KEGG   Homo sapiens (human): 3635Help
Entry
3635              CDS       T01001                                 

Gene name
INPP5D, SHIP, SHIP-1, SHIP1, SIP-145, hp51CN, p150Ship
Definition
(RefSeq) inositol polyphosphate-5-phosphatase D
  KO
K03084  phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 [EC:3.1.3.86]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00562  Inositol phosphate metabolism
hsa01100  Metabolic pathways
hsa04070  Phosphatidylinositol signaling system
hsa04662  B cell receptor signaling pathway
hsa04664  Fc epsilon RI signaling pathway
hsa04666  Fc gamma R-mediated phagocytosis
Drug target
Rosiptor (DG02961): D11275 D11276
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    3635 (INPP5D)
 09130 Environmental Information Processing
  09132 Signal transduction
   04070 Phosphatidylinositol signaling system
    3635 (INPP5D)
 09150 Organismal Systems
  09151 Immune system
   04662 B cell receptor signaling pathway
    3635 (INPP5D)
   04664 Fc epsilon RI signaling pathway
    3635 (INPP5D)
   04666 Fc gamma R-mediated phagocytosis
    3635 (INPP5D)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    3635 (INPP5D)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.86  phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
     3635 (INPP5D)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    3635 (INPP5D)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: SH2 Exo_endo_phos
Motif
Other DBs
NCBI-GeneID: 3635
NCBI-ProteinID: NP_001017915
OMIM: 601582
HGNC: 6079
Ensembl: ENSG00000168918
Vega: OTTHUMG00000133688
Pharos: Q92835(Tbio)
UniProt: Q92835
LinkDB All DBs
Structure
PDB: 

Position
2q37.1
AA seq 1189 aa AA seqDB search
MVPCWNHGNITRSKAEELLSRTGKDGSFLVRASESISRAYALCVLYRNCVYTYRILPNED
DKFTVQASEGVSMRFFTKLDQLIEFYKKENMGLVTHLQYPVPLEEEDTGDDPEEDTVESV
VSPPELPPRNIPLTASSCEAKEVPFSNENPRATETSRPSLSETLFQRLQSMDTSGLPEEH
LKAIQDYLSTQLAQDSEFVKTGSSSLPHLKKLTTLLCKELYGEVIRTLPSLESLQRLFDQ
QLSPGLRPRPQVPGEANPINMVSKLSQLTSLLSSIEDKVKALLHEGPESPHRPSLIPPVT
FEVKAESLGIPQKMQLKVDVESGKLIIKKSKDGSEDKFYSHKKILQLIKSQKFLNKLVIL
VETEKEKILRKEYVFADSKKREGFCQLLQQMKNKHSEQPEPDMITIFIGTWNMGNAPPPK
KITSWFLSKGQGKTRDDSADYIPHDIYVIGTQEDPLSEKEWLEILKHSLQEITSVTFKTV
AIHTLWNIRIVVLAKPEHENRISHICTDNVKTGIANTLGNKGAVGVSFMFNGTSLGFVNS
HLTSGSEKKLRRNQNYMNILRFLALGDKKLSPFNITHRFTHLFWFGDLNYRVDLPTWEAE
TIIQKIKQQQYADLLSHDQLLTERREQKVFLHFEEEEITFAPTYRFERLTRDKYAYTKQK
ATGMKYNLPSWCDRVLWKSYPLVHVVCQSYGSTSDIMTSDHSPVFATFEAGVTSQFVSKN
GPGTVDSQGQIEFLRCYATLKTKSQTKFYLEFHSSCLESFVKSQEGENEEGSEGELVVKF
GETLPKLKPIISDPEYLLDQHILISIKSSDSDESYGEGCIALRLEATETQLPIYTPLTHH
GELTGHFQGEIKLQTSQGKTREKLYDFVKTERDESSGPKTLKSLTSHDPMKQWEVTSRAP
PCSGSSITEIINPNYMGVGPFGPPMPLHVKQTLSPDQQPTAWSYDQPPKDSPLGPCRGES
PPTPPGQPPISPKKFLPSTANRGLPPRTQESRPSDLGKNAGDTLPQEDLPLTKPEMFENP
LYGSLSSFPKPAPRKDQESPKMPRKEPPPCPEPGILSPSIVLTKAQEADRGEGPGKQVPA
PRLRSFTCSSSAEGRAAGGDKSQGKPKTPVSSQAPVPAKRPIKPSRSEINQQTPPTPTPR
PPLPVKSPAVLHLQHSKGRDYRDNTELPHHGKHRPEEGPPGPLGRTAMQ
NT seq 3570 nt NT seq  +upstreamnt  +downstreamnt
atggtcccctgctggaaccatggcaacatcacccgctccaaggcggaggagctgctttcc
aggacaggcaaggacgggagcttcctcgtgcgtgccagcgagtccatctcccgggcatac
gcgctctgcgtgctgtatcggaattgcgtttacacttacagaattctgcccaatgaagat
gataaattcactgttcaggcatccgaaggcgtctccatgaggttcttcaccaagctggac
cagctcatcgagttttacaagaaggaaaacatggggctggtgacccatctgcaataccct
gtgccgctggaggaagaggacacaggcgacgaccctgaggaggacacagtagaaagtgtc
gtgtctccacccgagctgcccccaagaaacatcccgctgactgccagctcctgtgaggcc
aaggaggttcctttttcaaacgagaatccccgagcgaccgagaccagccggccgagcctc
tccgagacattgttccagcgactgcaaagcatggacaccagtgggcttccagaagagcat
cttaaggccatccaagattatttaagcactcagctcgcccaggactctgaatttgtgaag
acagggtccagcagtcttcctcacctgaagaaactgaccacactgctctgcaaggagctc
tatggagaagtcatccggaccctcccatccctggagtctctgcagaggttatttgaccag
cagctctccccgggcctccgtccacgtcctcaggttcctggtgaggccaatcccatcaac
atggtgtccaagctcagccaactgacaagcctgttgtcgtccattgaagacaaggtcaag
gccttgctgcacgagggtcctgagtctccgcaccggccctcccttatccctccagtcacc
tttgaggtgaaggcagagtctctggggattcctcagaaaatgcagctcaaagtcgacgtt
gagtctgggaaactgatcattaagaagtccaaggatggttctgaggacaagttctacagc
cacaagaaaatcctgcagctcattaagtcacagaaatttctgaataagttggtgatcttg
gtggaaacagagaaggagaagatcctgcggaaggaatatgtttttgctgactccaaaaag
agagaaggcttctgccagctcctgcagcagatgaagaacaagcactcagagcagccggag
cccgacatgatcaccatcttcatcggcacctggaacatgggtaacgccccccctcccaag
aagatcacgtcctggtttctctccaaggggcagggaaagacgcgggacgactctgcggac
tacatcccccatgacatttacgtgatcggcacccaagaggaccccctgagtgagaaggag
tggctggagatcctcaaacactccctgcaagaaatcaccagtgtgacttttaaaacagtc
gccatccacacgctctggaacatccgcatcgtggtgctggccaagcctgagcacgagaac
cggatcagccacatctgtactgacaacgtgaagacaggcattgcaaacacactggggaac
aagggagccgtgggggtgtcgttcatgttcaatggaacctccttagggttcgtcaacagc
cacttgacttcaggaagtgaaaagaaactcaggcgaaaccaaaactatatgaacattctc
cggttcctggccctgggcgacaagaagctgagtccctttaacatcactcaccgcttcacg
cacctcttctggtttggggatcttaactaccgtgtggatctgcctacctgggaggcagaa
accatcatccagaaaatcaagcagcagcagtacgcagacctcctgtcccacgaccagctg
ctcacagagaggagggagcagaaggtcttcctacacttcgaggaggaagaaatcacgttt
gccccaacctaccgttttgagagactgactcgggacaaatacgcctacaccaagcagaaa
gcgacagggatgaagtacaacttgccttcctggtgtgaccgagtcctctggaagtcttat
cccctggtgcacgtggtgtgtcagtcttatggcagtaccagcgacatcatgacgagtgac
cacagccctgtctttgccacatttgaggcaggagtcacttcccagtttgtctccaagaac
ggtcccgggactgttgacagccaaggacagattgagtttctcaggtgctatgccacattg
aagaccaagtcccagaccaaattctacctggagttccactcgagctgcttggagagtttt
gtcaagagtcaggaaggagaaaatgaagaaggaagtgagggggagctggtggtgaagttt
ggtgagactcttccaaagctgaagcccattatctctgaccctgagtacctgctagaccag
cacatcctcatcagcatcaagtcctctgacagcgacgaatcctatggcgagggctgcatt
gcccttcggttagaggccacagaaacgcagctgcccatctacacgcctctcacccaccat
ggggagttgacaggccacttccagggggagatcaagctgcagacctctcagggcaagacg
agggagaagctctatgactttgtgaagacggagcgtgatgaatccagtgggccaaagacc
ctgaagagcctcaccagccacgaccccatgaagcagtgggaagtcactagcagggcccct
ccgtgcagtggctccagcatcactgaaatcatcaaccccaactacatgggagtggggccc
tttgggccaccaatgcccctgcacgtgaagcagaccttgtcccctgaccagcagcccaca
gcctggagctacgaccagccgcccaaggactccccgctggggccctgcaggggagaaagt
cctccgacacctcccggccagccgcccatatcacccaagaagtttttaccctcaacagca
aaccggggtctccctcccaggacacaggagtcaaggcccagtgacctggggaagaacgca
ggggacacgctgcctcaggaggacctgccgctgacgaagcccgagatgtttgagaacccc
ctgtatgggtccctgagttccttccctaagcctgctcccaggaaggaccaggaatccccc
aaaatgccgcggaaggaacccccgccctgcccggaacccggcatcttgtcgcccagcatc
gtgctcaccaaagcccaggaggctgatcgcggcgaggggcccggcaagcaggtgcccgcg
ccccggctgcgctccttcacgtgctcatcctctgccgagggcagggcggccggcggggac
aagagccaagggaagcccaagaccccggtcagctcccaggccccggtgccggccaagagg
cccatcaagccttccagatcggaaatcaaccagcagaccccgcccaccccgacgccgcgg
ccgccgctgccagtcaagagcccggcggtgctgcacctccagcactccaagggccgcgac
taccgcgacaacaccgagctcccgcatcacggcaagcaccggccggaggaggggccacca
gggcctctaggcaggactgccatgcagtga

KEGG   Homo sapiens (human): 3636Help
Entry
3636              CDS       T01001                                 

Gene name
INPPL1, OPSMD, SHIP2
Definition
(RefSeq) inositol polyphosphate phosphatase like 1
  KO
K15909  phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2 [EC:3.1.3.86]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00562  Inositol phosphate metabolism
hsa01100  Metabolic pathways
hsa04070  Phosphatidylinositol signaling system
hsa04662  B cell receptor signaling pathway
hsa04666  Fc gamma R-mediated phagocytosis
hsa04910  Insulin signaling pathway
Disease
H01828  Opsismodysplasia
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    3636 (INPPL1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04070 Phosphatidylinositol signaling system
    3636 (INPPL1)
 09150 Organismal Systems
  09151 Immune system
   04662 B cell receptor signaling pathway
    3636 (INPPL1)
   04666 Fc gamma R-mediated phagocytosis
    3636 (INPPL1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    3636 (INPPL1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    3636 (INPPL1)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.86  phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
     3636 (INPPL1)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Clathrin-mediated endocytosis
   Inositol 5-phosphatases
    3636 (INPPL1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: SH2 Exo_endo_phos SAM_2 SAM_1 FlpD
Motif
Other DBs
NCBI-GeneID: 3636
NCBI-ProteinID: NP_001558
OMIM: 600829
HGNC: 6080
Ensembl: ENSG00000165458
Vega: OTTHUMG00000167879
Pharos: O15357(Tchem)
UniProt: O15357
LinkDB All DBs
Structure
PDB: 

Position
11q13.4
AA seq 1258 aa AA seqDB search
MASACGAPGPGGALGSQAPSWYHRDLSRAAAEELLARAGRDGSFLVRDSESVAGAFALCV
LYQKHVHTYRILPDGEDFLAVQTSQGVPVRRFQTLGELIGLYAQPNQGLVCALLLPVEGE
REPDPPDDRDASDGEDEKPPLPPRSGSTSISAPTGPSSPLPAPETPTAPAAESAPNGLST
VSHDYLKGSYGLDLEAVRGGASHLPHLTRTLATSCRRLHSEVDKVLSGLEILSKVFDQQS
SPMVTRLLQQQNLPQTGEQELESLVLKLSVLKDFLSGIQKKALKALQDMSSTAPPAPQPS
TRKAKTIPVQAFEVKLDVTLGDLTKIGKSQKFTLSVDVEGGRLVLLRRQRDSQEDWTTFT
HDRIRQLIKSQRVQNKLGVVFEKEKDRTQRKDFIFVSARKREAFCQLLQLMKNKHSKQDE
PDMISVFIGTWNMGSVPPPKNVTSWFTSKGLGKTLDEVTVTIPHDIYVFGTQENSVGDRE
WLDLLRGGLKELTDLDYRPIAMQSLWNIKVAVLVKPEHENRISHVSTSSVKTGIANTLGN
KGAVGVSFMFNGTSFGFVNCHLTSGNEKTARRNQNYLDILRLLSLGDRQLNAFDISLRFT
HLFWFGDLNYRLDMDIQEILNYISRKEFEPLLRVDQLNLEREKHKVFLRFSEEEISFPPT
YRYERGSRDTYAWHKQKPTGVRTNVPSWCDRILWKSYPETHIICNSYGCTDDIVTSDHSP
VFGTFEVGVTSQFISKKGLSKTSDQAYIEFESIEAIVKTASRTKFFIEFYSTCLEEYKKS
FENDAQSSDNINFLKVQWSSRQLPTLKPILADIEYLQDQHLLLTVKSMDGYESYGECVVA
LKSMIGSTAQQFLTFLSHRGEETGNIRGSMKVRVPTERLGTRERLYEWISIDKDEAGAKS
KAPSVSRGSQEPRSGSRKPAFTEASCPLSRLFEEPEKPPPTGRPPAPPRAAPREEPLTPR
LKPEGAPEPEGVAAPPPKNSFNNPAYYVLEGVPHQLLPPEPPSPARAPVPSATKNKVAIT
VPAPQLGHHRHPRVGEGSSSDEESGGTLPPPDFPPPPLPDSAIFLPPSLDPLPGPVVRGR
GGAEARGPPPPKAHPRPPLPPGPSPASTFLGEVASGDDRSCSVLQMAKTLSEVDYAPAGP
ARSALLPGPLELQPPRGLPSDYGRPLSFPPPRIRESIQEDLAEEAPCLQGGRASGLGEAG
MSAWLRAIGLERYEEGLVHNGWDDLEFLSDITEEDLEEAGVQDPAHKRLLLDTLQLSK
NT seq 3777 nt NT seq  +upstreamnt  +downstreamnt
atggcctcggcctgcggggcgccgggcccggggggcgccctgggcagccaggccccctcc
tggtaccaccgcgacctgagccgggcggccgcggaggagctgctggcccgggcgggccgc
gatggcagcttcctggtccgagacagcgagagcgtggcgggggccttcgcgctctgcgtc
ctgtatcagaagcatgtgcacacgtatcgcattctgcctgatggagaagatttcttggct
gtgcagacctcgcagggtgtgcctgtgcgccgcttccagaccctgggtgagctcatcggc
ctgtacgcccagcccaaccagggccttgtgtgcgccctgcttcttcctgtagagggtgag
cgagagccggacccaccggatgaccgggatgcctcagatggggaggatgagaagcccccg
ctgcccccgcgctctggctccaccagcatttctgcccccactgggcccagcagtcccctg
ccagctcctgagactcccacagctccagctgctgagagtgctcccaatgggctgagcacc
gtctcgcacgactacctgaaaggcagctatgggctggacctggaagctgtgaggggtgga
gccagccacctgccccacctcacccgtaccctcgctacctcatgccggaggctgcacagt
gaggtggacaaggtcctgtcaggcctggagatcctgtccaaggtgtttgaccagcagagc
tcgcccatggtgacccgccttttgcagcagcagaacctgccacagacaggggagcaggaa
ctagagagcctggtgctgaagctgtcagtgctaaaggacttcctgtcaggcatccagaag
aaggccctgaaggccctacaggacatgagctccacagcacccccagctccgcagccatcc
acacgtaaggccaagaccatccccgtgcaggcctttgaggtgaagctagatgtgaccctg
ggtgacctgaccaagattgggaagtcacagaagttcacgctgagcgtggatgtggagggt
gggcggctggtgctgctgcggagacagcgggactcccaggaggactggaccaccttcacg
cacgaccgcatccgccagctcattaagtcccagcgtgtccagaacaagctgggtgttgtg
tttgagaaggagaaggaccggactcagcgcaaggacttcatctttgtcagtgcccggaag
cgggaggccttctgccagctgttgcagctcatgaagaacaagcactccaagcaggacgag
cccgacatgatctcagtcttcataggcacctggaacatgggaagtgtaccacctccaaaa
aacgtgacatcctggttcacatcgaagggtctggggaagaccctggacgaggtcacagtg
accataccccatgacatctatgtctttgggacccaggagaactcagtgggcgaccgcgag
tggctggacctactgcgcgggggcctcaaggagcttacggatctggattaccgcccgatt
gccatgcaatcactgtggaatatcaaggtggcagtgctggtcaagccagagcacgagaac
cgtatcagccatgtcagtacgtccagtgtgaagactggcatcgccaacaccctggggaac
aagggggctgtgggcgtctccttcatgtttaatggcacctcatttggctttgtgaattgt
cacctcacctcgggaaatgagaagacggctcggaggaaccaaaactacttggacatcctg
cggctgctctcgctgggcgaccggcagctcaatgcctttgacatctctctgcgtttcaca
cacctcttctggtttggggacctcaactaccgcctggacatggatatccaggagatcctg
aactacatcagcaggaaagagtttgagcccctcctcagggtggaccagctcaacctggag
cgggagaagcacaaggtcttccttcgattcagtgaggaggagatctccttcccacccacc
taccgctatgagcggggttcccgggacacatatgcctggcacaagcagaagccaactggg
gtccggaccaatgtgccctcatggtgtgaccggattctgtggaaatcctaccctgaaact
cacatcatctgcaattcttatggttgcactgatgacatcgtcaccagcgaccattccccc
gtgtttgggacatttgaggttggagttacctcccagttcatctccaagaaagggctctca
aagacttcagaccaggcctacattgagtttgagagcatcgaggccattgtgaagacagcc
agccgcaccaagttcttcatcgagttctactctacctgcctggaggaatacaagaagagc
tttgagaatgatgcccagagcagtgacaacatcaacttcctcaaagtgcagtggtcttca
cgccagctgcccacgctcaaaccaattctggctgatatcgagtacctgcaggaccagcac
ctcctgctcacagtcaagtccatggatggctatgaatcctatggggagtgtgtggttgca
ctcaaatccatgatcggcagcacggcccaacagttcctgaccttcctatcccaccgtggc
gaggagacaggcaatatcagaggctccatgaaggtgcgggtgcccacggagcgcctgggc
acccgtgagcggctctacgagtggatcagcattgataaggatgaggcaggagcaaagagc
aaagccccctctgtgtcccgagggagccaggagcccaggtcagggagccgcaagccagcc
ttcacagaggcctcctgcccgctctccaggttatttgaagaaccagagaaaccgccacca
acggggaggcccccagccccaccccgagcagctccccgggaggagcccttgacccccagg
ttgaagccagagggagctcctgaaccagaaggggtggcggcccccccacccaagaacagc
ttcaataaccctgcctactacgtccttgaaggggtcccgcaccagctgctgcccccggag
ccaccctcgcctgccagggcccctgtcccatctgccaccaagaacaaagtggccattaca
gtgcctgctccacagcttgggcaccaccggcaccctcgtgtgggagaggggagttcttca
gatgaggagtctggaggcacactgccccctccagactttccacctccaccactgccggac
tcagccatcttcctgccccccagcctggatcctttaccagggccagtggtccggggccgt
ggtggggctgaggcccgtggcccaccacctcccaaggcccatccaaggcctccactgccc
ccaggcccctcaccagccagcactttcctgggggaagtggccagtggggatgaccggtcc
tgctcggtgctgcagatggccaagacgctgagcgaggtggactatgcccctgctgggcct
gcacgctcagcgctcctcccaggccccctggagctgcagcccccccggggactgccctcg
gactatggccggcccctcagcttccctccaccccgcatccgggagagcatccaggaagac
ctggcagaggaggctccgtgcctgcagggcgggcgggccagcgggctgggcgaggcaggc
atgagtgcctggctgcgggccatcggcttggagcgctatgaggagggcctggtgcataat
ggctgggacgacctggagtttctcagtgacatcaccgaggaggacttggaggaggctggg
gtgcaggacccggctcacaagcgcctccttctggacaccctgcagctcagcaagtga

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