KEGG T01001: 4322

Homo sapiens (human): 4322

Entry

4322 CDS T01001

Gene name

MMP13, CLG3, MANDP1, MDST, MMP-13

Definition

(RefSeq) matrix metallopeptidase 13

K07994

matrix metalloproteinase-13 (collagenase 3) [EC:3.4.24.-]

Organism

hsa Homo sapiens (human)

Pathway

hsa04657

IL-17 signaling pathway

hsa04926

Relaxin signaling pathway

hsa04928

Parathyroid hormone synthesis, secretion and action

Disease

H00479

Metaphyseal dysplasias

Drug target

Apratastat:

D08859

Cipemastat:

D03517

Prinomastat:

D03797

Brite

KEGG Orthology (KO) [BR:hsa00001]
09150 Organismal Systems
  09151 Immune system
   04657 IL-17 signaling pathway
    4322 (MMP13)
  09152 Endocrine system
   04926 Relaxin signaling pathway
    4322 (MMP13)
   04928 Parathyroid hormone synthesis, secretion and action
    4322 (MMP13)
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    4322 (MMP13)
Enzymes [BR:hsa01000]
3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.24  Metalloendopeptidases
    3.4.24.-
     4322 (MMP13)
Peptidases and inhibitors [BR:hsa01002]
Metallo peptidases
  Family M10
   4322 (MMP13)

SSDB

Motif

Pfam:

Peptidase_M10 Hemopexin PG_binding_1 Reprolysin_4 Reprolysin_3 DUF4953 Reprolysin_5

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

Vega:

Pharos:

P45452(Tclin)

UniProt:

P45452 Q53H33

LinkDB

Structure

PDB:

5B5O 3ZXH 4JP4 5UWK 5B5P 3WV3 830C 5UWM 4L19 2YIG 1XUC 6HV2 2OW9 5BPA 1XUD 5BOT 1XUR 3O2X 3KRY 3ELM 3I7G 3KEK 3WV1 4JPA 3LJZ 2E2D 1ZTQ 5BOY 3KEC 4A7B 3I7I 3WV2 3KEJ 2OZR 1YOU 2D1N 456C 3TVC 4FVL 4G0D 5UWL 1PEX 2PJT 4FU4 5UWN 1FLS 1FM1 1EUB

Position

11q22.2

AA seq 471 aa
MHPGVLAAFLFLSWTHCRALPLPSGGDEDDLSEEDLQFAERYLRSYYHPTNLAGILKENA
ASSMTERLREMQSFFGLEVTGKLDDNTLDVMKKPRCGVPDVGEYNVFPRTLKWSKMNLTY
RIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDG
PSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALM
FPIYTYTGKSHFMLPDDDVQGIQSLYGPGDEDPNPKHPKTPDKCDPSLSLDAITSLRGET
MIFKDRFFWRLHPQQVDAELFLTKSFWPELPNRIDAAYEHPSHDLIFIFRGRKFWALNGY
DILEGYPKKISELGLPKEVKKISAAVHFEDTGKTLLFSGNQVWRYDDTNHIMDKDYPRLI
EEDFPGIGDKVDAVYEKNGYIYFFNGPIQFEYSIWSNRIVRVMPANSILWC

NT seq 1416 nt +upstreamnt +downstreamnt
atgcatccaggggtcctggctgccttcctcttcttgagctggactcattgtcgggccctg
ccccttcccagtggtggtgatgaagatgatttgtctgaggaagacctccagtttgcagag
cgctacctgagatcatactaccatcctacaaatctcgcgggaatcctgaaggagaatgca
gcaagctccatgactgagaggctccgagaaatgcagtctttcttcggcttagaggtgact
ggcaaacttgacgataacaccttagatgtcatgaaaaagccaagatgcggggttcctgat
gtgggtgaatacaatgttttccctcgaactcttaaatggtccaaaatgaatttaacctac
agaattgtgaattacacccctgatatgactcattctgaagtcgaaaaggcattcaaaaaa
gccttcaaagtttggtccgatgtaactcctctgaattttaccagacttcacgatggcatt
gctgacatcatgatctcttttggaattaaggagcatggcgacttctacccatttgatggg
ccctctggcctgctggctcatgcttttcctcctgggccaaattatggaggagatgcccat
tttgatgatgatgaaacctggacaagtagttccaaaggctacaacttgtttcttgttgct
gcgcatgagttcggccactccttaggtcttgaccactccaaggaccctggagcactcatg
tttcctatctacacctacaccggcaaaagccactttatgcttcctgatgacgatgtacaa
gggatccagtctctctatggtccaggagatgaagaccccaaccctaaacatccaaaaacg
ccagacaaatgtgacccttccttatcccttgatgccattaccagtctccgaggagaaaca
atgatctttaaagacagattcttctggcgcctgcatcctcagcaggttgatgcggagctg
tttttaacgaaatcattttggccagaacttcccaaccgtattgatgctgcatatgagcac
ccttctcatgacctcatcttcatcttcagaggtagaaaattttgggctcttaatggttat
gacattctggaaggttatcccaaaaaaatatctgaactgggtcttccaaaagaagttaag
aagataagtgcagctgttcactttgaggatacaggcaagactctcctgttctcaggaaac
caggtctggagatatgatgatactaaccatattatggataaagactatccgagactaata
gaagaagacttcccaggaattggtgataaagtagatgctgtctatgagaaaaatggttat
atctattttttcaacggacccatacagtttgaatacagcatctggagtaaccgtattgtt
cgcgtcatgccagcaaattccattttgtggtgttaa

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