KEGG   Homo sapiens (human): 3981Help
Entry
3981              CDS       T01001                                 

Gene name
LIG4, LIG4S
Definition
(RefSeq) DNA ligase 4
  KO
K10777  DNA ligase 4 [EC:6.5.1.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03450  Non-homologous end-joining
Disease
H00094  Immunodeficiency associated with DNA repair defects
H02015  LIG4 syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03450 Non-homologous end-joining
    3981 (LIG4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03400 DNA repair and recombination proteins [BR:hsa03400]
    3981 (LIG4)
Enzymes [BR:hsa01000]
 6. Ligases
  6.5  Forming phosphoric-ester bonds
   6.5.1  Ligases that form phosphoric-ester bonds (only sub-subclass identified to date)
    6.5.1.1  DNA ligase (ATP)
     3981 (LIG4)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic Type
  DSBR (double strand breaks repair)
   NHEJ (non-homologous end-joining)
    DNA Ligase 4 complex
     3981 (LIG4)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: DNA_ligase_A_M DNA_ligase_A_N BRCT DNA_ligase_IV DNA_ligase_A_C BRCT_2 RNA_ligase mRNA_cap_enzyme APG17
Motif
Other DBs
NCBI-GeneID: 3981
NCBI-ProteinID: NP_001091738
OMIM: 601837
HGNC: 6601
Ensembl: ENSG00000174405
Vega: OTTHUMG00000017328
Pharos: P49917(Tbio)
UniProt: P49917 A0A024RE06
LinkDB All DBs
Structure
PDB: 

Position
13q33.3
AA seq 911 aa AA seqDB search
MAASQTSQTVASHVPFADLCSTLERIQKSKGRAEKIRHFREFLDSWRKFHDALHKNHKDV
TDSFYPAMRLILPQLERERMAYGIKETMLAKLYIELLNLPRDGKDALKLLNYRTPTGTHG
DAGDFAMIAYFVLKPRCLQKGSLTIQQVNDLLDSIASNNSAKRKDLIKKSLLQLITQSSA
LEQKWLIRMIIKDLKLGVSQQTIFSVFHNDAAELHNVTTDLEKVCRQLHDPSVGLSDISI
TLFSAFKPMLAAIADIEHIEKDMKHQSFYIETKLDGERMQMHKDGDVYKYFSRNGYNYTD
QFGASPTEGSLTPFIHNAFKADIQICILDGEMMAYNPNTQTFMQKGTKFDIKRMVEDSDL
QTCYCVFDVLMVNNKKLGHETLRKRYEILSSIFTPIPGRIEIVQKTQAHTKNEVIDALNE
AIDKREEGIMVKQPLSIYKPDKRGEGWLKIKPEYVSGLMDELDILIVGGYWGKGSRGGMM
SHFLCAVAEKPPPGEKPSVFHTLSRVGSGCTMKELYDLGLKLAKYWKPFHRKAPPSSILC
GTEKPEVYIEPCNSVIVQIKAAEIVPSDMYKTGCTLRFPRIEKIRDDKEWHECMTLDDLE
QLRGKASGKLASKHLYIGGDDEPQEKKRKAAPKMKKVIGIIEHLKAPNLTNVNKISNIFE
DVEFCVMSGTDSQPKPDLENRIAEFGGYIVQNPGPDTYCVIAGSENIRVKNIILSNKHDV
VKPAWLLECFKTKSFVPWQPRFMIHMCPSTKEHFAREYDCYGDSYFIDTDLNQLKEVFSG
IKNSNEQTPEEMASLIADLEYRYSWDCSPLSMFRRHTVYLDSYAVINDLSTKNEGTRLAI
KALELRFHGAKVVSCLAEGVSHVIIGEDHSRVADFKAFRRTFKRKFKILKESWVTDSIDK
CELQEENQYLI
NT seq 2736 nt NT seq  +upstreamnt  +downstreamnt
atggctgcctcacaaacttcacaaactgttgcatctcacgttccttttgcagatttgtgt
tcaactttagaacgaatacagaaaagtaaaggacgtgcagaaaaaatcagacacttcagg
gaatttttagattcttggagaaaatttcatgatgctcttcataagaaccacaaagatgtc
acagactctttttatccagcaatgagactaattcttcctcagctagaaagagagagaatg
gcctatggaattaaagaaactatgcttgctaagctttatattgagttgcttaatttacct
agagatggaaaagatgccctcaaacttttaaactacagaacacccactggaactcatgga
gatgctggagactttgcaatgattgcatattttgtgttgaagccaagatgtttacagaaa
ggaagtttaaccatacagcaagtaaacgaccttttagactcaattgccagcaataattct
gctaaaagaaaagacctaataaaaaagagccttcttcaacttataactcagagttcagca
cttgagcaaaagtggcttatacggatgatcataaaggatttaaagcttggtgttagtcag
caaactatcttttctgtttttcataatgatgctgctgagttgcataatgtcactacagat
ctggaaaaagtctgtaggcaactgcatgatccttctgtaggactcagtgatatttctatc
actttattttctgcatttaaaccaatgctagctgctattgcagatattgagcacattgag
aaggatatgaaacatcagagtttctacatagaaaccaagctagatggtgaacgtatgcaa
atgcacaaagatggagatgtatataaatacttctctcgaaatggatataactacactgat
cagtttggtgcttctcctactgaaggttctcttaccccattcattcataatgcattcaaa
gcagatatacaaatctgtattcttgatggtgagatgatggcctataatcctaatacacaa
actttcatgcaaaagggaactaagtttgatattaaaagaatggtagaggattctgatctg
caaacttgttattgtgtttttgatgtattgatggttaataataaaaagctagggcatgag
actctgagaaagaggtatgagattcttagtagtatttttacaccaattccaggtagaata
gaaatagtgcagaaaacacaagctcatactaagaatgaagtaattgatgcattgaatgaa
gcaatagataaaagagaagagggaattatggtaaaacaacctctatccatctacaagcca
gacaaaagaggtgaagggtggttaaaaattaaaccagagtatgtcagtggactaatggat
gaattggacattttaattgttggaggatattggggtaaaggatcacggggtggaatgatg
tctcattttctgtgtgcagtagcagagaagccccctcctggtgagaagccatctgtgttt
catactctctctcgtgttgggtctggctgcaccatgaaagaactgtatgatctgggtttg
aaattggccaagtattggaagccttttcatagaaaagctccaccaagcagcattttatgt
ggaacagagaagccagaagtatacattgaaccttgtaattctgtcattgttcagattaaa
gcagcagagatcgtacccagtgatatgtataaaactggctgcaccttgcgttttccacga
attgaaaagataagagatgacaaggagtggcatgagtgcatgaccctggacgacctagaa
caacttagggggaaggcatctggtaagctcgcatctaaacacctttatataggtggtgat
gatgaaccacaagaaaaaaagcggaaagctgccccaaagatgaagaaagttattggaatt
attgagcacttaaaagcacctaaccttactaacgttaacaaaatttctaatatatttgaa
gatgtagagttttgtgttatgagtggaacagatagccagccaaagcctgacctggagaac
agaattgcagaatttggtggttatatagtacaaaatccaggcccagacacgtactgtgta
attgcagggtctgagaacatcagagtgaaaaacataattttgtcaaataaacatgatgtt
gtcaagcctgcatggcttttagaatgttttaagaccaaaagctttgtaccatggcagcct
cgctttatgattcatatgtgcccatcaaccaaagaacattttgcccgtgaatatgattgc
tatggtgatagttatttcattgatacagacttgaaccaactgaaggaagtattctcagga
attaaaaattctaacgagcagactcctgaagaaatggcttctctgattgctgatttagaa
tatcggtattcctgggattgctctcctctcagtatgtttcgacgccacaccgtttatttg
gactcgtatgctgttattaatgacctgagtaccaaaaatgaggggacaaggttagctatt
aaagccttggagcttcggtttcatggagcaaaagtagtttcttgtttagctgagggagtg
tctcatgtaataattggggaagatcatagtcgtgttgcagattttaaagcttttagaaga
acttttaagagaaagtttaaaatcctaaaagaaagttgggtaactgattcaatagacaag
tgtgaattacaagaagaaaaccagtatttgatttaa

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