Homo sapiens (human): 4615
Entry
4615 CDS
T01001
Gene name
MYD88, MYD88D
Definition
(RefSeq) MYD88 innate immune signal transduction adaptor
KO
K04729
myeloid differentiation primary response protein MyD88
Organism
hsa
Homo sapiens (human)
Pathway
hsa04010
MAPK signaling pathway
hsa04064
NF-kappa B signaling pathway
hsa04620
Toll-like receptor signaling pathway
hsa04621
NOD-like receptor signaling pathway
hsa05132
Salmonella infection
hsa05133
Pertussis
hsa05134
Legionellosis
hsa05135
Yersinia infection
hsa05140
Leishmaniasis
hsa05142
Chagas disease (American trypanosomiasis)
hsa05143
African trypanosomiasis
hsa05144
Malaria
hsa05145
Toxoplasmosis
hsa05152
Tuberculosis
hsa05161
Hepatitis B
hsa05162
Measles
hsa05164
Influenza A
hsa05168
Herpes simplex virus 1 infection
hsa05169
Epstein-Barr virus infection
hsa05170
Human immunodeficiency virus 1 infection
hsa05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
Network
nt06110
MAPK signaling (virus)
nt06121
TLR signaling (virus)
nt06122
IFN signaling (virus)
nt06161
Human immunodeficiency virus type 1 (HIV-1)
nt06162
Hepatitis B virus (HBV)
nt06164
Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165
Epstein-Barr virus (EBV)
nt06168
Herpes simplex virus 1 (HSV-1)
nt06169
Measles virus (MV)
nt06211
Other MAPK signaling
nt06263
Hepatocellular carcinoma
Element
N00186
IL1-IL1R-p38 signaling pathway
N00188
IL1-IL1R-JNK signaling pathway
N00435
TLR2/4-NFKB signaling pathway
N00438
TLR2/4-MAPK signaling pathway
N00549
HBV HBeAg to TLR2/4-NFKB signaling pathway
N00556
HBV HBe to TLR2/4-NFKB signaling pathway
N00558
HBV pol to IFN signaling pathway
N00561
HSV ICP0 to TLR2/4-NFKB signaling pathway
N00690
TLR7/9-IRF7 signaling pathway
Disease
H00721
Pyogenic bacterial infections, recurrent, due to MYD88 deficiency
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
4615 (MYD88)
04064 NF-kappa B signaling pathway
4615 (MYD88)
09150 Organismal Systems
09151 Immune system
04620 Toll-like receptor signaling pathway
4615 (MYD88)
04621 NOD-like receptor signaling pathway
4615 (MYD88)
09160 Human Diseases
09161 Cancer: overview
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
4615 (MYD88)
09171 Infectious disease: bacterial
05132 Salmonella infection
4615 (MYD88)
05135 Yersinia infection
4615 (MYD88)
05133 Pertussis
4615 (MYD88)
05134 Legionellosis
4615 (MYD88)
05152 Tuberculosis
4615 (MYD88)
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
4615 (MYD88)
05162 Measles
4615 (MYD88)
05164 Influenza A
4615 (MYD88)
05161 Hepatitis B
4615 (MYD88)
05168 Herpes simplex virus 1 infection
4615 (MYD88)
05169 Epstein-Barr virus infection
4615 (MYD88)
09174 Infectious disease: parasitic
05144 Malaria
4615 (MYD88)
05145 Toxoplasmosis
4615 (MYD88)
05140 Leishmaniasis
4615 (MYD88)
05142 Chagas disease (American trypanosomiasis)
4615 (MYD88)
05143 African trypanosomiasis
4615 (MYD88)
SSDB
Motif
Pfam:
Death
TIR
TIR_2
Other DBs
NCBI-GeneID:
4615
NCBI-ProteinID:
NP_002459
OMIM:
602170
HGNC:
7562
Ensembl:
ENSG00000172936
Vega:
OTTHUMG00000131083
Pharos:
Q99836
(Tbio)
UniProt:
Q99836
A0A0A0MS70
LinkDB
Structure
PDB:
4EO7
4DOM
3MOP
2Z5V
2JS7
Position
3p22.2
AA seq
296 aa
MAAGGPGAGSAAPVSSTSSLPLAALNMRVRRRLSLFLNVRTQVAADWTALAEEMDFEYLE
IRQLETQADPTGRLLDAWQGRPGASVGRLLELLTKLGRDDVLLELGPSIEEDCQKYILKQ
QQEEAEKPLQVAAVDSSVPRTAELAGITTLDDPLGHMPERFDAFICYCPSDIQFVQEMIR
QLEQTNYRLKLCVSDRDVLPGTCVWSIASELIEKRCRRMVVVVSDDYLQSKECDFQTKFA
LSLSPGAHQKRLIPIKYKAMKKEFPSILRFITVCDYTNPCTKSWFWTRLAKALSLP
NT seq
891 nt
+upstream
nt +downstream
nt
atggctgcaggaggtcccggcgcggggtctgcggccccggtctcctccacatcctccctt
cccctggctgctctcaacatgcgagtgcggcgccgcctgtctctgttcttgaacgtgcgg
acacaggtggcggccgactggaccgcgctggcggaggagatggactttgagtacttggag
atccggcaactggagacacaagcggaccccactggcaggctgctggacgcctggcaggga
cgccctggcgcctctgtaggccgactgctcgagctgcttaccaagctgggccgcgacgac
gtgctgctggagctgggacccagcattgaggaggattgccaaaagtatatcttgaagcag
cagcaggaggaggctgagaagcctttacaggtggccgctgtagacagcagtgtcccacgg
acagcagagctggcgggcatcaccacacttgatgaccccctggggcatatgcctgagcgt
ttcgatgccttcatctgctattgccccagcgacatccagtttgtgcaggagatgatccgg
caactggaacagacaaactatcgactgaagttgtgtgtgtctgaccgcgatgtcctgcct
ggcacctgtgtctggtctattgctagtgagctcatcgaaaagaggtgccgccggatggtg
gtggttgtctctgatgattacctgcagagcaaggaatgtgacttccagaccaaatttgca
ctcagcctctctccaggtgcccatcagaagcgactgatccccatcaagtacaaggcaatg
aagaaagagttccccagcatcctgaggttcatcactgtctgcgactacaccaacccctgc
accaaatcttggttctggactcgccttgccaaggccttgtccctgccctga
DBGET
integrated database retrieval system
