KEGG   Homo sapiens (human): 3683Help
Entry
3683              CDS       T01001                                 

Gene name
ITGAL, CD11A, LFA-1, LFA1A
Definition
(RefSeq) integrin subunit alpha L
  KO
K05718  integrin alpha L
Organism
hsa  Homo sapiens (human)
Pathway
hsa04015  Rap1 signaling pathway
hsa04514  Cell adhesion molecules (CAMs)
hsa04650  Natural killer cell mediated cytotoxicity
hsa04670  Leukocyte transendothelial migration
hsa04810  Regulation of actin cytoskeleton
hsa05144  Malaria
hsa05150  Staphylococcus aureus infection
hsa05166  Human T-cell leukemia virus 1 infection
hsa05169  Epstein-Barr virus infection
hsa05323  Rheumatoid arthritis
hsa05416  Viral myocarditis
Drug target
Antithymocyte immunoglobulin (rabbit): D09190
Efalizumab: D03959
Erlizumab: D04045
Lifitegrast (DG01389): D10374 D10392
Rovelizumab: D08993
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    3683 (ITGAL)
  09133 Signaling molecules and interaction
   04514 Cell adhesion molecules (CAMs)
    3683 (ITGAL)
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    3683 (ITGAL)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    3683 (ITGAL)
   04670 Leukocyte transendothelial migration
    3683 (ITGAL)
 09160 Human Diseases
  09163 Immune disease
   05323 Rheumatoid arthritis
    3683 (ITGAL)
  09166 Cardiovascular disease
   05416 Viral myocarditis
    3683 (ITGAL)
  09171 Infectious disease: bacterial
   05150 Staphylococcus aureus infection
    3683 (ITGAL)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    3683 (ITGAL)
   05169 Epstein-Barr virus infection
    3683 (ITGAL)
  09174 Infectious disease: parasitic
   05144 Malaria
    3683 (ITGAL)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    3683 (ITGAL)
   04515 Cell adhesion molecules [BR:hsa04515]
    3683 (ITGAL)
   04090 CD molecules [BR:hsa04090]
    3683 (ITGAL)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   3683 (ITGAL)
Cell adhesion molecules [BR:hsa04515]
 Integrins
  Integrin alpha subunits
   3683 (ITGAL)
CD molecules [BR:hsa04090]
 Proteins
  3683 (ITGAL)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Integrin_alpha2 VWA FG-GAP VWA_2 VCBS FG-GAP_2 Integrin_alpha HisK_sensor
Motif
Other DBs
NCBI-GeneID: 3683
NCBI-ProteinID: NP_002200
OMIM: 153370
HGNC: 6148
Ensembl: ENSG00000005844
Vega: OTTHUMG00000176964
Pharos: P20701(Tclin)
UniProt: P20701 B2RAL6
LinkDB All DBs
Structure
PDB: 

Position
16p11.2
AA seq 1170 aa AA seqDB search
MKDSCITVMAMALLSGFFFFAPASSYNLDVRGARSFSPPRAGRHFGYRVLQVGNGVIVGA
PGEGNSTGSLYQCQSGTGHCLPVTLRGSNYTSKYLGMTLATDPTDGSILACDPGLSRTCD
QNTYLSGLCYLFRQNLQGPMLQGRPGFQECIKGNVDLVFLFDGSMSLQPDEFQKILDFMK
DVMKKLSNTSYQFAAVQFSTSYKTEFDFSDYVKRKDPDALLKHVKHMLLLTNTFGAINYV
ATEVFREELGARPDATKVLIIITDGEATDSGNIDAAKDIIRYIIGIGKHFQTKESQETLH
KFASKPASEFVKILDTFEKLKDLFTELQKKIYVIEGTSKQDLTSFNMELSSSGISADLSR
GHAVVGAVGAKDWAGGFLDLKADLQDDTFIGNEPLTPEVRAGYLGYTVTWLPSRQKTSLL
ASGAPRYQHMGRVLLFQEPQGGGHWSQVQTIHGTQIGSYFGGELCGVDVDQDGETELLLI
GAPLFYGEQRGGRVFIYQRRQLGFEEVSELQGDPGYPLGRFGEAITALTDINGDGLVDVA
VGAPLEEQGAVYIFNGRHGGLSPQPSQRIEGTQVLSGIQWFGRSIHGVKDLEGDGLADVA
VGAESQMIVLSSRPVVDMVTLMSFSPAEIPVHEVECSYSTSNKMKEGVNITICFQIKSLI
PQFQGRLVANLTYTLQLDGHRTRRRGLFPGGRHELRRNIAVTTSMSCTDFSFHFPVCVQD
LISPINVSLNFSLWEEEGTPRDQRAQGKDIPPILRPSLHSETWEIPFEKNCGEDKKCEAN
LRVSFSPARSRALRLTAFASLSVELSLSNLEEDAYWVQLDLHFPPGLSFRKVEMLKPHSQ
IPVSCEELPEESRLLSRALSCNVSSPIFKAGHSVALQMMFNTLVNSSWGDSVELHANVTC
NNEDSDLLEDNSATTIIPILYPINILIQDQEDSTLYVSFTPKGPKIHQVKHMYQVRIQPS
IHDHNIPTLEAVVGVPQPPSEGPITHQWSVQMEPPVPCHYEDLERLPDAAEPCLPGALFR
CPVVFRQEILVQVIGTLELVGEIEASSMFSLCSSLSISFNSSKHFHLYGSNASLAQVVMK
VDVVYEKQMLYLYVLSGIGGLLLLLLIFIVLYKVGFFKRNLKEKMEAGRGVPNGIPAEDS
EQLASGQEAGDPGCLKPLHEKDSESGGGKD
NT seq 3513 nt NT seq  +upstreamnt  +downstreamnt
atgaaggattcctgcatcactgtgatggccatggcgctgctgtctgggttctttttcttc
gcgccggcctcgagctacaacctggacgtgcggggcgcgcggagcttctccccaccgcgc
gccgggaggcactttggataccgcgtcctgcaggtcggaaacggggtcatcgtgggagct
ccaggggaggggaacagcacaggaagcctctatcagtgccagtcgggcacaggacactgc
ctgccagtcaccctgagaggttccaactatacctccaagtacttgggaatgaccttggca
acagaccccacagatggaagcattttggcctgtgaccctgggctgtctcgaacgtgtgac
cagaacacctatctgagtggcctgtgttacctcttccgccagaatctgcagggtcccatg
ctgcaggggcgccctggttttcaggaatgtatcaagggcaacgtagacctggtatttctg
tttgatggttcgatgagcttgcagccagatgaatttcagaaaattctggacttcatgaag
gatgtgatgaagaaactcagcaacacttcgtaccagtttgctgctgttcagttttccaca
agctacaaaacagaatttgatttctcagattatgttaaacggaaggaccctgatgctctg
ctgaagcatgtaaagcacatgttgctgttgaccaatacctttggtgccatcaattatgtc
gcgacagaggtgttccgggaggagctgggggcccggccagatgccaccaaagtgcttatc
atcatcacggatggggaggccactgacagtggcaacatcgatgcggccaaagacatcatc
cgctacatcatcgggattggaaagcattttcagaccaaggagagtcaggagaccctccac
aaatttgcatcaaaacccgcgagcgagtttgtgaaaattctggacacatttgagaagctg
aaagatctattcactgagctgcagaagaagatctatgtcattgagggcacaagcaaacag
gacctgacttccttcaacatggagctgtcctccagcggcatcagtgctgacctcagcagg
ggccatgcagtcgtgggggcagtaggagccaaggactgggctgggggctttcttgacctg
aaggcagacctgcaggatgacacatttattgggaatgaaccattgacaccagaagtgaga
gcaggctatttgggttacaccgtgacctggctgccctcccggcaaaagacttcgttgctg
gcctcgggagcccctcgataccagcacatgggccgagtgctgctgttccaagagccacag
ggcggaggacactggagccaggtccagacaatccatgggacccagattggctcttatttc
ggtggggagctgtgtggcgtcgacgtggaccaagatggggagacagagctgctgctgatt
ggtgccccactgttctatggggagcagagaggaggccgggtgtttatctaccagagaaga
cagttggggtttgaagaagtctcagagctgcagggggaccccggctacccactcgggcgg
tttggagaagccatcactgctctgacagacatcaacggcgatgggctggtagacgtggct
gtgggggcccctctggaggagcagggggctgtgtacatcttcaatgggaggcacgggggg
cttagtccccagccaagtcagcggatagaagggacccaagtgctctcaggaattcagtgg
tttggacgctccatccatggggtgaaggaccttgaaggggatggcttggcagatgtggct
gtgggggctgagagccagatgatcgtgctgagctcccggcccgtggtggatatggtcacc
ctgatgtccttctctccagctgagatcccagtgcatgaagtggagtgctcctattcaacc
agtaacaagatgaaagaaggagttaatatcacaatctgtttccagatcaagtctctcatc
ccccagttccaaggccgcctggttgccaatctcacttacactctgcagctggatggccac
cggaccagaagacgggggttgttcccaggagggagacatgaactcagaaggaatatagct
gtcaccaccagcatgtcatgcactgacttctcatttcatttcccggtatgtgttcaagac
ctcatctcccccatcaatgtttccctgaatttctctctttgggaggaggaagggacaccg
agggaccaaagggcgcagggcaaggacataccgcccatcctgagaccctccctgcactcg
gaaacctgggagatcccttttgagaagaactgtggggaggacaagaagtgtgaggcaaac
ttgagagtgtccttctctcctgcaagatccagagccctgcgtctaactgcttttgccagc
ctctctgtggagctgagcctgagtaacttggaagaagatgcttactgggtccagctggac
ctgcacttccccccgggactctccttccgcaaggtggagatgctgaagccccatagccag
atacctgtgagctgcgaggagcttcctgaagagtccaggcttctgtccagggcattatct
tgcaatgtgagctctcccatcttcaaagcaggccactcggttgctctgcagatgatgttt
aatacactggtaaacagctcctggggggactcggttgaattgcacgccaatgtgacctgt
aacaatgaggactcagacctcctggaggacaactcagccactaccatcatccccatcctg
taccccatcaacatcctcatccaggaccaagaagactccacactctatgtcagtttcacc
cccaaaggccccaagatccaccaagtcaagcacatgtaccaggtgaggatccagccttcc
atccacgaccacaacatacccaccctggaggctgtggttggggtgccacagcctcccagc
gaggggcccatcacacaccagtggagcgtgcagatggagcctcccgtgccctgccactat
gaggatctggagaggctcccggatgcagctgagccttgtctccccggagccctgttccgc
tgccctgttgtcttcaggcaggagatcctcgtccaagtgatcgggactctggagctggtg
ggagagatcgaggcctcttccatgttcagcctctgcagctccctctccatctccttcaac
agcagcaagcatttccacctctatggcagcaacgcctccctggcccaggttgtcatgaag
gttgacgtggtgtatgagaagcagatgctctacctctacgtgctgagcggcatcgggggg
ctgctgctgctgctgctcattttcatagtgctgtacaaggttggtttcttcaaacggaac
ctgaaggagaagatggaggctggcagaggtgtcccgaatggaatccctgcagaagactct
gagcagctggcatctgggcaagaggctggggatcccggctgcctgaagcccctccatgag
aaggactctgagagtggtggtggcaaggactga

KEGG   Homo sapiens (human): 3689Help
Entry
3689              CDS       T01001                                 

Gene name
ITGB2, CD18, LAD, LCAMB, LFA-1, MAC-1, MF17, MFI7
Definition
(RefSeq) integrin subunit beta 2
  KO
K06464  integrin beta 2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04015  Rap1 signaling pathway
hsa04145  Phagosome
hsa04390  Hippo signaling pathway
hsa04514  Cell adhesion molecules (CAMs)
hsa04610  Complement and coagulation cascades
hsa04650  Natural killer cell mediated cytotoxicity
hsa04670  Leukocyte transendothelial migration
hsa04810  Regulation of actin cytoskeleton
hsa05133  Pertussis
hsa05134  Legionellosis
hsa05140  Leishmaniasis
hsa05144  Malaria
hsa05146  Amoebiasis
hsa05150  Staphylococcus aureus infection
hsa05152  Tuberculosis
hsa05166  Human T-cell leukemia virus 1 infection
hsa05323  Rheumatoid arthritis
hsa05416  Viral myocarditis
Network
nt06136  Complement activation (virus)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06168  Herpes simplex virus 1 (HSV-1)
  Element
N00463  Alternative pathway of complement activation
Disease
H00099  Leukocyte adhesion deficiency
Drug target
Erlizumab: D04045
Rovelizumab: D08993
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    3689 (ITGB2)
   04390 Hippo signaling pathway
    3689 (ITGB2)
  09133 Signaling molecules and interaction
   04514 Cell adhesion molecules (CAMs)
    3689 (ITGB2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    3689 (ITGB2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    3689 (ITGB2)
 09150 Organismal Systems
  09151 Immune system
   04610 Complement and coagulation cascades
    3689 (ITGB2)
   04650 Natural killer cell mediated cytotoxicity
    3689 (ITGB2)
   04670 Leukocyte transendothelial migration
    3689 (ITGB2)
 09160 Human Diseases
  09163 Immune disease
   05323 Rheumatoid arthritis
    3689 (ITGB2)
  09166 Cardiovascular disease
   05416 Viral myocarditis
    3689 (ITGB2)
  09171 Infectious disease: bacterial
   05133 Pertussis
    3689 (ITGB2)
   05134 Legionellosis
    3689 (ITGB2)
   05150 Staphylococcus aureus infection
    3689 (ITGB2)
   05152 Tuberculosis
    3689 (ITGB2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    3689 (ITGB2)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    3689 (ITGB2)
   05144 Malaria
    3689 (ITGB2)
   05140 Leishmaniasis
    3689 (ITGB2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    3689 (ITGB2)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    3689 (ITGB2)
   04515 Cell adhesion molecules [BR:hsa04515]
    3689 (ITGB2)
   04090 CD molecules [BR:hsa04090]
    3689 (ITGB2)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Phagocytosis
   Integrins (complement receptors)
    3689 (ITGB2)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   3689 (ITGB2)
Cell adhesion molecules [BR:hsa04515]
 Integrins
  Integrin beta subunits
   3689 (ITGB2)
CD molecules [BR:hsa04090]
 Proteins
  3689 (ITGB2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Integrin_beta Integrin_B_tail Integrin_b_cyt PSI_integrin I-EGF_1 EGF_2
Motif
Other DBs
NCBI-GeneID: 3689
NCBI-ProteinID: NP_000202
OMIM: 600065
HGNC: 6155
Ensembl: ENSG00000160255
Vega: OTTHUMG00000090257
Pharos: P05107(Tclin)
UniProt: P05107 A0A494C0X7
LinkDB All DBs
Structure
PDB: 

Position
21q22.3
AA seq 769 aa AA seqDB search
MLGLRPPLLALVGLLSLGCVLSQECTKFKVSSCRECIESGPGCTWCQKLNFTGPGDPDSI
RCDTRPQLLMRGCAADDIMDPTSLAETQEDHNGGQKQLSPQKVTLYLRPGQAAAFNVTFR
RAKGYPIDLYYLMDLSYSMLDDLRNVKKLGGDLLRALNEITESGRIGFGSFVDKTVLPFV
NTHPDKLRNPCPNKEKECQPPFAFRHVLKLTNNSNQFQTEVGKQLISGNLDAPEGGLDAM
MQVAACPEEIGWRNVTRLLVFATDDGFHFAGDGKLGAILTPNDGRCHLEDNLYKRSNEFD
YPSVGQLAHKLAENNIQPIFAVTSRMVKTYEKLTEIIPKSAVGELSEDSSNVVHLIKNAY
NKLSSRVFLDHNALPDTLKVTYDSFCSNGVTHRNQPRGDCDGVQINVPITFQVKVTATEC
IQEQSFVIRALGFTDIVTVQVLPQCECRCRDQSRDRSLCHGKGFLECGICRCDTGYIGKN
CECQTQGRSSQELEGSCRKDNNSIICSGLGDCVCGQCLCHTSDVPGKLIYGQYCECDTIN
CERYNGQVCGGPGRGLCFCGKCRCHPGFEGSACQCERTTEGCLNPRRVECSGRGRCRCNV
CECHSGYQLPLCQECPGCPSPCGKYISCAECLKFEKGPFGKNCSAACPGLQLSNNPVKGR
TCKERDSEGCWVAYTLEQQDGMDRYLIYVDESRECVAGPNIAAIVGGTVAGIVLIGILLL
VIWKALIHLSDLREYRRFEKEKLKSQWNNDNPLFKSATTTVMNPKFAES
NT seq 2310 nt NT seq  +upstreamnt  +downstreamnt
atgctgggcctgcgccccccactgctcgccctggtggggctgctctccctcgggtgcgtc
ctctctcaggagtgcacgaagttcaaggtcagcagctgccgggaatgcatcgagtcgggg
cccggctgcacctggtgccagaagctgaacttcacagggccgggggatcctgactccatt
cgctgcgacacccggccacagctgctcatgaggggctgtgcggctgacgacatcatggac
cccacaagcctcgctgaaacccaggaagaccacaatgggggccagaagcagctgtcccca
caaaaagtgacgctttacctgcgaccaggccaggcagcagcgttcaacgtgaccttccgg
cgggccaagggctaccccatcgacctgtactatctgatggacctctcctactccatgctt
gatgacctcaggaatgtcaagaagctaggtggcgacctgctccgggccctcaacgagatc
accgagtccggccgcattggcttcgggtccttcgtggacaagaccgtgctgccgttcgtg
aacacgcaccctgataagctgcgaaacccatgccccaacaaggagaaagagtgccagccc
ccgtttgccttcaggcacgtgctgaagctgaccaacaactccaaccagtttcagaccgag
gtcgggaagcagctgatttccggaaacctggatgcacccgagggtgggctggacgccatg
atgcaggtcgccgcctgcccggaggaaatcggctggcgcaacgtcacgcggctgctggtg
tttgccactgatgacggcttccatttcgcgggcgacgggaagctgggcgccatcctgacc
cccaacgacggccgctgtcacctggaggacaacttgtacaagaggagcaacgaattcgac
tacccatcggtgggccagctggcgcacaagctggctgaaaacaacatccagcccatcttc
gcggtgaccagtaggatggtgaagacctacgagaaactcaccgagatcatccccaagtca
gccgtgggggagctgtctgaggactccagcaatgtggtccatctcattaagaatgcttac
aataaactctcctccagggtcttcctggatcacaacgccctccccgacaccctgaaagtc
acctacgactccttctgcagcaatggagtgacgcacaggaaccagcccagaggtgactgt
gatggcgtgcagatcaatgtcccgatcaccttccaggtgaaggtcacggccacagagtgc
atccaggagcagtcgtttgtcatccgggcgctgggcttcacggacatagtgaccgtgcag
gttcttccccagtgtgagtgccggtgccgggaccagagcagagaccgcagcctctgccat
ggcaagggcttcttggagtgcggcatctgcaggtgtgacactggctacattgggaaaaac
tgtgagtgccagacacagggccggagcagccaggagctggaaggaagctgccggaaggac
aacaactccatcatctgctcagggctgggggactgtgtctgcgggcagtgcctgtgccac
accagcgacgtccccggcaagctgatatacgggcagtactgcgagtgtgacaccatcaac
tgtgagcgctacaacggccaggtctgcggcggcccggggagggggctctgcttctgcggg
aagtgccgctgccacccgggctttgagggctcagcgtgccagtgcgagaggaccactgag
ggctgcctgaacccgcggcgtgttgagtgtagtggtcgtggccggtgccgctgcaacgta
tgcgagtgccattcaggctaccagctgcctctgtgccaggagtgccccggctgcccctca
ccctgtggcaagtacatctcctgcgccgagtgcctgaagttcgaaaagggcccctttggg
aagaactgcagcgcggcgtgtccgggcctgcagctgtcgaacaaccccgtgaagggcagg
acctgcaaggagagggactcagagggctgctgggtggcctacacgctggagcagcaggac
gggatggaccgctacctcatctatgtggatgagagccgagagtgtgtggcaggccccaac
atcgccgccatcgtcgggggcaccgtggcaggcatcgtgctgatcggcattctcctgctg
gtcatctggaaggctctgatccacctgagcgacctccgggagtacaggcgctttgagaag
gagaagctcaagtcccagtggaacaatgataatccccttttcaagagcgccaccacgacg
gtcatgaaccccaagtttgctgagagttag

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