Homo sapiens (human): 3593
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Entry
3593 CDS
T01001
Symbol
IL12B, CLMF, CLMF2, IL-12B, IMD28, IMD29, NKSF, NKSF2
Name
(RefSeq) interleukin 12B
KO
K05425
interleukin 12B
Organism
hsa
Homo sapiens (human)
Pathway
hsa04060
Cytokine-cytokine receptor interaction
hsa04620
Toll-like receptor signaling pathway
hsa04622
RIG-I-like receptor signaling pathway
hsa04625
C-type lectin receptor signaling pathway
hsa04630
JAK-STAT signaling pathway
hsa04658
Th1 and Th2 cell differentiation
hsa04936
Alcoholic liver disease
hsa04940
Type I diabetes mellitus
hsa05133
Pertussis
hsa05134
Legionellosis
hsa05140
Leishmaniasis
hsa05142
Chagas disease
hsa05143
African trypanosomiasis
hsa05145
Toxoplasmosis
hsa05146
Amoebiasis
hsa05152
Tuberculosis
hsa05162
Measles
hsa05164
Influenza A
hsa05168
Herpes simplex virus 1 infection
hsa05171
Coronavirus disease - COVID-19
hsa05200
Pathways in cancer
hsa05205
Proteoglycans in cancer
hsa05321
Inflammatory bowel disease
hsa05330
Allograft rejection
hsa05417
Lipid and atherosclerosis
Network
nt06160
Human T-cell leukemia virus 1 (HTLV-1)
nt06161
Human immunodeficiency virus 1 (HIV-1)
nt06162
Hepatitis B virus (HBV)
nt06164
Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165
Epstein-Barr virus (EBV)
nt06168
Herpes simplex virus 1 (HSV-1)
nt06169
Measles virus (MV)
nt06171
SARS coronavirus 2 (SARS-CoV-2)
nt06183
Yersinia
nt06219
JAK-STAT signaling (cancer)
nt06263
Hepatocellular carcinoma
nt06266
Non-small cell lung cancer
nt06276
Chronic myeloid leukemia
nt06517
TLR signaling
nt06518
JAK-STAT signaling
Element
N00053
Cytokine-Jak-STAT signaling pathway
N00435
TLR1/2/4-NFKB signaling pathway
N01307
SARS-CoV-2 S to AngII-AT1R-NOX2 signaling pathway
N01557
IL12/23 to Jak-STAT signaling pathway
N01566
TLR5-NFKB signaling pathway
Disease
H00089
IFN-gamma/IL-12 axis
Drug target
Apilimod mesylate:
D06556
Briakinumab:
D09588
Lisofylline:
D04748
Ustekinumab:
D09214
<JP/US>
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04630 JAK-STAT signaling pathway
3593 (IL12B)
09150 Organismal Systems
09151 Immune system
04620 Toll-like receptor signaling pathway
3593 (IL12B)
04658 Th1 and Th2 cell differentiation
3593 (IL12B)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
3593 (IL12B)
05205 Proteoglycans in cancer
3593 (IL12B)
09172 Infectious disease: viral
05171 Coronavirus disease - COVID-19
3593 (IL12B)
05164 Influenza A
3593 (IL12B)
05162 Measles
3593 (IL12B)
09171 Infectious disease: bacterial
05133 Pertussis
3593 (IL12B)
05134 Legionellosis
3593 (IL12B)
05152 Tuberculosis
3593 (IL12B)
09174 Infectious disease: parasitic
05146 Amoebiasis
3593 (IL12B)
05145 Toxoplasmosis
3593 (IL12B)
05140 Leishmaniasis
3593 (IL12B)
05142 Chagas disease
3593 (IL12B)
05143 African trypanosomiasis
3593 (IL12B)
09163 Immune disease
05321 Inflammatory bowel disease
3593 (IL12B)
05330 Allograft rejection
3593 (IL12B)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
3593 (IL12B)
09167 Endocrine and metabolic disease
04940 Type I diabetes mellitus
3593 (IL12B)
04936 Alcoholic liver disease
3593 (IL12B)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04052 Cytokines and neuropeptides [BR:
hsa04052
]
3593 (IL12B)
00536 Glycosaminoglycan binding proteins [BR:
hsa00536
]
3593 (IL12B)
Cytokines and neuropeptides [BR:
hsa04052
]
Cytokines
Interleukins
3593 (IL12B)
Glycosaminoglycan binding proteins [BR:
hsa00536
]
Heparan sulfate / Heparin
Cytokines
3593 (IL12B)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
IL12p40_C
Ig_3
Ig_5
Ig_2
Ig_4
fn3
ig
Motif
Other DBs
NCBI-GeneID:
3593
NCBI-ProteinID:
NP_002178
OMIM:
161561
HGNC:
5970
Ensembl:
ENSG00000113302
UniProt:
P29460
Structure
PDB
PDBj
LinkDB
All DBs
Position
5:complement(159314780..159330487)
Genome browser
AA seq
328 aa
AA seq
DB search
MCHQQLVISWFSLVFLASPLVAIWELKKDVYVVELDWYPDAPGEMVVLTCDTPEEDGITW
TLDQSSEVLGSGKTLTIQVKEFGDAGQYTCHKGGEVLSHSLLLLHKKEDGIWSTDILKDQ
KEPKNKTFLRCEAKNYSGRFTCWWLTTISTDLTFSVKSSRGSSDPQGVTCGAATLSAERV
RGDNKEYEYSVECQEDSACPAAEESLPIEVMVDAVHKLKYENYTSSFFIRDIIKPDPPKN
LQLKPLKNSRQVEVSWEYPDTWSTPHSYFSLTFCVQVQGKSKREKKDRVFTDKTSATVIC
RKNASISVRAQDRYYSSSWSEWASVPCS
NT seq
987 nt
NT seq
+upstream
nt +downstream
nt
atgtgtcaccagcagttggtcatctcttggttttccctggtttttctggcatctcccctc
gtggccatatgggaactgaagaaagatgtttatgtcgtagaattggattggtatccggat
gcccctggagaaatggtggtcctcacctgtgacacccctgaagaagatggtatcacctgg
accttggaccagagcagtgaggtcttaggctctggcaaaaccctgaccatccaagtcaaa
gagtttggagatgctggccagtacacctgtcacaaaggaggcgaggttctaagccattcg
ctcctgctgcttcacaaaaaggaagatggaatttggtccactgatattttaaaggaccag
aaagaacccaaaaataagacctttctaagatgcgaggccaagaattattctggacgtttc
acctgctggtggctgacgacaatcagtactgatttgacattcagtgtcaaaagcagcaga
ggctcttctgacccccaaggggtgacgtgcggagctgctacactctctgcagagagagtc
agaggggacaacaaggagtatgagtactcagtggagtgccaggaggacagtgcctgccca
gctgctgaggagagtctgcccattgaggtcatggtggatgccgttcacaagctcaagtat
gaaaactacaccagcagcttcttcatcagggacatcatcaaacctgacccacccaagaac
ttgcagctgaagccattaaagaattctcggcaggtggaggtcagctgggagtaccctgac
acctggagtactccacattcctacttctccctgacattctgcgttcaggtccagggcaag
agcaagagagaaaagaaagatagagtcttcacggacaagacctcagccacggtcatctgc
cgcaaaaatgccagcattagcgtgcgggcccaggaccgctactatagctcatcttggagc
gaatgggcatctgtgccctgcagttag
DBGET
integrated database retrieval system
