KEGG   Homo sapiens (human): 4157
Entry
4157              CDS       T01001                                 

Gene name
MC1R, CMM5, MSH-R, SHEP2
Definition
(RefSeq) melanocortin 1 receptor
  KO
K04199  melanocortin 1 receptor
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04916  Melanogenesis
Disease
H00168  Oculocutaneous albinism
Drug target
Giractide (DG01344): D09801 D09937
Seractide acetate: D05827
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    4157 (MC1R)
 09150 Organismal Systems
  09152 Endocrine system
   04916 Melanogenesis
    4157 (MC1R)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    4157 (MC1R)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Peptide
   Melanocortin
    4157 (MC1R)
SSDB
Motif
Pfam: 7tm_1 7tm_4 7TM_GPCR_Srsx 7TM_GPCR_Srx Pox_A14
Other DBs
NCBI-GeneID: 4157
NCBI-ProteinID: NP_002377
OMIM: 155555
HGNC: 6929
Ensembl: ENSG00000258839
Vega: OTTHUMG00000171163
Pharos: Q01726(Tclin)
UniProt: Q01726 Q1JUL4
LinkDB
Position
16q24.3
AA seq 317 aa
MAVQGSQRRLLGSLNSTPTAIPQLGLAANQTGARCLEVSISDGLFLSLGLVSLVENALVV
ATIAKNRNLHSPMYCFICCLALSDLLVSGSNVLETAVILLLEAGALVARAAVLQQLDNVI
DVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTLPRARRAVAAIWVASVVFSTLFI
AYYDHVAVLLCLVVFFLAMLVLMAVLYVHMLARACQHAQGIARLHKRQRPVHQGFGLKGA
VTLTILLGIFFLCWGPFFLHLTLIVLCPEHPTCGCIFKNFNLFLALIICNAIIDPLIYAF
HSQELRRTLKEVLTCSW
NT seq 954 nt   +upstreamnt  +downstreamnt
atggctgtgcagggatcccagagaagacttctgggctccctcaactccacccccacagcc
atcccccagctggggctggctgccaaccagacaggagcccggtgcctggaggtgtccatc
tctgacgggctcttcctcagcctggggctggtgagcttggtggagaacgcgctggtggtg
gccaccatcgccaagaaccggaacctgcactcacccatgtactgcttcatctgctgcctg
gccttgtcggacctgctggtgagcgggagcaacgtgctggagacggccgtcatcctcctg
ctggaggccggtgcactggtggcccgggctgcggtgctgcagcagctggacaatgtcatt
gacgtgatcacctgcagctccatgctgtccagcctctgcttcctgggcgccatcgccgtg
gaccgctacatctccatcttctacgcactgcgctaccacagcatcgtgaccctgccgcgg
gcgcggcgagccgttgcggccatctgggtggccagtgtcgtcttcagcacgctcttcatc
gcctactacgaccacgtggccgtcctgctgtgcctcgtggtcttcttcctggctatgctg
gtgctcatggccgtgctgtacgtccacatgctggcccgggcctgccagcacgcccagggc
atcgcccggctccacaagaggcagcgcccggtccaccagggctttggccttaaaggcgct
gtcaccctcaccatcctgctgggcattttcttcctctgctggggccccttcttcctgcat
ctcacactcatcgtcctctgccccgagcaccccacgtgcggctgcatcttcaagaacttc
aacctctttctcgccctcatcatctgcaatgccatcatcgaccccctcatctacgccttc
cacagccaggagctccgcaggacgctcaaggaggtgctgacatgctcctggtga

KEGG   Homo sapiens (human): 4158
Entry
4158              CDS       T01001                                 

Gene name
MC2R, ACTHR
Definition
(RefSeq) melanocortin 2 receptor
  KO
K04200  melanocortin 2 receptor
Organism
hsa  Homo sapiens (human)
Pathway
hsa04024  cAMP signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04925  Aldosterone synthesis and secretion
hsa04927  Cortisol synthesis and secretion
hsa04934  Cushing syndrome
Network
nt06310  CRH-ACTH-cortisol signaling
nt06360  Cushing syndrome
  Element
N00297  ACTH-cortisol signaling pathway
N00298  CYP11B1-CYP11B2 fusion to ACTH-cortisol signaling pathway
N00299  Mutation-inactivated MC2R to ACTH-cortisol signaling pathway
N00300  Mutation-inactivated MRAP to ACTH-cortisol signaling pathway
Disease
H00033  Adrenal carcinoma
H00256  Familial glucocorticoid deficiency
H01431  Cushing syndrome
H02049  Bilateral macronodular adrenal hyperplasia
Drug target
Alsactide: D07417
Corticotropin (DG00492): D00146<US> D03593 D06544
Giractide (DG01344): D09801 D09937
Seractide acetate: D05827
Tetracosactide (DG00493): D00284<US> D02105<JP>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04024 cAMP signaling pathway
    4158 (MC2R)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    4158 (MC2R)
 09150 Organismal Systems
  09152 Endocrine system
   04925 Aldosterone synthesis and secretion
    4158 (MC2R)
   04927 Cortisol synthesis and secretion
    4158 (MC2R)
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    4158 (MC2R)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    4158 (MC2R)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Peptide
   Melanocortin
    4158 (MC2R)
SSDB
Motif
Pfam: 7tm_1 7TM_GPCR_Srsx 7TM_GPCR_Srx 7tm_4
Other DBs
NCBI-GeneID: 4158
NCBI-ProteinID: NP_000520
OMIM: 607397
HGNC: 6930
Ensembl: ENSG00000185231
Vega: OTTHUMG00000131721
Pharos: Q01718(Tclin)
UniProt: Q01718
LinkDB
Position
18p11.21
AA seq 297 aa
MKHIINSYENINNTARNNSDCPRVVLPEEIFFTISIVGVLENLIVLLAVFKNKNLQAPMY
FFICSLAISDMLGSLYKILENILIILRNMGYLKPRGSFETTADDIIDSLFVLSLLGSIFS
LSVIAADRYITIFHALRYHSIVTMRRTVVVLTVIWTFCTGTGITMVIFSHHVPTVITFTS
LFPLMLVFILCLYVHMFLLARSHTRKISTLPRANMKGAITLTILLGVFIFCWAPFVLHVL
LMTFCPSNPYCACYMSLFQVNGMLIMCNAVIDPFIYAFRSPELRDAFKKMIFCSRYW
NT seq 894 nt   +upstreamnt  +downstreamnt
atgaagcacattatcaactcgtatgaaaacatcaacaacacagcaagaaataattccgac
tgtcctcgtgtggttttgccggaggagatatttttcacaatttccattgttggagttttg
gagaatctgatcgtcctgctggctgtgttcaagaataagaatctccaggcacccatgtac
tttttcatctgtagcttggccatatctgatatgctgggcagcctatataagatcttggaa
aatatcctgatcatattgagaaacatgggctatctcaagccacgtggcagttttgaaacc
acagccgatgacatcatcgactccctgtttgtcctctccctgcttggctccatcttcagc
ctgtctgtgattgctgcggaccgctacatcaccatcttccacgcactgcggtaccacagc
atcgtgaccatgcgccgcactgtggtggtgcttacggtcatctggacgttctgcacgggg
actggcatcaccatggtgatcttctcccatcatgtgcccacagtgatcaccttcacgtcg
ctgttcccgctgatgctggtcttcatcctgtgcctctatgtgcacatgttcctgctggct
cgatcccacaccaggaagatctccaccctccccagagccaacatgaaaggggccatcaca
ctgaccatcctgctcggggtcttcatcttctgctgggccccctttgtgcttcatgtcctc
ttgatgacattctgcccaagtaacccctactgcgcctgctacatgtctctcttccaggtg
aacggcatgttgatcatgtgcaatgccgtcattgaccccttcatatatgccttccggagc
ccagagctcagggacgcattcaaaaagatgatcttctgcagcaggtactggtag

KEGG   Homo sapiens (human): 4159
Entry
4159              CDS       T01001                                 

Gene name
MC3R, BMIQ9, MC3, MC3-R, OB20, OQTL
Definition
(RefSeq) melanocortin 3 receptor
  KO
K04201  melanocortin 3 receptor
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
Disease
H02106  Genetic obesity
Drug target
Giractide (DG01344): D09801 D09937
Seractide acetate: D05827
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    4159 (MC3R)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    4159 (MC3R)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Peptide
   Melanocortin
    4159 (MC3R)
SSDB
Motif
Pfam: 7tm_1 7tm_4 7TM_GPCR_Srsx
Other DBs
NCBI-GeneID: 4159
NCBI-ProteinID: NP_063941
OMIM: 155540
HGNC: 6931
Ensembl: ENSG00000124089
Vega: OTTHUMG00000032785
Pharos: P41968(Tchem)
UniProt: P41968
LinkDB
Position
20q13.2
AA seq 323 aa
MNASCCLPSVQPTLPNGSEHLQAPFFSNQSSSAFCEQVFIKPEVFLSLGIVSLLENILVI
LAVVRNGNLHSPMYFFLCSLAVADMLVSVSNALETIMIAIVHSDYLTFEDQFIQHMDNIF
DSMICISLVASICNLLAIAVDRYVTIFYALRYHSIMTVRKALTLIVAIWVCCGVCGVVFI
VYSESKMVIVCLITMFFAMMLLMGTLYVHMFLFARLHVKRIAALPPADGVAPQQHSCMKG
AVTITILLGVFIFCWAPFFLHLVLIITCPTNPYCICYTAHFNTYLVLIMCNSVIDPLIYA
FRSLELRNTFREILCGCNGMNLG
NT seq 972 nt   +upstreamnt  +downstreamnt
atgaatgcttcgtgctgcctgccctctgttcagccaacactgcctaatggctcggagcac
ctccaagcccctttcttcagcaaccagagcagcagcgccttctgtgagcaggtcttcatc
aagcccgaggttttcctgtctctgggcatcgtcagtctgctggaaaacatcctggttatc
ctggccgtggtcaggaacggcaacctgcactccccgatgtacttctttctctgcagcctg
gcggtggccgacatgctggtaagtgtgtccaatgccctggagaccatcatgatcgccatc
gtccacagcgactacctgaccttcgaggaccagtttatccagcacatggacaacatcttc
gactccatgatctgcatctccctggtggcctccatctgcaacctcctggccatcgccgtc
gacaggtacgtcaccatcttttacgcgctccgctaccacagcatcatgaccgtgaggaag
gccctcaccttgatcgtggccatctgggtctgctgcggcgtctgtggcgtggtgttcatc
gtctactcggagagcaaaatggtcattgtgtgcctcatcaccatgttcttcgccatgatg
ctcctcatgggcaccctctacgtgcacatgttcctctttgcgcggctgcacgtcaagcgc
atagcagcactgccacctgccgacggggtggccccacagcaacactcatgcatgaagggg
gcagtcaccatcaccattctcctgggcgtgttcatcttctgctgggcccccttcttcctc
cacctggtcctcatcatcacctgccccaccaacccctactgcatctgctacactgcccac
ttcaacacctacctggtcctcatcatgtgcaactccgtcatcgacccactcatctacgct
ttccggagcctggaattgcgcaacacctttagggagattctctgtggctgcaacggcatg
aacttgggatag

KEGG   Homo sapiens (human): 4160
Entry
4160              CDS       T01001                                 

Gene name
MC4R, BMIQ20
Definition
(RefSeq) melanocortin 4 receptor
  KO
K04202  melanocortin 4 receptor
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
Disease
H02106  Genetic obesity
Drug target
Bremelanotide (DG03063): D06569 D11629<US>
Giractide (DG01344): D09801 D09937
Seractide acetate: D05827
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    4160 (MC4R)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    4160 (MC4R)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Peptide
   Melanocortin
    4160 (MC4R)
SSDB
Motif
Pfam: 7tm_1 7TM_GPCR_Srsx 7tm_4 7TM_GPCR_Srx
Other DBs
NCBI-GeneID: 4160
NCBI-ProteinID: NP_005903
OMIM: 155541
HGNC: 6932
Ensembl: ENSG00000166603
Vega: OTTHUMG00000132766
Pharos: P32245(Tchem)
UniProt: P32245
LinkDB
Position
18q21.32
AA seq 332 aa
MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLL
ENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVN
IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVS
GILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGAN
MKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPL
IYALRSQELRKTFKEIICCYPLGGLCDLSSRY
NT seq 999 nt   +upstreamnt  +downstreamnt
atggtgaactccacccaccgtgggatgcacacttctctgcacctctggaaccgcagcagt
tacagactgcacagcaatgccagtgagtcccttggaaaaggctactctgatggagggtgc
tacgagcaactttttgtctctcctgaggtgtttgtgactctgggtgtcatcagcttgttg
gagaatatcttagtgattgtggcaatagccaagaacaagaatctgcattcacccatgtac
tttttcatctgcagcttggctgtggctgatatgctggtgagcgtttcaaatggatcagaa
accattgtcatcaccctattaaacagtacagatacggatgcacagagtttcacagtgaat
attgataatgtcattgactcggtgatctgtagctccttgcttgcatccatttgcagcctg
ctttcaattgcagtggacaggtactttactatcttctatgctctccagtaccataacatt
atgacagttaagcgggttgggatcatcataagttgtatctgggcagcttgcacggtttca
ggcattttgttcatcatttactcagatagtagtgctgtcatcatctgcctcatcaccatg
ttcttcaccatgctggctctcatggcttctctctatgtccacatgttcctgatggccagg
cttcacattaagaggattgctgtcctccccggcactggtgccatccgccaaggtgccaat
atgaagggagcgattaccttgaccatcctgattggcgtctttgttgtctgctgggcccca
ttcttcctccacttaatattctacatctcttgtcctcagaatccatattgtgtgtgcttc
atgtctcactttaacttgtatctcatactgatcatgtgtaattcaatcatcgatcctctg
atttatgcactccggagtcaagaactgaggaaaaccttcaaagagatcatctgttgctat
cccctgggaggcctttgtgacttgtctagcagatattaa

KEGG   Homo sapiens (human): 4161
Entry
4161              CDS       T01001                                 

Gene name
MC5R, MC2
Definition
(RefSeq) melanocortin 5 receptor
  KO
K04203  melanocortin 5 receptor
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
Drug target
Giractide (DG01344): D09801 D09937
Seractide acetate: D05827
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    4161 (MC5R)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    4161 (MC5R)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Peptide
   Melanocortin
    4161 (MC5R)
SSDB
Motif
Pfam: 7tm_1 7tm_4 7TM_GPCR_Srsx
Other DBs
NCBI-GeneID: 4161
NCBI-ProteinID: NP_005904
OMIM: 600042
HGNC: 6933
Ensembl: ENSG00000176136
Vega: OTTHUMG00000131720
Pharos: P33032(Tchem)
UniProt: P33032
LinkDB
Position
18p11.21
AA seq 325 aa
MNSSFHLHFLDLNLNATEGNLSGPNVKNKSSPCEDMGIAVEVFLTLGVISLLENILVIGA
IVKNKNLHSPMYFFVCSLAVADMLVSMSSAWETITIYLLNNKHLVIADAFVRHIDNVFDS
MICISVVASMCSLLAIAVDRYVTIFYALRYHHIMTARRSGAIIAGIWAFCTGCGIVFILY
SESTYVILCLISMFFAMLFLLVSLYIHMFLLARTHVKRIAALPGASSARQRTSMQGAVTV
TMLLGVFTVCWAPFFLHLTLMLSCPQNLYCSRFMSHFNMYLILIMCNSVMDPLIYAFRSQ
EMRKTFKEIICCRGFRIACSFPRRD
NT seq 978 nt   +upstreamnt  +downstreamnt
atgaattcctcatttcacctgcatttcttggatctcaacctgaatgccacagagggcaac
ctttcaggacccaatgtcaaaaacaagtcttcaccatgtgaagacatgggcattgctgtg
gaggtgtttctcactctgggtgtcatcagcctcttggagaacatcttggtcataggggcc
atagtgaagaacaaaaacctgcactcccccatgtacttcttcgtgtgcagcctggcagtg
gcggacatgctggtgagcatgtccagtgcctgggagaccatcaccatctacctactcaac
aacaagcacctagtgatagcagacgcctttgtgcgccacattgacaatgtgtttgactcc
atgatctgcatttccgtggtggcatccatgtgcagcttactggccattgcagtggatagg
tacgtcaccatcttctacgccctgcgctaccaccacatcatgacggcgaggcgctcaggg
gccatcatcgccggcatctgggctttctgcacgggctgcggcattgtcttcatcctgtac
tcagaatccacctacgtcatcctgtgcctcatctccatgttcttcgctatgctgttcctc
ctggtgtctctgtacatacacatgttcctcctggcgcggactcacgtcaagcggatcgcg
gctctgcccggggccagctctgcgcggcagaggaccagcatgcagggcgcggtcaccgtc
accatgctgctgggcgtgtttaccgtgtgctgggccccgttcttccttcatctcacttta
atgctttcttgccctcagaacctctactgctctcgcttcatgtctcacttcaatatgtac
ctcatactcatcatgtgtaattccgtgatggaccctctcatatatgccttccgcagccaa
gagatgcggaagacctttaaggagattatttgctgccgtggtttcaggatcgcctgcagc
tttcccagaagggattaa

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