Homo sapiens (human): 3560
Entry
3560 CDS
T01001
Gene name
IL2RB, CD122, IL15RB, P70-75
Definition
(RefSeq) interleukin 2 receptor subunit beta
KO
K05069
interleukin 2 receptor beta
Organism
hsa
Homo sapiens (human)
Pathway
hsa04060
Cytokine-cytokine receptor interaction
hsa04144
Endocytosis
hsa04151
PI3K-Akt signaling pathway
hsa04630
Jak-STAT signaling pathway
hsa04658
Th1 and Th2 cell differentiation
hsa04659
Th17 cell differentiation
hsa05162
Measles
hsa05166
HTLV-I infection
hsa05200
Pathways in cancer
hsa05202
Transcriptional misregulation in cancer
Network
N00053
Cytokine-Jak-STAT signaling pathway
N00137
EWSR1-WT1 fusion to transcriptional activation
Drug target
Aldesleukin:
D00748
Celmoleukin:
D02743
Denileukin diftitox:
D03682
Teceleukin:
D02749
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
Environmental Information Processing
Signal transduction
04630 Jak-STAT signaling pathway
3560 (IL2RB)
04151 PI3K-Akt signaling pathway
3560 (IL2RB)
Signaling molecules and interaction
04060 Cytokine-cytokine receptor interaction
3560 (IL2RB)
Cellular Processes
Transport and catabolism
04144 Endocytosis
3560 (IL2RB)
Organismal Systems
Immune system
04658 Th1 and Th2 cell differentiation
3560 (IL2RB)
04659 Th17 cell differentiation
3560 (IL2RB)
Human Diseases
Cancers
05200 Pathways in cancer
3560 (IL2RB)
05202 Transcriptional misregulation in cancers
3560 (IL2RB)
Infectious diseases
05166 HTLV-I infection
3560 (IL2RB)
05162 Measles
3560 (IL2RB)
Cytokine receptors [BR:
hsa04050
]
Interleukin receptor families
IL2 receptor family
3560 (IL2RB)
CD molecules [BR:
hsa04090
]
Proteins
3560 (IL2RB)
SSDB
Motif
Pfam:
Pur_ac_phosph_N
IL6Ra-bind
Other DBs
NCBI-GeneID:
3560
NCBI-ProteinID:
NP_000869
OMIM:
146710
HGNC:
6009
Ensembl:
ENSG00000100385
Vega:
OTTHUMG00000150534
Pharos:
P14784
(Tclin)
UniProt:
P14784
LinkDB
Structure
PDB:
5M5E
2B5I
4GS7
2ERJ
3QAZ
Position
22q12.3
AA seq
551 aa
MAAPALSWRLPLLILLLPLATSWASAAVNGTSQFTCFYNSRANISCVWSQDGALQDTSCQ
VHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMA
IQDFKPFENLRLMAPISLQVVHVETHRCNISWEISQASHYFERHLEFEARTLSPGHTWEE
APLLTLKQKQEWICLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAALGKDT
IPWLGHLLVGLSGAFGFIILVYLLINCRNTGPWLKKVLKCNTPDPSKFFSQLSSEHGGDV
QKWLSSPFPSSSFSPGGLAPEISPLEVLERDKVTQLLLQQDKVPEPASLSSNHSLTSCFT
NQGYFFFHLPDALEIEACQVYFTYDPYSEEDPDEGVAGAPTGSSPQPLQPLSGEDDAYCT
FPSRDDLLLFSPSLLGGPSPPSTAPGGSGAGEERMPPSLQERVPRDWDPQPLGPPTPGVP
DLVDFQPPPELVLREAGEEVPDAGPREGVSFPWSRPPGQGEFRALNARLPLNTDAYLSLQ
ELQGQDPTHLV
NT seq
1656 nt
+upstream
nt +downstream
nt
atggcggcccctgctctgtcctggcgtctgcccctcctcatcctcctcctgcccctggct
acctcttgggcatctgcagcggtgaatggcacttcccagttcacatgcttctacaactcg
agagccaacatctcctgtgtctggagccaagatggggctctgcaggacacttcctgccaa
gtccatgcctggccggacagacggcggtggaaccaaacctgtgagctgctccccgtgagt
caagcatcctgggcctgcaacctgatcctcggagccccagattctcagaaactgaccaca
gttgacatcgtcaccctgagggtgctgtgccgtgagggggtgcgatggagggtgatggcc
atccaggacttcaagccctttgagaaccttcgcctgatggcccccatctccctccaagtt
gtccacgtggagacccacagatgcaacataagctgggaaatctcccaagcctcccactac
tttgaaagacacctggagttcgaggcccggacgctgtccccaggccacacctgggaggag
gcccccctgctgactctcaagcagaagcaggaatggatctgcctggagacgctcacccca
gacacccagtatgagtttcaggtgcgggtcaagcctctgcaaggcgagttcacgacctgg
agcccctggagccagcccctggccttcaggacaaagcctgcagcccttgggaaggacacc
attccgtggctcggccacctcctcgtgggcctcagcggggcttttggcttcatcatctta
gtgtacttgctgatcaactgcaggaacaccgggccatggctgaagaaggtcctgaagtgt
aacaccccagacccctcgaagttcttttcccagctgagctcagagcatggaggagacgtc
cagaagtggctctcttcgcccttcccctcatcgtccttcagccctggcggcctggcacct
gagatctcgccactagaagtgctggagagggacaaggtgacgcagctgctcctgcagcag
gacaaggtgcctgagcccgcatccttaagcagcaaccactcgctgaccagctgcttcacc
aaccagggttacttcttcttccacctcccggatgccttggagatagaggcctgccaggtg
tactttacttacgacccctactcagaggaagaccctgatgagggtgtggccggggcaccc
acagggtcttccccccaacccctgcagcctctgtcaggggaggacgacgcctactgcacc
ttcccctccagggatgacctgctgctcttctcccccagtctcctcggtggccccagcccc
ccaagcactgcccctgggggcagtggggccggtgaagagaggatgcccccttctttgcaa
gaaagagtccccagagactgggacccccagcccctggggcctcccaccccaggagtccca
gacctggtggattttcagccaccccctgagctggtgctgcgagaggctggggaggaggtc
cctgacgctggccccagggagggagtcagtttcccctggtccaggcctcctgggcagggg
gagttcagggcccttaatgctcgcctgcccctgaacactgatgcctacttgtccctccaa
gaactccagggtcaggacccaactcacttggtgtag
DBGET
integrated database retrieval system
