KEGG   Homo sapiens (human): 4688Help
Entry
4688              CDS       T01001                                 

Gene name
NCF2, NCF-2, NOXA2, P67-PHOX, P67PHOX
Definition
(RefSeq) neutrophil cytosolic factor 2
  KO
K08010  neutrophil cytosolic factor 2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04145  Phagosome
hsa04380  Osteoclast differentiation
hsa04670  Leukocyte transendothelial migration
hsa05140  Leishmaniasis
hsa05418  Fluid shear stress and atherosclerosis
Disease
H00098  Chronic granulomatous disease
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Cellular Processes
  Transport and catabolism
   04145 Phagosome
    4688 (NCF2)
 Organismal Systems
  Immune system
   04670 Leukocyte transendothelial migration
    4688 (NCF2)
  Development
   04380 Osteoclast differentiation
    4688 (NCF2)
 Human Diseases
  Cardiovascular diseases
   05418 Fluid shear stress and atherosclerosis
    4688 (NCF2)
  Infectious diseases
   05140 Leishmaniasis
    4688 (NCF2)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Phagocytosis
   NADPH oxidase complex
    4688 (NCF2)
 Others
  NADPH oxidases (Nox) and associated proteins
   Nox associated proteins
    4688 (NCF2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: SH3_1 SH3_9 SH3_2 TPR_2 TPR_1 TPR_8 PB1 TPR_12 TPR_16 TPR_17 TPR_9 TPR_11
Motif
Other DBs
NCBI-GeneID: 4688
NCBI-ProteinID: NP_000424
OMIM: 608515
HGNC: 7661
Ensembl: ENSG00000116701
Vega: OTTHUMG00000035329
Pharos: P19878(Tbio)
UniProt: P19878 A0A0S2Z457
LinkDB All DBs
Structure
PDB: 

Position
1q25.3
AA seq 526 aa AA seqDB search
MSLVEAISLWNEGVLAADKKDWKGALDAFSAVQDPHSRICFNIGCMYTILKNMTEAEKAF
TRSINRDKHLAVAYFQRGMLYYQTEKYDLAIKDLKEALIQLRGNQLIDYKILGLQFKLFA
CEVLYNIAFMYAKKEEWKKAEEQLALATSMKSEPRHSKIDKAMECVWKQKLYEPVVIPVG
KLFRPNERQVAQLAKKDYLGKATVVASVVDQDSFSGFAPLQPQAAEPPPRPKTPEIFRAL
EGEAHRVLFGFVPETKEELQVMPGNIVFVLKKGNDNWATVMFNGQKGLVPCNYLEPVELR
IHPQQQPQEESSPQSDIPAPPSSKAPGRPQLSPGQKQKEEPKEVKLSVPMPYTLKVHYKY
TVVMKTQPGLPYSQVRDMVSKKLELRLEHTKLSYRPRDSNELVPLSEDSMKDAWGQVKNY
CLTLWCENTVGDQGFPDEPKESEKADANNQTTEPQLKKGSQVEALFSYEATQPEDLEFQE
GDIILVLSKVNEEWLEGECKGKVGIFPKVFVEDCATTDLESTRREV
NT seq 1581 nt NT seq  +upstreamnt  +downstreamnt
atgtccctggtggaggccatcagcctctggaatgaaggggtgctggcagcggacaagaag
gactggaagggagccctggatgccttcagtgccgtccaggacccccactcccggatttgc
ttcaacattggctgcatgtacactatcctgaagaacatgactgaagcagagaaggccttt
accagaagcattaaccgagacaagcacttggcagtggcttacttccaacgagggatgctc
tactaccagacagagaaatatgatttggctatcaaagaccttaaagaagccttgattcag
cttcgagggaaccagctgatagactataagatcctggggctccagttcaagctgtttgcc
tgtgaggtgttatataacattgctttcatgtatgccaagaaggaggaatggaaaaaagct
gaagaacagttagcattggccacgagcatgaagtctgagcccagacattccaaaatcgac
aaggcgatggagtgtgtctggaagcagaagctatatgagccagtggtgatccctgtgggc
aagctgtttcgaccaaatgagagacaagtggctcagctggccaagaaggattacctaggc
aaggcgacggtcgtggcatctgtggtggatcaagacagtttctctgggtttgcccctctg
caaccacaggcagctgagcctccacccagaccgaaaaccccagagatcttcagggctctg
gaaggggaggctcaccgtgtgctatttgggtttgtgcctgagacaaaagaagagctccag
gtcatgccagggaacattgtctttgtcttgaagaagggcaatgataactgggccacggtc
atgttcaacgggcagaaggggcttgttccctgcaactaccttgaaccagttgagctgcgg
atccaccctcagcagcagccccaggaggaaagctctccgcagtccgacatcccagctcct
cctagttccaaagcccctggaagaccccagctgtcaccaggccagaaacaaaaagaagag
cctaaggaagtgaagctcagtgttcccatgccctacacactcaaggtgcactacaagtac
acggtagtcatgaagactcagcccgggctcccctacagccaggtccgggacatggtgtct
aagaaactggagctccggctggaacacactaagctgagctatcggcctcgggacagcaat
gagctggtgcccctttcagaagacagcatgaaggatgcctggggccaggtgaaaaactac
tgcctgactctgtggtgtgagaacacagtgggtgaccaaggctttccagatgaacccaag
gaaagtgaaaaagctgatgctaataaccagacaacagaacctcagcttaagaaaggcagc
caagtggaggcactcttcagttatgaggctacccaaccagaggacctggagtttcaggaa
ggggatataatcctggtgttatcaaaggtgaatgaagaatggctggaaggggagtgcaaa
gggaaggtgggcattttccccaaagtttttgttgaagactgcgcaactacagatttggaa
agcactcggagagaagtctag

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