pathway |
N00467 | EBV BPLF1 to TLR2/4-NFKB signaling pathway |
N00501 | HTLV-1 Tax to EGFR-PI3K-NFKB signaling pathway |
N00504 | HTLV-1 Tax to NFKB signaling pathway |
N00559 | LIGHT-HVEM-NFKB signaling pathway |
N00560 | HSV gD to HVEM-NFKB signaling pathway |
N00563 | TLR3-NFKB signaling pathway |
N00688 | RIG-I-NFKB signaling pathway |
N00860 | Yersinia YopP/J to TLR2/4-NFKB signaling pathway |
N00940 | NOD-NFKB signaling pathway |
N01112 | Salmonella SopE/E2 to NOD-NFKB signaling pathway |
|
Disease |
H00093 | Combined immunodeficiency |
|
Drug target |
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Brite |
KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
3551 (IKBKB)
04014 Ras signaling pathway
3551 (IKBKB)
04064 NF-kappa B signaling pathway
3551 (IKBKB)
04668 TNF signaling pathway
3551 (IKBKB)
04068 FoxO signaling pathway
3551 (IKBKB)
04151 PI3K-Akt signaling pathway
3551 (IKBKB)
04150 mTOR signaling pathway
3551 (IKBKB)
09140 Cellular Processes
09143 Cell growth and death
04210 Apoptosis
3551 (IKBKB)
09150 Organismal Systems
09151 Immune system
04620 Toll-like receptor signaling pathway
3551 (IKBKB)
04621 NOD-like receptor signaling pathway
3551 (IKBKB)
04622 RIG-I-like receptor signaling pathway
3551 (IKBKB)
04623 Cytosolic DNA-sensing pathway
3551 (IKBKB)
04625 C-type lectin receptor signaling pathway
3551 (IKBKB)
04660 T cell receptor signaling pathway
3551 (IKBKB)
04658 Th1 and Th2 cell differentiation
3551 (IKBKB)
04659 Th17 cell differentiation
3551 (IKBKB)
04657 IL-17 signaling pathway
3551 (IKBKB)
04662 B cell receptor signaling pathway
3551 (IKBKB)
04062 Chemokine signaling pathway
3551 (IKBKB)
09152 Endocrine system
04910 Insulin signaling pathway
3551 (IKBKB)
04920 Adipocytokine signaling pathway
3551 (IKBKB)
09156 Nervous system
04722 Neurotrophin signaling pathway
3551 (IKBKB)
09158 Development and regeneration
04380 Osteoclast differentiation
3551 (IKBKB)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
3551 (IKBKB)
05206 MicroRNAs in cancer
3551 (IKBKB)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
3551 (IKBKB)
09162 Cancer: specific types
05212 Pancreatic cancer
3551 (IKBKB)
05221 Acute myeloid leukemia
3551 (IKBKB)
05220 Chronic myeloid leukemia
3551 (IKBKB)
05215 Prostate cancer
3551 (IKBKB)
05222 Small cell lung cancer
3551 (IKBKB)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
3551 (IKBKB)
05170 Human immunodeficiency virus 1 infection
3551 (IKBKB)
05161 Hepatitis B
3551 (IKBKB)
05160 Hepatitis C
3551 (IKBKB)
05171 Coronavirus disease - COVID-19
3551 (IKBKB)
05164 Influenza A
3551 (IKBKB)
05162 Measles
3551 (IKBKB)
05168 Herpes simplex virus 1 infection
3551 (IKBKB)
05163 Human cytomegalovirus infection
3551 (IKBKB)
05167 Kaposi sarcoma-associated herpesvirus infection
3551 (IKBKB)
05169 Epstein-Barr virus infection
3551 (IKBKB)
05165 Human papillomavirus infection
3551 (IKBKB)
09171 Infectious disease: bacterial
05120 Epithelial cell signaling in Helicobacter pylori infection
3551 (IKBKB)
05130 Pathogenic Escherichia coli infection
3551 (IKBKB)
05132 Salmonella infection
3551 (IKBKB)
05131 Shigellosis
3551 (IKBKB)
05135 Yersinia infection
3551 (IKBKB)
09174 Infectious disease: parasitic
05145 Toxoplasmosis
3551 (IKBKB)
05142 Chagas disease
3551 (IKBKB)
09164 Neurodegenerative disease
05010 Alzheimer disease
3551 (IKBKB)
09166 Cardiovascular disease
05418 Fluid shear stress and atherosclerosis
3551 (IKBKB)
09167 Endocrine and metabolic disease
04930 Type II diabetes mellitus
3551 (IKBKB)
04932 Non-alcoholic fatty liver disease
3551 (IKBKB)
04931 Insulin resistance
3551 (IKBKB)
09176 Drug resistance: antineoplastic
01523 Antifolate resistance
3551 (IKBKB)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:hsa01001]
3551 (IKBKB)
Enzymes [BR:hsa01000]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.10 IkappaB kinase
3551 (IKBKB)
Protein kinases [BR:hsa01001]
Serine/threonine kinases: Other
IKK family [OT]
3551 (IKBKB)
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SSDB |
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Motif |
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Other DBs |
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LinkDB |
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Structure |
PDB: |
Position |
8p11.21
|
AA seq |
756 aa
MSWSPSLTTQTCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCL
EIQIMRRLTHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREG
AILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCT
SFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSE
VDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPTYGPNGCF
KALDDILNLKLVHILNMVTGTIHTYPVTEDESLQSLKARIQQDTGIPEEDQELLQEAGLA
LIPDKPATQCISDGKLNEGHTLDMDLVFLFDNSKITYETQISPRPQPESVSCILQEPKRN
LAFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMMNLLRNNSCLSKMKNSMASMSQQLK
AKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAVELCGRENEVKLLVERMMAL
QTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLREKPRDQRTEGDSQEMVRLLLQAIQS
FEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLMNEDEKTVVRLQEKRQKELWNLLKI
ACSKVRGPVSGSPDSMNASRLSQPGQLMSQPSTASNSLPEPAKKSEELVAEAHNLCTLLE
NAIQDTVREQDQSFTALDWSWLQTEEEEHSCLEQAS |
NT seq |
2271 nt +upstreamnt +downstreamnt
atgagctggtcaccttccctgacaacgcagacatgtggggcctgggaaatgaaagagcgc
cttgggacagggggatttggaaatgtcatccgatggcacaatcaggaaacaggtgagcag
attgccatcaagcagtgccggcaggagctcagcccccggaaccgagagcggtggtgcctg
gagatccagatcatgagaaggctgacccaccccaatgtggtggctgcccgagatgtccct
gaggggatgcagaacttggcgcccaatgacctgcccctgctggccatggagtactgccaa
ggaggagatctccggaagtacctgaaccagtttgagaactgctgtggtctgcgggaaggt
gccatcctcaccttgctgagtgacattgcctctgcgcttagataccttcatgaaaacaga
atcatccatcgggatctaaagccagaaaacatcgtcctgcagcaaggagaacagaggtta
atacacaaaattattgacctaggatatgccaaggagctggatcagggcagtctttgcaca
tcattcgtggggaccctgcagtacctggccccagagctactggagcagcagaagtacaca
gtgaccgtcgactactggagcttcggcaccctggcctttgagtgcatcacgggcttccgg
cccttcctccccaactggcagcccgtgcagtggcattcaaaagtgcggcagaagagtgag
gtggacattgttgttagcgaagacttgaatggaacggtgaagttttcaagctctttaccc
taccccaataatcttaacagtgtcctggctgagcgactggagaagtggctgcaactgatg
ctgatgtggcacccccgacagaggggcacggatcccacgtatgggcccaatggctgcttc
aaggccctggatgacatcttaaacttaaagctggttcatatcttgaacatggtcacgggc
accatccacacctaccctgtgacagaggatgagagtctgcagagcttgaaggccagaatc
caacaggacacgggcatcccagaggaggaccaggagctgctgcaggaagcgggcctggcg
ttgatccccgataagcctgccactcagtgtatttcagacggcaagttaaatgagggccac
acattggacatggatcttgtttttctctttgacaacagtaaaatcacctatgagactcag
atctccccacggccccaacctgaaagtgtcagctgtatccttcaagagcccaagaggaat
ctcgccttcttccagctgaggaaggtgtggggccaggtctggcacagcatccagaccctg
aaggaagattgcaaccggctgcagcagggacagcgagccgccatgatgaatctcctccga
aacaacagctgcctctccaaaatgaagaattccatggcttccatgtctcagcagctcaag
gccaagttggatttcttcaaaaccagcatccagattgacctggagaagtacagcgagcaa
accgagtttgggatcacatcagataaactgctgctggcctggagggaaatggagcaggct
gtggagctctgtgggcgggagaacgaagtgaaactcctggtagaacggatgatggctctg
cagaccgacattgtggacttacagaggagccccatgggccggaagcaggggggaacgctg
gacgacctagaggagcaagcaagggagctgtacaggagactaagggaaaaacctcgagac
cagcgaactgagggtgacagtcaggaaatggtacggctgctgcttcaggcaattcagagc
ttcgagaagaaagtgcgagtgatctatacgcagctcagtaaaactgtggtttgcaagcag
aaggcgctggaactgttgcccaaggtggaagaggtggtgagcttaatgaatgaggatgag
aagactgttgtccggctgcaggagaagcggcagaaggagctctggaatctcctgaagatt
gcttgtagcaaggtccgtggtcctgtcagtggaagcccggatagcatgaatgcctctcga
cttagccagcctgggcagctgatgtctcagccctccacggcctccaacagcttacctgag
ccagccaagaagagtgaagaactggtggctgaagcacataacctctgcaccctgctagaa
aatgccatacaggacactgtgagggaacaagaccagagtttcacggccctagactggagc
tggttacagacggaagaagaagagcacagctgcctggagcaggcctcatga |