KEGG   Homo sapiens (human): 4791Help
Entry
4791              CDS       T01001                                 

Gene name
NFKB2, CVID10, H2TF1, LYT-10, LYT10, NF-kB2, p100, p49/p100, p52
Definition
(RefSeq) nuclear factor kappa B subunit 2
  KO
K04469  nuclear factor of kappa light polypeptide gene enhancer in B-cells 2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04010  MAPK signaling pathway
hsa04064  NF-kappa B signaling pathway
hsa04380  Osteoclast differentiation
hsa04625  C-type lectin receptor signaling pathway
hsa05134  Legionellosis
hsa05166  Human T-cell leukemia virus 1 infection
hsa05169  Epstein-Barr virus infection
hsa05200  Pathways in cancer
hsa05203  Viral carcinogenesis
hsa05224  Breast cancer
Network
nt06123  TNF signaling (virus)
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06223  TNF-NFKB signaling
  Element
N00505  CD40-NFKB signaling pathway
N00506  HTLV-1 Tax to CD40-NFKB signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    4791 (NFKB2)
   04064 NF-kappa B signaling pathway
    4791 (NFKB2)
 09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    4791 (NFKB2)
  09158 Development
   04380 Osteoclast differentiation
    4791 (NFKB2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    4791 (NFKB2)
   05203 Viral carcinogenesis
    4791 (NFKB2)
  09162 Cancer: specific types
   05224 Breast cancer
    4791 (NFKB2)
  09171 Infectious disease: bacterial
   05134 Legionellosis
    4791 (NFKB2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    4791 (NFKB2)
   05169 Epstein-Barr virus infection
    4791 (NFKB2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    4791 (NFKB2)
Transcription factors [BR:hsa03000]
 Eukaryotic Type
  beta-Scaffold factors with minor groove contacts
   RHR (Rel homology region) Rel/Ankyrin
    4791 (NFKB2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: RHD_DNA_bind RHD_dimer Ank_2 Ank Ank_3 Ank_5 Ank_4 Death
Motif
Other DBs
NCBI-GeneID: 4791
NCBI-ProteinID: NP_001070962
OMIM: 164012
HGNC: 7795
Ensembl: ENSG00000077150
Vega: OTTHUMG00000018962
Pharos: Q00653(Tchem)
UniProt: Q00653
LinkDB All DBs
Structure
PDB: 

Position
10q24.32
AA seq 900 aa AA seqDB search
MESCYNPGLDGIIEYDDFKLNSSIVEPKEPAPETADGPYLVIVEQPKQRGFRFRYGCEGP
SHGGLPGASSEKGRKTYPTVKICNYEGPAKIEVDLVTHSDPPRAHAHSLVGKQCSELGIC
AVSVGPKDMTAQFNNLGVLHVTKKNMMGTMIQKLQRQRLRSRPQGLTEAEQRELEQEAKE
LKKVMDLSIVRLRFSAFLRASDGSFSLPLKPVISQPIHDSKSPGASNLKISRMDKTAGSV
RGGDEVYLLCDKVQKDDIEVRFYEDDENGWQAFGDFSPTDVHKQYAIVFRTPPYHKMKIE
RPVTVFLQLKRKRGGDVSDSKQFTYYPLVEDKEEVQRKRRKALPTFSQPFGGGSHMGGGS
GGAAGGYGGAGGGGSLGFFPSSLAYSPYQSGAGPMGCYPGGGGGAQMAATVPSRDSGEEA
AEPSAPSRTPQCEPQAPEMLQRAREYNARLFGLAQRSARALLDYGVTADARALLAGQRHL
LTAQDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLHQTPLHLAVITGQT
SVVSFLLRVGADPALLDRHGDSAMHLALRAGAGAPELLRALLQSGAPAVPQLLHMPDFEG
LYPVHLAVRARSPECLDLLVDSGAEVEATERQGGRTALHLATEMEELGLVTHLVTKLRAN
VNARTFAGNTPLHLAAGLGYPTLTRLLLKAGADIHAENEEPLCPLPSPPTSDSDSDSEGP
EKDTRSSFRGHTPLDLTCSTKVKTLLLNAAQNTMEPPLTPPSPAGPGLSLGDTALQNLEQ
LLDGPEAQGSWAELAERLGLRSLVDTYRQTTSPSGSLLRSYELAGGDLAGLLEALSDMGL
EEGVRLLRGPETRDKLPSTAEVKEDSAYGSQSVEQEAEKLGPPPEPPGGLCHGHPQPQVH
NT seq 2703 nt NT seq  +upstreamnt  +downstreamnt
atggagagttgctacaacccaggtctggatggtattattgaatatgatgatttcaaattg
aactcctccattgtggaacccaaggagccagccccagaaacagctgatggcccctacctg
gtgatcgtggaacagcctaagcagagaggcttccgatttcgatatggctgtgaaggcccc
tcccatggaggactgcccggtgcctccagtgagaagggccgaaagacctatcccactgtc
aagatctgtaactacgagggaccagccaagatcgaggtggacctggtaacacacagtgac
ccacctcgtgctcatgcccacagtctggtgggcaagcaatgctcggagctggggatctgc
gccgtttctgtggggcccaaggacatgactgcccaatttaacaacctgggtgtcctgcat
gtgactaagaagaacatgatggggactatgatacaaaaacttcagaggcagcggctccgc
tctaggccccagggccttacggaggccgagcagcgggagctggagcaagaggccaaagaa
ctgaagaaggtgatggatctgagtatagtgcggctgcgcttctctgccttccttagagcc
agtgatggctccttctccctgcccctgaagccagtcatctcccagcccatccatgacagc
aaatctccgggggcatcaaacctgaagatttctcgaatggacaagacagcaggctctgtg
cggggtggagatgaagtttatctgctttgtgacaaggtgcagaaagatgacattgaggtt
cggttctatgaggatgatgagaatggatggcaggcctttggggacttctctcccacagat
gtgcataaacagtatgccattgtgttccggacacccccctatcacaagatgaagattgag
cggcctgtaacagtgtttctgcaactgaaacgcaagcgaggaggggacgtgtctgattcc
aaacagttcacctattaccctctggtggaagacaaggaagaggtgcagcggaagcggagg
aaggccttgcccaccttctcccagcccttcgggggtggctcccacatgggtggaggctct
gggggtgcagccgggggctacggaggagctggaggaggtggcagcctcggtttcttcccc
tcctccctggcctacagcccctaccagtccggcgcgggccccatgggctgctacccggga
ggcgggggcggggcgcagatggccgccacggtgcccagcagggactccggggaggaagcc
gcggagccgagcgccccctccaggaccccccagtgcgagccgcaggccccggagatgctg
cagcgagctcgagagtacaacgcgcgcctgttcggcctggcgcagcgcagcgcccgagcc
ctactcgactacggcgtcaccgcggacgcgcgcgcgctgctggcgggacagcgccacctg
ctgacggcgcaggacgagaacggagacacaccactgcacctagccatcatccacgggcag
accagtgtcattgagcagatagtctatgtcatccaccacgcccaggacctcggcgttgtc
aacctcaccaaccacctgcaccagacgcccctgcacctggcggtgatcacggggcagacg
agtgtggtgagctttctgctgcgggtaggtgcagacccagctctgctggatcggcatgga
gactcagccatgcatctggcgctgcgggcaggcgctggtgctcctgagctgctgcgtgca
ctgcttcagagtggagctcctgctgtgccccagctgttgcatatgcctgactttgaggga
ctgtatccagtacacctggcggtccgagcccgaagccctgagtgcctggatctgctggtg
gacagtggggctgaagtggaggccacagagcggcaggggggacgaacagccttgcatcta
gccacagagatggaggagctggggttggtcacccatctggtcaccaagctccgggccaac
gtgaacgctcgcacctttgcgggaaacacacccctgcacctggcagctggactggggtac
ccgaccctcacccgcctccttctgaaggctggtgctgacatccatgctgaaaacgaggag
cccctgtgcccactgccttcaccccctacctctgatagcgactcggactctgaagggcct
gagaaggacacccgaagcagcttccggggccacacgcctcttgacctcacttgcagcacc
aaggtgaagaccttgctgctaaatgctgctcagaacaccatggagccacccctgaccccg
cccagcccagcagggccgggactgtcacttggtgatacagctctgcagaacctggagcag
ctgctagacgggccagaagcccagggcagctgggcagagctggcagagcgtctggggctg
cgcagcctggtagacacgtaccgacagacaacctcacccagtggcagcctcctgcgcagc
tacgagctggctggcggggacctggcaggtctactggaggccctgtctgacatgggccta
gaggagggagtgaggctgctgaggggtccagaaacccgagacaagctgcccagcacagca
gaggtgaaggaagacagtgcgtacgggagccagtcagtggagcaggaggcagagaagctg
ggcccaccccctgagccaccaggagggctctgccacgggcacccccagcctcaggtgcac
tga

KEGG   Homo sapiens (human): 5971Help
Entry
5971              CDS       T01001                                 

Gene name
RELB, I-REL, IMD53, IREL, REL-B
Definition
(RefSeq) RELB proto-oncogene, NF-kB subunit
  KO
K09253  transcription factor RelB
Organism
hsa  Homo sapiens (human)
Pathway
hsa04010  MAPK signaling pathway
hsa04064  NF-kappa B signaling pathway
hsa04380  Osteoclast differentiation
hsa04625  C-type lectin receptor signaling pathway
hsa05166  Human T-cell leukemia virus 1 infection
hsa05169  Epstein-Barr virus infection
Network
nt06123  TNF signaling (virus)
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06223  TNF-NFKB signaling
  Element
N00505  CD40-NFKB signaling pathway
N00506  HTLV-1 Tax to CD40-NFKB signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    5971 (RELB)
   04064 NF-kappa B signaling pathway
    5971 (RELB)
 09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    5971 (RELB)
  09158 Development
   04380 Osteoclast differentiation
    5971 (RELB)
 09160 Human Diseases
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    5971 (RELB)
   05169 Epstein-Barr virus infection
    5971 (RELB)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    5971 (RELB)
Transcription factors [BR:hsa03000]
 Eukaryotic Type
  beta-Scaffold factors with minor groove contacts
   RHR (Rel homology region) Rel/Ankyrin
    5971 (RELB)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: RelB_transactiv RHD_DNA_bind RelB_leu_zip RHD_dimer
Motif
Other DBs
NCBI-GeneID: 5971
NCBI-ProteinID: NP_006500
OMIM: 604758
HGNC: 9956
Ensembl: ENSG00000104856
Vega: OTTHUMG00000162116
Pharos: Q01201(Tbio)
UniProt: Q01201
LinkDB All DBs
Position
19q13.32
AA seq 579 aa AA seqDB search
MLRSGPASGPSVPTGRAMPSRRVARPPAAPELGALGSPDLSSLSLAVSRSTDELEIIDEY
IKENGFGLDGGQPGPGEGLPRLVSRGAASLSTVTLGPVAPPATPPPWGCPLGRLVSPAPG
PGPQPHLVITEQPKQRGMRFRYECEGRSAGSILGESSTEASKTLPAIELRDCGGLREVEV
TACLVWKDWPHRVHPHSLVGKDCTDGICRVRLRPHVSPRHSFNNLGIQCVRKKEIEAAIE
RKIQLGIDPYNAGSLKNHQEVDMNVVRICFQASYRDQQGQMRRMDPVLSEPVYDKKSTNT
SELRICRINKESGPCTGGEELYLLCDKVQKEDISVVFSRASWEGRADFSQADVHRQIAIV
FKTPPYEDLEIVEPVTVNVFLQRLTDGVCSEPLPFTYLPRDHDSYGVDKKRKRGMPDVLG
ELNSSDPHGIESKRRKKKPAILDHFLPNHGSGPFLPPSALLPDPDFFSGTVSLPGLEPPG
GPDLLDDGFAYDPTAPTLFTMLDLLPPAPPHASAVVCSGGAGAVVGETPGPEPLTLDSYQ
APGPGDGGTASLVGSNMFPNHYREAAFGGGLLSPGPEAT
NT seq 1740 nt NT seq  +upstreamnt  +downstreamnt
atgcttcggtctgggccagcctctgggccgtccgtccccactggccgggccatgccgagt
cgccgcgtcgccagaccgccggctgcgccggagctgggggccttagggtcccccgacctc
tcctcactctcgctcgccgtttccaggagcacagatgaattggagatcatcgacgagtac
atcaaggagaacggcttcggcctggacgggggacagccgggcccgggcgaggggctgcca
cgcctggtgtctcgcggggctgcgtccctgagcacggtcaccctgggccctgtggcgccc
ccagccacgccgccgccttggggctgccccctgggccgactagtgtccccagcgccgggc
ccgggcccgcagccgcacctggtcatcacggagcagcccaagcagcgcggcatgcgcttc
cgctacgagtgcgagggccgctcggccggcagcatccttggggagagcagcaccgaggcc
agcaagacgctgcccgccatcgagctccgggattgtggagggctgcgggaggtggaggtg
actgcctgcctggtgtggaaggactggcctcaccgagtccacccccacagcctcgtgggg
aaagactgcaccgacggcatctgcagggtgcggctccggcctcacgtcagcccccggcac
agttttaacaacctgggcatccagtgtgtgaggaagaaggagattgaggctgccattgag
cggaagattcaactgggcattgacccctacaacgctgggtccctgaagaaccatcaggaa
gtagacatgaatgtggtgaggatctgcttccaggcctcatatcgggaccagcagggacag
atgcgccggatggatcctgtgctttccgagcccgtctatgacaagaaatccacaaacaca
tcagagctgcggatttgccgaattaacaaggaaagcgggccgtgcaccggtggcgaggag
ctctacttgctctgcgacaaggtgcagaaagaggacatatcagtggtgttcagcagggcc
tcctgggaaggtcgggctgacttctcccaggccgacgtgcaccgccagattgccattgtg
ttcaagacgccgccctacgaggacctggagattgtcgagcccgtgacagtcaacgtcttc
ctgcagcggctcaccgatggggtctgcagcgagccattgcctttcacgtacctgcctcgc
gaccatgacagctacggcgtggacaagaagcggaaacgggggatgcccgacgtccttggg
gagctgaacagctctgacccccatggcatcgagagcaaacggcggaagaaaaagccggcc
atcctggaccacttcctgcccaaccacggctcaggcccgttcctcccgccgtcagccctg
ctgccagaccctgacttcttctctggcaccgtgtccctgcccggcctggagccccctggc
gggcctgacctcctggacgatggctttgcctacgaccctacggcccccacactcttcacc
atgctggacctgctgcccccggcaccgccacacgctagcgctgttgtgtgcagcggaggt
gccggggccgtggttggggagacccccggccctgaaccactgacactggactcgtaccag
gccccgggccccggggatggaggcaccgccagccttgtgggcagcaacatgttccccaat
cattaccgcgaggcggcctttgggggcggcctcctatccccggggcctgaagccacgtag

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