KEGG   Homo sapiens (human): 4543
Entry
4543              CDS       T01001                                 

Gene name
MTNR1A, MEL-1A-R, MT1
Definition
(RefSeq) melatonin receptor 1A
  KO
K04285  melatonin receptor type 1A
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04713  Circadian entrainment
Drug target
Agomelatine: D02578
Melatonin: D08170<JP>
Ramelteon: D02689<JP/US>
Tasimelteon: D09388<US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    4543 (MTNR1A)
 09150 Organismal Systems
  09159 Environmental adaptation
   04713 Circadian entrainment
    4543 (MTNR1A)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    4543 (MTNR1A)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Others
   Melatonin
    4543 (MTNR1A)
SSDB
Motif
Pfam: 7tm_1 7TM_GPCR_Srx 7TM_GPCR_Srsx 7tm_4 TctB
Other DBs
NCBI-GeneID: 4543
NCBI-ProteinID: NP_005949
OMIM: 600665
HGNC: 7463
Ensembl: ENSG00000168412
Vega: OTTHUMG00000185575
Pharos: P48039(Tclin)
UniProt: P48039
LinkDB
Position
4q35.2
AA seq 350 aa
MQGNGSALPNASQPVLRGDGARPSWLASALACVLIFTIVVDILGNLLVILSVYRNKKLRN
AGNIFVVSLAVADLVVAIYPYPLVLMSIFNNGWNLGYLHCQVSGFLMGLSVIGSIFNITG
IAINRYCYICHSLKYDKLYSSKNSLCYVLLIWLLTLAAVLPNLRAGTLQYDPRIYSCTFA
QSVSSAYTIAVVVFHFLVPMIIVIFCYLRIWILVLQVRQRVKPDRKPKLKPQDFRNFVTM
FVVFVLFAICWAPLNFIGLAVASDPASMVPRIPEWLFVASYYMAYFNSCLNAIIYGLLNQ
NFRKEYRRIIVSLCTARVFFVDSSNDVADRVKWKPSPLMTNNNVVKVDSV
NT seq 1053 nt   +upstreamnt  +downstreamnt
atgcagggcaacggcagcgcgctgcccaacgcctcccagcccgtgctccgcggggacggc
gcgcggccctcgtggctggcgtccgccctggcctgcgtcctcatcttcaccatcgtggtg
gacatcctgggcaacctcctggtcatcctgtcggtgtatcggaacaagaagctcaggaac
gcaggaaacatctttgtggtgagcttagcggtggcagacctggtggtggccatttatccg
tacccgttggtgctgatgtcgatatttaacaacgggtggaacctgggctatctgcactgc
caagtcagtgggttcctgatgggcctgagcgtcatcggctccatattcaacatcaccggc
atcgccatcaaccgctactgctacatctgccacagtctcaagtacgacaaactgtacagc
agcaagaactccctctgctacgtgctcctcatatggctcctgacgctggcggccgtcctg
cccaacctccgtgcagggactctccagtacgacccgaggatctactcgtgcaccttcgcc
cagtccgtcagctccgcctacaccatcgccgtggtggttttccacttcctcgtccccatg
atcatagtcatcttctgttacctgagaatatggatcctggttctccaggtcagacagagg
gtgaaacctgaccgcaaacccaaactgaaaccacaggacttcaggaattttgtcaccatg
tttgtggtttttgtcctttttgccatttgctgggctcctctgaacttcattggcctggcc
gtggcctctgaccccgccagcatggtgcctaggatcccagagtggctgtttgtggccagt
tactacatggcgtatttcaacagctgcctcaatgccattatatacgggctactgaaccaa
aatttcaggaaggaatacaggagaattatagtctcgctctgtacagccagggtgttcttt
gtggacagctctaacgacgtggccgatagggttaaatggaaaccgtctccactgatgacc
aacaataatgtagtaaaggtggactccgtttaa

KEGG   Homo sapiens (human): 4544
Entry
4544              CDS       T01001                                 

Gene name
MTNR1B, FGQTL2, MEL-1B-R, MT2
Definition
(RefSeq) melatonin receptor 1B
  KO
K04286  melatonin receptor type 1B
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04713  Circadian entrainment
Disease
H00409  Type 2 diabetes mellitus
Drug target
Agomelatine: D02578
Melatonin: D08170<JP>
Ramelteon: D02689<JP/US>
Tasimelteon: D09388<US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    4544 (MTNR1B)
 09150 Organismal Systems
  09159 Environmental adaptation
   04713 Circadian entrainment
    4544 (MTNR1B)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    4544 (MTNR1B)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Others
   Melatonin
    4544 (MTNR1B)
SSDB
Motif
Pfam: 7tm_1 7TM_GPCR_Srsx 7TM_GPCR_Srx 7tm_4
Other DBs
NCBI-GeneID: 4544
NCBI-ProteinID: NP_005950
OMIM: 600804
HGNC: 7464
Ensembl: ENSG00000134640
Vega: OTTHUMG00000167364
Pharos: P49286(Tclin)
UniProt: P49286
LinkDB
Position
11q14.3
AA seq 362 aa
MSENGSFANCCEAGGWAVRPGWSGAGSARPSRTPRPPWVAPALSAVLIVTTAVDVVGNLL
VILSVLRNRKLRNAGNLFLVSLALADLVVAFYPYPLILVAIFYDGWALGEEHCKASAFVM
GLSVIGSVFNITAIAINRYCYICHSMAYHRIYRRWHTPLHICLIWLLTVVALLPNFFVGS
LEYDPRIYSCTFIQTASTQYTAAVVVIHFLLPIAVVSFCYLRIWVLVLQARRKAKPESRL
CLKPSDLRSFLTMFVVFVIFAICWAPLNCIGLAVAINPQEMAPQIPEGLFVTSYLLAYFN
SCLNAIVYGLLNQNFRREYKRILLALWNPRHCIQDASKGSHAEGLQSPAPPIIGVQHQAD
AL
NT seq 1089 nt   +upstreamnt  +downstreamnt
atgtcagagaacggctccttcgccaactgctgcgaggcgggcgggtgggcagtgcgcccg
ggctggtcgggggctggcagcgcgcggccctccaggacccctcgacctccctgggtggct
ccagcgctgtccgcggtgctcatcgtcaccaccgccgtggacgtcgtgggcaacctcctg
gtgatcctctccgtgctcaggaaccgcaagctccggaacgcaggtaatttgttcttggtg
agtctggcattggctgacctggtggtggccttctacccctacccgctaatcctcgtggcc
atcttctatgacggctgggccctgggggaggagcactgcaaggccagcgcctttgtgatg
ggcctgagcgtcatcggctctgtcttcaatatcactgccatcgccattaaccgctactgc
tacatctgccacagcatggcctaccaccgaatctaccggcgctggcacacccctctgcac
atctgcctcatctggctcctcaccgtggtggccttgctgcccaacttctttgtggggtcc
ctggagtacgacccacgcatctattcctgcaccttcatccagaccgccagcacccagtac
acggcggcagtggtggtcatccacttcctcctccctatcgctgtcgtgtccttctgctac
ctgcgcatctgggtgctggtgcttcaggcccgcaggaaagccaagccagagagcaggctg
tgcctgaagcccagcgacttgcggagctttctaaccatgtttgtggtgtttgtgatcttt
gccatctgctgggctccacttaactgcatcggcctcgctgtggccatcaacccccaagaa
atggctccccagatccctgaggggctatttgtcactagctacttactggcttatttcaac
agctgcctgaatgccattgtctatgggctcttgaaccaaaacttccgcagggaatacaag
aggatcctcttggccctttggaacccacggcactgcattcaagatgcttccaagggcagc
cacgcggaggggctgcagagcccagctccacccatcattggtgtgcagcaccaggcagat
gctctctag

KEGG   Homo sapiens (human): 9248
Entry
9248              CDS       T01001                                 

Gene name
GPR50, H9, Mel1c
Definition
(RefSeq) G protein-coupled receptor 50
  KO
K04287  G protein-coupled receptor 50
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    9248 (GPR50)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    9248 (GPR50)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Others
   Orphan GPCRs / unclassified GPCRs
    9248 (GPR50)
SSDB
Motif
Pfam: 7tm_1 7TM_GPCR_Srx 7TM_GPCR_Srsx 7tm_4
Other DBs
NCBI-GeneID: 9248
NCBI-ProteinID: NP_004215
OMIM: 300207
HGNC: 4506
Ensembl: ENSG00000102195
Vega: OTTHUMG00000024166
Pharos: Q13585(Tbio)
UniProt: Q13585
LinkDB
Position
Xq28
AA seq 617 aa
MGPTLAVPTPYGCIGCKLPQPEYPPALIIFMFCAMVITIVVDLIGNSMVILAVTKNKKLR
NSGNIFVVSLSVADMLVAIYPYPLMLHAMSIGGWDLSQLQCQMVGFITGLSVVGSIFNIV
AIAINRYCYICHSLQYERIFSVRNTCIYLVITWIMTVLAVLPNMYIGTIEYDPRTYTCIF
NYLNNPVFTVTIVCIHFVLPLLIVGFCYVRIWTKVLAARDPAGQNPDNQLAEVRNFLTMF
VIFLLFAVCWCPINVLTVLVAVSPKEMAGKIPNWLYLAAYFIAYFNSCLNAVIYGLLNEN
FRREYWTIFHAMRHPIIFFSGLISDIREMQEARTLARARAHARDQAREQDRAHACPAVEE
TPMNVRNVPLPGDAAAGHPDRASGHPKPHSRSSSAYRKSASTHHKSVFSHSKAASGHLKP
VSGHSKPASGHPKSATVYPKPASVHFKADSVHFKGDSVHFKPDSVHFKPASSNPKPITGH
HVSAGSHSKSAFSAATSHPKPTTGHIKPATSHAEPTTADYPKPATTSHPKPTAADNPELS
ASHCPEIPAIAHPVSDDSDLPESASSPAAGPTKPAASQLESDTIADLPDPTVVTTSTNDY
HDVVVIDVEDDPDEMAV
NT seq 1854 nt   +upstreamnt  +downstreamnt
atggggcccaccctagcggttcccaccccctatggctgtattggctgtaagctaccccag
ccagaatacccaccggctctaatcatctttatgttctgcgcgatggttatcaccatcgtt
gtagacctaatcggcaactccatggtcattttggctgtgacgaagaacaagaagctccgg
aattctggcaacatcttcgtggtcagtctctctgtggccgatatgctggtggccatctac
ccataccctttgatgctgcatgccatgtccattgggggctgggatctgagccagttacag
tgccagatggtcgggttcatcacagggctgagtgtggtcggctccatcttcaacatcgtg
gcaatcgctatcaaccgttactgctacatctgccacagcctccagtacgaacggatcttc
agtgtgcgcaatacctgcatctacctggtcatcacctggatcatgaccgtcctggctgtc
ctgcccaacatgtacattggcaccatcgagtacgatcctcgcacctacacctgcatcttc
aactatctgaacaaccctgtcttcactgttaccatcgtctgcatccacttcgtcctccct
ctcctcatcgtgggtttctgctacgtgaggatctggaccaaagtgctggcggcccgtgac
cctgcagggcagaatcctgacaaccaacttgctgaggttcgcaattttctaaccatgttt
gtgatcttcctcctctttgcagtgtgctggtgccctatcaacgtgctcactgtcttggtg
gctgtcagtccgaaggagatggcaggcaagatccccaactggctttatcttgcagcctac
ttcatagcctacttcaacagctgcctcaacgctgtgatctacgggctcctcaatgagaat
ttccgaagagaatactggaccatcttccatgctatgcggcaccctatcatattcttctct
ggcctcatcagtgatattcgtgagatgcaggaggcccgtaccctggcccgcgcccgtgcc
catgctcgcgaccaagctcgtgaacaagaccgtgcccatgcctgtcctgctgtggaggaa
accccgatgaatgtccggaatgttccattacctggtgatgctgcagctggccaccccgac
cgtgcctctggccaccctaagccccattccagatcctcctctgcctatcgcaaatctgcc
tctacccaccacaagtctgtctttagccactccaaggctgcctctggtcacctcaagcct
gtctctggccactccaagcctgcctctggtcaccccaagtctgccactgtctaccctaag
cctgcctctgtccatttcaaggctgactctgtccatttcaagggtgactctgtccatttc
aagcctgactctgttcatttcaagcctgcttccagcaaccccaagcccatcactggccac
catgtctctgctggcagccactccaagtctgccttcagtgctgccaccagccaccctaaa
cccaccactggccacatcaagccagctaccagccatgctgagcccaccactgctgactat
cccaagcctgccactaccagccaccctaagcccactgctgctgacaaccctgagctctct
gcctcccattgccccgagatccctgccattgcccaccctgtgtctgacgacagtgacctc
cctgagtcggcctctagccctgccgctgggcccaccaagcctgctgccagccagctggag
tctgacaccatcgctgaccttcctgaccctactgtagtcactaccagtaccaatgattac
catgatgtcgtggttattgatgttgaagatgatcctgatgaaatggctgtgtga

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