KEGG   Homo sapiens (human): 4688
Entry
4688              CDS       T01001                                 

Gene name
NCF2, NCF-2, NOXA2, P67-PHOX, P67PHOX
Definition
(RefSeq) neutrophil cytosolic factor 2
  KO
K08010  neutrophil cytosolic factor 2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04145  Phagosome
hsa04380  Osteoclast differentiation
hsa04670  Leukocyte transendothelial migration
hsa05020  Prion disease
hsa05140  Leishmaniasis
hsa05418  Fluid shear stress and atherosclerosis
Network
nt06415  PI3K signaling
nt06465  Prion disease
  Element
N01204  PRNP-PI3K-NOX2 signaling pathway
N01205  Scrapie conformation PrPSc to PRNP-PI3K-NOX2 signaling pathway
Disease
H00098  Chronic granulomatous disease
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    4688 (NCF2)
 09150 Organismal Systems
  09151 Immune system
   04670 Leukocyte transendothelial migration
    4688 (NCF2)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    4688 (NCF2)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05020 Prion disease
    4688 (NCF2)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    4688 (NCF2)
  09174 Infectious disease: parasitic
   05140 Leishmaniasis
    4688 (NCF2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    4688 (NCF2)
Membrane trafficking [BR:hsa04131]
 Others
  NADPH oxidases (Nox) and associated proteins
   Nox associated proteins
    4688 (NCF2)
SSDB
Motif
Pfam: SH3_1 SH3_9 SH3_2 TPR_2 TPR_1 PB1 TPR_8 TPR_12 TPR_16 TPR_17 TPR_9 TPR_11
Other DBs
NCBI-GeneID: 4688
NCBI-ProteinID: NP_000424
OMIM: 608515
HGNC: 7661
Ensembl: ENSG00000116701
Vega: OTTHUMG00000035329
Pharos: P19878(Tbio)
UniProt: P19878 A0A0S2Z457
LinkDB
Structure
PDB: 

Position
1q25.3
AA seq 526 aa
MSLVEAISLWNEGVLAADKKDWKGALDAFSAVQDPHSRICFNIGCMYTILKNMTEAEKAF
TRSINRDKHLAVAYFQRGMLYYQTEKYDLAIKDLKEALIQLRGNQLIDYKILGLQFKLFA
CEVLYNIAFMYAKKEEWKKAEEQLALATSMKSEPRHSKIDKAMECVWKQKLYEPVVIPVG
KLFRPNERQVAQLAKKDYLGKATVVASVVDQDSFSGFAPLQPQAAEPPPRPKTPEIFRAL
EGEAHRVLFGFVPETKEELQVMPGNIVFVLKKGNDNWATVMFNGQKGLVPCNYLEPVELR
IHPQQQPQEESSPQSDIPAPPSSKAPGRPQLSPGQKQKEEPKEVKLSVPMPYTLKVHYKY
TVVMKTQPGLPYSQVRDMVSKKLELRLEHTKLSYRPRDSNELVPLSEDSMKDAWGQVKNY
CLTLWCENTVGDQGFPDEPKESEKADANNQTTEPQLKKGSQVEALFSYEATQPEDLEFQE
GDIILVLSKVNEEWLEGECKGKVGIFPKVFVEDCATTDLESTRREV
NT seq 1581 nt   +upstreamnt  +downstreamnt
atgtccctggtggaggccatcagcctctggaatgaaggggtgctggcagcggacaagaag
gactggaagggagccctggatgccttcagtgccgtccaggacccccactcccggatttgc
ttcaacattggctgcatgtacactatcctgaagaacatgactgaagcagagaaggccttt
accagaagcattaaccgagacaagcacttggcagtggcttacttccaacgagggatgctc
tactaccagacagagaaatatgatttggctatcaaagaccttaaagaagccttgattcag
cttcgagggaaccagctgatagactataagatcctggggctccagttcaagctgtttgcc
tgtgaggtgttatataacattgctttcatgtatgccaagaaggaggaatggaaaaaagct
gaagaacagttagcattggccacgagcatgaagtctgagcccagacattccaaaatcgac
aaggcgatggagtgtgtctggaagcagaagctatatgagccagtggtgatccctgtgggc
aagctgtttcgaccaaatgagagacaagtggctcagctggccaagaaggattacctaggc
aaggcgacggtcgtggcatctgtggtggatcaagacagtttctctgggtttgcccctctg
caaccacaggcagctgagcctccacccagaccgaaaaccccagagatcttcagggctctg
gaaggggaggctcaccgtgtgctatttgggtttgtgcctgagacaaaagaagagctccag
gtcatgccagggaacattgtctttgtcttgaagaagggcaatgataactgggccacggtc
atgttcaacgggcagaaggggcttgttccctgcaactaccttgaaccagttgagctgcgg
atccaccctcagcagcagccccaggaggaaagctctccgcagtccgacatcccagctcct
cctagttccaaagcccctggaagaccccagctgtcaccaggccagaaacaaaaagaagag
cctaaggaagtgaagctcagtgttcccatgccctacacactcaaggtgcactacaagtac
acggtagtcatgaagactcagcccgggctcccctacagccaggtccgggacatggtgtct
aagaaactggagctccggctggaacacactaagctgagctatcggcctcgggacagcaat
gagctggtgcccctttcagaagacagcatgaaggatgcctggggccaggtgaaaaactac
tgcctgactctgtggtgtgagaacacagtgggtgaccaaggctttccagatgaacccaag
gaaagtgaaaaagctgatgctaataaccagacaacagaacctcagcttaagaaaggcagc
caagtggaggcactcttcagttatgaggctacccaaccagaggacctggagtttcaggaa
ggggatataatcctggtgttatcaaaggtgaatgaagaatggctggaaggggagtgcaaa
gggaaggtgggcattttccccaaagtttttgttgaagactgcgcaactacagatttggaa
agcactcggagagaagtctag

DBGET integrated database retrieval system