Homo sapiens (human): 4322
Entry
4322 CDS
T01001
Gene name
MMP13, CLG3, MANDP1, MDST, MMP-13
Definition
(RefSeq) matrix metallopeptidase 13
KO
K07994
matrix metalloproteinase-13 (collagenase 3) [EC:3.4.24.-]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04657
IL-17 signaling pathway
hsa04926
Relaxin signaling pathway
hsa04928
Parathyroid hormone synthesis, secretion and action
Disease
H00479
Metaphyseal dysplasias
Drug target
Apratastat:
D08859
Cipemastat:
D03517
Prinomastat:
D03797
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09150 Organismal Systems
09151 Immune system
04657 IL-17 signaling pathway
4322 (MMP13)
09152 Endocrine system
04926 Relaxin signaling pathway
4322 (MMP13)
04928 Parathyroid hormone synthesis, secretion and action
4322 (MMP13)
09180 Brite Hierarchies
09181 Protein families: metabolism
01002 Peptidases and inhibitors [BR:
hsa01002
]
4322 (MMP13)
Enzymes [BR:
hsa01000
]
3. Hydrolases
3.4 Acting on peptide bonds (peptidases)
3.4.24 Metalloendopeptidases
3.4.24.-
4322 (MMP13)
Peptidases and inhibitors [BR:
hsa01002
]
Metallo peptidases
Family M10
4322 (MMP13)
SSDB
Motif
Pfam:
Peptidase_M10
Hemopexin
PG_binding_1
Reprolysin_4
Reprolysin_3
DUF4953
Reprolysin_5
Other DBs
NCBI-GeneID:
4322
NCBI-ProteinID:
NP_002418
OMIM:
600108
HGNC:
7159
Ensembl:
ENSG00000137745
Vega:
OTTHUMG00000165850
Pharos:
P45452
(Tclin)
UniProt:
P45452
Q53H33
LinkDB
Structure
PDB:
5B5O
3ZXH
4JP4
5UWK
5B5P
3WV3
830C
5UWM
4L19
2YIG
1XUC
6HV2
2OW9
5BPA
1XUD
5BOT
1XUR
3O2X
3KRY
3ELM
3I7G
3KEK
3WV1
4JPA
3LJZ
2E2D
1ZTQ
5BOY
3KEC
4A7B
3I7I
3WV2
3KEJ
2OZR
1YOU
2D1N
456C
3TVC
4FVL
4G0D
5UWL
1PEX
2PJT
4FU4
5UWN
1FLS
1FM1
1EUB
Position
11q22.2
AA seq
471 aa
MHPGVLAAFLFLSWTHCRALPLPSGGDEDDLSEEDLQFAERYLRSYYHPTNLAGILKENA
ASSMTERLREMQSFFGLEVTGKLDDNTLDVMKKPRCGVPDVGEYNVFPRTLKWSKMNLTY
RIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDG
PSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALM
FPIYTYTGKSHFMLPDDDVQGIQSLYGPGDEDPNPKHPKTPDKCDPSLSLDAITSLRGET
MIFKDRFFWRLHPQQVDAELFLTKSFWPELPNRIDAAYEHPSHDLIFIFRGRKFWALNGY
DILEGYPKKISELGLPKEVKKISAAVHFEDTGKTLLFSGNQVWRYDDTNHIMDKDYPRLI
EEDFPGIGDKVDAVYEKNGYIYFFNGPIQFEYSIWSNRIVRVMPANSILWC
NT seq
1416 nt
+upstream
nt +downstream
nt
atgcatccaggggtcctggctgccttcctcttcttgagctggactcattgtcgggccctg
ccccttcccagtggtggtgatgaagatgatttgtctgaggaagacctccagtttgcagag
cgctacctgagatcatactaccatcctacaaatctcgcgggaatcctgaaggagaatgca
gcaagctccatgactgagaggctccgagaaatgcagtctttcttcggcttagaggtgact
ggcaaacttgacgataacaccttagatgtcatgaaaaagccaagatgcggggttcctgat
gtgggtgaatacaatgttttccctcgaactcttaaatggtccaaaatgaatttaacctac
agaattgtgaattacacccctgatatgactcattctgaagtcgaaaaggcattcaaaaaa
gccttcaaagtttggtccgatgtaactcctctgaattttaccagacttcacgatggcatt
gctgacatcatgatctcttttggaattaaggagcatggcgacttctacccatttgatggg
ccctctggcctgctggctcatgcttttcctcctgggccaaattatggaggagatgcccat
tttgatgatgatgaaacctggacaagtagttccaaaggctacaacttgtttcttgttgct
gcgcatgagttcggccactccttaggtcttgaccactccaaggaccctggagcactcatg
tttcctatctacacctacaccggcaaaagccactttatgcttcctgatgacgatgtacaa
gggatccagtctctctatggtccaggagatgaagaccccaaccctaaacatccaaaaacg
ccagacaaatgtgacccttccttatcccttgatgccattaccagtctccgaggagaaaca
atgatctttaaagacagattcttctggcgcctgcatcctcagcaggttgatgcggagctg
tttttaacgaaatcattttggccagaacttcccaaccgtattgatgctgcatatgagcac
ccttctcatgacctcatcttcatcttcagaggtagaaaattttgggctcttaatggttat
gacattctggaaggttatcccaaaaaaatatctgaactgggtcttccaaaagaagttaag
aagataagtgcagctgttcactttgaggatacaggcaagactctcctgttctcaggaaac
caggtctggagatatgatgatactaaccatattatggataaagactatccgagactaata
gaagaagacttcccaggaattggtgataaagtagatgctgtctatgagaaaaatggttat
atctattttttcaacggacccatacagtttgaatacagcatctggagtaaccgtattgtt
cgcgtcatgccagcaaattccattttgtggtgttaa
DBGET
integrated database retrieval system
