| Entry |
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| Gene name |
MYD88, IMD68, MYD88D
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| Definition |
(RefSeq) MYD88 innate immune signal transduction adaptor
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| KO |
| K04729 | myeloid differentiation primary response protein MyD88 |
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| Organism |
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| Pathway |
| hsa04620 | Toll-like receptor signaling pathway |
| hsa04621 | NOD-like receptor signaling pathway |
| hsa05130 | Pathogenic Escherichia coli infection |
| hsa05168 | Herpes simplex virus 1 infection |
| hsa05170 | Human immunodeficiency virus 1 infection |
| hsa05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer |
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| Network |
nt06110 MAPK signaling (viruses and bacteria) nt06121 TLR signaling (viruses and bacteria) nt06161 Human immunodeficiency virus type 1 (HIV-1) nt06162 Hepatitis B virus (HBV) nt06164 Kaposi sarcoma-associated herpesvirus (KSHV) nt06165 Epstein-Barr virus (EBV) nt06168 Herpes simplex virus 1 (HSV-1) nt06169 Measles virus (MV) nt06211 Other MAPK signaling nt06263 Hepatocellular carcinoma |
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| Element |
| N00186 | IL1-IL1R-p38 signaling pathway |
| N00188 | IL1-IL1R-JNK signaling pathway |
| N00435 | TLR2/4-NFKB signaling pathway |
| N00438 | TLR2/4-MAPK signaling pathway |
| N00549 | HBV HBeAg to TLR2/4-NFKB signaling pathway |
| N00561 | HSV ICP0 to TLR2/4-NFKB signaling pathway |
| N00690 | TLR7/9-IRF7 signaling pathway |
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| Disease |
| H00721 | Pyogenic bacterial infections, recurrent, due to MYD88 deficiency |
| H02424 | Primary central nervous system lymphoma |
| H02434 | Diffuse large B-cell lymphoma, not otherwise specified |
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| Brite |
KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
4615 (MYD88)
04064 NF-kappa B signaling pathway
4615 (MYD88)
09150 Organismal Systems
09151 Immune system
04620 Toll-like receptor signaling pathway
4615 (MYD88)
04621 NOD-like receptor signaling pathway
4615 (MYD88)
09160 Human Diseases
09161 Cancer: overview
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
4615 (MYD88)
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
4615 (MYD88)
05161 Hepatitis B
4615 (MYD88)
05171 Coronavirus disease - COVID-19
4615 (MYD88)
05164 Influenza A
4615 (MYD88)
05162 Measles
4615 (MYD88)
05168 Herpes simplex virus 1 infection
4615 (MYD88)
05169 Epstein-Barr virus infection
4615 (MYD88)
09171 Infectious disease: bacterial
05130 Pathogenic Escherichia coli infection
4615 (MYD88)
05132 Salmonella infection
4615 (MYD88)
05131 Shigellosis
4615 (MYD88)
05135 Yersinia infection
4615 (MYD88)
05133 Pertussis
4615 (MYD88)
05134 Legionellosis
4615 (MYD88)
05152 Tuberculosis
4615 (MYD88)
09174 Infectious disease: parasitic
05144 Malaria
4615 (MYD88)
05145 Toxoplasmosis
4615 (MYD88)
05140 Leishmaniasis
4615 (MYD88)
05142 Chagas disease
4615 (MYD88)
05143 African trypanosomiasis
4615 (MYD88)
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| SSDB |
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| Motif |
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| Other DBs |
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| LinkDB |
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| Structure |
PDB: |
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| Position |
3p22.2
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| AA seq |
296 aa
MAAGGPGAGSAAPVSSTSSLPLAALNMRVRRRLSLFLNVRTQVAADWTALAEEMDFEYLE
IRQLETQADPTGRLLDAWQGRPGASVGRLLELLTKLGRDDVLLELGPSIEEDCQKYILKQ
QQEEAEKPLQVAAVDSSVPRTAELAGITTLDDPLGHMPERFDAFICYCPSDIQFVQEMIR
QLEQTNYRLKLCVSDRDVLPGTCVWSIASELIEKRCRRMVVVVSDDYLQSKECDFQTKFA
LSLSPGAHQKRLIPIKYKAMKKEFPSILRFITVCDYTNPCTKSWFWTRLAKALSLP |
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| NT seq |
891 nt +upstreamnt +downstreamnt
atggctgcaggaggtcccggcgcggggtctgcggccccggtctcctccacatcctccctt
cccctggctgctctcaacatgcgagtgcggcgccgcctgtctctgttcttgaacgtgcgg
acacaggtggcggccgactggaccgcgctggcggaggagatggactttgagtacttggag
atccggcaactggagacacaagcggaccccactggcaggctgctggacgcctggcaggga
cgccctggcgcctctgtaggccgactgctcgagctgcttaccaagctgggccgcgacgac
gtgctgctggagctgggacccagcattgaggaggattgccaaaagtatatcttgaagcag
cagcaggaggaggctgagaagcctttacaggtggccgctgtagacagcagtgtcccacgg
acagcagagctggcgggcatcaccacacttgatgaccccctggggcatatgcctgagcgt
ttcgatgccttcatctgctattgccccagcgacatccagtttgtgcaggagatgatccgg
caactggaacagacaaactatcgactgaagttgtgtgtgtctgaccgcgatgtcctgcct
ggcacctgtgtctggtctattgctagtgagctcatcgaaaagaggtgccgccggatggtg
gtggttgtctctgatgattacctgcagagcaaggaatgtgacttccagaccaaatttgca
ctcagcctctctccaggtgcccatcagaagcgactgatccccatcaagtacaaggcaatg
aagaaagagttccccagcatcctgaggttcatcactgtctgcgactacaccaacccctgc
accaaatcttggttctggactcgccttgccaaggccttgtccctgccctga |
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