KEGG   Homo sapiens (human): 3678Help
Entry
3678              CDS       T01001                                 

Gene name
ITGA5, CD49e, FNRA, VLA-5, VLA5A
Definition
(RefSeq) integrin subunit alpha 5
  KO
K06484  integrin alpha 5
Organism
hsa  Homo sapiens (human)
Pathway
hsa04145  Phagosome
hsa04151  PI3K-Akt signaling pathway
hsa04510  Focal adhesion
hsa04512  ECM-receptor interaction
hsa04640  Hematopoietic cell lineage
hsa04810  Regulation of actin cytoskeleton
hsa05100  Bacterial invasion of epithelial cells
hsa05131  Shigellosis
hsa05133  Pertussis
hsa05135  Yersinia infection
hsa05165  Human papillomavirus infection
hsa05168  Herpes simplex virus 1 infection
hsa05205  Proteoglycans in cancer
hsa05206  MicroRNAs in cancer
hsa05410  Hypertrophic cardiomyopathy (HCM)
hsa05412  Arrhythmogenic right ventricular cardiomyopathy (ARVC)
hsa05414  Dilated cardiomyopathy (DCM)
Network
nt06135  Cytoskeletal regulation (virus)
nt06167  Human cytomegalovirus (HCMV)
  Element
N00393  ITGA/B-RhoA signaling pathway
Drug target
Volociximab: D06319
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04151 PI3K-Akt signaling pathway
    3678 (ITGA5)
  09133 Signaling molecules and interaction
   04512 ECM-receptor interaction
    3678 (ITGA5)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    3678 (ITGA5)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    3678 (ITGA5)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    3678 (ITGA5)
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    3678 (ITGA5)
 09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    3678 (ITGA5)
   05205 Proteoglycans in cancer
    3678 (ITGA5)
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy (HCM)
    3678 (ITGA5)
   05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
    3678 (ITGA5)
   05414 Dilated cardiomyopathy (DCM)
    3678 (ITGA5)
  09171 Infectious disease: bacterial
   05131 Shigellosis
    3678 (ITGA5)
   05135 Yersinia infection
    3678 (ITGA5)
   05133 Pertussis
    3678 (ITGA5)
   05100 Bacterial invasion of epithelial cells
    3678 (ITGA5)
  09172 Infectious disease: viral
   05168 Herpes simplex virus 1 infection
    3678 (ITGA5)
   05165 Human papillomavirus infection
    3678 (ITGA5)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    3678 (ITGA5)
   04515 Cell adhesion molecules [BR:hsa04515]
    3678 (ITGA5)
   04090 CD molecules [BR:hsa04090]
    3678 (ITGA5)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   3678 (ITGA5)
Cell adhesion molecules [BR:hsa04515]
 Integrins
  Integrin alpha subunits
   3678 (ITGA5)
CD molecules [BR:hsa04090]
 Proteins
  3678 (ITGA5)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Integrin_alpha2 FG-GAP VCBS Integrin_alpha
Motif
Other DBs
NCBI-GeneID: 3678
NCBI-ProteinID: NP_002196
OMIM: 135620
HGNC: 6141
Ensembl: ENSG00000161638
Vega: OTTHUMG00000169841
Pharos: P08648(Tbio)
UniProt: P08648 B2R627
LinkDB All DBs
Structure
PDB: 

Position
12q13.13
AA seq 1049 aa AA seqDB search
MGSRTPESPLHAVQLRWGPRRRPPLLPLLLLLLPPPPRVGGFNLDAEAPAVLSGPPGSFF
GFSVEFYRPGTDGVSVLVGAPKANTSQPGVLQGGAVYLCPWGASPTQCTPIEFDSKGSRL
LESSLSSSEGEEPVEYKSLQWFGATVRAHGSSILACAPLYSWRTEKEPLSDPVGTCYLST
DNFTRILEYAPCRSDFSWAAGQGYCQGGFSAEFTKTGRVVLGGPGSYFWQGQILSATQEQ
IAESYYPEYLINLVQGQLQTRQASSIYDDSYLGYSVAVGEFSGDDTEDFVAGVPKGNLTY
GYVTILNGSDIRSLYNFSGEQMASYFGYAVAATDVNGDGLDDLLVGAPLLMDRTPDGRPQ
EVGRVYVYLQHPAGIEPTPTLTLTGHDEFGRFGSSLTPLGDLDQDGYNDVAIGAPFGGET
QQGVVFVFPGGPGGLGSKPSQVLQPLWAASHTPDFFGSALRGGRDLDGNGYPDLIVGSFG
VDKAVVYRGRPIVSASASLTIFPAMFNPEERSCSLEGNPVACINLSFCLNASGKHVADSI
GFTVELQLDWQKQKGGVRRALFLASRQATLTQTLLIQNGAREDCREMKIYLRNESEFRDK
LSPIHIALNFSLDPQAPVDSHGLRPALHYQSKSRIEDKAQILLDCGEDNICVPDLQLEVF
GEQNHVYLGDKNALNLTFHAQNVGEGGAYEAELRVTAPPEAEYSGLVRHPGNFSSLSCDY
FAVNQSRLLVCDLGNPMKAGASLWGGLRFTVPHLRDTKKTIQFDFQILSKNLNNSQSDVV
SFRLSVEAQAQVTLNGVSKPEAVLFPVSDWHPRDQPQKEEDLGPAVHHVYELINQGPSSI
SQGVLELSCPQALEGQQLLYVTRVTGLNCTTNHPINPKGLELDPEGSLHHQQKREAPSRS
SASSGPQILKCPEAECFRLRCELGPLHQQESQSLQLHFRVWAKTFLQREHQPFSLQCEAV
YKALKMPYRILPRQLPQKERQVATAVQWTKAEGSYGVPLWIIILAILFGLLLLGLLIYIL
YKLGFFKRSLPYGTAMEKAQLKPPATSDA
NT seq 3150 nt NT seq  +upstreamnt  +downstreamnt
atggggagccggacgccagagtcccctctccacgccgtgcagctgcgctggggcccccgg
cgccgacccccgctgctgccgctgctgttgctgctgctgccgccgccacccagggtcggg
ggcttcaacttagacgcggaggccccagcagtactctcggggcccccgggctccttcttc
ggattctcagtggagttttaccggccgggaacagacggggtcagtgtgctggtgggagca
cccaaggctaataccagccagccaggagtgctgcagggtggtgctgtctacctctgtcct
tggggtgccagccccacacagtgcacccccattgaatttgacagcaaaggctctcggctc
ctggagtcctcactgtccagctcagagggagaggagcctgtggagtacaagtccttgcag
tggttcggggcaacagttcgagcccatggctcctccatcttggcatgcgctccactgtac
agctggcgcacagagaaggagccactgagcgaccccgtgggcacctgctacctctccaca
gataacttcacccgaattctggagtatgcaccctgccgctcagatttcagctgggcagca
ggacagggttactgccaaggaggcttcagtgccgagttcaccaagactggccgtgtggtt
ttaggtggaccaggaagctatttctggcaaggccagatcctgtctgccactcaggagcag
attgcagaatcttattaccccgagtacctgatcaacctggttcaggggcagctgcagact
cgccaggccagttccatctatgatgacagctacctaggatactctgtggctgttggtgaa
ttcagtggtgatgacacagaagactttgttgctggtgtgcccaaagggaacctcacttac
ggctatgtcaccatccttaatggctcagacattcgatccctctacaacttctcaggggaa
cagatggcctcctactttggctatgcagtggccgccacagacgtcaatggggacgggctg
gatgacttgctggtgggggcacccctgctcatggatcggacccctgacgggcggcctcag
gaggtgggcagggtctacgtctacctgcagcacccagccggcatagagcccacgcccacc
cttaccctcactggccatgatgagtttggccgatttggcagctccttgacccccctgggg
gacctggaccaggatggctacaatgatgtggccatcggggctccctttggtggggagacc
cagcagggagtagtgtttgtatttcctgggggcccaggagggctgggctctaagccttcc
caggttctgcagcccctgtgggcagccagccacaccccagacttctttggctctgccctt
cgaggaggccgagacctggatggcaatggatatcctgatctgattgtggggtcctttggt
gtggacaaggctgtggtatacaggggccgccccatcgtgtccgctagtgcctccctcacc
atcttccccgccatgttcaacccagaggagcggagctgcagcttagaggggaaccctgtg
gcctgcatcaaccttagcttctgcctcaatgcttctggaaaacacgttgctgactccatt
ggtttcacagtggaacttcagctggactggcagaagcagaagggaggggtacggcgggca
ctgttcctggcctccaggcaggcaaccctgacccagaccctgctcatccagaatggggct
cgagaggattgcagagagatgaagatctacctcaggaacgagtcagaatttcgagacaaa
ctctcgccgattcacatcgctctcaacttctccttggacccccaagccccagtggacagc
cacggcctcaggccagccctacattatcagagcaagagccggatagaggacaaggctcag
atcttgctggactgtggagaagacaacatctgtgtgcctgacctgcagctggaagtgttt
ggggagcagaaccatgtgtacctgggtgacaagaatgccctgaacctcactttccatgcc
cagaatgtgggtgagggtggcgcctatgaggctgagcttcgggtcaccgcccctccagag
gctgagtactcaggactcgtcagacacccagggaacttctccagcctgagctgtgactac
tttgccgtgaaccagagccgcctgctggtgtgtgacctgggcaaccccatgaaggcagga
gccagtctgtggggtggccttcggtttacagtccctcatctccgggacactaagaaaacc
atccagtttgacttccagatcctcagcaagaatctcaacaactcgcaaagcgacgtggtt
tcctttcggctctccgtggaggctcaggcccaggtcaccctgaacggtgtctccaagcct
gaggcagtgctattcccagtaagcgactggcatccccgagaccagcctcagaaggaggag
gacctgggacctgctgtccaccatgtctatgagctcatcaaccaaggccccagctccatt
agccagggtgtgctggaactcagctgtccccaggctctggaaggtcagcagctcctatat
gtgaccagagttacgggactcaactgcaccaccaatcaccccattaacccaaagggcctg
gagttggatcccgagggttccctgcaccaccagcaaaaacgggaagctccaagccgcagc
tctgcttcctcgggacctcagatcctgaaatgcccggaggctgagtgtttcaggctgcgc
tgtgagctcgggcccctgcaccaacaagagagccaaagtctgcagttgcatttccgagtc
tgggccaagactttcttgcagcgggagcaccagccatttagcctgcagtgtgaggctgtg
tacaaagccctgaagatgccctaccgaatcctgcctcggcagctgccccaaaaagagcgt
caggtggccacagctgtgcaatggaccaaggcagaaggcagctatggcgtcccactgtgg
atcatcatcctagccatcctgtttggcctcctgctcctaggtctactcatctacatcctc
tacaagcttggattcttcaaacgctccctcccatatggcaccgccatggaaaaagctcag
ctcaagcctccagccacctctgatgcctga

KEGG   Homo sapiens (human): 3688Help
Entry
3688              CDS       T01001                                 

Gene name
ITGB1, CD29, FNRB, GPIIA, MDF2, MSK12, VLA-BETA, VLAB
Definition
(RefSeq) integrin subunit beta 1
  KO
K05719  integrin beta 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04015  Rap1 signaling pathway
hsa04145  Phagosome
hsa04151  PI3K-Akt signaling pathway
hsa04360  Axon guidance
hsa04510  Focal adhesion
hsa04512  ECM-receptor interaction
hsa04514  Cell adhesion molecules (CAMs)
hsa04530  Tight junction
hsa04611  Platelet activation
hsa04670  Leukocyte transendothelial migration
hsa04810  Regulation of actin cytoskeleton
hsa05100  Bacterial invasion of epithelial cells
hsa05130  Pathogenic Escherichia coli infection
hsa05131  Shigellosis
hsa05133  Pertussis
hsa05135  Yersinia infection
hsa05140  Leishmaniasis
hsa05145  Toxoplasmosis
hsa05165  Human papillomavirus infection
hsa05200  Pathways in cancer
hsa05205  Proteoglycans in cancer
hsa05222  Small cell lung cancer
hsa05410  Hypertrophic cardiomyopathy (HCM)
hsa05412  Arrhythmogenic right ventricular cardiomyopathy (ARVC)
hsa05414  Dilated cardiomyopathy (DCM)
Network
nt06135  Cytoskeletal regulation (virus)
nt06167  Human cytomegalovirus (HCMV)
  Element
N00393  ITGA/B-RhoA signaling pathway
Drug target
Valategrast hydrochloride: D10028
Volociximab: D06319
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    3688 (ITGB1)
   04151 PI3K-Akt signaling pathway
    3688 (ITGB1)
  09133 Signaling molecules and interaction
   04512 ECM-receptor interaction
    3688 (ITGB1)
   04514 Cell adhesion molecules (CAMs)
    3688 (ITGB1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    3688 (ITGB1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    3688 (ITGB1)
   04530 Tight junction
    3688 (ITGB1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    3688 (ITGB1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    3688 (ITGB1)
   04670 Leukocyte transendothelial migration
    3688 (ITGB1)
  09158 Development
   04360 Axon guidance
    3688 (ITGB1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    3688 (ITGB1)
   05205 Proteoglycans in cancer
    3688 (ITGB1)
  09162 Cancer: specific types
   05222 Small cell lung cancer
    3688 (ITGB1)
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy (HCM)
    3688 (ITGB1)
   05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
    3688 (ITGB1)
   05414 Dilated cardiomyopathy (DCM)
    3688 (ITGB1)
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    3688 (ITGB1)
   05131 Shigellosis
    3688 (ITGB1)
   05135 Yersinia infection
    3688 (ITGB1)
   05133 Pertussis
    3688 (ITGB1)
   05100 Bacterial invasion of epithelial cells
    3688 (ITGB1)
  09172 Infectious disease: viral
   05165 Human papillomavirus infection
    3688 (ITGB1)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    3688 (ITGB1)
   05140 Leishmaniasis
    3688 (ITGB1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    3688 (ITGB1)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    3688 (ITGB1)
   04515 Cell adhesion molecules [BR:hsa04515]
    3688 (ITGB1)
   04090 CD molecules [BR:hsa04090]
    3688 (ITGB1)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Phagocytosis
   Integrins (complement receptors)
    3688 (ITGB1)
Exosome [BR:hsa04147]
 Exosomal proteins
  Proteins found in most exosomes
   3688 (ITGB1)
Cell adhesion molecules [BR:hsa04515]
 Integrins
  Integrin beta subunits
   3688 (ITGB1)
CD molecules [BR:hsa04090]
 Proteins
  3688 (ITGB1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Integrin_beta Integrin_b_cyt Integrin_B_tail PSI_integrin I-EGF_1 EGF_2
Motif
Other DBs
NCBI-GeneID: 3688
NCBI-ProteinID: NP_002202
OMIM: 135630
HGNC: 6153
Ensembl: ENSG00000150093
Vega: OTTHUMG00000017928
Pharos: P05556(Tclin)
UniProt: P05556
LinkDB All DBs
Structure
PDB: 

Position
10p11.22
AA seq 798 aa AA seqDB search
MNLQPIFWIGLISSVCCVFAQTDENRCLKANAKSCGECIQAGPNCGWCTNSTFLQEGMPT
SARCDDLEALKKKGCPPDDIENPRGSKDIKKNKNVTNRSKGTAEKLKPEDITQIQPQQLV
LRLRSGEPQTFTLKFKRAEDYPIDLYYLMDLSYSMKDDLENVKSLGTDLMNEMRRITSDF
RIGFGSFVEKTVMPYISTTPAKLRNPCTSEQNCTSPFSYKNVLSLTNKGEVFNELVGKQR
ISGNLDSPEGGFDAIMQVAVCGSLIGWRNVTRLLVFSTDAGFHFAGDGKLGGIVLPNDGQ
CHLENNMYTMSHYYDYPSIAHLVQKLSENNIQTIFAVTEEFQPVYKELKNLIPKSAVGTL
SANSSNVIQLIIDAYNSLSSEVILENGKLSEGVTISYKSYCKNGVNGTGENGRKCSNISI
GDEVQFEISITSNKCPKKDSDSFKIRPLGFTEEVEVILQYICECECQSEGIPESPKCHEG
NGTFECGACRCNEGRVGRHCECSTDEVNSEDMDAYCRKENSSEICSNNGECVCGQCVCRK
RDNTNEIYSGKFCECDNFNCDRSNGLICGGNGVCKCRVCECNPNYTGSACDCSLDTSTCE
ASNGQICNGRGICECGVCKCTDPKFQGQTCEMCQTCLGVCAEHKECVQCRAFNKGEKKDT
CTQECSYFNITKVESRDKLPQPVQPDPVSHCKEKDVDDCWFYFTYSVNGNNEVMVHVVEN
PECPTGPDIIPIVAGVVAGIVLIGLALLLIWKLLMIIHDRREFAKFEKEKMNAKWDTGEN
PIYKSAVTTVVNPKYEGK
NT seq 2397 nt NT seq  +upstreamnt  +downstreamnt
atgaatttacaaccaattttctggattggactgatcagttcagtttgctgtgtgtttgct
caaacagatgaaaatagatgtttaaaagcaaatgccaaatcatgtggagaatgtatacaa
gcagggccaaattgtgggtggtgcacaaattcaacatttttacaggaaggaatgcctact
tctgcacgatgtgatgatttagaagccttaaaaaagaagggttgccctccagatgacata
gaaaatcccagaggctccaaagatataaagaaaaataaaaatgtaaccaaccgtagcaaa
ggaacagcagagaagctcaagccagaggatattactcagatccaaccacagcagttggtt
ttgcgattaagatcaggggagccacagacatttacattaaaattcaagagagctgaagac
tatcccattgacctctactaccttatggacctgtcttactcaatgaaagacgatttggag
aatgtaaaaagtcttggaacagatctgatgaatgaaatgaggaggattacttcggacttc
agaattggatttggctcatttgtggaaaagactgtgatgccttacattagcacaacacca
gctaagctcaggaacccttgcacaagtgaacagaactgcaccagcccatttagctacaaa
aatgtgctcagtcttactaataaaggagaagtatttaatgaacttgttggaaaacagcgc
atatctggaaatttggattctccagaaggtggtttcgatgccatcatgcaagttgcagtt
tgtggatcactgattggctggaggaatgttacacggctgctggtgttttccacagatgcc
gggtttcactttgctggagatgggaaacttggtggcattgttttaccaaatgatggacaa
tgtcacctggaaaataatatgtacacaatgagccattattatgattatccttctattgct
caccttgtccagaaactgagtgaaaataatattcagacaatttttgcagttactgaagaa
tttcagcctgtttacaaggagctgaaaaacttgatccctaagtcagcagtaggaacatta
tctgcaaattctagcaatgtaattcagttgatcattgatgcatacaattccctttcctca
gaagtcattttggaaaacggcaaattgtcagaaggcgtaacaataagttacaaatcttac
tgcaagaacggggtgaatggaacaggggaaaatggaagaaaatgttccaatatttccatt
ggagatgaggttcaatttgaaattagcataacttcaaataagtgtccaaaaaaggattct
gacagctttaaaattaggcctctgggctttacggaggaagtagaggttattcttcagtac
atctgtgaatgtgaatgccaaagcgaaggcatccctgaaagtcccaagtgtcatgaagga
aatgggacatttgagtgtggcgcgtgcaggtgcaatgaagggcgtgttggtagacattgt
gaatgcagcacagatgaagttaacagtgaagacatggatgcttactgcaggaaagaaaac
agttcagaaatctgcagtaacaatggagagtgcgtctgcggacagtgtgtttgtaggaag
agggataatacaaatgaaatttattctggcaaattctgcgagtgtgataatttcaactgt
gatagatccaatggcttaatttgtggaggaaatggtgtttgcaagtgtcgtgtgtgtgag
tgcaaccccaactacactggcagtgcatgtgactgttctttggatactagtacttgtgaa
gccagcaacggacagatctgcaatggccggggcatctgcgagtgtggtgtctgtaagtgt
acagatccgaagtttcaagggcaaacgtgtgagatgtgtcagacctgccttggtgtctgt
gctgagcataaagaatgtgttcagtgcagagccttcaataaaggagaaaagaaagacaca
tgcacacaggaatgttcctattttaacattaccaaggtagaaagtcgggacaaattaccc
cagccggtccaacctgatcctgtgtcccattgtaaggagaaggatgttgacgactgttgg
ttctattttacgtattcagtgaatgggaacaacgaggtcatggttcatgttgtggagaat
ccagagtgtcccactggtccagacatcattccaattgtagctggtgtggttgctggaatt
gttcttattggccttgcattactgctgatatggaagcttttaatgataattcatgacaga
agggagtttgctaaatttgaaaaggagaaaatgaatgccaaatgggacacgggtgaaaat
cctatttataagagtgccgtaacaactgtggtcaatccgaagtatgagggaaaatga

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