Homo sapiens (human): 4087
Entry
4087 CDS
T01001
Gene name
SMAD2, JV18, JV18-1, MADH2, MADR2, hMAD-2, hSMAD2
Definition
(RefSeq) SMAD family member 2
KO
K04500
mothers against decapentaplegic homolog 2/3
Organism
hsa
Homo sapiens (human)
Pathway
hsa04068
FoxO signaling pathway
hsa04110
Cell cycle
hsa04144
Endocytosis
hsa04218
Cellular senescence
hsa04350
TGF-beta signaling pathway
hsa04371
Apelin signaling pathway
hsa04390
Hippo signaling pathway
hsa04520
Adherens junction
hsa04550
Signaling pathways regulating pluripotency of stem cells
hsa04659
Th17 cell differentiation
hsa04926
Relaxin signaling pathway
hsa04933
AGE-RAGE signaling pathway in diabetic complications
hsa05142
Chagas disease (American trypanosomiasis)
hsa05161
Hepatitis B
hsa05166
Human T-cell leukemia virus 1 infection
hsa05200
Pathways in cancer
hsa05205
Proteoglycans in cancer
hsa05210
Colorectal cancer
hsa05212
Pancreatic cancer
hsa05225
Hepatocellular carcinoma
hsa05226
Gastric cancer
hsa05321
Inflammatory bowel disease (IBD)
Network
nt06118
TGFB signaling (virus)
nt06160
Human T-cell leukemia virus 1 (HTLV-1)
nt06162
Hepatitis B virus (HBV)
nt06218
TGFB signaling
nt06260
Colorectal cancer
nt06261
Gastric cancer
nt06263
Hepatocellular carcinoma
nt06276
Chronic myeloid leukemia
Element
N00063
TGF-beta signaling pathway
N00064
Mutation-inactivated TGFBR2 to TGF-beta signaling pathway
N00065
Mutation-inactivated SMAD2 to TGF-beta signaling pathway
N00241
TGFBR2-reduced expression to TGF-beta signaling pathway
N00256
TGFBR1-reduced expression to TGF-beta signaling pathway
N00507
HTLV-1 Tax to TGF-beta signaling pathway
N00531
HBV HBx to TGF-beta signaling pathway
Disease
H00020
Colorectal cancer
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04350 TGF-beta signaling pathway
4087 (SMAD2)
04390 Hippo signaling pathway
4087 (SMAD2)
04371 Apelin signaling pathway
4087 (SMAD2)
04068 FoxO signaling pathway
4087 (SMAD2)
09140 Cellular Processes
09141 Transport and catabolism
04144 Endocytosis
4087 (SMAD2)
09143 Cell growth and death
04110 Cell cycle
4087 (SMAD2)
04218 Cellular senescence
4087 (SMAD2)
09144 Cellular community - eukaryotes
04520 Adherens junction
4087 (SMAD2)
04550 Signaling pathways regulating pluripotency of stem cells
4087 (SMAD2)
09150 Organismal Systems
09151 Immune system
04659 Th17 cell differentiation
4087 (SMAD2)
09152 Endocrine system
04926 Relaxin signaling pathway
4087 (SMAD2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
4087 (SMAD2)
05205 Proteoglycans in cancer
4087 (SMAD2)
09162 Cancer: specific types
05210 Colorectal cancer
4087 (SMAD2)
05212 Pancreatic cancer
4087 (SMAD2)
05225 Hepatocellular carcinoma
4087 (SMAD2)
05226 Gastric cancer
4087 (SMAD2)
09163 Immune disease
05321 Inflammatory bowel disease (IBD)
4087 (SMAD2)
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
4087 (SMAD2)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
4087 (SMAD2)
05161 Hepatitis B
4087 (SMAD2)
09174 Infectious disease: parasitic
05142 Chagas disease (American trypanosomiasis)
4087 (SMAD2)
SSDB
Motif
Pfam:
MH2
MH1
IRF-3
Other DBs
NCBI-GeneID:
4087
NCBI-ProteinID:
NP_001003652
OMIM:
601366
HGNC:
6768
Ensembl:
ENSG00000175387
Vega:
OTTHUMG00000132652
Pharos:
Q15796
(Tbio)
UniProt:
Q15796
Q53XR6
LinkDB
Structure
PDB:
1KHX
5XOD
1DEV
1U7V
5ZOJ
Position
18q21.1
AA seq
467 aa
MSSILPFTPPVVKRLLGWKKSAGGSGGAGGGEQNGQEEKWCEKAVKSLVKKLKKTGRLDE
LEKAITTQNCNTKCVTIPSTCSEIWGLSTPNTIDQWDTTGLYSFSEQTRSLDGRLQVSHR
KGLPHVIYCRLWRWPDLHSHHELKAIENCEYAFNLKKDEVCVNPYHYQRVETPVLPPVLV
PRHTEILTELPPLDDYTHSIPENTNFPAGIEPQSNYIPETPPPGYISEDGETSDQQLNQS
MDTGSPAELSPTTLSPVNHSLDLQPVTYSEPAFWCSIAYYELNQRVGETFHASQPSLTVD
GFTDPSNSERFCLGLLSNVNRNATVEMTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSP
NCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVK
GWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSVRCSSMS
NT seq
1404 nt
+upstream
nt +downstream
nt
atgtcgtccatcttgccattcacgccgccagttgtgaagagactgctgggatggaagaag
tcagctggtgggtctggaggagcaggcggaggagagcagaatgggcaggaagaaaagtgg
tgtgagaaagcagtgaaaagtctggtgaagaagctaaagaaaacaggacgattagatgag
cttgagaaagccatcaccactcaaaactgtaatactaaatgtgttaccataccaagcact
tgctctgaaatttggggactgagtacaccaaatacgatagatcagtgggatacaacaggc
ctttacagcttctctgaacaaaccaggtctcttgatggtcgtctccaggtatcccatcga
aaaggattgccacatgttatatattgccgattatggcgctggcctgatcttcacagtcat
catgaactcaaggcaattgaaaactgcgaatatgcttttaatcttaaaaaggatgaagta
tgtgtaaacccttaccactatcagagagttgagacaccagttttgcctccagtattagtg
ccccgacacaccgagatcctaacagaacttccgcctctggatgactatactcactccatt
ccagaaaacactaacttcccagcaggaattgagccacagagtaattatattccagaaacg
ccacctcctggatatatcagtgaagatggagaaacaagtgaccaacagttgaatcaaagt
atggacacaggctctccagcagaactatctcctactactctttcccctgttaatcatagc
ttggatttacagccagttacttactcagaacctgcattttggtgttcgatagcatattat
gaattaaatcagagggttggagaaaccttccatgcatcacagccctcactcactgtagat
ggctttacagacccatcaaattcagagaggttctgcttaggtttactctccaatgttaac
cgaaatgccacggtagaaatgacaagaaggcatataggaagaggagtgcgcttatactac
ataggtggggaagtttttgctgagtgcctaagtgatagtgcaatctttgtgcagagcccc
aattgtaatcagagatatggctggcaccctgcaacagtgtgtaaaattccaccaggctgt
aatctgaagatcttcaacaaccaggaatttgctgctcttctggctcagtctgttaatcag
ggttttgaagccgtctatcagctaactagaatgtgcaccataagaatgagttttgtgaaa
gggtggggagcagaataccgaaggcagacggtaacaagtactccttgctggattgaactt
catctgaatggacctctacagtggttggacaaagtattaactcagatgggatccccttca
gtgcgttgctcaagcatgtcataa
Homo sapiens (human): 4088
Entry
4088 CDS
T01001
Gene name
SMAD3, HSPC193, HsT17436, JV15-2, LDS1C, LDS3, MADH3
Definition
(RefSeq) SMAD family member 3
KO
K04500
mothers against decapentaplegic homolog 2/3
Organism
hsa
Homo sapiens (human)
Pathway
hsa04068
FoxO signaling pathway
hsa04110
Cell cycle
hsa04144
Endocytosis
hsa04218
Cellular senescence
hsa04310
Wnt signaling pathway
hsa04350
TGF-beta signaling pathway
hsa04371
Apelin signaling pathway
hsa04390
Hippo signaling pathway
hsa04520
Adherens junction
hsa04550
Signaling pathways regulating pluripotency of stem cells
hsa04659
Th17 cell differentiation
hsa04926
Relaxin signaling pathway
hsa04933
AGE-RAGE signaling pathway in diabetic complications
hsa05142
Chagas disease (American trypanosomiasis)
hsa05161
Hepatitis B
hsa05166
Human T-cell leukemia virus 1 infection
hsa05200
Pathways in cancer
hsa05210
Colorectal cancer
hsa05212
Pancreatic cancer
hsa05220
Chronic myeloid leukemia
hsa05225
Hepatocellular carcinoma
hsa05226
Gastric cancer
hsa05321
Inflammatory bowel disease (IBD)
Network
nt06118
TGFB signaling (virus)
nt06160
Human T-cell leukemia virus 1 (HTLV-1)
nt06162
Hepatitis B virus (HBV)
nt06218
TGFB signaling
nt06260
Colorectal cancer
nt06261
Gastric cancer
nt06263
Hepatocellular carcinoma
nt06276
Chronic myeloid leukemia
Element
N00063
TGF-beta signaling pathway
N00064
Mutation-inactivated TGFBR2 to TGF-beta signaling pathway
N00065
Mutation-inactivated SMAD2 to TGF-beta signaling pathway
N00106
AML1-EVI1 fusion to TGF-beta signaling pathway
N00107
EVI-1 overexpression to TGF-beta signaling pathway
N00241
TGFBR2-reduced expression to TGF-beta signaling pathway
N00256
TGFBR1-reduced expression to TGF-beta signaling pathway
N00507
HTLV-1 Tax to TGF-beta signaling pathway
N00531
HBV HBx to TGF-beta signaling pathway
Disease
H00800
Loeys-Dietz syndrome
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04310 Wnt signaling pathway
4088 (SMAD3)
04350 TGF-beta signaling pathway
4088 (SMAD3)
04390 Hippo signaling pathway
4088 (SMAD3)
04371 Apelin signaling pathway
4088 (SMAD3)
04068 FoxO signaling pathway
4088 (SMAD3)
09140 Cellular Processes
09141 Transport and catabolism
04144 Endocytosis
4088 (SMAD3)
09143 Cell growth and death
04110 Cell cycle
4088 (SMAD3)
04218 Cellular senescence
4088 (SMAD3)
09144 Cellular community - eukaryotes
04520 Adherens junction
4088 (SMAD3)
04550 Signaling pathways regulating pluripotency of stem cells
4088 (SMAD3)
09150 Organismal Systems
09151 Immune system
04659 Th17 cell differentiation
4088 (SMAD3)
09152 Endocrine system
04926 Relaxin signaling pathway
4088 (SMAD3)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
4088 (SMAD3)
09162 Cancer: specific types
05210 Colorectal cancer
4088 (SMAD3)
05212 Pancreatic cancer
4088 (SMAD3)
05225 Hepatocellular carcinoma
4088 (SMAD3)
05226 Gastric cancer
4088 (SMAD3)
05220 Chronic myeloid leukemia
4088 (SMAD3)
09163 Immune disease
05321 Inflammatory bowel disease (IBD)
4088 (SMAD3)
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
4088 (SMAD3)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
4088 (SMAD3)
05161 Hepatitis B
4088 (SMAD3)
09174 Infectious disease: parasitic
05142 Chagas disease (American trypanosomiasis)
4088 (SMAD3)
SSDB
Motif
Pfam:
MH2
MH1
IRF-3
Other DBs
NCBI-GeneID:
4088
NCBI-ProteinID:
NP_005893
OMIM:
603109
HGNC:
6769
Ensembl:
ENSG00000166949
Vega:
OTTHUMG00000133230
Pharos:
P84022
(Tbio)
UniProt:
P84022
A0A024R5Z3
Q9P0T0
LinkDB
Structure
PDB:
1MJS
5OD6
5ODG
5XOC
1OZJ
1U7F
1MK2
1MHD
Position
15q22.33
AA seq
425 aa
MSSILPFTPPIVKRLLGWKKGEQNGQEEKWCEKAVKSLVKKLKKTGQLDELEKAITTQNV
NTKCITIPRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELRAMELCEFAFNMKKDEV
CVNPYHYQRVETPVLPPVLVPRHTEIPAEFPPLDDYSHSIPENTNFPAGIEPQSNIPETP
PPGYLSEDGETSDHQMNHSMDAGSPNLSPNPMSPAHNNLDLQPVTYCEPAFWCSISYYEL
NQRVGETFHASQPSMTVDGFTDPSNSERFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIG
GEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGF
EAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIR
CSSVS
NT seq
1278 nt
+upstream
nt +downstream
nt
atgtcgtccatcctgcctttcactcccccgatcgtgaagcgcctgctgggctggaagaag
ggcgagcagaacgggcaggaggagaaatggtgcgagaaggcggtcaagagcctggtcaag
aaactcaagaagacggggcagctggacgagctggagaaggccatcaccacgcagaacgtc
aacaccaagtgcatcaccatccccaggtccctggatggccggttgcaggtgtcccatcgg
aaggggctccctcatgtcatctactgccgcctgtggcgatggccagacctgcacagccac
cacgagctacgggccatggagctgtgtgagttcgccttcaatatgaagaaggacgaggtc
tgcgtgaatccctaccactaccagagagtagagacaccagttctacctcctgtgttggtg
ccacgccacacagagatcccggccgagttccccccactggacgactacagccattccatc
cccgaaaacactaacttccccgcaggcatcgagccccagagcaatattccagagacccca
ccccctggctacctgagtgaagatggagaaaccagtgaccaccagatgaaccacagcatg
gacgcaggttctccaaacctatccccgaatccgatgtccccagcacataataacttggac
ctgcagccagttacctactgcgagccggccttctggtgctccatctcctactacgagctg
aaccagcgcgtcggggagacattccacgcctcgcagccatccatgactgtggatggcttc
accgacccctccaattcggagcgcttctgcctagggctgctctccaatgtcaacaggaat
gcagcagtggagctgacacggagacacatcggaagaggcgtgcggctctactacatcgga
ggggaggtcttcgcagagtgcctcagtgacagcgctatttttgtccagtctcccaactgt
aaccagcgctatggctggcacccggccaccgtctgcaagatcccaccaggatgcaacctg
aagatcttcaacaaccaggagttcgctgccctcctggcccagtcggtcaaccagggcttt
gaggctgtctaccagttgacccgaatgtgcaccatccgcatgagcttcgtcaaaggctgg
ggagcggagtacaggagacagactgtgaccagtaccccctgctggattgagctgcacctg
aatgggcctttgcagtggcttgacaaggtcctcacccagatgggctccccaagcatccgc
tgttccagtgtgtcttag
DBGET
integrated database retrieval system
